TEK
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Homo sapiens |
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TEK is differentially expressed in 246 experiments: 157 organism parts: lung, bone marrow, ... (155 more);, 231 disease states: normal, lung adenocarcinoma, ... (229 more);, 82 cell types 200 cell lines 21 compound treatments and 68 other conditions. |
| Synonyms |
TIE-2, VMCM, VMCM1, TIE2, CD202b |
| Orthologs |
tie2
(Danio rerio)
Tek
(Rattus norvegicus)
F6XRE1_CIOIN
(Ciona intestinalis)
TEK
(Gallus gallus)
Tek
(Mus musculus)
TIE2_BOVIN
(Bos taurus)
Cad96Ca
(Drosophila melanogaster)
tek
(Xenopus laevis)
Q9MYX5_CANFA
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR003961, IPR001245, IPR017442, IPR000719, IPR000742, IPR006210, IPR007110, IPR020635, IPR018941 |
| Gene Ontology Term |
angiogenesis, plasma membrane, protein binding, cell-cell adhesion, microvillus, membrane, protein tyrosine kinase activity, cell-cell signaling, blood coagulation, membrane raft, anti-apoptosis, transmembrane receptor protein tyrosine kinase signaling pathway, basolateral plasma membrane, protein oligomerization, hemopoiesis, ATP binding, cell-matrix adhesion, integral to plasma membrane, regulation of cell migration, receptor activity, nucleotide binding, protein serine/threonine kinase activity, transmembrane receptor protein tyrosine kinase activity, apical plasma membrane, integral to membrane, cell surface, signal transduction, protein kinase activity, positive regulation of peptidyl-serine phosphorylation, positive regulation of cell adhesion, regulation of angiogenesis, leukocyte migration, positive regulation of ERK1 and ERK2 cascade, response to retinoic acid, positive regulation of protein kinase B signaling cascade, protein phosphorylation |
| Gene Ontology ID |
GO:0009986, GO:0016020, GO:0016021, GO:0007160, GO:0007169, GO:0007165, GO:0007267, GO:0016337, GO:0016323, GO:0016324, GO:0005902, GO:0051259, GO:0007596, GO:0004713, GO:0004714, GO:0005524, GO:0005515, GO:0004872, GO:0006916, GO:0005886, GO:0005887, GO:0004672, GO:0004674, GO:0006468, GO:0000166, GO:0001525, GO:0045121, GO:0030097, GO:0030334, GO:0032526, GO:0045785, GO:0045765, GO:0051897, GO:0070374, GO:0050900, GO:0033138 |
| InterPro Term |
Prot_kinase_cat_dom, Ig-like, EGF_3, EGF-like, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom, Fibronectin_type3, Tyr_kin_Tie2_Ig-like_dom-1_N |
| Ensembl Family |
ENSFM00420000140591 |
| Ensembl Family Description |
TYROSINE KINASE RECEPTOR TIE |
| EMBL-Bank ID |
AL355432, AL355433, L06139, AL133411, CH471071, AK291775, HM447041, HM447040, HM447044, HM447043, HM447042 |
| Ensembl Gene ID |
ENSG00000120156 |
| HGNC Symbol |
TEK |
| Entrez Gene ID |
7010 |
| Ensembl Protein ID |
ENSP00000383977, ENSP00000369375, ENSP00000428337, ENSP00000430233, ENSP00000343716, ENSP00000430686 |
| UniProt Accession |
Q02763, E5RIV9, E7EWI2, D9MND0, D9MND2 |
| UniGene ID |
Hs.89640 |
| Description |
TEK tyrosine kinase, endothelial [Source:HGNC Symbol;Acc:11724] |
| RefSeq ID |
NP_000450, NM_000459 |
| Ensembl Transcript ID |
ENST00000380036, ENST00000406359, ENST00000519080, ENST00000488798, ENST00000519097, ENST00000346448 |
| Gene-Disease Assocation |
VENOUS MALFORMATIONS, MULTIPLE CUTANEOUS AND MUCOSAL; VMCM |
| Design Element |
L06139_at, 1596_g_at, ENST00000380036, ENST00000346448, 217711_at, Hs.287335.0.A1_3p_at, Hs.287335.0.A1_3p_x_at, g4557868_3p_at, ENST00000519080, 206702_at, ENST00000488798, ENST00000519097, ENST00000406359, 1595_at |
| Search EB-eye |
ENSG00000120156
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