NOTCH1
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Homo sapiens |
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NOTCH1 is differentially expressed in 240 experiments: 108 organism parts: bone marrow, lung, ... (106 more);, 165 disease states: normal, control, ... (163 more);, 96 cell types 334 cell lines 20 compound treatments and 74 other conditions. |
| Synonyms |
TAN1 |
| Orthologs |
notch1b
(Danio rerio)
Q3MU93_BOVIN
(Bos taurus)
NOTCH1 (2 of 3)
(Danio rerio)
Q2L697_CIOIN
(Ciona intestinalis)
Q9W737_CHICK
(Gallus gallus)
NOTCH1 (3 of 3)
(Danio rerio)
Notch1
(Mus musculus)
Notch1
(Rattus norvegicus)
N
(Drosophila melanogaster)
notch1
(Xenopus laevis)
NOTCH1
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology Term |
neuron differentiation, cytosol, plasma membrane, positive regulation of JAK-STAT cascade, embryo development, negative regulation of transcription, DNA-dependent, protein binding, regulation of transcription, DNA-dependent, cytoplasm, negative regulation of photoreceptor cell differentiation, somatic stem cell division, regulation of cell proliferation, transcription, DNA-dependent, positive regulation of cell proliferation, membrane, negative regulation of apoptosis, Golgi apparatus, foregut morphogenesis, spermatogenesis, positive regulation of BMP signaling pathway, extracellular region, regulation of neurogenesis, cell fate specification, positive regulation of apoptosis, glial cell differentiation, cell differentiation, acrosomal vesicle, positive regulation of neuroblast proliferation, sequence-specific DNA binding, tissue regeneration, Notch receptor processing, endoderm development, positive regulation of transcription from RNA polymerase II promoter, multicellular organismal development, nucleus, epidermis development, heart development, negative regulation of BMP signaling pathway, regulation of gene expression, response to lipopolysaccharide, chromatin DNA binding, receptor activity, immune response, cell fate commitment, Notch signaling pathway, regulation of developmental process, chromatin binding, axonogenesis, integral to membrane, nucleoplasm, negative regulation of transcription from RNA polymerase II promoter, negative regulation of cell differentiation, regulation of transcription from RNA polymerase II promoter, determination of left/right symmetry, epithelial to mesenchymal transition, endoplasmic reticulum lumen, positive regulation of transcription, DNA-dependent, calcium ion binding, positive regulation of epithelial to mesenchymal transition, response to corticosteroid stimulus, Golgi lumen, negative regulation of myoblast differentiation, secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development, oligodendrocyte differentiation, negative regulation of oligodendrocyte differentiation, positive regulation of astrocyte differentiation, regulation of epithelial cell proliferation involved in prostate gland development, positive regulation of glial cell differentiation, in utero embryonic development, embryonic hindlimb morphogenesis, positive regulation of keratinocyte differentiation, cardiac right ventricle formation, negative regulation of osteoblast differentiation, forebrain development, negative regulation of cell-substrate adhesion, negative regulation of calcium ion-dependent exocytosis, auditory receptor cell fate commitment, gene expression, astrocyte differentiation, hair follicle morphogenesis, positive regulation of transcription of Notch receptor target, keratinocyte differentiation, branching morphogenesis of a tube, positive regulation of epithelial