RUNX1
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Homo sapiens |
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RUNX1 is differentially expressed in 422 experiments: 188 organism parts: kidney, bone marrow, ... (186 more);, 322 disease states: normal, glioblastoma, ... (320 more);, 138 cell types 557 cell lines 62 compound treatments and 93 other conditions. |
| Synonyms |
AML1, AMLCR1, PEBP2A2, CBFA2 |
| Orthologs |
ENSCING00000002253
(Ciona intestinalis)
RUNX1
(Danio rerio)
Runx1
(Rattus norvegicus)
RUNX1
(Bos taurus)
Q90813_CHICK
(Gallus gallus)
Runx1
(Mus musculus)
RunxB
(Drosophila melanogaster)
RunxA
(Drosophila melanogaster)
run
(Drosophila melanogaster)
lz
(Drosophila melanogaster)
runx1
(Xenopus laevis)
RUNX1
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0008134, GO:0003677, GO:0003700, GO:0007417, GO:0048666, GO:0042803, GO:0005524, GO:0005509, GO:0005515, GO:0005634, GO:0006355, GO:0006351, GO:0046982, GO:0043231, GO:0045944, GO:0045893, GO:0030182, GO:0030097, GO:0070491, GO:0035162, GO:0060216, GO:0002318, GO:0048266, GO:0030853, GO:0030854, GO:0032526, GO:0045766, GO:0001701, GO:0001889, GO:0048935, GO:0001501, GO:0030099 |
| Gene Ontology Term |
neuron differentiation, DNA binding, protein binding, regulation of transcription, DNA-dependent, transcription, DNA-dependent, intracellular membrane-bounded organelle, transcription factor binding, hemopoiesis, ATP binding, positive regulation of transcription from RNA polymerase II promoter, nucleus, protein heterodimerization activity, neuron development, protein homodimerization activity, positive regulation of transcription, DNA-dependent, calcium ion binding, embryonic hemopoiesis, central nervous system development, peripheral nervous system neuron development, negative regulation of granulocyte differentiation, in utero embryonic development, definitive hemopoiesis, myeloid progenitor cell differentiation, response to retinoic acid, skeletal system development, liver development, positive regulation of granulocyte differentiation, positive regulation of angiogenesis, behavioral response to pain, myeloid cell differentiation, sequence-specific DNA binding transcription factor activity, repressing transcription factor binding |
| InterPro ID |
IPR000040, IPR013524, IPR016554, IPR013711 |
| InterPro Term |
AML1_Runt, AML1/Runt_N, RunxI, TF_Runt-rel_RUNX |
| Ensembl Family |
ENSFM00250000000641 |
| Ensembl Family Description |
RUNT RELATED TRANSCRIPTION FACTOR ACUTE MYELOID LEUKEMIA CORE BINDING FACTOR SUBUNIT ALPHA CBF ALPHA ONCOGENE AML POLYOMAVIRUS ENHANCER BINDING 2 ALPHA SUBUNIT PEA2 ALPHA PEBP2 ALPHA SL3 3 ENHANCER FACTOR 1 ALPHA SUBUNIT SL3/AKV CORE BINDING FACTOR ALPHA |
| Description |
runt-related transcription factor 1 [Source:HGNC Symbol;Acc:10471] |
| EMBL-Bank ID |
S78158, S78159, S60998, S50186, D13979, D43969, D43968, D43967, X79549, S78496, D89788, D89789, D89790, AF129108, AF129107, D10570, AF025841, U19601, X90976, X90979, AF027207, CH471079, L34598, S69002, L21756, D14823, D14822, AP000333, AP000334, AP000332, AP000331, AP000330, AF022141, AP000687, AF015720, AF015723, AF015724, AF015721, AF015722, AF015726, AF015725, AJ229043, S76350, AF015262, S76345, S76346, BC136381, BC136380, AF022794, AF051934, AF020802, AF020801, AF020803, AF020800, BC144053, S74092 |
| Ensembl Protein ID |
ENSP00000388189, ENSP00000409227, ENSP00000351123, ENSP00000405158, ENSP00000340690, ENSP00000300305, ENSP00000395947, ENSP00000382184, ENSP00000382182, ENSP00000382189, ENSP00000319459, ENSP00000438019 |
| UniGene ID |
Hs.536609, Hs.149261, Hs.717697, Hs.589909, Hs.617234, Hs.610169 |
| RefSeq ID |
NP_001001890, NP_001116079, NP_001745, NM_001754, NM_001122607, NM_001001890 |
| Ensembl Gene ID |
ENSG00000159216 |
| HGNC Symbol |
RUNX1 |
| UniProt Accession |
A8MZI9, C9JFJ4, Q01196, C9JK12, C9JWM1, F5H139 |
| Gene-Disease Assocation |
PLATELET DISORDER, FAMILIAL, WITH ASSOCIATED MYELOID MALIGNANCY, LEUKEMIA, ACUTE MYELOID; AML, RHEUMATOID ARTHRITIS; RA |
| Entrez Gene ID |
861 |
| Ensembl Transcript ID |
ENST00000467577, ENST00000467692, ENST00000482318, ENST00000469087, ENST00000431176, ENST00000399237, ENST00000399245, ENST00000399240, ENST00000416754, ENST00000358356, ENST00000460207, ENST00000494829, ENST00000479325, ENST00000468726, ENST00000486278, ENST00000300305, ENST00000475045, ENST00000437180, ENST00000325074, ENST00000344691, ENST00000455571 |
| Design Element |
ENST00000437180, ENST00000399237, 943_at, ENST00000486278, ENST00000469087, ENST00000467692, Hs2.390526.1.S1_3p_at, 211180_x_at, ENST00000344691, 39421_at, 31443_at, ENST00000494829, 211182_x_at, Hs.145090.0.A1_3p_at, 210805_x_at, g966996_3p_a_at, X90976_s_at, 210365_at, Hs.166060.0.S1_3p_at, ENST00000460207, ENST00000399240, ENST00000416754, g1932819_3p_x_at, ENST00000399245, 209360_s_at, 209359_x_at, g1752816_3p_a_at, ENST00000482318, ENST00000455571, 1570350_3p_at, Hs2.377023.1.S1_3p_at, X90978_at, D43968_at, g966994_3p_at, 393_s_at, 780_at, ENST00000300305, 211620_3p_x_at, 79867_at, 208129_x_at, Hs.166060.0.S1_3p_x_at, 2026_at, ENST00000325074, ENST00000468726, ENST00000467577, g1932819_3p_a_at, 1563591_at, 211620_x_at, 211181_x_at, 237697_at, 217263_x_at, 1570350_at, ENST00000431176, ENST00000475045, 210805_3p_x_at, ENST00000479325, ENST00000358356 |
| Search EB-eye |
ENSG00000159216
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