APC
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Homo sapiens |
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APC is differentially expressed in 335 experiments: 194 organism parts: bone marrow, liver, ... (192 more);, 266 disease states: normal, control, ... (264 more);, 103 cell types 429 cell lines 45 compound treatments and 91 other conditions. |
| Synonyms |
DP2, DP3, DP2.5 |
| Orthologs |
Q4A1V5_CHICK
(Gallus gallus)
apc
(Danio rerio)
Apc
(Rattus norvegicus)
Apc
(Mus musculus)
APC
(Bos taurus)
Apc
(Drosophila melanogaster)
Apc2
(Drosophila melanogaster)
apc
(Xenopus laevis)
APC
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology Term |
cytosol, cell migration, pattern specification process, plasma membrane, positive regulation of cell division, microtubule plus-end binding, establishment or maintenance of cell polarity, microtubule binding, protein binding, apoptosis, cell-cell adherens junction, cytoskeleton, stem cell maintenance, kinetochore, cytoplasm, beta-catenin binding, muscle cell homeostasis, cytoplasmic microtubule organization, axis specification, negative regulation of cell proliferation, negative regulation of apoptosis, tight junction, cell cycle arrest, negative regulation of microtubule depolymerization, protein complex assembly, cell junction, proximal/distal pattern formation, positive regulation of apoptosis, negative regulation of Wnt receptor signaling pathway, protein kinase regulator activity, cell adhesion, neuron projection, Wnt receptor signaling pathway, centrosome, neuron projection development, microtubule, regulation of cell cycle, protein kinase binding, nucleus, cell projection, positive regulation of microtubule polymerization, regulation of cell migration, cytoplasmic microtubule, lamellipodium, somatic stem cell maintenance, canonical Wnt receptor signaling pathway, cytokinesis after mitosis, growth cone, regulation of cell differentiation, response to drug, synapse, axonogenesis, binding, response to DNA damage stimulus, negative regulation of MAPKKK cascade, negative regulation of epithelial cell proliferation, lateral plasma membrane, negative regulation of cyclin-dependent protein kinase activity, chromosome organization, mitotic cell cycle spindle assembly checkpoint, regulation of apoptosis, dorsal/ventral pattern formation, neuronal cell body, beta-catenin destruction complex, positive regulation of cell adhesion, regulation of epithelial cell differentiation, negative regulation of epithelial cell proliferation involved in prostate gland development, hair follicle development, negative regulation of odontogenesis, kidney development, mitotic metaphase/anaphase transition, regulation of nitrogen compound metabolic process, positive regulation of protein catabolic process, axon part, positive regulation of cell migration, gamma-catenin binding, cell projection membrane, positive regulation of pseudopodium assembly, pancreas development, retina development in camera-type eye, positive regulation of cell differentiation, regulation of osteoblast differentiation, skin development, regulation of osteoclast differentiation, regulation of microtubule-based process, positive regulation of epithelial cell differentiation, thymus development, negative regulation of canonical Wnt receptor signaling pathway, Axin-APC-beta-catenin-GSK3B complex, regulation of attachment of spindle microtubules to kinetochore, ruffle membrane, tight junction assembly, T cell differentiation in thymus, axonal growth cone, cellular component disassembly involved in apoptosis, microtubule plus end, APC-Axin-1-beta-catenin complex, anterior/posterior pattern specification |
