RARA
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Homo sapiens |
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RARA is differentially expressed in 321 experiments: 147 organism parts: lung, hypothalamus, ... (145 more);, 227 disease states: normal, glioblastoma, ... (225 more);, 103 cell types 388 cell lines 50 compound treatments and 82 other conditions. |
| Synonyms |
NR1B1, RAR |
| Orthologs |
Rara
(Mus musculus)
raraa
(Danio rerio)
rarab
(Danio rerio)
F1MWQ3_BOVIN
(Bos taurus)
F6VND6_CIOIN
(Ciona intestinalis)
Rara
(Rattus norvegicus)
rara
(Xenopus laevis)
RARA_CANFA
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0003677, GO:0010629, GO:0010628, GO:0008284, GO:0009986, GO:0008270, GO:0003714, GO:0003713, GO:0003700, GO:0003707, GO:0007165, GO:0007283, GO:0007281, GO:0051018, GO:0030425, GO:0005515, GO:0004879, GO:0004872, GO:0005737, GO:0005634, GO:0005654, GO:0005102, GO:0019904, GO:0000790, GO:0006468, GO:0019899, GO:0043025, GO:0000122, GO:0045787, GO:0046872, GO:0006355, GO:0006351, GO:0046982, GO:0043277, GO:0045596, GO:0045947, GO:0045944, GO:0043565, GO:0031490, GO:0045892, GO:0045893, GO:0035264, GO:0010467, GO:0003708, GO:0060591, GO:0030522, GO:0030520, GO:0051099, GO:0048384, GO:0061037, GO:0003417, GO:0030852, GO:0030853, GO:0055012, GO:0032526, GO:0001972, GO:0032689, GO:0032720, GO:0032753, GO:0045630, GO:0044212, GO:0001657, GO:0043401, GO:0043422, GO:0071391, GO:0071300, GO:0071222, GO:0034339, GO:0032355, GO:0044323, GO:0032736, GO:0032754, GO:0060010 |
| InterPro ID |
IPR001628, IPR000536, IPR001723, IPR001728, IPR003078, IPR003070, IPR000003 |
| Gene Ontology Term |
DNA binding, negative regulation of transcription, DNA-dependent, protein binding, regulation of transcription, DNA-dependent, negative regulation of translational initiation, cytoplasm, nuclear chromatin, apoptotic cell clearance, ligand-dependent nuclear receptor activity, transcription, DNA-dependent, positive regulation of cell proliferation, positive regulation of gene expression, transcription corepressor activity, metal ion binding, spermatogenesis, receptor binding, protein domain specific binding, multicellular organism growth, sequence-specific DNA binding, protein kinase A binding, positive regulation of transcription from RNA polymerase II promoter, transcription coactivator activity, nucleus, protein heterodimerization activity, dendrite, chromatin DNA binding, germ cell development, receptor activity, positive regulation of cell cycle, nucleoplasm, negative regulation of transcription from RNA polymerase II promoter, cell surface, negative regulation of cell differentiation, negative regulation of gene expression, enzyme binding, steroid hormone receptor activity, signal transduction, positive regulation of transcription, DNA-dependent, zinc ion binding, neuronal cell body, retinoic acid binding, chondroblast differentiation, cellular response to retinoic acid, positive regulation of interleukin-4 production, retinoic acid receptor activity, steroid hormone mediated signaling pathway, estrogen receptor signaling pathway, growth plate cartilage development, negative regulation of granulocyte differentiation, intracellular receptor mediated signaling pathway, gene expression, cellular response to estrogen stimulus, negative regulation of interferon-gamma production, response to retinoic acid, regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor, response to estradiol stimulus, negative regulation of tumor necrosis factor production, ventricular cardiac muscle cell differentiation, regulation of granulocyte differentiation, protein kinase B binding, positive regulation of binding, cellular response to lipopolysaccharide, ureteric bud development, retinoic acid receptor signaling pathway, negative regulation of cartilage development, positive regulation of T-helper 2 cell differentiation, sequence-specific DNA binding transcription factor activity, protein phosphorylation, positive regulation of interleukin-13 production, positive regulation of interleukin-5 production, retinoic acid-responsive element binding, transcription regulatory region DNA binding, Sertoli cell fate commitment |
| InterPro Term |
Nucl_hrmn_rcpt_lig-bd_core, ThyrH_rcpt, Str_hrmn_rcpt, Znf_hrmn_rcpt, Nuc_orph_rcpt, Retinoic_acid_rcpt, Retinoid-X_rcpt |
| Ensembl Family Description |
RETINOIC ACID RECEPTOR RAR NUCLEAR RECEPTOR SUBFAMILY 1 GROUP B MEMBER |
| Ensembl Family |
ENSFM00260000050405 |
| Ensembl Protein ID |
ENSP00000254066, ENSP00000389993, ENSP00000377643, ENSP00000377648, ENSP00000377649, ENSP00000316769, ENSP00000388570 |
| RefSeq ID |
NM_000964, NP_001138774, NP_001138773, NM_001024809, NM_001145301, NM_001145302, NP_000955, NP_001019980 |
| EMBL-Bank ID |
CR457438, AF088889, AF088895, AF088892, AF088891, AF088894, AF088893, AF088890, X56058, FJ487576, X06614, X06538, BC071733, X58685, CH471152, AB067754, AK312564, BC008727, AC080112, AF283809, U41743, U41742, HQ692826, HQ692827 |
| UniProt Accession |
A8MUP8, Q6I9R7, P10276, C9JS86, B8Y636, F1D8N9, F8W8A4 |
| Ensembl Gene ID |
ENSG00000131759 |
| Entrez Gene ID |
5914 |
| Description |
retinoic acid receptor, alpha [Source:HGNC Symbol;Acc:9864] |
| HGNC Symbol |
RARA |
| UniGene ID |
Hs.654583 |
| Ensembl Transcript ID |
ENST00000420042, ENST00000475125, ENST00000254066, ENST00000425707, ENST00000319149, ENST00000394081, ENST00000394086, ENST00000394089 |
| Gene-Disease Assocation |
ACUTE PROMYELOCYTIC LEUKEMIA; APL |
| Design Element |
ENST00000420042, ENST00000394089, 203750_s_at, 1337_s_at, ENST00000319149, ENST00000394081, ENST00000394086, ENST00000254066, 211605_s_at, 1565358_at, X06614_at, ENST00000425707, 216300_x_at, ENST00000475125, 203749_s_at, g4506418_3p_a_at, Hs2.433206.2.S1_3p_at, Hs.250505.0.A1_3p_s_at |
| Search EB-eye |
ENSG00000131759
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