RAF1
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Homo sapiens |
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RAF1 is differentially expressed in 261 experiments: 138 organism parts: placenta, cerebellum, ... (136 more);, 159 disease states: normal, glioblastoma, ... (157 more);, 84 cell types 309 cell lines 34 compound treatments and 76 other conditions. |
| Synonyms |
c-Raf, Raf-1, CRAF |
| Orthologs |
F6U6W3_CIOIN
(Ciona intestinalis)
raf1a
(Danio rerio)
RAF1_CHICK
(Gallus gallus)
Raf1
(Mus musculus)
raf1b
(Danio rerio)
phl
(Drosophila melanogaster)
Raf1
(Rattus norvegicus)
raf1
(Xenopus laevis)
RAF1
(Bos taurus)
RAF1
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR001245, IPR017442, IPR000719, IPR002219, IPR020635, IPR003116, IPR020454 |
| Gene Ontology Term |
cytosol, plasma membrane, receptor signaling protein activity, cytoskeleton organization, protein binding, apoptosis, cytoplasm, cell proliferation, epidermal growth factor receptor signaling pathway, negative regulation of cell proliferation, MAP kinase kinase kinase activity, negative regulation of apoptosis, MAPKKK cascade, metal ion binding, protein tyrosine kinase activity, insoluble fraction, insulin receptor signaling pathway, blood coagulation, response to hypoxia, mitochondrial outer membrane, activation of MAPKK activity, ATP binding, Ras protein signal transduction, axon guidance, small GTPase mediated signal transduction, synaptic transmission, heart development, protein heterodimerization activity, nucleotide binding, protein serine/threonine kinase activity, signal transduction, protein kinase activity, pseudopodium, positive regulation of peptidyl-serine phosphorylation, Ras GTPase binding, nerve growth factor receptor signaling pathway, mitogen-activated protein kinase kinase binding, platelet activation, negative regulation of protein complex assembly, protein phosphorylation, intracellular signal transduction |
| Gene Ontology ID |
GO:0008286, GO:0008283, GO:0008285, GO:0007010, GO:0007173, GO:0007165, GO:0007264, GO:0007265, GO:0007268, GO:0007411, GO:0007596, GO:0007507, GO:0004709, GO:0004713, GO:0005626, GO:0005524, GO:0005515, GO:0006915, GO:0005737, GO:0005741, GO:0005886, GO:0005829, GO:0004672, GO:0004674, GO:0005057, GO:0043066, GO:0006468, GO:0000165, GO:0000166, GO:0000186, GO:0046872, GO:0046982, GO:0001666, GO:0048011, GO:0031333, GO:0031143, GO:0031434, GO:0030168, GO:0033138, GO:0017016, GO:0035556 |
| Ensembl Family |
ENSFM00290000065522 |
| Ensembl Family Description |
SERINE/THREONINE KINASE EC_2.7.11.1 PROTO ONCOGENE RAF |
| InterPro Term |
Prot_kinase_cat_dom, Raf-like_ras-bd, Prot_Kinase_C-like_PE/DAG-bd, DAG/PE-bd, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| EMBL-Bank ID |
X03484, X54851, AY271661, AK303920, L00206, L00207, L00208, L00209, L00212, L00213, L00210, L00211, AC018500, AK303561, AK312248, BC018119, CH471055, EU332868, M11376, AC026170 |
| Ensembl Protein ID |
ENSP00000398591, ENSP00000401888, ENSP00000391265, ENSP00000401088, ENSP00000251849, ENSP00000443567, ENSP00000441186 |
| Description |
v-raf-1 murine leukemia viral oncogene homolog 1 [Source:HGNC Symbol;Acc:9829] |
| RefSeq ID |
NP_002871, NM_002880 |
| UniGene ID |
Hs.632896 |
| UniProt Accession |
P04049, B4E0X2, B4E1N6 |
| Gene-Disease Assocation |
LEOPARD SYNDROME 2, NOONAN SYNDROME 5; NS5 |
| Entrez Gene ID |
5894 |
| HGNC Symbol |
RAF1 |
| Ensembl Gene ID |
ENSG00000132155 |
| Ensembl Transcript ID |
ENST00000491290, ENST00000442415, ENST00000251849, ENST00000460610, ENST00000471449, ENST00000465826, ENST00000542177, ENST00000534997, ENST00000492690, ENST00000475353, ENST00000432427, ENST00000416093, ENST00000494557, ENST00000423275 |
| Design Element |
ENST00000494557, Hs2.345050.1.A1_3p_at, ENST00000460610, 67881_at, 1917_at, ENST00000465826, ENST00000492690, ENST00000416093, ENST00000442415, 201244_s_at, 91863_at, g4506400_3p_a_at, ENST00000491290, 38742_s_at, ENST00000475353, ENST00000534997, ENST00000423275, ENST00000542177, 38743_f_at, ENST00000471449, X03484_at, 1557675_at, ENST00000251849, ENST00000432427 |
| Search EB-eye |
ENSG00000132155
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