ASCL1
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Homo sapiens |
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ASCL1 is differentially expressed in 239 experiments: 155 organism parts: brain, thymus, ... (153 more);, 142 disease states: normal, lung adenocarcinoma, ... (140 more);, 68 cell types 329 cell lines 29 compound treatments and 76 other conditions. |
| Synonyms |
HASH1, ASH1, bHLHa46 |
| Orthologs |
ascl1a
(Danio rerio)
Q4JF73_CIOIN
(Ciona intestinalis)
Ascl1
(Rattus norvegicus)
Ascl1
(Mus musculus)
Q4H3X5_CIOIN
(Ciona intestinalis)
ASCL1
(Bos taurus)
ase
(Drosophila melanogaster)
l(1)sc
(Drosophila melanogaster)
ASCL1
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology Term |
neuron differentiation, pattern specification process, neuroblast proliferation, DNA binding, negative regulation of transcription, DNA-dependent, protein binding, double-stranded DNA binding, regulation of cell proliferation, neurogenesis, transcription, DNA-dependent, negative regulation of apoptosis, positive regulation of Notch signaling pathway, glial cell differentiation, cell differentiation, sequence-specific DNA binding, neuroblast fate determination, positive regulation of transcription from RNA polymerase II promoter, nucleus, regulation of gene expression, regulation of Notch signaling pathway, neuron development, nervous system development, Notch signaling pathway, protein homodimerization activity, central nervous system neuron development, regulation of transcription from RNA polymerase II promoter, bHLH transcription factor binding, neuron migration, neuronal cell body, response to lithium ion, forebrain neuron differentiation, oligodendrocyte differentiation, positive regulation of neuron differentiation, adrenal chromaffin cell differentiation, positive regulation of neurogenesis, cerebral cortex development, spinal cord oligodendrocyte cell fate specification, noradrenergic neuron fate commitment, stomach neuroendocrine cell differentiation, E-box binding, lung neuroendocrine cell differentiation, subpallium neuron fate commitment, carotid body glomus cell differentiation, response to epidermal growth factor stimulus, response to retinoic acid, negative regulation of neuron differentiation, cellular response to magnetism, spinal cord oligodendrocyte cell differentiation, lung epithelial cell differentiation, oligodendrocyte cell fate commitment, olfactory pit development, sympathetic nervous system development, spinal cord association neuron differentiation, neuron fate commitment, positive regulation of neuron apoptosis, oligodendrocyte development, response to folic acid, regulation of timing of subpallium neuron differentiation, neuron fate specification, cerebral cortex GABAergic interneuron differentiation, sequence-specific DNA binding transcription factor activity, transcription factor binding transcription factor activity |
| Gene Ontology ID |
GO:0003677, GO:0003690, GO:0010468, GO:0003700, GO:0022008, GO:0007219, GO:0010001, GO:0007399, GO:0007389, GO:0008593, GO:0007405, GO:0007400, GO:0048666, GO:0042803, GO:0005515, GO:0005634, GO:0043066, GO:0043025, GO:0045747, GO:0001764, GO:0042127, GO:0006357, GO:0006351, GO:0045944, GO:0043565, GO:0045892, GO:0043425, GO:0021954, GO:0030154, GO:0030182, GO:0060487, GO:0010226, GO:0060163, GO:0060165, GO:0060166, GO:0048709, GO:0048663, GO:0048665, GO:0048485, GO:0061102, GO:0061100, GO:0061103, GO:0061104, GO:0014003, GO:0003359, GO:0032526, GO:0050769, GO:0045665, GO:0045666, GO:0043525, GO:0070849, GO:0070888, GO:0051593, GO:0021987, GO:0021892, GO:0021879, GO:0071259, GO:0021779, GO:0021527, GO:0021529, GO:0021530, GO:0000989 |
| InterPro ID |
IPR011598 |
| Ensembl Family Description |
ACHAETE SCUTE HOMOLOG 1 |
| Ensembl Family |
ENSFM00500000273289 |
| InterPro Term |
HLH_DNA-bd |
| EMBL-Bank ID |
BC001638, BC031299, BC002341, BC004425, AK290539, CH471054, L08424, BC003134 |
| Ensembl Gene ID |
ENSG00000139352 |
| UniGene ID |
Hs.703065, Hs.703025 |
| Description |
achaete-scute complex homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:738] |
| UniProt Accession |
P50553 |
| HGNC Symbol |
ASCL1 |
| Ensembl Protein ID |
ENSP00000266744 |
| RefSeq ID |
NM_004316, NP_004307 |
| Entrez Gene ID |
429 |
| Gene-Disease Assocation |
CENTRAL HYPOVENTILATION SYNDROME, CONGENITAL; CCHS |
| Ensembl Transcript ID |
ENST00000266744 |
| Design Element |
209985_s_at, Hs.1619.1.S1_3p_a_at, ENST00000266744, 209988_s_at, 40543_at, g12803078_3p_a_at, g12804462_3p_a_at, 209987_s_at, 40544_g_at, 213768_s_at, L08424_at, 57815_at, Hs.1619.0.A1_3p_a_at |
| Search EB-eye |
ENSG00000139352
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