CDK4
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Homo sapiens |
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CDK4 is differentially expressed in 290 experiments: 136 organism parts: ovary, blood, ... (134 more);, 213 disease states: normal, lung adenocarcinoma, ... (211 more);, 95 cell types 337 cell lines 40 compound treatments and 77 other conditions. |
| Synonyms |
PSK-J3 |
| Orthologs |
CDC28
(Saccharomyces cerevisiae)
LOC100362034
(Rattus norvegicus)
ENSCING00000002540
(Ciona intestinalis)
CDK4_BOVIN
(Bos taurus)
CDK4
(Danio rerio)
F1LXG5_RAT
(Rattus norvegicus)
Cdk4
(Mus musculus)
Cdk4
(Drosophila melanogaster)
cdk4
(Xenopus laevis)
ENSBTAG00000046091
(Bos taurus)
ENSBTAG00000045571
(Bos taurus)
LOC612475
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR002575, IPR001245, IPR017442, IPR000719, IPR020635 |
| Gene Ontology Term |
cyclin-dependent protein kinase activity, cytosol, cell division, protein binding, cytoplasm, regulation of cell proliferation, positive regulation of cell proliferation, membrane, mitotic cell cycle, protein tyrosine kinase activity, G1 phase of mitotic cell cycle, ATP binding, cell cycle, transferase activity, transferring phosphorus-containing groups, regulation of cell cycle, G1/S transition of mitotic cell cycle, nucleus, regulation of gene expression, nucleotide binding, kinase activity, transcription factor complex, protein serine/threonine kinase activity, response to drug, chromatin, nucleoplasm, S phase of mitotic cell cycle, signal transduction, protein kinase activity, nucleolus, nuclear membrane, positive regulation of fibroblast proliferation, cyclin-dependent protein kinase holoenzyme complex, protein phosphorylation |
| Gene Ontology ID |
GO:0008284, GO:0016020, GO:0010468, GO:0007049, GO:0007165, GO:0016301, GO:0031965, GO:0051301, GO:0042493, GO:0016772, GO:0004693, GO:0000080, GO:0000082, GO:0000084, GO:0004713, GO:0005524, GO:0005515, GO:0005730, GO:0005737, GO:0005634, GO:0005654, GO:0005667, GO:0005829, GO:0004672, GO:0004674, GO:0000785, GO:0006468, GO:0000166, GO:0051726, GO:0042127, GO:0000278, GO:0048146, GO:0000307 |
| InterPro Term |
Aminoglycoside_PTrfase, Prot_kinase_cat_dom, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| Ensembl Family |
ENSFM00550000743165 |
| EMBL-Bank ID |
CR542247, U79269, AC025165, AF507942, M14505, BC015669, AK297901, BC010153, U37022, CH471054, CR407668, Z48970, U81031, BC003644, S67448, BC005864 |
| Ensembl Gene ID |
ENSG00000135446 |
| UniProt Accession |
P11802, Q6LC83, B4DNF9, Q96BE9, F8VZZ0, F8VTV8, F8VZ51, F8VYY1, F8VZ13, F8VYH9, F8VXD2, F8VWX7, F8W1L8 |
| Entrez Gene ID |
1019 |
| Description |
cyclin-dependent kinase 4 [Source:HGNC Symbol;Acc:1773] |
| Ensembl Protein ID |
ENSP00000257904, ENSP00000316889, ENSP00000446763, ENSP00000439076, ENSP00000448098, ENSP00000448885, ENSP00000448963, ENSP00000447005, ENSP00000449391, ENSP00000449179, ENSP00000449725, ENSP00000447779, ENSP00000447274 |
| RefSeq ID |
NP_000066, NM_000075 |
| HGNC Symbol |
CDK4 |
| Ensembl Family Description |
CYCLIN DEPENDENT KINASE 4 EC_2.7.11.22 CELL DIVISION KINASE 4 |
| Ensembl Transcript ID |
ENST00000551706, ENST00000551800, ENST00000551888, ENST00000547853, ENST00000549606, ENST00000547281, ENST00000257904, ENST00000553237, ENST00000540325, ENST00000550419, ENST00000312990, ENST00000552862, ENST00000546489, ENST00000552713, ENST00000552388, ENST00000552254 |
| Gene-Disease Assocation |
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3; CMM3 |
| Design Element |
ENST00000552388, g4502734_3p_s_at, ENST00000551706, 202246_s_at, ENST00000551888, ENST00000540325, ENST00000257904, ENST00000552713, U37022_rna1_at, ENST00000551800, ENST00000550419, ENST00000552862, ENST00000553237, ENST00000546489, 1942_s_at, gnf1h01036_at, ENST00000312990, ENST00000547281, ENST00000549606, ENST00000552254, ENST00000547853 |
| Search EB-eye |
ENSG00000135446
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