IL6
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Homo sapiens |
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IL6 is differentially expressed in 257 experiments: 106 organism parts: lung, blood, ... (104 more);, 118 disease states: normal, lung adenocarcinoma, ... (116 more);, 83 cell types 328 cell lines 39 compound treatments and 65 other conditions. |
| Synonyms |
HSF, HGF, IFNB2, IL-6, BSF2 |
| Orthologs |
IL6_CHICK
(Gallus gallus)
IL6_BOVIN
(Bos taurus)
Il6
(Mus musculus)
Il6
(Rattus norvegicus)
il6
(Xenopus laevis)
IL6_CANFA
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0009897, GO:0010628, GO:0008285, GO:0008284, GO:0008360, GO:0016049, GO:0008083, GO:0009409, GO:0009408, GO:0009617, GO:0009611, GO:0009612, GO:0007568, GO:0042493, GO:0048635, GO:0005615, GO:0005515, GO:0005576, GO:0006959, GO:0006953, GO:0006955, GO:0042832, GO:0042981, GO:0005102, GO:0005125, GO:0032494, GO:0032496, GO:0046427, GO:0043066, GO:0043154, GO:0031000, GO:0006469, GO:0050829, GO:0050830, GO:0031175, GO:0045740, GO:0045727, GO:0042127, GO:0019221, GO:0045944, GO:0051607, GO:0045893, GO:0046716, GO:0046677, GO:0045454, GO:0045429, GO:0034097, GO:0060445, GO:0010574, GO:0060664, GO:0051384, GO:0005896, GO:0002675, GO:0002690, GO:0048661, GO:0051024, GO:0051091, GO:0002548, GO:0042517, GO:0002446, GO:0014070, GO:0006954, GO:0005138, GO:0050679, GO:0051971, GO:0050731, GO:0050710, GO:0031018, GO:0032722, GO:0050871, GO:0032755, GO:0045721, GO:0031667, GO:0046849, GO:0032868, GO:0046888, GO:0045765, GO:0045768, GO:0042102, GO:0001781, GO:0042110, GO:0045666, GO:0045669, GO:0032966, GO:0045630, GO:0051897, GO:0045599, GO:0043200, GO:0043526, GO:0051602, GO:0043410, GO:0051592, GO:0030168, GO:0045188, GO:0070102, GO:0070374, GO:0070301, GO:0033138, GO:0033160, GO:0045079, GO:0010888, GO:0070091, GO:0002384, GO:2000366 |
| Gene Ontology Term |
regulation of cell shape, defense response to virus, humoral immune response, positive regulation of JAK-STAT cascade, response to antibiotic, positive regulation of nitric oxide biosynthetic process, negative regulation of muscle organ development, protein binding, positive regulation of translation, response to wounding, cytokine-mediated signaling pathway, muscle cell homeostasis, regulation of cell proliferation, negative regulation of cell proliferation, extracellular space, negative regulation of protein kinase activity, acute-phase response, positive regulation of cell proliferation, positive regulation of gene expression, cell redox homeostasis, negative regulation of apoptosis, growth factor activity, extracellular region, receptor binding, cytokine activity, external side of plasma membrane, cell growth, defense response to protozoan, defense response to Gram-positive bacterium, positive regulation of transcription from RNA polymerase II promoter, response to peptidoglycan, neuron projection development, response to bacterium, response to caffeine, response to lipopolysaccharide, aging, positive regulation of DNA replication, defense response to Gram-negative bacterium, immune response, response to drug, response to cold, response to heat, positive regulation of transcription, DNA-dependent, response to mechanical stimulus, negative regulation of caspase activity, regulation of apoptosis, bone remodeling, positive regulation of immunoglobulin secretion, negative regulation of gluconeogenesis, response to cytokine stimulus, positive regulation of peptidyl-serine phosphorylation, response to nutrient levels, regulation of angiogenesis, neutrophil mediated immunity, negative regulation of collagen biosynthetic process, positive regulation of neuron