PPARG
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Homo sapiens |
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PPARG is differentially expressed in 264 experiments: 128 organism parts: adipose tissue, placenta, ... (126 more);, 197 disease states: normal, lung adenocarcinoma, ... (195 more);, 79 cell types 463 cell lines 31 compound treatments and 58 other conditions. |
| Synonyms |
NR1C3, PPARG2, PPARG1, PPARgamma |
| Orthologs |
Q9I878_CHICK
(Gallus gallus)
PPARG_BOVIN
(Bos taurus)
Pparg
(Mus musculus)
pparg
(Danio rerio)
F6VU23_CIOIN
(Ciona intestinalis)
Pparg
(Rattus norvegicus)
pparg
(Xenopus laevis)
PPARG_CANFA
(Canis familiaris)
Eip78C
(Drosophila melanogaster)
(Compare orthologs)
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| Gene Ontology Term |
cytosol, negative regulation of cell growth, DNA binding, negative regulation of transcription, DNA-dependent, protein binding, regulation of transcription, DNA-dependent, regulation of lipid metabolic process, negative regulation of cell proliferation, innate immune response, ligand-dependent nuclear receptor activity, transcription, DNA-dependent, negative regulation of sequestering of triglyceride, metal ion binding, activation of caspase activity, lipid homeostasis, glucose homeostasis, sequence-specific DNA binding, response to nutrient, fatty acid oxidation, induction of apoptosis, positive regulation of transcription from RNA polymerase II promoter, lipid metabolic process, nucleus, heart development, response to caffeine, receptor activity, cell fate commitment, response to drug, chromatin binding, nucleoplasm, negative regulation of transcription from RNA polymerase II promoter, response to cold, regulation of transcription from RNA polymerase II promoter, enzyme binding, steroid hormone receptor activity, signal transduction, positive regulation of transcription, DNA-dependent, zinc ion binding, negative regulation of cytokine production, negative regulation of macrophage derived foam cell differentiation, steroid hormone mediated signaling pathway, cellular response to insulin stimulus, response to vitamin A, positive regulation of fatty acid oxidation, retinoid X receptor binding, negative regulation of cholesterol storage, fat cell differentiation, negative regulation of receptor biosynthetic process, negative regulation of telomerase activity, drug binding, intracellular receptor mediated signaling pathway, gene expression, placenta development, long-chain fatty acid transport, response to estrogen stimulus, cellular response to lithium ion, prostaglandin receptor activity, organ regeneration, negative regulation of interferon-gamma-mediated signaling pathway, positive regulation of oligodendrocyte differentiation, negative regulation of acute inflammatory response, cell maturation, regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor, response to lipid, arachidonic acid binding, regulation of blood pressure, monocyte differentiation, lipoprotein transport, regulation of fat cell differentiation, response to organic substance, brown fat cell differentiation, positive regulation of fat cell differentiation, white fat cell differentiation, epithelial cell differentiation, sequence-specific DNA binding transcription factor activity, activating transcription factor binding, regulation of cholesterol transporter activity, response to organic cyclic compound, low-density lipoprotein particle receptor biosynthetic process, cellular response to organic cyclic compound, transcription regulatory region DNA binding, positive regulation of sequence-specific DNA binding transcription factor activity, response to low-density lipoprotein particle stimulus, RNA polymerase II regulatory region DNA binding |
