MDM2
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Homo sapiens |
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MDM2 is differentially expressed in 352 experiments: 158 organism parts: bone marrow, liver, ... (156 more);, 226 disease states: normal, control, ... (224 more);, 101 cell types 465 cell lines 52 compound treatments and 83 other conditions. |
| Synonyms |
MGC5370, HDMX, HDM2 |
| Orthologs |
MDM2
(Bos taurus)
MDM2
(Gallus gallus)
ENSCING00000001188
(Ciona intestinalis)
mdm2
(Danio rerio)
Mdm2
(Mus musculus)
Mdm2
(Rattus norvegicus)
mdm2
(Xenopus laevis)
MDM2_CANFA
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0048015, GO:0008284, GO:0008270, GO:0016604, GO:0016567, GO:0007268, GO:0008543, GO:0016874, GO:0000075, GO:0005626, GO:0005622, GO:0042787, GO:0005515, GO:0004842, GO:0005730, GO:0005737, GO:0005634, GO:0005654, GO:0005886, GO:0005829, GO:0032436, GO:0043066, GO:0006461, GO:0019899, GO:0000122, GO:0045787, GO:0046872, GO:0042176, GO:0043234, GO:0045931, GO:0045892, GO:0046677, GO:0030163, GO:0045184, GO:0048011, GO:0007089, GO:0002039, GO:0006977, GO:0031648, GO:0044419, GO:0043518, GO:0071456, GO:0071157, GO:0034504, GO:0030666 |
| Gene Ontology Term |
cytosol, ligase activity, plasma membrane, response to antibiotic, negative regulation of transcription, DNA-dependent, protein binding, establishment of protein localization, regulation of protein catabolic process, cytoplasm, protein catabolic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, intracellular, protein complex, protein ubiquitination, positive regulation of cell proliferation, negative regulation of apoptosis, metal ion binding, insoluble fraction, protein complex assembly, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, fibroblast growth factor receptor signaling pathway, positive regulation of mitotic cell cycle, synaptic transmission, nucleus, ubiquitin-protein ligase activity, positive regulation of cell cycle, nuclear body, nucleoplasm, cell cycle checkpoint, negative regulation of transcription from RNA polymerase II promoter, enzyme binding, nucleolus, zinc ion binding, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, negative regulation of cell cycle arrest, cellular response to hypoxia, protein destabilization, interspecies interaction between organisms, p53 binding, nerve growth factor receptor signaling pathway, negative regulation of DNA damage response, signal transduction by p53 class mediator, traversing start control point of mitotic cell cycle, protein localization to nucleus, endocytic vesicle membrane, phosphatidylinositol-mediated signaling |
| InterPro Term |
SWIB_MDM2_domain, Znf_RanBP2, Znf_RING, p53_neg-reg_MDM_2/4 |
| InterPro ID |
IPR001876, IPR001841, IPR003121, IPR016495 |
| Ensembl Family |
ENSFM00500000270168 |
| Ensembl Family Description |
E3 UBIQUITIN LIGASE MDM2 EC_6.3.2.- DOUBLE MINUTE 2 P53 BINDING MDM2 |
| EMBL-Bank ID |
BT007258, AC025423, AJ278975, AJ278977, AF201370, AJ251943, BC009893, M92424, BC152390, BC152384, U28935, AK290341, U39736, EU076746, EU076749, AF385322, AF092845, AF092844, AF527840, U33200, U33201, U33202, U33203, Z12020, U33199, AJ517839, AJ517838, AJ517840, AJ491699, EU076747, AF385327, AJ550519 |
