PDGFRB
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Homo sapiens |
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PDGFRB is differentially expressed in 232 experiments: 163 organism parts: bone marrow, thymus, ... (161 more);, 190 disease states: normal, glioblastoma, ... (188 more);, 75 cell types 295 cell lines 20 compound treatments and 64 other conditions. |
| Synonyms |
CD140b, PDGFR, PDGFR1, JTK12 |
| Orthologs |
Pdgfrb
(Mus musculus)
pdgfrb2
(Danio rerio)
F1N868_CHICK
(Gallus gallus)
F1MBP1_BOVIN
(Bos taurus)
Pdgfrb
(Rattus norvegicus)
Pvr
(Drosophila melanogaster)
PDGFRB
(Xenopus laevis)
PGFRB_CANFA
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR001245, IPR017442, IPR000719, IPR007110, IPR009134, IPR013151, IPR020635, IPR003598, IPR003599, IPR016243, IPR013098 |
| Gene Ontology Term |
plasma membrane, phosphorylation, protein binding, cytoplasm, positive regulation of cell proliferation, membrane, peptidyl-tyrosine phosphorylation, protein tyrosine kinase activity, receptor binding, positive regulation of MAP kinase activity, transmembrane receptor protein tyrosine kinase signaling pathway, signal transducer activity, hemopoiesis, ATP binding, integral to plasma membrane, nucleus, receptor activity, nucleotide binding, kinase activity, protein serine/threonine kinase activity, transmembrane receptor protein tyrosine kinase activity, apical plasma membrane, integral to membrane, tissue homeostasis, regulation of actin cytoskeleton organization, nitrogen compound metabolic process, signal transduction, protein kinase activity, cell chemotaxis, positive regulation of smooth muscle cell migration, in utero embryonic development, regulation of peptidyl-tyrosine phosphorylation, platelet-derived growth factor beta-receptor activity, kidney development, positive regulation of ERK1 and ERK2 cascade, adrenal gland development, platelet-derived growth factor receptor signaling pathway, positive regulation of cell migration, cardiac myofibril assembly, platelet activating factor receptor activity, positive regulation of chemotaxis, smooth muscle tissue development, growth factor binding, platelet-derived growth factor binding, skeletal system morphogenesis, positive regulation of smooth muscle cell proliferation, platelet-derived growth factor receptor binding, positive regulation of mitosis, protein autophosphorylation, protein phosphorylation, retina vasculature development in camera-type eye, positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway, metanephric glomerular mesangial cell proliferation involved in metanephros development, platelet-derived growth factor receptor-beta signaling pathway, positive regulation of reactive oxygen species metabolic process, metanephric glomerular capillary formation, positive regulation of calcium ion import, positive regulation of phosphatidylinositol 3-kinase cascade, positive regulation of DNA biosynthetic process, aorta morphogenesis, smooth muscle cell chemotaxis, vascular endothelial growth factor-activated receptor activity, platelet-derived growth factor-activated receptor activity |
| Gene Ontology ID |
GO:0008284, GO:0016020, GO:0016021, GO:0007169, GO:0007165, GO:0016310, GO:0016301, GO:0016324, GO:0004713, GO:0004714, GO:0005524, GO:0005515, GO:0004871, GO:0004872, GO:0005737, GO:0005634, GO:0005886, GO:0005887, GO:0004672, GO:0004674, GO:0005102, GO:0006807, GO:0006468, GO:0000166, GO:0018108, GO:0046777, GO:0032956, GO:0001894, GO:0043406, GO:0030097, GO:0048008, GO:0060326, GO:0004992, GO:0048705, GO:0048745, GO:0048661, GO:0048407, GO:0014068, GO:0005161, GO:0055003, GO:0005019, GO:0005017, GO:0005021, GO:0050730, GO:0019838, GO:0001701, GO:0001822, GO:0014911, GO:0045840, GO:0030335, GO:0030325, GO:0070374, GO:0050921, GO:2000573, GO:0035791, GO:0035793, GO:0072262, GO:0072277, GO:0061298, GO:0090280, GO:2000379, GO:0071670, GO:0035909 |
| InterPro Term |
Ig_sub, Immunoglobulin, Prot_kinase_cat_dom, Ig-like, Ig_sub2, Ig_I-set, Tyr_kinase_VEGFR_rcpt_N, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Tyr_kinase_CSF1/PDGF_rcpt, Se/Thr_kinase-like_dom |
| Ensembl Family |
ENSFM00440000236844 |
| Ensembl Family Description |
FACTOR RECEPTOR PRECURSOR EC_2.7.10.1 |
| HGNC Symbol |
PDGFRB |
| Gene-Disease Assocation |
MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA |
| EMBL-Bank ID |
AC005895, J03278, AB209657, AC011382, M21616, BC032224, U33172 |
| Ensembl Protein ID |
ENSP00000261799, ENSP00000429218, ENSP00000430026, ENSP00000430715, ENSP00000441057 |
| Description |
platelet-derived growth factor receptor, beta polypeptide [Source:HGNC Symbol;Acc:8804] |
| Ensembl Gene ID |
ENSG00000113721 |
| UniProt Accession |
Q59F04, P09619, E5RJ14, E5RII0, E5RH16 |
| RefSeq ID |
NP_002600, NM_002609 |
| UniGene ID |
Hs.509067 |
| Entrez Gene ID |
5159 |
| Ensembl Transcript ID |
ENST00000521723, ENST00000261799, ENST00000544453, ENST00000520579, ENST00000520229, ENST00000519575, ENST00000517957, ENST00000517488, ENST00000522466, ENST00000520851 |
| Design Element |
ENST00000521723, ENST00000520851, ENST00000519575, ENST00000522466, ENST00000517957, ENST00000520579, ENST00000544453, ENST00000261799, g4505682_3p_x_at, J03278_at, g4505682_3p_at, 36993_at, ENST00000517488, 74696_r_at, 1771_s_at, ENST00000520229, 202273_at |
| Search EB-eye |
ENSG00000113721
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