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AIFM1 Homo sapiens
AIFM1 is differentially expressed in 123 experiments [148 up/135 dn]: 35 organism parts: kidney [3 up/0 dn], peripheral blood [0 up/3 dn], ...; 32 disease states: normal [6 up/9 dn], breast carcinoma [2 up/0 dn], ...; 40 cell types, 26 cell lines, 22 compound treatments and 21 other conditions.
Synonyms AIF, AIFM1, PDCD8
Orthologs AIFM1_RAT (Rattus norvegicus)  wah-1 (Caenorhabditis elegans)  AIF (Drosophila melanogaster)  Aifm1 (Mus musculus)  (Compare orthologs)
InterPro Term FAD-dependent pyridine nucleotide-disulphide oxidoreductase, FAD/NAD-linked reductase, dimerisation, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, Pyridine nucleotide-disulphide oxidoreductase, dimerisation
GO Terms DNA binding, DNA damage response, signal transduction resulting in induction of apoptosis, DNA fragmentation involved in apoptosis, apoptotic chromosome condensation, electron carrier activity
Uniprot O95831  Q1L6K4  Q1L6K6  Q5RZ99  Q5RZA0  Q2QKE4 
Search EB-eye ENSG00000156709
REST API
Expression Summary
230 factor values, click each to filter
Factor Value Factor Up/Down
Legend: - number of studies the gene is up/down in
Normal Disease state
9
6
Kidney Organism part
3
Peripheral blood Organism part
3
None Compound treatment
2
1
Monocyte Cell type
3
Primary Disease staging
3
Bone marrow Organism part
1
2
HeLa Cell line
1
2
SW480 Cell line
2
SW620 Cell line
2
MDA-MB-231 Cell line
2
Invasive ductal carcinoma Histology
2
FLAP Compound treatment
2
0 cm away from the tumor bound... Observation
2
MK886 Compound treatment
2
N/a Test result
2
Not applicable Histology
2
Breast carcinoma Disease state
2
HNRPA2B Compound treatment
2
Uninfected Infection
2
PC3 Cell line
1
1
Testis Organism part
2
Epithelial cell Cell type
2
Control Compound treatment
2
Estrogen receptor 1 positive; ... Test result
2
Stromal cell Cell type
1
1
Lymph node metastasis Disease staging
2
HL-60 Cell line
1
1
Acute promyelocytic leukemia Disease state
1
1
Dendritic cell Cell type
2
Normal Histology
2
Macrophage Cell type
1
1
Pancreas Organism part
2
White blood cells Organism part
1
Glucocorticoid resistant Phenotype
1
Glucocorticoid sensitive Phenotype
1
Pretreatment primary sample Clinical info
1
Rapamycin Compound treatment
1
Benign prostatic hyperplasia Disease state
1
Prostate carcinoma Disease state
1
Primary cells Cell line
1
Dimethyl sulfoxide Compound treatment
1
Lymphatic endothelial cell Cell type
1
Enzo Labeling Protocol type
1
Cervical cancer Disease state
1
Adipose-derived stem cell Cell type
1
M1 macrophage Cell type
1
Skin Organism part
1
Cerebellum Organism part
1
A549 Cell line
1
Hypericin incubated, not irrad... Growth condition
1
Hypericin incubated, irradiate... Growth condition
1
Superior cervical ganglion Organism part
1
HaCaT Cell line
1
Malignant melanoma Disease state
1
U937 Cell line
1
Epidermal keratinocyte Cell type
1
SkinEthic keratinocyte Cell type
1
Superficial transitional cell ... Disease state
1
Training set Population
1
Test set Population
1
Uterine cervix Organism part
1
Prostate Organism part
1
Tumor Organism part
1
Atrial mycocardium Organism part
1
Ventricular myocardium Organism part
1
BT-474 Cell line
1
Vascular smooth muscle cell Cell type
1
HPL1 Cell line
1
Chondrocyte Cell type
1
Monocyte at intermediate diffe... Cell type
1
Interferon-gamma + lipopolysac... Compound treatment
1
Affymetrix Labeling Protocol type
1
M2 macrophage Cell type
1
Testicular seminoma Disease state
1
T3aNxM1 Disease staging
1
Chronic lymphocytic leukemia Disease state
1
T47D Cell line
1
IL-4 Compound treatment
1
Unknown_sex Sex
1
IgV status unknown Genotype
1
Adenocarcinoma Disease state
1
Organism_part Material type
1
Cell Material type
1
Carcinoma in situ lesion Disease state
1
Multiple myeloma Disease state
1
M-CSF Compound treatment
1
Johnsen score count 2: Sertoli... Histology
1
Stage II Disease staging
1
Spermatid Cell type
1
Atrioventricular node Organism part
1
Smooth muscle Organism part
1
Duodenum Organism part
1
Beas2B Cell line
1
CodeLink Labeling Protocol type
1
Astrocyte Cell type
1
17beta-estradiol Compound treatment
1
Native skin Cell type
1
Pan troglodytes Organism
1
Keratinocyte Cell type
1
Kidney cell Cell type
1
CD14+ monocyte Cell type
1
Lung adenocarcinoma Disease state
1
Synovial fluid Organism part
1
Uninfected control RNAi
1
CD3+ CD4+ CD8- CD45RA+ CD62L+ Phenotype
1
Naive T cell Cell type
1
Chronic myelogenous leukemia Disease state
1
Adrenal cortex cell Cell type
1
Seminiferous tubule Organism part
1
Serum starvation synchronizati... Growth condition
1
Psoriatic lesional biopsy Clinical info
1
Uninvolved biopsy Clinical info
1
T3bN0M0 Disease staging
1
Kaposi's sarcoma Disease state
1
Johnsen score count 3.2: Serto... Histology
1
Skeletal muscle Organism part
1