| Description |
Mdm2 p53 binding protein homolog (mouse) [Source:HGNC Symbol;Acc:6973] |
| Ensembl Protein ID |
ENSP00000311302, ENSP00000431110, ENSP00000429692, ENSP00000427828, ENSP00000353611, ENSP00000430906, ENSP00000335096, ENSP00000351270, ENSP00000429021, ENSP00000377067, ENSP00000377064, ENSP00000377065, ENSP00000377062, ENSP00000377068, ENSP00000266624, ENSP00000348637, ENSP00000430257, ENSP00000310742, ENSP00000417281, ENSP00000258148, ENSP00000258149, ENSP00000410694, ENSP00000299252, ENSP00000441841, ENSP00000444430, ENSP00000444566, ENSP00000444597, ENSP00000444028, ENSP00000439238, ENSP00000443450, ENSP00000443274, ENSP00000440932, ENSP00000445222, ENSP00000445030 |
| UniProt Accession |
Q96DS5, Q9H4C5, Q9H4C3, A7UKX7, A7UKY0, Q546E6, A8WFP2, Q00987, Q8NDW1, F5GWH7, E7EMW5, F5GZB0, F5GZC3, Q96DS0, E7EPE2, E5RJQ0, A7UKX8, E5RHE2, E9PF57, F5H1M7, F5H4Q8, Q86WA3 |
| Ensembl Gene ID |
ENSG00000135679 |
| Entrez Gene ID |
4193 |
| HGNC Symbol |
MDM2 |
| RefSeq ID |
NP_002383, NM_002392 |
| UniGene ID |
Hs.484551, Hs.658568 |
| Ensembl Transcript ID |
ENST00000543323, ENST00000493419, ENST00000478070, ENST00000543046, ENST00000471946, ENST00000360430, ENST00000350057, ENST00000523991, ENST00000540062, ENST00000537182, ENST00000358483, ENST00000542502, ENST00000311440, ENST00000311420, ENST00000356290, ENST00000545204, ENST00000393415, ENST00000393413, ENST00000393412, ENST00000393417, ENST00000393416, ENST00000393410, ENST00000539479, ENST00000544561, ENST00000400501, ENST00000544648, ENST00000496959, ENST00000462284, ENST00000517852, ENST00000481186, ENST00000540827, ENST00000540709, ENST00000536089, ENST00000540352, ENST00000258148, ENST00000258149, ENST00000546048, ENST00000348801, ENST00000428863, ENST00000544125, ENST00000299252 |
| Design Element |
64993_r_at, ENST00000537182, U33202_s_at, ENST00000544648, ENST00000299252, 1859_s_at, 244616_3p_x_at, ENST00000350057, 225160_x_at, 237891_at, ENST00000478070, ENST00000540827, ENST00000536089, ENST00000462284, M92424_at, ENST00000496959, ENST00000311420, ENST00000539479, Hs.168732.0.A1_3p_x_at, ENST00000546048, 205386_s_at, ENST00000471946, ENST00000543323, ENST00000358483, 61888_at, ENST00000517852, Hs.116932.0.A1_3p_at, 1880_at, 211832_s_at, 75871_at, ENST00000356290, ENST00000481186, 62280_at, 217373_x_at, ENST00000540062, g7230489_3p_s_at, ENST00000428863, ENST00000493419, 244616_x_at, ENST00000258148, ENST00000543046, ENST00000258149, 238733_at, ENST00000540709, Hs.166835.0.A1_3p_at, ENST00000360430, gnf1h00912_at, U33203_s_at, ENST00000542502, Hs.166835.0.A1_3p_x_at, 64992_i_at, ENST00000544561, Hs.272346.0.S1_3p_s_at, ENST00000400501, Hs.332938.1.S1_3p_a_at, Hs.168732.0.A1_3p_at, 38509_at, 2008_s_at, ENST00000393416, ENST00000348801, ENST00000311440, ENST00000393417, ENST00000393415, 217542_at, ENST00000540352, ENST00000545204, 46744_s_at, ENST00000523991, 229711_s_at, 53464_at, Hs.37494.0.A1_3p_at, ENST00000393413, ENST00000393412, ENST00000544125, ENST00000393410 |
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ENSG00000135679
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