RB1
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Homo sapiens |
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RB1 is differentially expressed in 318 experiments: 104 organism parts: liver, blood, ... (102 more);, 199 disease states: normal, Burkitt's lymphoma, ... (197 more);, 104 cell types 435 cell lines 45 compound treatments and 74 other conditions. |
| Synonyms |
RB, OSRC |
| Orthologs |
Rb1
(Rattus norvegicus)
RB1
(Bos taurus)
Rbf
(Drosophila melanogaster)
RB1
(Gallus gallus)
Rbf2
(Drosophila melanogaster)
rb1
(Danio rerio)
Rb1
(Mus musculus)
LOC100493114
(Xenopus laevis)
ENSXETG00000034017
(Xenopus laevis)
Q9N122_CANFA
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0034088, GO:0008134, GO:0003674, GO:0003677, GO:0008285, GO:0003713, GO:0003700, GO:0007050, GO:0007265, GO:0016310, GO:0016301, GO:0007346, GO:0051402, GO:0051219, GO:0051301, GO:0051318, GO:0048667, GO:0048565, GO:0000080, GO:0000082, GO:0000084, GO:0000075, GO:0005515, GO:0005634, GO:0005654, GO:0005667, GO:0005819, GO:0050680, GO:0019900, GO:0000785, GO:0006469, GO:0031175, GO:0031134, GO:0019899, GO:0045749, GO:0031625, GO:0000122, GO:0006338, GO:0045786, GO:0051726, GO:0006355, GO:0006351, GO:0000278, GO:0045944, GO:0045842, GO:0045879, GO:0045892, GO:0045893, GO:0043433, GO:0030182, GO:0030308, GO:0035189, GO:0016605, GO:0016514, GO:0007090, GO:0051146, GO:0030521, GO:0042551, GO:0000083, GO:0050681, GO:0043353, GO:0044419, GO:0045651, GO:0043550, GO:0031575, GO:0071459, GO:0045445, GO:0000279, GO:0001102, GO:0071922, GO:0071930, GO:0090230 |
| Gene Ontology Term |
negative regulation of S phase of mitotic cell cycle, neuron differentiation, negative regulation of cell growth, cell division, phosphorylation, DNA binding, negative regulation of transcription, DNA-dependent, protein binding, regulation of transcription, DNA-dependent, maintenance of mitotic sister chromatid cohesion, negative regulation of cell proliferation, negative regulation of protein kinase activity, transcription, DNA-dependent, negative regulation of smoothened signaling pathway, mitotic cell cycle, kinase binding, cell cycle arrest, cell morphogenesis involved in neuron differentiation, G1 phase of mitotic cell cycle, regulation of mitotic cell cycle, positive regulation of mitotic metaphase/anaphase transition, transcription factor binding, molecular_function, G1 phase, Ras protein signal transduction, sister chromatid biorientation, positive regulation of transcription from RNA polymerase II promoter, spindle, neuron projection development, transcription coactivator activity, regulation of cell cycle, G1/S transition of mitotic cell cycle, nucleus, chromatin remodeling, Rb-E2F complex, kinase activity, transcription factor complex, phosphoprotein binding, chromatin, nucleoplasm, cell cycle checkpoint, negative regulation of transcription from RNA polymerase II promoter, S phase of mitotic cell cycle, negative regulation of epithelial cell proliferation, enzyme binding, negative regulation of cell cycle, neuron apoptosis, positive regulation of transcription, DNA-dependent, digestive tract development, ubiquitin protein ligase binding, androgen receptor binding, androgen receptor signaling pathway, striated muscle cell differentiation, neuron maturation, SWI/SNF complex, enucleate erythrocyte differentiation, myoblast differentiation, regulation of lipid kinase activity, protein localization to chromosome, centromeric region, interspecies interaction between organisms, PML body, regulation of S phase of mitotic cell cycle, positive regulation of macrophage differentiation, sequence-specific DNA binding transcription factor activity, M phase, mitotic cell cycle G1/S transition checkpoint, regulation of transcription involved in G1/S phase of mitotic cell cycle, negative regulation of sequence-specific DNA binding transcription factor activity, regulation of cohesin localization to chromatin, negative regulation of transcription involved in G1/S phase of mitotic cell cycle, RNA polymerase II activating transcription factor binding, regulation of centromere complex assembly |
| InterPro ID |
IPR002719, IPR002720, IPR015030, IPR013763, IPR024599 |
| InterPro Term |
Cyclin-like, RB_A, RB_B, Rb_C, DUF3452_retinoblatoma-assoc |
| Ensembl Family |
ENSFM00250000004695 |
| Ensembl Family Description |
RETINOBLASTOMA ASSOCIATED PRB RB |
| EMBL-Bank ID |
AK291258, X16439, L35146, L35147, M33647, L11910, BC039060, BC040540, AF551763, L41870, L41890, L41891, L41896, L41897, L41898, L41899, L41893, L41894, L41895, L41889, L41908, L41909, L41904, L41912, L41910, L41914, L41997, CH471075, M15400, AK299179, M28419, AL392048, AY643840, L49225, L49232, L49231, M27864, M27865, M27866, M27860, M27862, M27863, M27847, M27846, M27845, M27849, M27857, M27856, M27859, M27858, M27853, M27852, M27855, M27854, M27851, M27850, AL136960, M19701 |
| HGNC Symbol |
RB1 |
| Ensembl Protein ID |
ENSP00000267163, ENSP00000437642, ENSP00000434702 |
| UniProt Accession |
Q6LE81, Q6LE82, Q6LE80, Q6LE77, Q6LE79, Q6LE65, Q6DUF0, Q7KZ60, Q7KZ61, P06400, P78495, B4DRB3, Q92728, F5H6G1 |
| UniGene ID |
Hs.408528, Hs.605217 |
| Description |
retinoblastoma 1 [Source:HGNC Symbol;Acc:9884] |
| Ensembl Gene ID |
ENSG00000139687 |
| Gene-Disease Assocation |
BLADDER CANCER, OSTEOGENIC SARCOMA, SMALL CELL CANCER OF THE LUNG, RETINOBLASTOMA; RB1 |
| RefSeq ID |
NP_000312, NM_000321 |
| Entrez Gene ID |
5925 |
| Ensembl Transcript ID |
ENST00000467505, ENST00000480491, ENST00000542917, ENST00000267163, ENST00000525036, ENST00000531171, ENST00000484879 |
| Design Element |
g4506434_3p_at, 1571_f_at, 203132_at, L49209_s_at, L49229_f_at, ENST00000542917, 1672_f_at, L49218_f_at, ENST00000267163, ENST00000484879, ENST00000525036, L41870_at, ENST00000467505, g190967_3p_a_at, 2044_s_at, ENST00000531171, 211540_s_at, 1905_s_at, ENST00000480491, 1900_at |
| Search EB-eye |
ENSG00000139687
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