FLT3
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Homo sapiens |
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FLT3 is differentially expressed in 186 experiments: 63 organism parts: cerebellum, blood, ... (61 more);, 78 disease states: normal, acute myeloid leukemia, ... (76 more);, 66 cell types 117 cell lines 24 compound treatments and 74 other conditions. |
| Synonyms |
CD135, FLK2, STK1 |
| Orthologs |
F1P380_CHICK
(Gallus gallus)
flt3
(Danio rerio)
Flt3
(Mus musculus)
F1MRU0_BOVIN
(Bos taurus)
Flt3
(Rattus norvegicus)
Pvr
(Drosophila melanogaster)
FLT3
(Xenopus laevis)
NP_001018647.1
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR001245, IPR017442, IPR000719, IPR007110, IPR013151, IPR020635, IPR016243 |
| Gene Ontology ID |
GO:0008285, GO:0008284, GO:0009986, GO:0016020, GO:0016021, GO:0007169, GO:0016772, GO:0004713, GO:0004714, GO:0042803, GO:0005524, GO:0005515, GO:0004896, GO:0004872, GO:0005887, GO:0005788, GO:0005783, GO:0004672, GO:0004674, GO:0042981, GO:0006468, GO:0000166, GO:0018108, GO:0046777, GO:0019221, GO:0043548, GO:0043406, GO:0030097, GO:0048010, GO:0002572, GO:0042531, GO:0014068, GO:0002328, GO:0002320, GO:0002318, GO:0005021, GO:0045578, GO:0043552, GO:0043410, GO:0030098, GO:0071345 |
| Gene Ontology Term |
endoplasmic reticulum, protein binding, cytokine-mediated signaling pathway, negative regulation of cell proliferation, positive regulation of cell proliferation, membrane, peptidyl-tyrosine phosphorylation, protein tyrosine kinase activity, positive regulation of MAP kinase activity, transmembrane receptor protein tyrosine kinase signaling pathway, hemopoiesis, ATP binding, transferase activity, transferring phosphorus-containing groups, integral to plasma membrane, receptor activity, nucleotide binding, protein serine/threonine kinase activity, transmembrane receptor protein tyrosine kinase activity, protein homodimerization activity, integral to membrane, cell surface, endoplasmic reticulum lumen, cytokine receptor activity, protein kinase activity, regulation of apoptosis, pro-B cell differentiation, negative regulation of B cell differentiation, myeloid progenitor cell differentiation, lymphocyte differentiation, lymphoid progenitor cell differentiation, positive regulation of tyrosine phosphorylation of STAT protein, pro-T cell differentiation, vascular endothelial growth factor receptor signaling pathway, positive regulation of MAPKKK cascade, protein autophosphorylation, protein phosphorylation, cellular response to cytokine stimulus, positive regulation of phosphatidylinositol 3-kinase activity, phosphatidylinositol 3-kinase binding, positive regulation of phosphatidylinositol 3-kinase cascade, vascular endothelial growth factor-activated receptor activity |
| InterPro Term |
Immunoglobulin, Prot_kinase_cat_dom, Ig-like, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Tyr_kinase_CSF1/PDGF_rcpt, Se/Thr_kinase-like_dom |
| Ensembl Family |
ENSFM00440000236844 |
| Ensembl Family Description |
FACTOR RECEPTOR PRECURSOR EC_2.7.10.1 |
| Description |
fms-related tyrosine kinase 3 [Source:HGNC Symbol;Acc:3765] |
| EMBL-Bank ID |
AL445262, AL591024, U02687, Z26652, CH471075, AL356915, L36162, BC144040, BC126350, BC144039 |
| UniGene ID |
Hs.507590, Hs.717775 |
| Ensembl Protein ID |
ENSP00000241453, ENSP00000370369, ENSP00000370374, ENSP00000438139 |
| Entrez Gene ID |
2322 |
| Ensembl Gene ID |
ENSG00000122025 |
| HGNC Symbol |
FLT3 |
| UniProt Accession |
Q5VTU6, P36888, E7ER61 |
| RefSeq ID |
NM_004119, NP_004110 |
| Ensembl Transcript ID |
ENST00000469894, ENST00000537084, ENST00000380987, ENST00000380982, ENST00000241453 |
| Gene-Disease Assocation |
LEUKEMIA, ACUTE MYELOID; AML |
| Design Element |
34583_at, ENST00000469894, ENST00000380987, ENST00000241453, ENST00000537084, ENST00000380982, 206674_at, U02687_at, g4758395_3p_at, 1065_at |
| Search EB-eye |
ENSG00000122025
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