BRAF
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Homo sapiens |
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BRAF is differentially expressed in 278 experiments: 117 organism parts: testis, blood, ... (115 more);, 154 disease states: normal, control, ... (152 more);, 88 cell types 327 cell lines 40 compound treatments and 73 other conditions. |
| Synonyms |
BRAF1 |
| Orthologs |
F6U6W3_CIOIN
(Ciona intestinalis)
BRAF_CHICK
(Gallus gallus)
braf
(Danio rerio)
Braf
(Rattus norvegicus)
F1MDL4_BOVIN
(Bos taurus)
Braf
(Mus musculus)
phl
(Drosophila melanogaster)
braf
(Xenopus laevis)
Q698R1_CANFA
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR001245, IPR017442, IPR000719, IPR002219, IPR020635, IPR003116, IPR020454 |
| Gene Ontology ID |
GO:0009887, GO:0007165, GO:0007264, GO:0007268, GO:0004709, GO:0004713, GO:0005624, GO:0005625, GO:0005524, GO:0005515, GO:0006916, GO:0005737, GO:0005634, GO:0005886, GO:0005829, GO:0004672, GO:0004674, GO:0019717, GO:0005057, GO:0043066, GO:0006468, GO:0000165, GO:0000166, GO:0000186, GO:0046872, GO:0046982, GO:0043524, GO:0051591, GO:0048011, GO:0031434, GO:0043434, GO:0070374, GO:0033138, GO:0035556 |
| Gene Ontology Term |
cytosol, plasma membrane, receptor signaling protein activity, protein binding, cytoplasm, MAP kinase kinase kinase activity, negative regulation of apoptosis, MAPKKK cascade, metal ion binding, protein tyrosine kinase activity, anti-apoptosis, membrane fraction, synaptosome, soluble fraction, activation of MAPKK activity, ATP binding, response to cAMP, small GTPase mediated signal transduction, synaptic transmission, nucleus, protein heterodimerization activity, nucleotide binding, protein serine/threonine kinase activity, signal transduction, organ morphogenesis, protein kinase activity, negative regulation of neuron apoptosis, positive regulation of peptidyl-serine phosphorylation, positive regulation of ERK1 and ERK2 cascade, response to peptide hormone stimulus, nerve growth factor receptor signaling pathway, mitogen-activated protein kinase kinase binding, protein phosphorylation, intracellular signal transduction |
| Ensembl Family |
ENSFM00290000065522 |
| Ensembl Family Description |
SERINE/THREONINE KINASE EC_2.7.11.1 PROTO ONCOGENE RAF |
| InterPro Term |
Prot_kinase_cat_dom, Raf-like_ras-bd, Prot_Kinase_C-like_PE/DAG-bd, DAG/PE-bd, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| Description |
v-raf murine sarcoma viral oncogene homolog B1 [Source:HGNC Symbol;Acc:1097] |
| Ensembl Protein ID |
ENSP00000418033, ENSP00000288602, ENSP00000419060, ENSP00000420119 |
| EMBL-Bank ID |
AM989473, AM989472, BC112079, X65187, GU149303, EU600171, BC101757, AC006006, AC006344, AC006347, M21001, CH236950, M95712, AM989477, AM989476, AM989475, AM989474, HM459603 |
| Ensembl Gene ID |
ENSG00000157764 |
| Gene-Disease Assocation |
LYMPHOMA, NON-HODGKIN, FAMILIAL, CARDIOFACIOCUTANEOUS SYNDROME, LUNG CANCER, COLORECTAL CANCER; CRC, NOONAN SYNDROME 7; NS7, LEOPARD SYNDROME 3 |
| UniGene ID |
Hs.613773, Hs.550061 |
| UniProt Accession |
D7PBN4, P15056, Q75MQ8, E5FF37 |
| RefSeq ID |
NM_004333, NP_004324 |
| HGNC Symbol |
BRAF |
| Entrez Gene ID |
673 |
| Ensembl Transcript ID |
ENST00000288602, ENST00000469930, ENST00000497784, ENST00000496384, ENST00000479537 |
| Design Element |
40306_at, Hs.299137.0.A1_3p_at, Hs.162967.0.A1_3p_at, ENST00000496384, 1654_at, M95712_at, ENST00000288602, 243829_at, 236402_at, 86199_r_at, 91686_at, 206044_s_at, ENST00000497784, ENST00000479537, ENST00000469930, g4757867_3p_a_at |
| Search EB-eye |
ENSG00000157764
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