CASP1
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Homo sapiens |
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CASP1 is differentially expressed in 359 experiments: 145 organism parts: lung, bone marrow, ... (143 more);, 257 disease states: normal, glioblastoma, ... (255 more);, 151 cell types 547 cell lines 46 compound treatments and 74 other conditions. |
| Synonyms |
ICE, IL1BC |
| Orthologs |
caspb
(Danio rerio)
F1P0X7_CHICK
(Gallus gallus)
zgc:171731
(Danio rerio)
caspa
(Danio rerio)
CU896655.3
(Danio rerio)
Casp1
(Mus musculus)
ENSCING00000008214
(Ciona intestinalis)
Casp1
(Rattus norvegicus)
Nc
(Drosophila melanogaster)
si:ch211-15j1.6
(Danio rerio)
casp1
(Xenopus laevis)
(Compare orthologs)
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| Gene Ontology ID |
GO:0008234, GO:0008233, GO:0008219, GO:0008656, GO:0007165, GO:0016485, GO:0009636, GO:0042221, GO:0007494, GO:0007520, GO:0042493, GO:0007613, GO:0004197, GO:0005622, GO:0005515, GO:0005576, GO:0006915, GO:0006919, GO:0006917, GO:0005737, GO:0005634, GO:0005829, GO:0042981, GO:0032496, GO:0043065, GO:0006508, GO:0001666, GO:0045087, GO:0046010, GO:0014070, GO:0002218, GO:0050715, GO:0050718, GO:0050717, GO:0043123, GO:0001774, GO:0071310, GO:0071260, GO:0030324, GO:0033198, GO:0032611 |
| Gene Ontology Term |
cytosol, protein binding, apoptosis, cytoplasm, memory, intracellular, innate immune response, response to toxin, response to chemical stimulus, myoblast fusion, peptidase activity, activation of caspase activity, extracellular region, response to hypoxia, positive regulation of apoptosis, midgut development, induction of apoptosis, cysteine-type endopeptidase activity, nucleus, protein processing, caspase activator activity, response to lipopolysaccharide, cell death, response to drug, proteolysis, signal transduction, cysteine-type peptidase activity, regulation of apoptosis, positive regulation of I-kappaB kinase/NF-kappaB cascade, positive regulation of interleukin-1 beta secretion, cellular response to mechanical stimulus, activation of innate immune response, positive regulation of interleukin-1 alpha secretion, positive regulation of circadian sleep/wake cycle, non-REM sleep, positive regulation of cytokine secretion, response to ATP, lung development, cellular response to organic substance, microglial cell activation, response to organic cyclic compound, interleukin-1 beta production |
| InterPro Term |
Pept_C14_p10, Pept_C14_ICE_p20, Pept_C14_p45_core, Pept_C14_cat, Caspase_IL-1_beta, CARD |
| InterPro ID |
IPR001309, IPR011600, IPR017350, IPR015917, IPR002138, IPR001315 |
| Ensembl Family |
ENSFM00250000001340 |
| Ensembl Family Description |
CASPASE PRECURSOR CASP INTERLEUKIN 1 BETA CONVERTING ENZYME [CONTAINS CASPASE SUBUNIT CASPASE SUBUNIT |
| RefSeq ID |
NM_033294, NM_033295, NM_033292, NM_033293, NP_150635, NP_150634, NP_150637, NP_150636, NP_001214, NM_001223 |
| EMBL-Bank ID |
M87507, AP001153, X65019, AK223503, AK301037, U13698, U13697, U13699, U13700, BC041689, BC062327, AY660536, AB102878 |
| Ensembl Protein ID |
ENSP00000376844, ENSP00000403260, ENSP00000408446, ENSP00000344132, ENSP00000410076, ENSP00000436875, ENSP00000431947, ENSP00000433138, ENSP00000435536, ENSP00000432340, ENSP00000434259, ENSP00000434250, ENSP00000434303, ENSP00000434779 |
| UniGene ID |
Hs.2490 |
| Ensembl Gene ID |
ENSG00000137752 |
| UniProt Accession |
P29466, B4DVD8, Q5FBZ0 |
| Description |
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) [Source:HGNC Symbol;Acc:1499] |
| Entrez Gene ID |
834 |
| HGNC Symbol |
CASP1 |
| Ensembl Transcript ID |
ENST00000532520, ENST00000436863, ENST00000526568, ENST00000526511, ENST00000528974, ENST00000528424, ENST00000534497, ENST00000393136, ENST00000532439, ENST00000527625, ENST00000527979, ENST00000531166, ENST00000525825, ENST00000529871, ENST00000415981, ENST00000353247, ENST00000533400, ENST00000446369 |
| Design Element |
ENST00000531166, ENST00000532520, ENST00000528424, ENST00000436863, ENST00000529871, 206011_at, 209970_x_at, ENST00000527979, 211367_s_at, ENST00000532439, Hs2.348365.1.S1_3p_s_at, ENST00000526568, ENST00000534497, ENST00000353247, 211366_x_at, Hs.2490.0.S2_3p_at, ENST00000533400, ENST00000446369, M87507_s_at, 1552703_s_at, ENST00000526511, ENST00000415981, 574_s_at, ENST00000528974, 211368_s_at, ENST00000525825, 39320_at, ENST00000393136, g717041_3p_a_at, ENST00000527625 |
| Search EB-eye |
ENSG00000137752
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