PDGFRA
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Homo sapiens |
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PDGFRA is differentially expressed in 296 experiments: 157 organism parts: bone marrow, ovary, ... (155 more);, 254 disease states: normal, glioblastoma, ... (252 more);, 107 cell types 299 cell lines 32 compound treatments and 76 other conditions. |
| Synonyms |
CD140a, PDGFR2 |
| Orthologs |
F1N870_CHICK
(Gallus gallus)
Pdgfra
(Mus musculus)
F1MX49_BOVIN
(Bos taurus)
Pdgfra
(Rattus norvegicus)
Pvr
(Drosophila melanogaster)
pdgfra
(Xenopus laevis)
Q6E7G6_CANFA
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR001245, IPR017442, IPR000719, IPR007110, IPR009134, IPR020635, IPR003598, IPR003599, IPR016243, IPR013098 |
| Gene Ontology ID |
GO:0009887, GO:0008210, GO:0008284, GO:0016020, GO:0016021, GO:0007169, GO:0009653, GO:0009725, GO:0008585, GO:0030539, GO:0016772, GO:0004713, GO:0004714, GO:0042803, GO:0005524, GO:0005515, GO:0004872, GO:0005737, GO:0005634, GO:0005886, GO:0005887, GO:0004672, GO:0004674, GO:0006468, GO:0000166, GO:0045740, GO:0018108, GO:0046777, GO:0042063, GO:0042060, GO:0043548, GO:0030198, GO:0034097, GO:0048008, GO:0048010, GO:0060325, GO:0060021, GO:0010035, GO:0010033, GO:0048839, GO:0048705, GO:0042475, GO:0048407, GO:0043627, GO:0048146, GO:0055093, GO:0005161, GO:0055003, GO:0005018, GO:0005021, GO:0019838, GO:0001775, GO:0001701, GO:0001553, GO:0030335, GO:0030324, GO:0030325, GO:0033327, GO:0032355, GO:0035790, GO:0072277, GO:0071230, GO:0061298, GO:0023019 |
| Gene Ontology Term |
plasma membrane, gliogenesis, protein binding, cytoplasm, wound healing, positive regulation of cell proliferation, membrane, peptidyl-tyrosine phosphorylation, male genitalia development, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase signaling pathway, female gonad development, ATP binding, anatomical structure morphogenesis, transferase activity, transferring phosphorus-containing groups, integral to plasma membrane, estrogen metabolic process, nucleus, response to hormone stimulus, positive regulation of DNA replication, receptor activity, nucleotide binding, protein serine/threonine kinase activity, transmembrane receptor protein tyrosine kinase activity, protein homodimerization activity, integral to membrane, extracellular matrix organization, organ morphogenesis, protein kinase activity, response to cytokine stimulus, luteinization, in utero embryonic development, adrenal gland development, inner ear development, platelet-derived growth factor receptor signaling pathway, positive regulation of cell migration, platelet-derived growth factor alpha-receptor activity, response to estrogen stimulus, cardiac myofibril assembly, response to inorganic substance, positive regulation of fibroblast proliferation, response to estradiol stimulus, lung development, growth factor binding, platelet-derived growth factor binding, skeletal system morphogenesis, palate development, response to organic substance, odontogenesis of dentine-containing tooth, vascular endothelial growth factor receptor signaling pathway, response to hyperoxia, cell activation, platelet-derived growth factor receptor binding, face morphogenesis, Leydig cell differentiation, protein autophosphorylation, protein phosphorylation, retina vasculature development in camera-type eye, signal transduction involved in regulation of gene expression, platelet-derived growth factor receptor-alpha signaling pathway, cellular response to amino acid stimulus, metanephric glomerular capillary formation, phosphatidylinositol 3-kinase binding, vascular endothelial growth factor-activated receptor activity |
| InterPro Term |
Ig_sub, Prot_kinase_cat_dom, Ig-like, Ig_sub2, Ig_I-set, Tyr_kinase_VEGFR_rcpt_N, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Tyr_kinase_CSF1/PDGF_rcpt, Se/Thr_kinase-like_dom |
| Ensembl Family |
ENSFM00440000236844 |
| Ensembl Family Description |
FACTOR RECEPTOR PRECURSOR EC_2.7.10.1 |
| HGNC Symbol |
PDGFRA |
| RefSeq ID |
NP_006197, NM_006206 |
| Ensembl Protein ID |
ENSP00000425232, ENSP00000424218, ENSP00000257290, ENSP00000426472, ENSP00000425626, ENSP00000425648, ENSP00000425902 |
| EMBL-Bank ID |
AK316578, AC098587, AC138779, M22734, BC015186, M21574, D50017, AY229892 |
| UniGene ID |
Hs.74615, Hs.609382 |
| UniProt Accession |
P16234, D6RDX0, D6RIG5, D6RG11, D6RJH0, E9PBH0 |
| Description |
platelet-derived growth factor receptor, alpha polypeptide [Source:HGNC Symbol;Acc:8803] |
| Ensembl Gene ID |
ENSG00000134853 |
| Entrez Gene ID |
5156 |
| Ensembl Transcript ID |
ENST00000507536, ENST00000503856, ENST00000508170, ENST00000257290, ENST00000509490, ENST00000512522, ENST00000504461, ENST00000512143, ENST00000509092, ENST00000461294 |
| Gene-Disease Assocation |
HYPEREOSINOPHILIC SYNDROME, IDIOPATHIC; HES, GASTROINTESTINAL STROMAL TUMOR; GIST |
| Design Element |
M21574_at, 1554828_at, 1987_at, 1731_at, 84284_at, ENST00000503856, ENST00000512143, 1988_at, ENST00000461294, ENST00000509490, ENST00000508170, ENST00000507536, 203131_at, ENST00000257290, Hs2.74615.2.A1_3p_at, 215305_at, Hs.166074.0.S1_3p_at, Hs2.74615.2.A1_3p_s_at, ENST00000509092, ENST00000512522, g5453869_3p_at, 1968_g_at, ENST00000504461 |
| Search EB-eye |
ENSG00000134853
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