ITK
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Homo sapiens |
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ITK is differentially expressed in 196 experiments: 68 organism parts: thymus, lung, ... (66 more);, 206 disease states: normal, acute lymphoblastic leukemia, ... (204 more);, 92 cell types 149 cell lines 23 compound treatments and 66 other conditions. |
| Synonyms |
PSCTK2, LYK, EMT |
| Orthologs |
ITK
(Gallus gallus)
Itk
(Mus musculus)
Itk
(Rattus norvegicus)
itk
(Danio rerio)
A7Z039_BOVIN
(Bos taurus)
ITK
(Xenopus laevis)
ITK
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR001562, IPR002290, IPR001452, IPR011511, IPR001245, IPR017442, IPR000719, IPR000980, IPR001849, IPR020635 |
| Gene Ontology Term |
cytosol, protein binding, cytoplasm, metal ion binding, protein tyrosine kinase activity, ATP binding, activation of phospholipase C activity, nucleotide binding, protein serine/threonine kinase activity, cellular defense response, non-membrane spanning protein tyrosine kinase activity, signal transduction, protein kinase activity, T cell receptor signaling pathway, T cell activation, adaptive immune response, cytokine production, interferon-gamma production, protein phosphorylation, intracellular signal transduction, NK T cell differentiation, interleukin-4 production |
| InterPro Term |
SH2, SH3_domain, Znf_Btk_motif, Prot_kinase_cat_dom, Pleckstrin_homology, SH3_2, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| Gene Ontology ID |
GO:0007165, GO:0007202, GO:0004713, GO:0004715, GO:0005524, GO:0005515, GO:0005737, GO:0005829, GO:0006968, GO:0004672, GO:0004674, GO:0006468, GO:0000166, GO:0046872, GO:0002250, GO:0032609, GO:0050852, GO:0042110, GO:0001816, GO:0035556, GO:0032633, GO:0001865 |
| Ensembl Family |
ENSFM00280000058686 |
| Ensembl Family Description |
TYROSINE KINASE EC_2.7.10.2 |
| EMBL-Bank ID |
S65186, D13720, BC109078, BC109077, BX538196, CH471062, AK312846, L10717, AC010609 |
| Gene-Disease Assocation |
LYMPHOPROLIFERATIVE SYNDROME, EBV-ASSOCIATED, AUTOSOMAL, 1 |
| Description |
IL2-inducible T-cell kinase [Source:HGNC Symbol;Acc:6171] |
| Ensembl Protein ID |
ENSP00000431054, ENSP00000398655, ENSP00000430327 |
| RefSeq ID |
NM_005546, NP_005537 |
| Ensembl Gene ID |
ENSG00000113263 |
| Entrez Gene ID |
3702 |
| UniProt Accession |
Q08881, Q7Z318, E5RFR5, E5RJY4 |
| HGNC Symbol |
ITK |
| UniGene ID |
Hs.558348 |
| Ensembl Transcript ID |
ENST00000422843, ENST00000523926, ENST00000521769, ENST00000520173, ENST00000520555, ENST00000519402, ENST00000517779, ENST00000519749, ENST00000519759, ENST00000522616 |
| Design Element |
ENST00000517779, 211339_s_at, 1479_g_at, ENST00000519759, ENST00000519749, ENST00000422843, g399657_3p_a_at, ENST00000522616, ENST00000521769, ENST00000520555, ENST00000523926, ENST00000520173, ENST00000519402, D13720_s_at, 1478_at, L10717_at |
| Search EB-eye |
ENSG00000113263
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