| Gene Ontology ID |
GO:0003682, GO:0003677, GO:0008285, GO:0008270, GO:0003700, GO:0003707, GO:0009409, GO:0007165, GO:0007584, GO:0007507, GO:0042493, GO:0042593, GO:0005515, GO:0004879, GO:0004872, GO:0006919, GO:0006917, GO:0005634, GO:0005654, GO:0005829, GO:0055088, GO:0006629, GO:0031000, GO:0019899, GO:0019395, GO:0000122, GO:0046872, GO:0006355, GO:0006357, GO:0006351, GO:0019216, GO:0045944, GO:0043565, GO:0045892, GO:0045893, GO:0033613, GO:0045165, GO:0030308, GO:0045087, GO:0010891, GO:0010745, GO:0008144, GO:0008217, GO:0060336, GO:0004955, GO:0010467, GO:0010033, GO:0048714, GO:0002674, GO:0030522, GO:0051091, GO:0015909, GO:0048469, GO:0014070, GO:0043627, GO:0030855, GO:0042953, GO:0055098, GO:0050544, GO:0046321, GO:0051974, GO:0031100, GO:0050872, GO:0050873, GO:0045713, GO:0032869, GO:0045600, GO:0046965, GO:0001890, GO:0045598, GO:0001818, GO:0044212, GO:0033993, GO:0043401, GO:0071407, GO:0045444, GO:0071285, GO:0030224, GO:0033189, GO:0034339, GO:0010887, GO:0010871, GO:0060694, GO:0001012 |
| InterPro ID |
IPR001628, IPR000536, IPR001723, IPR003077, IPR003074, IPR022590 |
| InterPro Term |
Nucl_hrmn_rcpt_lig-bd_core, Str_hrmn_rcpt, Znf_hrmn_rcpt, 1Cnucl_rcpt, 1Cnucl_rcpt_G, PPARgamma_N |
| Ensembl Family |
ENSFM00250000000390 |
| Ensembl Family Description |
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR PPAR NUCLEAR RECEPTOR SUBFAMILY 1 GROUP C MEMBER |
| EMBL-Bank ID |
BT007281, U79012, L40904, U63415, D83233, DQ356894, AC090947, AJ698135, AB097931, AK290581, BC006811, X90563, AB472042, CH471055, AB107271, AC093174, AC091492, AY157024, AB451337, AB005520, AB005526, AB451486, HQ692866 |
| RefSeq ID |
NM_005037, NM_015869, NP_005028, NM_138712, NM_138711, NP_056953, NP_619726, NP_619725 |
| UniProt Accession |
Q0QJH8, Q4W448, Q6L9M1, Q9UEF6, D2KUA6, P37231, E7EUD1, E7EU07, E9PFJ1, E9PFX5, E9PFV3, E9PFV2 |
| UniGene ID |
Hs.162646 |
| Ensembl Protein ID |
ENSP00000411931, ENSP00000392285, ENSP00000287820, ENSP00000312472, ENSP00000380224, ENSP00000380221, ENSP00000380207, ENSP00000380205, ENSP00000380218, ENSP00000380210, ENSP00000380196, ENSP00000380195, ENSP00000438940 |
| Description |
peroxisome proliferator-activated receptor gamma [Source:HGNC Symbol;Acc:9236] |
| Gene-Disease Assocation |
OBESITY, CAROTID INTIMAL MEDIAL THICKNESS 1, GLIOMA SUSCEPTIBILITY 1; GLM1, LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3; FPLD3, BODY MASS INDEX; BMI, LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 2; FPLD2, DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM |
| HGNC Symbol |
PPARG |
| Entrez Gene ID |
5468 |
| Ensembl Gene ID |
ENSG00000132170 |
| Ensembl Transcript ID |
ENST00000539812, ENST00000497594, ENST00000438682, ENST00000477039, ENST00000287820, ENST00000397000, ENST00000397010, ENST00000397012, ENST00000397015, ENST00000397026, ENST00000397023, ENST00000397029, ENST00000396999, ENST00000309576, ENST00000455517 |
| Design Element |
ENST00000438682, L40904_at, ENST00000397026, ENST00000397015, ENST00000396999, ENST00000497594, ENST00000397029, ENST00000455517, ENST00000309576, ENST00000397000, ENST00000539812, ENST00000397012, 37104_at, ENST00000477039, ENST00000397023, ENST00000397010, g7705548_3p_a_at, ENST00000287820, 208510_s_at |
| Search EB-eye |
ENSG00000132170
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