differentiation, neuroprotection, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of ERK1 and ERK2 cascade, response to calcium ion, positive regulation of protein import into nucleus, translocation, regulation of vascular endothelial growth factor production, negative regulation of hormone secretion, branching involved in salivary gland morphogenesis, positive regulation of transmission of nerve impulse, T cell activation, regulation of circadian sleep/wake cycle, non-REM sleep, negative regulation of cytokine secretion, positive regulation of anti-apoptosis, positive regulation of epithelial cell proliferation, positive regulation of leukocyte chemotaxis, positive regulation of B cell activation, positive regulation of interleukin-6 production, negative regulation of lipid storage, negative regulation of fat cell differentiation, response to amino acid stimulus, interleukin-6 receptor complex, cellular response to hydrogen peroxide, response to insulin stimulus, neutrophil apoptosis, response to electrical stimulus, interleukin-6-mediated signaling pathway, epithelial cell proliferation involved in salivary gland morphogenesis, inflammatory response, positive regulation of osteoblast differentiation, monocyte chemotaxis, interleukin-6 receptor binding, endocrine pancreas development, positive regulation of T cell proliferation, positive regulation of smooth muscle cell proliferation, positive regulation of acute inflammatory response, positive regulation of MAPKKK cascade, positive regulation of chemokine production, positive regulation of protein kinase B signaling cascade, glucagon secretion, positive regulation of T-helper 2 cell differentiation, negative regulation of chemokine biosynthetic process, response to glucocorticoid stimulus, platelet activation, positive regulation of tyrosine phosphorylation of Stat3 protein, hepatic immune response, response to organic cyclic compound, positive regulation of sequence-specific DNA binding transcription factor activity, positive regulation of STAT protein import into nucleus |
| InterPro Term |
IL6_MGF_GCSF, Interleukin_6 |
| Ensembl Family Description |
INTERLEUKIN 6 PRECURSOR IL 6 |
| InterPro ID |
IPR003574, IPR003573 |
| Ensembl Family |
ENSFM00500000271086 |
| Ensembl Protein ID |
ENSP00000405994, ENSP00000385675, ENSP00000385718, ENSP00000385227, ENSP00000385043, ENSP00000405150, ENSP00000384928, ENSP00000258743 |
| UniProt Accession |
P05231, C9J5B0, B5MC21, B5MC14, B5MCZ3, B4DNV3, B4DNQ5, Q75MH2 |
| EMBL-Bank ID |
M29150, AK298013, AK298077, M14584, CR450296, AF372214, Y00081, BC015511, BT019748, BT019749, X04602, X04402, X04403, X04430, CH471073, M54894, CH236948, S56892, M18403, AC073072 |
| Gene-Disease Assocation |
RHEUMATOID ARTHRITIS, SYSTEMIC JUVENILE, OSTEOPOROSIS, ARTERIOVENOUS MALFORMATIONS OF THE BRAIN, KAPOSI SARCOMA, INFLAMMATORY BOWEL DISEASE 1; IBD1, DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM |
| Description |
interleukin 6 (interferon, beta 2) [Source:HGNC Symbol;Acc:6018] |
| Entrez Gene ID |
3569 |
| RefSeq ID |
NP_000591, NM_000600 |
| Ensembl Gene ID |
ENSG00000136244 |
| HGNC Symbol |
IL6 |
| Ensembl Transcript ID |
ENST00000401630, ENST00000401651, ENST00000485300, ENST00000426291, ENST00000420258, ENST00000406575, ENST00000404625, ENST00000407492, ENST00000258743, ENST00000464710 |
| Design Element |
ENST00000464710, ENST00000258743, ENST00000407492, ENST00000420258, g10834983_3p_at, ENST00000401651, 38299_at, ENST00000404625, 205207_at, Y00081_s_at, ENST00000485300, X04602_s_at, ENST00000401630, ENST00000406575, ENST00000426291 |
| Search EB-eye |
ENSG00000136244
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