CBL
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Homo sapiens |
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CBL is differentially expressed in 270 experiments: 123 organism parts: bone marrow, skeletal muscle, ... (121 more);, 153 disease states: normal, breast carcinoma, ... (151 more);, 80 cell types 376 cell lines 37 compound treatments and 79 other conditions. |
| Synonyms |
CBL2, RNF55, c-Cbl |
| Orthologs |
D4A407_RAT
(Rattus norvegicus)
ENSCING00000002655
(Ciona intestinalis)
cbl
(Danio rerio)
Cbl
(Mus musculus)
CBL
(Bos taurus)
Cbl
(Drosophila melanogaster)
cbl
(Xenopus laevis)
CBL
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology Term |
cytosol, ligase activity, plasma membrane, negative regulation of epidermal growth factor receptor signaling pathway, protein binding, regulation of transcription, DNA-dependent, cytoplasm, epidermal growth factor receptor signaling pathway, transcription, DNA-dependent, protein ubiquitination, flotillin complex, negative regulation of apoptosis, SH3 domain binding, ephrin receptor binding, signal transducer activity, cell surface receptor linked signaling pathway, nucleus, ubiquitin-protein ligase activity, calcium ion binding, zinc ion binding, phosphotyrosine binding, positive regulation of receptor-mediated endocytosis, sequence-specific DNA binding transcription factor activity, positive regulation of phosphatidylinositol 3-kinase cascade, regulation of signaling |
| InterPro ID |
IPR018957, IPR000449, IPR001841, IPR014742, IPR014741, IPR015940, IPR003153 |
| Gene Ontology ID |
GO:0008270, GO:0003700, GO:0016600, GO:0016567, GO:0007173, GO:0007166, GO:0016874, GO:0005509, GO:0005515, GO:0004842, GO:0004871, GO:0005737, GO:0005634, GO:0005886, GO:0005829, GO:0043066, GO:0046875, GO:0006355, GO:0006351, GO:0042059, GO:0017124, GO:0014068, GO:0048260, GO:0001784, GO:0023051 |
| InterPro Term |
UBA/transl_elong_EF1B_N_euk, UBA/transl_elong_EF1B_N, Znf_RING, Znf_C3HC4_RING-type, Adaptor_Cbl_SH2-like, Adaptor_Cbl_EF_hand-like, Adaptor_Cbl_N_hlx |
| Ensembl Family |
ENSFM00250000001327 |
| Ensembl Family Description |
E3 UBIQUITIN LIGASE CBL EC_6.3.2.- CASITAS B LINEAGE LYMPHOMA PROTO ONCOGENE CBL SIGNAL TRANSDUCTION CBL |
| Description |
Cas-Br-M (murine) ecotropic retroviral transforming sequence [Source:HGNC Symbol;Acc:1541] |
| RefSeq ID |
NM_005188, NP_005179 |
| Ensembl Gene ID |
ENSG00000110395 |
| EMBL-Bank ID |
BC132733, AP002956, BC136463, X57110 |
| UniProt Accession |
P22681 |
| Ensembl Protein ID |
ENSP00000264033 |
| HGNC Symbol |
CBL |
| UniGene ID |
Hs.504096 |
| Entrez Gene ID |
867 |
| Ensembl Transcript ID |
ENST00000264033 |
| Gene-Disease Assocation |
NOONAN SYNDROME-LIKE DISORDER WITH OR WITHOUT JUVENILE MYELOMONOCYTIC |
| Design Element |
g4885116_3p_at, X57110_s_at, 1568191_at, 206607_at, Hs.196521.0.A1_3p_at, 47569_at, Hs.41324.0.A1_3p_at, 68600_at, 51017_at, 34416_at, 229010_at, 225231_at, Hs.90960.0.A2_3p_at, ENST00000264033, Hs.90960.0.A1_3p_at, 243475_at, 225234_at, 55605_at, Hs2.423675.1.A1_3p_at |
| Search EB-eye |
ENSG00000110395
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