ERBB2
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Homo sapiens |
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ERBB2 is differentially expressed in 293 experiments: 154 organism parts: bone marrow, prostate, ... (152 more);, 193 disease states: normal, prostate carcinoma, ... (191 more);, 96 cell types 461 cell lines 46 compound treatments and 79 other conditions. |
| Synonyms |
NGL, NEU, CD340, HER2, HER-2 |
| Orthologs |
Erbb2
(Mus musculus)
erbb2
(Danio rerio)
ERBB2
(Gallus gallus)
ERBB2
(Bos taurus)
Erbb2
(Rattus norvegicus)
LOC100492078
(Xenopus laevis)
ERBB2_CANFA
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR001245, IPR017442, IPR000719, IPR006211, IPR006212, IPR000494, IPR020635, IPR016245 |
| Gene Ontology ID |
GO:0048015, GO:0003677, GO:0008283, GO:0008284, GO:0009925, GO:0016020, GO:0016021, GO:0008022, GO:0008045, GO:0007173, GO:0007169, GO:0007166, GO:0007165, GO:0010008, GO:0010001, GO:0016323, GO:0016324, GO:0007399, GO:0007422, GO:0007411, GO:0005902, GO:0007507, GO:0007519, GO:0007528, GO:0042493, GO:0048678, GO:0048471, GO:0004713, GO:0004714, GO:0042802, GO:0005524, GO:0005515, GO:0004872, GO:0004888, GO:0005737, GO:0005634, GO:0005886, GO:0004672, GO:0004674, GO:0005006, GO:0043066, GO:0006468, GO:0000166, GO:0045727, GO:0031625, GO:0046777, GO:0006355, GO:0046983, GO:0046982, GO:0051879, GO:0042060, GO:0046579, GO:0043406, GO:0045211, GO:0045121, GO:0030307, GO:0060056, GO:0007167, GO:0060209, GO:0042552, GO:0048485, GO:0004716, GO:0014065, GO:0014068, GO:0030879, GO:0050679, GO:0032570, GO:0019903, GO:0001948, GO:0043125, GO:0019838, GO:0045785, GO:0045765, GO:0032886, GO:0001889, GO:0043235, GO:0043219, GO:0045945, GO:0045943, GO:0043586, GO:0043410, GO:0070372, GO:0033088, GO:0001042 |
| Gene Ontology Term |
plasma membrane, DNA binding, protein binding, positive regulation of translation, regulation of transcription, DNA-dependent, neuromuscular junction development, cytoplasm, microvillus, cell proliferation, epidermal growth factor receptor signaling pathway, wound healing, positive regulation of cell proliferation, membrane, negative regulation of apoptosis, postsynaptic membrane, protein tyrosine kinase activity, positive regulation of MAP kinase activity, membrane raft, transmembrane receptor protein tyrosine kinase signaling pathway, motor axon guidance, endosome membrane, glial cell differentiation, basolateral plasma membrane, identical protein binding, ATP binding, axon guidance, protein dimerization activity, cell surface receptor linked signaling pathway, nucleus, response to axon injury, heart development, protein heterodimerization activity, Hsp90 protein binding, receptor activity, nucleotide binding, protein serine/threonine kinase activity, response to drug, transmembrane receptor protein tyrosine kinase activity, perinuclear region of cytoplasm, nervous system development, apical plasma membrane, integral to membrane, positive regulation of cell growth, protein C-terminus binding, basal plasma membrane, skeletal muscle tissue development, signal transduction, protein kinase activity, peripheral nervous system development, positive regulation of Ras protein signal transduction, ubiquitin protein ligase binding, positive regulation of cell adhesion, receptor signaling protein tyrosine kinase activity, regulation of angiogenesis, myelination, regulation of ERK1 and ERK2 cascade, ErbB-3 class receptor binding, response to progesterone stimulus, mammary gland development, estrus, positive regulation of epithelial cell proliferation, receptor complex, lateral loop, glycoprotein binding, sympathetic nervous system development, growth factor binding, positive regulation of transcription from RNA polymerase I promoter, positive regulation of transcription from RNA polymerase III promoter, regulation of microtubule-based process, liver development, mammary gland involution, protein phosphatase binding, enzyme linked receptor protein signaling pathway, tongue development, positive regulation of MAPKKK cascade, protein autophosphorylation, protein phosphorylation, phosphatidylinositol-mediated signaling, phosphatidylinositol 3-kinase cascade, positive regulation of phosphatidylinositol 3-kinase cascade, negative regulation of immature T cell proliferation in thymus, epidermal growth factor-activated receptor activity, transmembrane signaling receptor activity, RNA polymerase I core binding |
| InterPro Term |
Furin-like_Cys-rich_dom, Prot_kinase_cat_dom, EGF_rcpt_L, Furin_repeat, Tyr_kinase_EGF/ERB/XmrK_rcpt, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| Ensembl Family Description |
RECEPTOR TYROSINE KINASE ERBB PRECURSOR EC_2.7.10.1 PROTO ONCOGENE C ERBB |
| Ensembl Family |
ENSFM00410000138465 |
| Description |
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) [Source:HGNC Symbol;Acc:3430] |
| UniGene ID |
Hs.446352 |
| EMBL-Bank ID |
X03363, AC079199, M12036, AC087491, AK295195, M86910, M95667, AK300321, CH471152, BC167147, M11761, M11763, M11762, M11765, M11764, M11767, M11766, M11730, AY208911, M16791, M16790, M16792, M16789, L29395 |
| RefSeq ID |
NM_001005862, NP_001005862, NM_004448, NP_004439 |
| UniProt Accession |
Q9NP09, B4DTR1, P04626, F5H1T4 |
| HGNC Symbol |
ERBB2 |
| Gene-Disease Assocation |
OVARIAN CANCER, LUNG CANCER, GASTRIC CANCER, GASTRIC CANCER, HEREDITARY DIFFUSE; HDGC, GLIOMA SUSCEPTIBILITY 1; GLM1 |
| Entrez Gene ID |
2064 |
| Ensembl Protein ID |
ENSP00000385185, ENSP00000404047, ENSP00000269571, ENSP00000446382, ENSP00000446466, ENSP00000443562 |
| Ensembl Gene ID |
ENSG00000141736 |
| Ensembl Transcript ID |
ENST00000541774, ENST00000540042, ENST00000406381, ENST00000540147, ENST00000445658, ENST00000269571 |
| Design Element |
ENST00000445658, Hs.241524.0.S1_3p_at, g10181232_3p_a_at, ENST00000540042, 1901_s_at, 210930_3p_s_at, ENST00000269571, ENST00000540147, 216836_s_at, X03363_s_at, 1802_s_at, 210930_s_at, Hs.323910.2.A1_3p_a_at, ENST00000541774, 234354_x_at, 33218_at, ENST00000406381 |
| Search EB-eye |
ENSG00000141736
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