CDKN2A
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Homo sapiens |
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CDKN2A is differentially expressed in 300 experiments: 141 organism parts: prostate, lung, ... (139 more);, 240 disease states: normal, acute lymphoblastic leukemia, ... (238 more);, 83 cell types 576 cell lines 32 compound treatments and 77 other conditions. |
| Synonyms |
p16, MTS1, p14, p19, INK4, CDK4I, CDKN2, INK4a, MLM, ARF, p19Arf, p16INK4a, CMM2 |
| Orthologs |
CDKN2A
(Bos taurus)
CDKN2B
(Danio rerio)
Cdkn2a
(Rattus norvegicus)
Cdkn2a
(Mus musculus)
cdkn2b
(Xenopus laevis)
(Compare orthologs)
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| Gene Ontology ID |
GO:0008134, GO:0003677, GO:0008285, GO:0010468, GO:0003700, GO:0010389, GO:0016604, GO:0007049, GO:0007050, GO:0007265, GO:0016301, GO:0008544, GO:0007568, GO:0000080, GO:0000082, GO:0000079, GO:0000075, GO:0004861, GO:0005515, GO:0006919, GO:0006917, GO:0005730, GO:0005737, GO:0005634, GO:0005654, GO:0005829, GO:0048103, GO:0019901, GO:0006469, GO:0050821, GO:0045736, GO:0006309, GO:0031647, GO:0046822, GO:0045786, GO:0006355, GO:0006351, GO:0006364, GO:0000278, GO:0043234, GO:0000209, GO:0045944, GO:0045892, GO:0045893, GO:0030308, GO:0009303, GO:0035019, GO:0060058, GO:0008637, GO:0051444, GO:0007569, GO:0042326, GO:0051059, GO:0051091, GO:0002039, GO:0030889, GO:0001953, GO:0031648, GO:0046825, GO:0070534, GO:0043517, GO:0001652, GO:0070215, GO:0033600, GO:0071158, GO:0034393, GO:0033235, GO:0032088, GO:0033088, GO:0055105, GO:0090399, GO:0090398, GO:2000111, GO:2000774, GO:0035985, GO:0035986 |
| Gene Ontology Term |
cytosol, rRNA processing, negative regulation of cell growth, DNA binding, protein stabilization, negative regulation of transcription, DNA-dependent, protein binding, regulation of transcription, DNA-dependent, cytoplasm, somatic stem cell division, negative regulation of cell proliferation, negative regulation of protein kinase activity, protein complex, transcription, DNA-dependent, mitotic cell cycle, regulation of cyclin-dependent protein kinase activity, regulation of G2/M transition of mitotic cell cycle, cell cycle arrest, regulation of protein stability, activation of caspase activity, G1 phase of mitotic cell cycle, transcription factor binding, regulation of nucleocytoplasmic transport, rRNA transcription, induction of apoptosis, cell cycle, Ras protein signal transduction, positive regulation of transcription from RNA polymerase II promoter, protein kinase binding, G1/S transition of mitotic cell cycle, nucleus, protein polyubiquitination, epidermis development, regulation of gene expression, somatic stem cell maintenance, aging, kinase activity, nuclear body, DNA fragmentation involved in apoptotic nuclear change, nucleoplasm, cell cycle checkpoint, cyclin-dependent protein kinase inhibitor activity, negative regulation of cell cycle, positive regulation of transcription, DNA-dependent, negative regulation of cyclin-dependent protein kinase activity, nucleolus, negative regulation of ubiquitin-protein ligase activity, granular component, cell aging, negative regulation of NF-kappaB transcription factor activity, positive regulation of smooth muscle cell apoptosis, apoptotic mitochondrial changes, MDM2 binding, protein destabilization, positive regulation of apoptosis involved in mammary gland involution, regulation of protein export from nucleus, NF-kappaB binding, negative regulation of phosphorylation, positive regulation of protein sumoylation, p53 binding, positive regulation of cell cycle arrest, negative regulation of B cell proliferation, positive regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of cell-matrix adhesion, negative regulation of mammary gland epithelial cell proliferation, protein K63-linked ubiquitination, sequence-specific DNA binding transcription factor activity, ubiquitin-protein ligase inhibitor activity, replicative senescence, cellular senescence, positive regulation of macrophage apoptosis, positive regulation of sequence-specific DNA binding transcription factor activity, negative regulation of immature T cell proliferation in thymus, positive regulation of cellular senescence, senescence-associated heterochromatin focus formation, senescence-associated heterochromatin focus |
| InterPro Term |
Ankyrin_rpt-contain_dom, Cyclin_kinase-Inhib_2A |
| InterPro ID |
IPR020683, IPR010868 |
| Ensembl Family Description |
CYCLIN DEPENDENT KINASE 4 INHIBITOR B P14 INK4B P15 INK4B |
| Ensembl Family |
ENSFM00500000272520 |
| EMBL-Bank ID |
AF044170, EU038281, BT007020, AJ844636, AF115544, S78535, U12819, U12818, U12820, U26727, BC021998, U38945, L27211, S69822, S69824, S69804, AL449423, CH471071, AB060808, DQ406745, BC015960, DQ318021, X94154, AF527803 |
| Ensembl Protein ID |
ENSP00000355153, ENSP00000418915, ENSP00000307101, ENSP00000369496, ENSP00000394932, ENSP00000432664 |
| UniProt Accession |
A7LNE7, Q9UPB7, Q5ZEY9, Q208B5, Q8N726, P42771, A5X2G7 |
| Entrez Gene ID |
1029 |
| RefSeq ID |
NP_001182061, NM_001195132, NP_478104, NP_478102, NP_000068, NM_000077, NM_058197, NM_058195 |
| Gene-Disease Assocation |
MELANOMA-PANCREATIC CANCER SYNDROME, MELANOMA-ASTROCYTOMA SYNDROME, MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 2; CMM2, LI-FRAUMENI SYNDROME 1; LFS1 |
| Ensembl Gene ID |
ENSG00000147889 |
| HGNC Symbol |
CDKN2A |
| Description |
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) [Source:HGNC Symbol;Acc:1787] |
| Ensembl Transcript ID |
ENST00000530628, ENST00000380151, ENST00000380150, ENST00000497750, ENST00000304494, ENST00000470819, ENST00000494262, ENST00000498124, ENST00000361570, ENST00000446177, ENST00000498628, ENST00000479692 |
| Design Element |
ENST00000530628, g4206166_3p_a_at, 73130_s_at, ENST00000380150, g1353569_3p_a_at, 49757_at, ENST00000497750, ENST00000446177, ENST00000380151, ENST00000479692, ENST00000361570, ENST00000498124, 1713_s_at, 209644_x_at, ENST00000498628, ENST00000470819, U26727_at, g4502748_3p_at, 73132_r_at, g1353569_3p_x_at, 211156_at, 207039_at, ENST00000304494, ENST00000494262 |
| Search EB-eye |
ENSG00000147889
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