Cartilage Organism part
1
Whole blood Organism part
1
Idiopathic dilated cardiomyopa... Disease state
1
P53 knockdown RNAi
1
Trigeminal ganglion Organism part
1
Blood Organism part
1
MCF7 Cell line
1
Superficial transitional cell ... Disease state
1
X-linked chronic granulomatous Disease state
1
Lung Organism part
1
ERalpha transfected Genotype
1
ERbeta transfected Genotype
1
IgV mutated Genotype
1
Heart Organism part
1
Control for heregulin Compound treatment
1
Epilepsy Disease state
1
Bacterial endotoxin Compound treatment
1
Adult Developmental stage
1
Infant Developmental stage
1
Plasma cell Cell type
1
B lymphocyte Cell type
1
HGF stimulation Growth condition
1
Trichostatin A Compound treatment
1
Carboplatin resistant Test result
1
Carboplatin sensitive Test result
1
Mononuclear cell Cell type
1
Pancreatic cancer Disease state
1
Leydig cell Cell type
1
SsMCF7 Cell line
1
Endometrioid carcinoma Disease state
1
Muscle invasive carcinoma Disease state
1
Female Sex
1
Frontal cortex, superior motor... Organism part
1
Johnsen score count 10: full s... Histology
1
Hydroxyurea Compound treatment
1
Lymph node Organism part
1
Fibroblast Cell type
1
Endothelial cell Cell type
1
White blood cell Cell type
1
Platelet Cell type
1
Ciliary ganglion Organism part
1
Monoclonal gammopathy of undet... Disease state
1
Frontal cortex, primary motor ... Organism part
1
Germ cell Cell type
1
Ultraviolet light Light
1
Secretory cell Cell type
1
SKBR3 Cell line
1
BC-3 Cell line
1
Male Sex
1
Methotrexate Compound treatment
1
Cadmium chloride 2.5-hydrate Compound treatment
1
Nocodazole Compound treatment
1
Geriatric Developmental stage
1
Pediatric Developmental stage
1
Johnsen score count 5: no sper... Histology
1
Kaposi's sarcoma-associated he... Infection
1
T-cell acute lymphoblastic leu... Disease state
1
Ovary Organism part
1
Primary gastric tumor Organism part
1
Anaplastic mixed oligo-astrocy... Disease state
1
B-precursor acute lymphoblasti... Disease state
1
Arsenic oxide Compound treatment
1
Spermatocyte Cell type
1
Estrogen receptor 1 negative; ... Test result
1
Measles virus Chicago-1 strain Infection
1
Neutrophil Cell type
1
IgV unmutated Genotype
1
CD3int CD4+ CD8+ Phenotype
1
Double positive thymocyte Cell type
1
Metastatic Disease staging
1
CD16+ dendritic cell Cell type
1
MCF10A Cell line
1
Tissue culture polystyrene dis... Growth condition
1
Collagen/chondroitin tissue en... Growth condition
1
Neuroblastoma cell Cell type
1
TIVE Cell line
1
Grade IV Tumor grading
1
2,3-dimethoxy-1,4-naphthoquino... Compound treatment
1
Glioblastoma Disease state
1
Heat-killed HL60 cell lysate Infection
1
Control RNAi
1
SIM2s RNAi
1
BDCA3+ dendritic cell Cell type
1
PT1 Disease staging
1
U266 Cell line
1
Clear cell sarcoma of the kidn... Disease state
1
Appendix Organism part
1
Molecular class type 1 Test result
1
Molecular class type 2 Test result
1
Fetal liver Organism part
1
Osteoblast Cell type
1
Ethanol Vehicle
1
Dermatomyositis Disease state
1
Cyclosporin A, mycophenolate m... Clinical treatment
1
Sirolimus, mycophenolate mofet... Clinical treatment
1
Bis [(+)-tartrato] diantimonat... Compound treatment
1
PT2 Disease staging
1
Proliferative Developmental stage
1
Differentiated Developmental stage
1
Primary fibroblast Cell type
1
Benign nevi Disease state
1
Type 2B Histology
1
Fetal lung Organism part
1
Baseline uninfected Disease state
1
Homo sapiens Organism
1
T47-D Cell line
1
Macaca mulatta Organism
1
Cancer20 Replicate
1
17-allylamino-geldanamycin Compound treatment
1
MKN28 Cell line
1
BL41K3 Cell line
1
BJABK3 Cell line
1
GLI60 Cell line
1
Expression Profiles
E-GEOD-5824: Transcription profiling of human Acute Lymphoblastic Leukemia CEM_C1 cells treated with rapamycin identifies rapamycin as a glucocorticoid resistance reversal agent
Experimental Factors
Phenotype Time Clinical info Dose Compound treatment
Show expression profile  /  experiment details

 
E-MEXP-1014: Transcription profiling of two human colon cancer cell lines treated with n-3 PUFA docosahexaenoic acid for 3 different time points
Experimental Factors
Show expression profile  /  experiment details

 
E-AFMX-5: Transcription profiling of human cell lines and tissues (GNF/Novartis)
Experimental Factors
Cell type Organism part Disease state
Show expression profile  /  experiment details

 
E-GEOD-1563: Transcription profiling of human kidney and peripheral blood lymphocytes from kidney transplant patients
Experimental Factors
Clinical info Organism part
Show expression profile  /  experiment details

 
E-GEOD-4646: Transcription profiling of human HUVEC cells infected with Neisseria meningitidis wild type and mutants vs uninfected sampled at 3 time points
Experimental Factors
Time Infection
Show expression profile  /  experiment details

 
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