EIF2B5
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Homo sapiens |
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EIF2B5 is differentially expressed in 231 experiments: 89 organism parts: trigeminal ganglion, mammary gland, ... (87 more);, 135 disease states: normal, acute myeloid leukemia, ... (133 more);, 68 cell types 288 cell lines 73 compound treatments and 51 other conditions. |
| Synonyms |
EIF-2B, EIF2Bepsilon |
| Orthologs |
GCD6
(Saccharomyces cerevisiae)
EIF2B5
(Bos taurus)
eif2b5
(Danio rerio)
Eif2b5
(Rattus norvegicus)
ENSCING00000000067
(Ciona intestinalis)
ENSCING00000014650
(Ciona intestinalis)
Eif2b5
(Mus musculus)
EIF2B5
(Gallus gallus)
eIF2B-epsilon
(Drosophila melanogaster)
eif2b5
(Xenopus tropicalis)
EIF2B5
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology Term |
cytosol, protein binding, cytoplasm, translation initiation factor binding, RNA metabolic process, response to stress, cellular protein metabolic process, regulation of translation, translation, guanyl-nucleotide exchange factor activity, eukaryotic translation initiation factor 2B complex, translational initiation, nucleus, translation initiation factor activity, transferase activity, binding, response to heat, myelination, cellular response to stimulus, gene expression, astrocyte differentiation, ovarian follicle development, response to peptide hormone stimulus, negative regulation of translational initiation in response to stress, astrocyte development, positive regulation of translational initiation, oligodendrocyte development, response to glucose stimulus |
| Gene Ontology ID |
GO:0016070, GO:0003743, GO:0009408, GO:0016740, GO:0005488, GO:0005515, GO:0006950, GO:0005737, GO:0005634, GO:0005851, GO:0005829, GO:0031369, GO:0005085, GO:0006417, GO:0006413, GO:0006412, GO:0044267, GO:0010467, GO:0009749, GO:0048708, GO:0042552, GO:0014003, GO:0014002, GO:0051716, GO:0045948, GO:0001541, GO:0043434, GO:0032057 |
| Ensembl Family Description |
TRANSLATION INITIATION FACTOR EIF 2B SUBUNIT EPSILON EIF 2B GDP GTP EXCHANGE FACTOR SUBUNIT EPSILON |
| Ensembl Family |
ENSFM00250000005067 |
| InterPro ID |
IPR003307 |
| Description |
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa [Source:HGNC Symbol;Acc:3261] |
| Ensembl Protein ID |
ENSP00000414775, ENSP00000408198, ENSP00000409142, ENSP00000273783, ENSP00000442939 |
| UniGene ID |
Hs.608550, Hs.283551 |
| UniProt Accession |
Q13144, C9JRD9, Q59HD8, E9PC74 |
| RefSeq ID |
NM_003907, NP_003898 |
| EMBL-Bank ID |
AC128714, AC078797, U23028, AC131235, CH471052, AC117455, AB208821, BC013590, AC112643, AC061705, AK091646 |
| Entrez Gene ID |
8893 |
| Ensembl Gene ID |
ENSG00000145191 |
| HGNC Symbol |
EIF2B5 |
| Ensembl Transcript ID |
ENST00000491144, ENST00000491008, ENST00000493740, ENST00000444495, ENST00000471832, ENST00000465218, ENST00000492773, ENST00000273783, ENST00000468748, ENST00000479250, ENST00000432982, ENST00000492226, ENST00000481054, ENST00000484154, ENST00000432569, ENST00000544027, ENST00000498831, ENST00000479833 |
| Gene-Disease Assocation |
LEUKOENCEPHALOPATHY WITH VANISHING WHITE MATTER; VWM |
| InterPro Term |
eIF4-gamma/eIF5/eIF2-epsilon |
| GeneSigDB ID |
20068109-SuppTable3, 15735024-SuppTable2, 18310505-TableS7, 19341462-SuppTable2, 12917485-Table6, 15284076-TableE2, 19218430-TableS3, 16467079-Table3a |
| Design Element |
ENST00000498831, 34758_at, ENST00000492773, ENST00000444495, ENST00000481054, ENST00000492226, 81013_at, Hs2.350779.1.S1_3p_x_at, ENST00000465218, ENST00000491008, ENST00000468748, Hs.2437.0.S1_3p_at, ENST00000493740, ENST00000484154, ENST00000479833, 212351_at, 80651_at, ENST00000432569, ENST00000479250, ENST00000491144, ENST00000471832, ENST00000432982, ENST00000544027, U23028_at, Hs.2437.0.S1_3p_x_at, ENST00000273783, Hs2.350779.1.S1_3p_at |
| EMAGE ID |
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| Search EB-eye |
ENSG00000145191
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