BRCA2
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Homo sapiens |
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BRCA2 is differentially expressed in 259 experiments: 94 organism parts: bone marrow, skin, ... (92 more);, 154 disease states: normal, acute lymphoblastic leukemia, ... (152 more);, 74 cell types 313 cell lines 35 compound treatments and 79 other conditions. |
| Synonyms |
FANCD1, BRCC2, FAD1, FACD, FANCD, FAD |
| Orthologs |
Brca2
(Mus musculus)
BRCA2
(Bos taurus)
brca2
(Danio rerio)
BRCA2
(Gallus gallus)
Brca2
(Rattus norvegicus)
brca2
(Xenopus laevis)
NP_001006654.2
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0003697, GO:0008283, GO:0010332, GO:0008630, GO:0007141, GO:0010165, GO:0007283, GO:0008585, GO:0007420, GO:0051276, GO:0007584, GO:0048478, GO:0042771, GO:0005515, GO:0005737, GO:0005634, GO:0006974, GO:0000724, GO:0006302, GO:0006310, GO:0006281, GO:0045931, GO:0001556, GO:0030097, GO:0035264, GO:0010225, GO:0007090, GO:0007569, GO:0030879, GO:0006978, GO:0032465, GO:0043009, GO:0001833, GO:0032355, GO:0031619 |
| Gene Ontology Term |
male meiosis I, double-strand break repair via homologous recombination, protein binding, DNA repair, cytoplasm, cell proliferation, DNA damage response, signal transduction resulting in induction of apoptosis, spermatogenesis, female gonad development, single-stranded DNA binding, double-strand break repair, replication fork protection, multicellular organism growth, response to nutrient, hemopoiesis, positive regulation of mitotic cell cycle, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, nucleus, DNA recombination, oocyte maturation, response to DNA damage stimulus, response to gamma radiation, response to X-ray, brain development, chromosome organization, inner cell mass cell proliferation, cell aging, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, mammary gland development, response to UV-C, chordate embryonic development, regulation of cytokinesis, regulation of S phase of mitotic cell cycle, response to estradiol stimulus, homologous chromosome orientation involved in meiotic metaphase I plate congression |
| InterPro Term |
BRCA2_repeat, DNA_recomb/repair_BRCA2_hlx, DNA_recomb/repair_BRCA2, Tower, BRCA2_OB_1, BRCA2_OB_3 |
| InterPro ID |
IPR002093, IPR015252, IPR015205, IPR015187, IPR015188, IPR011370 |
| Ensembl Family |
ENSFM00250000003235 |
| Ensembl Family Description |
BREAST CANCER TYPE 2 SUSCEPTIBILITY HOMOLOG FANCONI ANEMIA GROUP D1 HOMOLOG |
| Description |
breast cancer 2, early onset [Source:HGNC Symbol;Acc:1101] |
| EMBL-Bank ID |
AF507079, AF507090, AF507089, AF507086, AF507085, AF507088, AF507087, AF507082, AF507081, AF507080, AF507084, AF507083, AL445212, AY151039, AF489726, AF489727, AF489728, AF489729, AF489725, AF489737, AF489736, AF489735, AF489734, AF489738, AF489733, AF489732, AF489731, AF489730, AL137247, AY008850, DQ889340, EU625579 |
| UniProt Accession |
Q9H4L3, B2ZAH0, Q8IU82, Q8IU77, Q8IU64, P51587, E9PIQ1 |
| Ensembl Gene ID |
ENSG00000139618 |
| Ensembl Protein ID |
ENSP00000369497, ENSP00000433168, ENSP00000435699, ENSP00000439902, ENSP00000434898 |
| UniGene ID |
Hs.34012 |
| Gene-Disease Assocation |
PANCREATIC CANCER, PROSTATE CANCER, BREAST CANCER, PANCREATIC CANCER, SUSCEPTIBILITY TO, 2, WILMS TUMOR 1; WT1, GLIOMA SUSCEPTIBILITY 1; GLM1, FANCONI ANEMIA, COMPLEMENTATION GROUP D1; FANCD1, GLIOMA SUSCEPTIBILITY 3; GLM3, BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 2; BROVCA2, MEDULLOBLASTOMA; MDB, FANCONI ANEMIA, COMPLEMENTATION GROUP A; FANCA |
| RefSeq ID |
NP_000050, NM_000059 |
| Entrez Gene ID |
675 |
| HGNC Symbol |
BRCA2 |
| Ensembl Transcript ID |
ENST00000530893, ENST00000380152, ENST00000528762, ENST00000544455, ENST00000470094, ENST00000533776 |
| Design Element |
ENST00000530893, X95152_rna1_at, 214727_at, ENST00000380152, ENST00000544455, 208368_s_at, 1989_at, g4502450_3p_a_at, 1503_at, 208368_3p_s_at, ENST00000528762, ENST00000470094, ENST00000533776, 1990_g_at, Hs.34012.1.S1_3p_at |
| Search EB-eye |
ENSG00000139618
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