IGF1R
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Homo sapiens |
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IGF1R is differentially expressed in 362 experiments: 145 organism parts: liver, prostate, ... (143 more);, 228 disease states: normal, glioblastoma, ... (226 more);, 117 cell types 520 cell lines 51 compound treatments and 97 other conditions. |
| Synonyms |
CD221, MGC18216, JTK13, IGFIR, IGFR |
| Orthologs |
F1NG99_CHICK
(Gallus gallus)
igf1rb
(Danio rerio)
IGF1R_BOVIN
(Bos taurus)
Igf1r
(Mus musculus)
igf1ra
(Danio rerio)
Igf1r
(Rattus norvegicus)
InR
(Drosophila melanogaster)
igf1r
(Xenopus laevis)
Q6QHH2_CANFA
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR003961, IPR001245, IPR017442, IPR000719, IPR006211, IPR006212, IPR000494, IPR020635, IPR016246 |
| Gene Ontology Term |
establishment of cell polarity, plasma membrane, protein binding, positive regulation of cell proliferation, membrane, insulin binding, insulin receptor binding, metal ion binding, insulin-like growth factor receptor signaling pathway, protein tyrosine kinase activity, insulin receptor signaling pathway, insulin receptor substrate binding, anti-apoptosis, transmembrane receptor protein tyrosine kinase signaling pathway, insulin-like growth factor binding, identical protein binding, ATP binding, neuron projection, microsome, neuron projection development, integral to plasma membrane, positive regulation of DNA replication, receptor activity, nucleotide binding, immune response, protein serine/threonine kinase activity, transmembrane receptor protein tyrosine kinase activity, negative regulation of protein kinase B signaling cascade, axonogenesis, integral to membrane, negative regulation of MAPKKK cascade, brain development, signal transduction, organ morphogenesis, protein kinase activity, caveola, response to vitamin E, exocrine pancreas development, mammary gland development, positive regulation of cell migration, positive regulation of anti-apoptosis, positive regulation of cytokinesis, insulin-like growth factor I binding, protein tetramerization, prostate gland epithelium morphogenesis, male sex determination, positive regulation of MAPKKK cascade, positive regulation of protein kinase B signaling cascade, positive regulation of DNA metabolic process, protein heterooligomerization, protein autophosphorylation, protein phosphorylation, phosphatidylinositol-mediated signaling, phosphatidylinositol 3-kinase cascade, phosphatidylinositol 3-kinase binding, positive regulation of steroid hormone biosynthetic process, insulin-like growth factor-activated receptor activity |
| Gene Ontology ID |
GO:0009887, GO:0048009, GO:0048015, GO:0008286, GO:0008284, GO:0016020, GO:0016021, GO:0007169, GO:0007165, GO:0007420, GO:0005901, GO:0007409, GO:0004713, GO:0004714, GO:0042802, GO:0005520, GO:0005524, GO:0005515, GO:0004872, GO:0006916, GO:0006955, GO:0005886, GO:0005887, GO:0005792, GO:0004672, GO:0004674, GO:0005158, GO:0006468, GO:0031175, GO:0043005, GO:0000166, GO:0045740, GO:0046872, GO:0046777, GO:0051898, GO:0043560, GO:0043559, GO:0043548, GO:0043409, GO:0030010, GO:0031994, GO:0051262, GO:0051291, GO:0051054, GO:0014065, GO:0030879, GO:0032467, GO:0005010, GO:0031017, GO:0045768, GO:0051897, GO:0043410, GO:0060740, GO:0030335, GO:0030238, GO:0033197, GO:0090031 |
| Ensembl Family Description |
INSULIN RECEPTOR PRECURSOR EC_2.7.10.1 [CONTAINS INSULIN RECEPTOR ALPHA CHAIN; INSULIN RECEPTOR BETA CHAIN] |
| InterPro Term |
Furin-like_Cys-rich_dom, Prot_kinase_cat_dom, EGF_rcpt_L, Furin_repeat, Tyr_kinase_insulin-like_rcpt, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom, Fibronectin_type3 |
| Ensembl Family |
ENSFM00260000050330 |
| EMBL-Bank ID |
AC118660, AC118658, AC055807, AC069029, X04434, BC113612, BC113610, M69229, AY332722, AB425196 |
| UniGene ID |
Hs.643120, Hs.714012, Hs.714162 |
| HGNC Symbol |
IGF1R |
| Ensembl Protein ID |
ENSP00000268035, ENSP00000453007, ENSP00000454115, ENSP00000453630, ENSP00000453180 |
| UniProt Accession |
C9J5X1, P08069 |
| Gene-Disease Assocation |
INSULIN-LIKE GROWTH FACTOR I, RESISTANCE TO |
| Entrez Gene ID |
3480 |
| Description |
insulin-like growth factor 1 receptor [Source:HGNC Symbol;Acc:5465] |
| RefSeq ID |
NM_000875, NP_000866 |
| Ensembl Gene ID |
ENSG00000140443 |
| Ensembl Transcript ID |
ENST00000268035, ENST00000559925, ENST00000559582, ENST00000560972, ENST00000560277, ENST00000560186, ENST00000560343, ENST00000560144, ENST00000560432, ENST00000558762, ENST00000558751, ENST00000557938, ENST00000561049, ENST00000557873, ENST00000558355, ENST00000558947, ENST00000558898 |
| Design Element |
243358_at, Hs.239176.0.S3_3p_at, ENST00000558898, 225330_at, ENST00000268035, 203627_at, ENST00000557873, ENST00000560277, ENST00000558751, ENST00000560432, ENST00000557938, Hs.104679.0.S1_3p_at, ENST00000560972, ENST00000558355, ENST00000560144, 34718_at, 1335_at, 203628_at, 60450_at, Hs.239176.0.S2_3p_at, ENST00000560186, ENST00000559582, 31335_at, ENST00000558762, ENST00000560343, ENST00000561049, g7705673_3p_at, ENST00000559925, 64981_at, 208441_at, 64083_at, X04434_at, Hs.293960.0.A1_3p_at, ENST00000558947 |
| Search EB-eye |
ENSG00000140443
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