MET
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Homo sapiens |
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MET is differentially expressed in 357 experiments: 171 organism parts: lung, bone marrow, ... (169 more);, 303 disease states: normal, colon carcinoma, ... (301 more);, 121 cell types 585 cell lines 42 compound treatments and 81 other conditions. |
| Synonyms |
HGFR, RCCP2 |
| Orthologs |
Q9BE46_BOVIN
(Bos taurus)
Met
(Mus musculus)
F6UN86_CIOIN
(Ciona intestinalis)
met
(Danio rerio)
F1P040_CHICK
(Gallus gallus)
Met
(Rattus norvegicus)
met
(Xenopus laevis)
MET_CANFA
(Canis familiaris)
(Compare orthologs)
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| InterPro Term |
Plexin_repeat, Plexin-like, Prot_kinase_cat_dom, Semaphorin/CD100_Ag, IPT_TIG_rcpt, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Tyr_kinase_HGF/MSP_rcpt, Se/Thr_kinase-like_dom |
| InterPro ID |
IPR002290, IPR001627, IPR001245, IPR002909, IPR017442, IPR000719, IPR002165, IPR020635, IPR003659, IPR016244 |
| Gene Ontology Term |
plasma membrane, protein binding, response to wounding, flagellum, positive regulation of peptidyl-threonine phosphorylation, cytoplasm, beta-catenin binding, cell proliferation, myoblast proliferation, extracellular space, positive regulation of gene expression, membrane, postsynaptic membrane, male gonad development, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase signaling pathway, membrane fraction, glucose homeostasis, activation of MAPK activity, sperm motility, ATP binding, axon guidance, neuron projection, transferase activity, transferring phosphorus-containing groups, multicellular organismal development, cell surface receptor linked signaling pathway, integral to plasma membrane, muscle organ development, postsynaptic density, protein heterodimerization activity, dendrite, positive regulation of DNA replication, receptor activity, nucleotide binding, protein serine/threonine kinase activity, response to drug, adult behavior, transmembrane receptor protein tyrosine kinase activity, integral to membrane, basal plasma membrane, brain development, skeletal muscle tissue development, signal transduction, protein kinase activity, neuron migration, neuronal cell body, positive regulation of peptidyl-serine phosphorylation, positive regulation of neuron projection development, cellular response to glucose stimulus, cellular response to growth factor stimulus, central nervous system neuron differentiation, cell aging, lactation, hepatocyte growth factor receptor signaling pathway, cellular response to peptide hormone stimulus, myotube differentiation, placenta development, pancreas development, excitatory synapse, negative regulation of peptidyl-threonine phosphorylation, response to peptide hormone stimulus, regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling, response to acid, liver development, oligodendrocyte development, positive regulation of glucose transport, protein complex binding, phospholipase binding, positive regulation of mitosis, cellular response to interleukin-6, muscle cell migration, positive regulation of dendrite morphogenesis, protein autophosphorylation, protein phosphorylation, cellular response to inorganic substance, response to organic cyclic compound, phosphatidylinositol 3-kinase binding, cellular response to arsenic-containing substance, hepatocyte growth factor-activated receptor activity |
| Gene Ontology ID |
GO:0010628, GO:0008283, GO:0009925, GO:0016020, GO:0016021, GO:0008013, GO:0007169, GO:0007166, GO:0007165, GO:0009611, GO:0007275, GO:0008584, GO:0007420, GO:0007411, GO:0051450, GO:0007519, GO:0007517, GO:0042493, GO:0030534, GO:0042593, GO:0030425, GO:0016772, GO:0004713, GO:0004714, GO:0005624, GO:0005615, GO:0005524, GO:0014069, GO:0005515, GO:0004872, GO:0005737, GO:0005886, GO:0005887, GO:0004672, GO:0004674, GO:0006468, GO:0019861, GO:0043005, GO:0043025, GO:0000166, GO:0045740, GO:0000187, GO:0001764, GO:0046777, GO:0046982, GO:0043548, GO:0045211, GO:0030317, GO:0010800, GO:0048012, GO:0060665, GO:0060076, GO:0007569, GO:0007595, GO:0001101, GO:0014070, GO:0014003, GO:0032403, GO:0005008, GO:0050775, GO:0031016, GO:0014812, GO:0043274, GO:0001889, GO:0001890, GO:0014902, GO:0045840, GO:0043434, GO:0021953, GO:0071375, GO:0071333, GO:0071354, GO:0071363, GO:0033138, GO:0010801, GO:0010828, GO:0010976, GO:0071241, GO:0071243 |
| Ensembl Family |
ENSFM00500000269847 |
| Ensembl Family Description |
HEPATOCYTE GROWTH FACTOR RECEPTOR PRECURSOR HGF RECEPTOR EC_2.7.10.1 HGF/SF RECEPTOR PROTO ONCOGENE C MET SCATTER FACTOR RECEPTOR SF RECEPTOR TYROSINE KINASE MET |
| Ensembl Gene ID |
ENSG00000105976 |
| Ensembl Protein ID |
ENSP00000398140, ENSP00000398776, ENSP00000380860, ENSP00000400890, ENSP00000413857, ENSP00000410980, ENSP00000317272, ENSP00000445020 |
| EMBL-Bank ID |
X54559, U08818, BC130420, M15325, M35074, J02958, CH471070, AC002080, AC004416, AC002543, AK298552, CH236947, AK296974 |
| Description |
met proto-oncogene (hepatocyte growth factor receptor) [Source:HGNC Symbol;Acc:7029] |
| RefSeq ID |
NM_001127500, NP_001120972, NP_000236, NM_000245 |
| UniProt Accession |
Q9UEJ3, A1L467, P08581, C9JKM5, B4DPY6, C9JVH4, B4DLF5, E7EQ94 |
| Entrez Gene ID |
4233 |
| Gene-Disease Assocation |
HEPATOCELLULAR CARCINOMA, AUTISM, SUSCEPTIBILITY TO, 9; AUTS9, RENAL CELL CARCINOMA, PAPILLARY, 1; RCCP1 |
| UniGene ID |
Hs.132966, Hs.619431 |
| HGNC Symbol |
MET |
| Ensembl Transcript ID |
ENST00000495962, ENST00000454623, ENST00000436117, ENST00000422097, ENST00000318493, ENST00000539704, ENST00000397752, ENST00000437703, ENST00000456159 |
| Design Element |
ENST00000436117, 213807_x_at, 46302_at, 211599_x_at, 203510_at, ENST00000495962, g625085_3p_s_at, ENST00000437703, ENST00000318493, ENST00000539704, ENST00000454623, 1609_g_at, ENST00000456159, 35684_at, 213816_s_at, 1812_s_at, Hs.285754.1.S1_3p_a_at, Hs.285754.0.S2_3p_at, ENST00000422097, ENST00000397752 |
| Search EB-eye |
ENSG00000105976
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