KIT
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Homo sapiens |
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KIT is differentially expressed in 250 experiments: 87 organism parts: cerebellum, liver, ... (85 more);, 133 disease states: normal, acute myeloid leukemia, ... (131 more);, 90 cell types 329 cell lines 18 compound treatments and 75 other conditions. |
| Synonyms |
SCFR, CD117, C-Kit, PBT |
| Orthologs |
kitb
(Danio rerio)
kita
(Danio rerio)
Kit
(Mus musculus)
F1NKK2_CHICK
(Gallus gallus)
KIT_BOVIN
(Bos taurus)
Kit
(Rattus norvegicus)
Pvr
(Drosophila melanogaster)
NP_001135545.1
(Xenopus laevis)
KIT_CANFA
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0009897, GO:0048066, GO:0048070, GO:0010628, GO:0008284, GO:0009986, GO:0016020, GO:0016021, GO:0007169, GO:0007165, GO:0007286, GO:0007283, GO:0007243, GO:0008584, GO:0004713, GO:0004714, GO:0042803, GO:0005615, GO:0005524, GO:0005515, GO:0004872, GO:0005887, GO:0004672, GO:0004674, GO:0046427, GO:0043069, GO:0019955, GO:0006468, GO:0019827, GO:0000166, GO:0000187, GO:0018108, GO:0046777, GO:0042127, GO:0019221, GO:0043406, GO:0030097, GO:0009314, GO:0035234, GO:0002020, GO:0051091, GO:0002573, GO:0042523, GO:0042511, GO:0042517, GO:0004716, GO:0014068, GO:0002320, GO:0002318, GO:0006687, GO:0005021, GO:0005020, GO:0043552, GO:0043410, GO:0043473, GO:0030318, GO:0010863, GO:0060374, GO:0070662 |
| InterPro ID |
IPR002290, IPR001245, IPR017442, IPR000719, IPR007110, IPR009134, IPR013151, IPR020635, IPR003598, IPR003599, IPR016243, IPR013098 |
| Gene Ontology Term |
positive regulation of JAK-STAT cascade, protein binding, negative regulation of programmed cell death, stem cell maintenance, cytokine-mediated signaling pathway, regulation of cell proliferation, extracellular space, positive regulation of cell proliferation, positive regulation of gene expression, membrane, peptidyl-tyrosine phosphorylation, spermatogenesis, male gonad development, protein tyrosine kinase activity, positive regulation of MAP kinase activity, transmembrane receptor protein tyrosine kinase signaling pathway, external side of plasma membrane, activation of MAPK activity, developmental pigmentation, hemopoiesis, ATP binding, germ cell programmed cell death, integral to plasma membrane, cytokine binding, spermatid development, receptor activity, nucleotide binding, protein serine/threonine kinase activity, transmembrane receptor protein tyrosine kinase activity, protein homodimerization activity, integral to membrane, cell surface, regulation of developmental pigmentation, response to radiation, signal transduction, protein kinase activity, intracellular protein kinase cascade, protease binding, myeloid leukocyte differentiation, positive regulation of tyrosine phosphorylation of Stat1 protein, receptor signaling protein tyrosine kinase activity, melanocyte differentiation, glycosphingolipid metabolic process, myeloid progenitor cell differentiation, lymphoid progenitor cell differentiation, pigmentation, positive regulation of tyrosine phosphorylation of Stat5 protein, positive regulation of MAPKKK cascade, stem cell factor receptor activity, positive regulation of tyrosine phosphorylation of Stat3 protein, protein autophosphorylation, protein phosphorylation, positive regulation of phospholipase C activity, positive regulation of phosphatidylinositol 3-kinase activity, positive regulation of phosphatidylinositol 3-kinase cascade, positive regulation of sequence-specific DNA binding transcription factor activity, vascular endothelial growth factor-activated receptor activity, mast cell differentiation, mast cell proliferation |
| InterPro Term |
Ig_sub, Immunoglobulin, Prot_kinase_cat_dom, Ig-like, Ig_sub2, Ig_I-set, Tyr_kinase_VEGFR_rcpt_N, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Tyr_kinase_CSF1/PDGF_rcpt, Se/Thr_kinase-like_dom |
| Ensembl Family |
ENSFM00440000236844 |
| Ensembl Family Description |
FACTOR RECEPTOR PRECURSOR EC_2.7.10.1 |
| EMBL-Bank ID |
AJ438313, AC092545, GU983671, U63834, X06182, X69304, X69303, X69302, X69301, X69309, X69305, X69306, X69307, X69308, X69314, X69313, X69316, X69315, X69310, X69312, X69311, HM015525, AC006552, FJ189474, AK304031, S67773, FJ177639 |
| UniProt Accession |
B6E0M6, D5LXN2, Q8TCG9, B6DXN3, P10721, F5H8F8 |
| Ensembl Gene ID |
ENSG00000157404 |
| Description |
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog [Source:HGNC Symbol;Acc:6342] |
| UniGene ID |
Hs.479754, Hs.717339 |
| Ensembl Protein ID |
ENSP00000288135, ENSP00000390987, ENSP00000443604 |
| Gene-Disease Assocation |
TESTICULAR TUMORS, LEUKEMIA, ACUTE MYELOID; AML, PIEBALD TRAIT; PBT, GASTROINTESTINAL STROMAL TUMOR; GIST |
| RefSeq ID |
NP_001087241, NP_000213, NM_001093772, NM_000222 |
| Entrez Gene ID |
3815 |
| HGNC Symbol |
KIT |
| Ensembl Transcript ID |
ENST00000288135, ENST00000536403, ENST00000512959, ENST00000412167, ENST00000514582 |
| Design Element |
ENST00000512959, 205051_s_at, 1888_s_at, g4557694_3p_a_at, ENST00000514582, X06182_s_at, ENST00000288135, ENST00000412167, ENST00000536403 |
| Search EB-eye |
ENSG00000157404
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