ADAM10
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Homo sapiens |
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ADAM10 is differentially expressed in 349 experiments: 143 organism parts: liver, lung, ... (141 more);, 244 disease states: normal, control, ... (242 more);, 120 cell types 467 cell lines 52 compound treatments and 88 other conditions. |
| Synonyms |
kuz, CD156c, HsT18717, MADM |
| Orthologs |
adam10a
(Danio rerio)
Adam10
(Mus musculus)
Adam10
(Rattus norvegicus)
ENSCING00000009495
(Ciona intestinalis)
adam10b
(Danio rerio)
ADA10_BOVIN
(Bos taurus)
Q5F3N4_CHICK
(Gallus gallus)
kuz
(Drosophila melanogaster)
adam10
(Xenopus laevis)
Q56JJ2_CANFA
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR001590, IPR002870, IPR001762 |
| Gene Ontology ID |
GO:0008237, GO:0008233, GO:0008284, GO:0009986, GO:0008270, GO:0016021, GO:0007173, GO:0007267, GO:0007220, GO:0007219, GO:0007229, GO:0004222, GO:0004175, GO:0042803, GO:0014069, GO:0005515, GO:0012505, GO:0005737, GO:0005634, GO:0005886, GO:0005794, GO:0005798, GO:0005102, GO:0005178, GO:0006508, GO:0006509, GO:0019901, GO:0006468, GO:0046872, GO:0030307, GO:0017124, GO:0007162, GO:0051088, GO:0051089, GO:0042117, GO:0001701, GO:0030335, GO:0034612, GO:0010820 |
| Gene Ontology Term |
endomembrane system, plasma membrane, protein binding, cytoplasm, metalloendopeptidase activity, epidermal growth factor receptor signaling pathway, Golgi-associated vesicle, positive regulation of cell proliferation, metallopeptidase activity, peptidase activity, SH3 domain binding, Golgi apparatus, membrane protein ectodomain proteolysis, metal ion binding, receptor binding, cell-cell signaling, integrin-mediated signaling pathway, Notch receptor processing, protein kinase binding, nucleus, postsynaptic density, endopeptidase activity, integrin binding, Notch signaling pathway, proteolysis, protein homodimerization activity, integral to membrane, positive regulation of cell growth, cell surface, zinc ion binding, monocyte activation, in utero embryonic development, response to tumor necrosis factor, positive regulation of cell migration, PMA-inducible membrane protein ectodomain proteolysis, positive regulation of T cell chemotaxis, constitutive protein ectodomain proteolysis, negative regulation of cell adhesion, protein phosphorylation |
| Ensembl Family |
ENSFM00390000126345 |
| InterPro Term |
Peptidase_M12B_N, Blood-coag_inhib_Disintegrin, Peptidase_M12B |
| Ensembl Family Description |
DISINTEGRIN AND METALLOPROTEINASE DOMAIN CONTAINING 10 PRECURSOR ADAM 10 EC_3.4.24.81 KUZBANIAN HOMOLOG MAMMALIAN DISINTEGRIN METALLOPROTEASE CD156C ANTIGEN |
| HGNC Symbol |
ADAM10 |
| RefSeq ID |
NP_001101, NM_001110 |
| Ensembl Protein ID |
ENSP00000391930, ENSP00000260408, ENSP00000379444, ENSP00000386056, ENSP00000452704, ENSP00000452639, ENSP00000453952 |
| Ensembl Gene ID |
ENSG00000137845 |
| UniProt Accession |
B5MC71, A8MY20, C9J994, C9J9B4, O14672, B4DU28 |
| EMBL-Bank ID |
AC018904, AK300472, CH471082, AC091046, AF009615, Z48579 |
| Description |
ADAM metallopeptidase domain 10 [Source:HGNC Symbol;Acc:188] |
| UniGene ID |
Hs.578508, Hs.172028 |
| Entrez Gene ID |
102 |
| Ensembl Transcript ID |
ENST00000482945, ENST00000260408, ENST00000396140, ENST00000396136, ENST00000475898, ENST00000497846, ENST00000462061, ENST00000481164, ENST00000470269, ENST00000402627, ENST00000439637, ENST00000461408, ENST00000559053, ENST00000560608, ENST00000558733, ENST00000561288, ENST00000558004, ENST00000561149 |
| Design Element |
ENST00000559053, ENST00000558733, ENST00000396140, 40798_s_at, 202604_x_at, ENST00000470269, ENST00000561149, 214895_s_at, 68865_r_at, ENST00000461408, ENST00000558004, ENST00000462061, ENST00000475898, g4557250_3p_a_at, 31934_at, ENST00000439637, Hs.172028.0.A2_3p_at, Z48579_at, ENST00000497846, 202603_at, ENST00000402627, ENST00000560608, ENST00000396136, ENST00000482945, ENST00000260408, ENST00000561288, 40797_at, ENST00000481164 |
| Search EB-eye |
ENSG00000137845
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