| Gene Ontology ID |
GO:0016055, GO:0009953, GO:0009954, GO:0009952, GO:0008285, GO:0008013, GO:0008017, GO:0060070, GO:0007026, GO:0007050, GO:0007094, GO:0007155, GO:0007163, GO:0016477, GO:0016328, GO:0009798, GO:0007389, GO:0005913, GO:0005923, GO:0007409, GO:0051276, GO:0042493, GO:0051010, GO:0030426, GO:0005488, GO:0005515, GO:0006915, GO:0005737, GO:0005634, GO:0005881, GO:0005886, GO:0005874, GO:0005856, GO:0005829, GO:0005813, GO:0042995, GO:0006974, GO:0042981, GO:0050680, GO:0043065, GO:0043066, GO:0019901, GO:0000776, GO:0006461, GO:0019827, GO:0031175, GO:0043005, GO:0019887, GO:0043025, GO:0031122, GO:0031116, GO:0045736, GO:0051781, GO:0051726, GO:0000281, GO:0045595, GO:0046716, GO:0043409, GO:0045202, GO:0030178, GO:0030027, GO:0030054, GO:0030334, GO:0035019, GO:0060041, GO:0007091, GO:0042483, GO:0051171, GO:0048538, GO:0030877, GO:0030856, GO:0030858, GO:0031253, GO:0031274, GO:0032587, GO:0051988, GO:0090090, GO:0001942, GO:0031016, GO:0045732, GO:0045785, GO:0032886, GO:0045670, GO:0045667, GO:0045597, GO:0001822, GO:0043588, GO:0070830, GO:0045295, GO:0030335, GO:0060770, GO:0033267, GO:0033077, GO:0034747, GO:0044295, GO:0006921, GO:0035371, GO:0034742 |
| InterPro ID |
IPR000225, IPR009240, IPR009223, IPR009224, IPR009232, IPR009234 |
| Ensembl Family Description |
ADENOMATOUS POLYPOSIS COLI |
| Ensembl Family |
ENSFM00250000001676 |
| InterPro Term |
Armadillo, SAMP, EB1-bd, APC_15aa_rpt, APC_basic_dom, APC_Cys-rich_rpt |
| Ensembl Protein ID |
ENSP00000427089, ENSP00000257430, ENSP00000424265, ENSP00000413133, ENSP00000426541, ENSP00000423828, ENSP00000423224 |
| EMBL-Bank ID |
S78214, M73548, AC136500, EU681276, EU681189, M74088, EF125077, CH471086, AB210001, AK294544, EF026097, AC008575, EF575700, AF127034, AF127506, S67788, EF432779, AH009913 |
| UniProt Accession |
A1YIQ7, Q9UM98, A5HB97, A5HB96, A5HB94, A5HB95, D6RFL6, Q9HAW6, A1YR11, B2ZRG1, B2ZRE1, P25054, Q4LE70, A5JUM8, B7Z2B6, Q9P119, E7EMH9, E9PFT7 |
| Gene-Disease Assocation |
DESMOID DISEASE, HEREDITARY, HEPATOCELLULAR CARCINOMA, GASTRIC CANCER, MISMATCH REPAIR CANCER SYNDROME, GASTRIC CANCER, HEREDITARY DIFFUSE; HDGC, COLORECTAL CANCER; CRC, MEDULLOBLASTOMA; MDB, ADENOMATOUS POLYPOSIS OF THE COLON; APC |
| RefSeq ID |
NM_001127510, NM_001127511, NP_001120983, NP_001120982, NP_000029, NM_000038 |
| Ensembl Gene ID |
ENSG00000134982 |
| UniGene ID |
Hs.621884, Hs.727274, Hs.158932, Hs.645638 |
| Description |
adenomatous polyposis coli [Source:HGNC Symbol;Acc:583] |
| HGNC Symbol |
APC |
| Entrez Gene ID |
324 |
| Ensembl Transcript ID |
ENST00000505084, ENST00000505350, ENST00000457016, ENST00000508624, ENST00000257430, ENST00000508376, ENST00000509732, ENST00000514164, ENST00000506342, ENST00000512211, ENST00000504915, ENST00000507379, ENST00000502371 |
| Design Element |
g182396_3p_a_at, ENST00000505084, Hs.167825.0.S1_3p_at, M73548_at, ENST00000257430, ENST00000506342, 203526_s_at, ENST00000502371, ENST00000505350, ENST00000508624, ENST00000504915, ENST00000508376, 215310_at, 203527_s_at, 36182_at, 203525_s_at, g4557318_3p_a_at, M74088_s_at, ENST00000514164, 216933_3p_x_at, Hs.75081.1.S1_3p_a_at, Hs.75081.0.S2_3p_a_at, ENST00000457016, ENST00000512211, 1912_s_at, ENST00000507379, 35433_s_at, 216933_x_at, ENST00000509732 |
| Search EB-eye |
ENSG00000134982
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