cell proliferation, regulation of epithelial cell proliferation, organ regeneration, negative regulation of neuron differentiation, sprouting angiogenesis, anagen, neural tube development, positive regulation of endothelial cell differentiation, lung development, aortic valve morphogenesis, prostate gland epithelium morphogenesis, negative regulation of cell death, neuron fate commitment, liver development, embryonic limb morphogenesis, negative regulation of canonical Wnt receptor signaling pathway, regulation of somitogenesis, sequence-specific DNA binding transcription factor activity, cell differentiation in spinal cord, core promoter binding, regulation of cardioblast proliferation, negative regulation of glial cell proliferation, Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation, negative regulation of pro-B cell differentiation, neuronal stem cell maintenance, MAML1-RBP-Jkappa- ICN1 complex, negative regulation of stem cell differentiation, compartment pattern specification |
| InterPro Term |
Notch_dom, Notch_NOD_dom, Ankyrin_rpt, Ankyrin_rpt-contain_dom, EGF_extracell, EGF, EGF_3, Notch, Notch_NODP_dom, EGF-like, Notch_1, DUF3454_notch, EGF-like_Ca-bd |
| Gene Ontology ID |
GO:0003682, GO:0008284, GO:0016020, GO:0016021, GO:0010468, GO:0003700, GO:0007283, GO:0007275, GO:0007220, GO:0007219, GO:0010001, GO:0009790, GO:0008544, GO:0007368, GO:0007386, GO:0007440, GO:0007492, GO:0042246, GO:0007409, GO:0007507, GO:0030513, GO:0030514, GO:0005509, GO:0005515, GO:0005576, GO:0004872, GO:0006955, GO:0005737, GO:0005634, GO:0005654, GO:0005886, GO:0002052, GO:0005829, GO:0048103, GO:0005788, GO:0005794, GO:0032496, GO:0046427, GO:0043065, GO:0043066, GO:0050767, GO:0050793, GO:0000122, GO:0042127, GO:0006355, GO:0006357, GO:0006351, GO:0001708, GO:0045596, GO:0001837, GO:0045944, GO:0046533, GO:0043565, GO:0031490, GO:0045892, GO:0045893, GO:0001669, GO:0030154, GO:0030182, GO:0045165, GO:0010718, GO:0009912, GO:0010467, GO:0060548, GO:0060528, GO:0007221, GO:0031960, GO:0048708, GO:0048709, GO:0048715, GO:0048711, GO:0048754, GO:0048663, GO:0042640, GO:0003180, GO:0003219, GO:0030900, GO:0002040, GO:0005796, GO:0050678, GO:0050679, GO:0090090, GO:0031069, GO:0031100, GO:0001701, GO:0045603, GO:0045618, GO:0014807, GO:0045662, GO:0045665, GO:0045668, GO:0045687, GO:0001889, GO:0045955, GO:0021915, GO:0060740, GO:0060768, GO:0030324, GO:0030326, GO:0030216, GO:0035116, GO:0010812, GO:0021515, GO:0001047, GO:0003264, GO:0060253, GO:2000737, GO:2000974, GO:0097150, GO:0003270, GO:0002193 |
| InterPro ID |
IPR010660, IPR011656, IPR000742, IPR000800, IPR006209, IPR006210, IPR001881, IPR008297, IPR013111, IPR020683, IPR002110, IPR022362, IPR024600 |
| Ensembl Family |
ENSFM00500000269589 |
| Description |
notch 1 [Source:HGNC Symbol;Acc:7881] |
| EMBL-Bank ID |
M73980, AF308602, AB209873, AL354671, AL592301 |
| UniGene ID |
Hs.495473 |
| Entrez Gene ID |
4851 |
| UniProt Accession |
P46531 |
| Ensembl Gene ID |
ENSG00000148400 |
| Gene-Disease Assocation |
AORTIC VALVE DISEASE |
| RefSeq ID |
NP_060087, NM_017617 |
| Ensembl Protein ID |
ENSP00000277541 |
| HGNC Symbol |
NOTCH1 |
| Ensembl Family Description |
NEUROGENIC LOCUS NOTCH HOMOLOG PRECURSOR NOTCH [CONTAINS NOTCH EXTRACELLULAR TRUNCATION; NOTCH INTRACELLULAR |
| Ensembl Transcript ID |
ENST00000494783, ENST00000277541, ENST00000491649 |
| Design Element |
76569_at, 218902_at, g8923012_3p_at, 86254_r_at, ENST00000491649, 223508_at, gnf1h09127_at, ENST00000494783, ENST00000277541, 65751_at |
| Search EB-eye |
ENSG00000148400
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