SMAD4
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Homo sapiens |
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SMAD4 is differentially expressed in 316 experiments: 145 organism parts: lung, bone marrow, ... (143 more);, 200 disease states: normal, control, ... (198 more);, 97 cell types 426 cell lines 45 compound treatments and 87 other conditions. |
| Synonyms |
MADH4, DPC4 |
| Orthologs |
B0JYL0_BOVIN
(Bos taurus)
SMAD4_RAT
(Rattus norvegicus)
Smad4
(Mus musculus)
SMAD4 (1 of 2)
(Danio rerio)
ENSCING00000015941
(Ciona intestinalis)
SMAD4 (2 of 2)
(Danio rerio)
Q4H2T4_CIOIN
(Ciona intestinalis)
Med
(Drosophila melanogaster)
smad4
(Xenopus laevis)
Q6JDJ5_CANFA
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology Term |
cytosol, negative regulation of cell growth, DNA binding, negative regulation of transcription, DNA-dependent, protein binding, regulation of transcription, DNA-dependent, cytoplasm, cell proliferation, regulation of cell proliferation, intracellular, negative regulation of cell proliferation, protein complex, transcription, DNA-dependent, developmental growth, BMP signaling pathway, transforming growth factor beta receptor signaling pathway, response to hypoxia, positive regulation of transforming growth factor beta receptor signaling pathway, regulation of transforming growth factor beta receptor signaling pathway, sequence-specific DNA binding, identical protein binding, endoderm development, positive regulation of transcription from RNA polymerase II promoter, centrosome, nucleus, mesoderm development, transcription factor complex, chromatin binding, protein homodimerization activity, SMAD binding, nucleoplasm, gastrulation, regulation of transcription from RNA polymerase II promoter, positive regulation of transcription, DNA-dependent, positive regulation of epithelial to mesenchymal transition, regulation of binding, sebaceous gland development, in utero embryonic development, kidney development, branching involved in ureteric bud morphogenesis, somite rostral/caudal axis specification, response to transforming growth factor beta stimulus, gastrulation with mouth forming second, tissue morphogenesis, activin responsive factor complex, SMAD protein complex assembly, transforming growth factor beta receptor, common-partner cytoplasmic mediator activity, neural crest cell differentiation, negative regulation of cell death, collagen binding, neuron fate commitment, palate development, nephrogenic mesenchyme morphogenesis, formation of anatomical boundary, R-SMAD binding, SMAD protein signal transduction, negative regulation of protein catabolic process, positive regulation of pathway-restricted SMAD protein phosphorylation, I-SMAD binding, metanephric mesenchyme morphogenesis, sequence-specific DNA binding transcription factor activity, core promoter proximal region sequence-specific DNA binding, positive regulation of SMAD protein import into nucleus, protein binding transcription factor activity, transcription regulatory region DNA binding, SMAD protein complex, anterior/posterior pattern specification, regulation of hair follicle development, regulation of transforming growth factor beta2 production |
| Gene Ontology ID |
GO:0003682, GO:0003677, GO:0009952, GO:0008283, GO:0008285, GO:0003700, GO:0007179, GO:0007369, GO:0007492, GO:0007498, GO:0030509, GO:0030511, GO:0048589, GO:0042803, GO:0042802, GO:0005622, GO:0005515, GO:0005737, GO:0005634, GO:0005654, GO:0005667, GO:0005829, GO:0005813, GO:0046332, GO:0042127, GO:0006355, GO:0006357, GO:0006351, GO:0043234, GO:0045944, GO:0043565, GO:0045892, GO:0045893, GO:0001666, GO:0030308, GO:0017015, GO:0010718, GO:0060391, GO:0060395, GO:0060548, GO:0060021, GO:0007183, GO:0072133, GO:0072134, GO:0048859, GO:0048733, GO:0048729, GO:0030616, GO:0048663, GO:0051098, GO:0005518, GO:0014033, GO:0032444, GO:0032525, GO:0042177, GO:0001701, GO:0001702, GO:0032909, GO:0001822, GO:0044212, GO:0001658, GO:0070412, GO:0070411, GO:0010862, GO:0071559, GO:0000987, GO:0000988, GO:0051797, GO:0071141 |
| InterPro Term |
MAD_homology1_Dwarfin-type, SMAD_dom_Dwarfin-type, MAD_homology_MH1 |
| InterPro ID |
IPR001132, IPR013019, IPR003619 |
| Ensembl Family |
ENSFM00420000140579 |
| Ensembl Family Description |
MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4 MAD HOMOLOG 4 MOTHERS AGAINST DPP HOMOLOG 4 DELETION TARGET IN PANCREATIC CARCINOMA 4 SMAD FAMILY MEMBER 4 SMAD 4 SMAD4 |
| EMBL-Bank ID |
AF045439, AF045438, AF045440, AF045441, AF045442, AF045444, AF045443, AF045446, AF045445, AF045447, U44378, BC002379, AB043547, AK290770, CH471096, AC087687, AC091551 |
| RefSeq ID |
NM_005359, NP_005350 |
| Ensembl Protein ID |
ENSP00000409551, ENSP00000381452, ENSP00000341551, ENSP00000443830 |
| Gene-Disease Assocation |
JUVENILE POLYPOSIS/HEREDITARY HEMORRHAGIC TELANGIECTASIA SYNDROME;, PANCREATIC CANCER, COLORECTAL CANCER; CRC, JUVENILE POLYPOSIS SYNDROME; JPS |
| UniProt Accession |
Q13485, Q9BYG6, E7EUB6 |
| UniGene ID |
Hs.707908, Hs.621831, Hs.610854, Hs.75862 |
| Entrez Gene ID |
4089 |
| Ensembl Gene ID |
ENSG00000141646 |
| HGNC Symbol |
SMAD4 |
| Description |
SMAD family member 4 [Source:HGNC Symbol;Acc:6770] |
| Ensembl Transcript ID |
ENST00000452201, ENST00000342988, ENST00000544926, ENST00000398417 |
| Design Element |
57902_at, Hs.75862.0.S2_3p_at, g4885456_3p_a_at, ENST00000398417, 235725_at, 74813_at, ENST00000544926, 509_at, ENST00000452201, 46885_at, Hs.50438.0.A1_3p_at, U44378_at, 36953_at, 510_g_at, 202526_at, 202527_s_at, ENST00000342988, 58962_at |
| Search EB-eye |
ENSG00000141646
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