CDKN1A
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Homo sapiens |
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CDKN1A is differentially expressed in 341 experiments: 118 organism parts: bone marrow, cerebellum, ... (116 more);, 167 disease states: normal, glioblastoma, ... (165 more);, 113 cell types 433 cell lines 56 compound treatments and 68 other conditions. |
| Synonyms |
p21Cip1/Waf1, p21CIP1, CAP20, CIP1, P21, WAF1, CDKN1, SDI1 |
| Orthologs |
CDKN1A
(Gallus gallus)
Cdkn1a
(Mus musculus)
A5PKM2_BOVIN
(Bos taurus)
cdkn1a
(Danio rerio)
Cdkn1a
(Rattus norvegicus)
cdkn1a
(Xenopus laevis)
Q683K8_CANFA
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology Term |
response to UV, cyclin-dependent protein kinase activity, cytosol, negative regulation of cell growth, phosphorylation, protein binding, cytoplasm, negative regulation of cell proliferation, response to toxin, mitotic cell cycle, regulation of cyclin-dependent protein kinase activity, negative regulation of apoptosis, cell cycle arrest, metal ion binding, G1 phase of mitotic cell cycle, regulation of mitotic cell cycle, cell cycle, Ras protein signal transduction, regulation of cell cycle, G1/S transition of mitotic cell cycle, nucleus, G2/M transition of mitotic cell cycle, kinase activity, cyclin binding, response to drug, positive regulation of programmed cell death, nucleoplasm, cell cycle checkpoint, response to DNA damage stimulus, S phase of mitotic cell cycle, cyclin-dependent protein kinase inhibitor activity, negative regulation of gene expression, negative regulation of cyclin-dependent protein kinase activity, response to corticosterone stimulus, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, positive regulation of B cell proliferation, response to organic nitrogen, regulation of protein import into nucleus, translocation, protein kinase inhibitor activity, induction of apoptosis by intracellular signals, positive regulation of anti-apoptosis, cellular response to extracellular stimulus, organ regeneration, PCNA-p21 complex, positive regulation of fibroblast proliferation, negative regulation of phosphorylation, response to organic substance, response to hyperoxia, cyclin-dependent protein kinase holoenzyme complex, response to glucocorticoid stimulus, cyclin-dependent protein kinase activating kinase activity, response to arsenic-containing substance, regulation of DNA biosynthetic process, response to organic cyclic compound, positive regulation of reactive oxygen species metabolic process, cellular senescence, cellular response to ionizing radiation, stress-induced premature senescence |
| Gene Ontology ID |
GO:0010629, GO:0008285, GO:0009411, GO:0007049, GO:0007050, GO:0009636, GO:0007265, GO:0016310, GO:0016301, GO:0007346, GO:0042493, GO:0004693, GO:0000080, GO:0000082, GO:0000084, GO:0000086, GO:0000079, GO:0000075, GO:0004861, GO:0005515, GO:0005737, GO:0005634, GO:0005654, GO:0005829, GO:0006974, GO:0043068, GO:0043066, GO:0045736, GO:0051726, GO:0046872, GO:0000278, GO:0030308, GO:0030332, GO:0008629, GO:0010243, GO:0010033, GO:0051384, GO:0051412, GO:0042326, GO:0014070, GO:0004860, GO:0048146, GO:0006977, GO:0030890, GO:0055093, GO:0031100, GO:0031668, GO:0045768, GO:0070557, GO:0000307, GO:0046685, GO:0033158, GO:0019912, GO:0071479, GO:0090398, GO:2000379, GO:2000278, GO:0090400 |
| InterPro Term |
CDI |
| InterPro ID |
IPR003175 |
| Ensembl Family |
ENSFM00250000009219 |
| Description |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) [Source:HGNC Symbol;Acc:1784] |
| UniGene ID |
Hs.370771 |
| EMBL-Bank ID |
BC001935, L47232, L47233, CR536533, L25610, AF497972, CH471081, BC000275, BC000312, Z85996, BT006719, L26165, S67388, U03106, AB451290, BC013967, U09579, AB451422 |
| Ensembl Protein ID |
ENSP00000409259, ENSP00000362815, ENSP00000244741, ENSP00000384849 |
| RefSeq ID |
NP_510867, NP_000380, NM_000389, NM_078467, NM_001220777, NM_001220778, NP_001207706, NP_001207707 |
| Entrez Gene ID |
1026 |
| Ensembl Gene ID |
ENSG00000124762 |
| UniProt Accession |
Q6FI05, P38936 |
| HGNC Symbol |
CDKN1A |
| Ensembl Family Description |
CYCLIN DEPENDENT KINASE INHIBITOR 1 CDK INTERACTING 1 MELANOMA DIFFERENTIATION ASSOCIATED P21 |
| Ensembl Transcript ID |
ENST00000373711, ENST00000462537, ENST00000244741, ENST00000459970, ENST00000478800, ENST00000448526, ENST00000405375 |
| Design Element |
ENST00000244741, ENST00000373711, ENST00000478800, g11386202_3p_a_at, ENST00000448526, 202284_s_at, ENST00000405375, 2031_s_at, ENST00000462537, ENST00000459970, U09579_at |
| Search EB-eye |
ENSG00000124762
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