JAK3
close
Please copy/paste those URLs into your code to get same results in machine-readable formats:
|
Homo sapiens |
|
JAK3 is differentially expressed in 299 experiments: 124 organism parts: bone marrow, kidney, ... (122 more);, 246 disease states: normal, chronic lymphocytic leukemia, ... (244 more);, 95 cell types 365 cell lines 40 compound treatments and 80 other conditions. |
| Synonyms |
L-JAK, LJAK, JAKL, JAK-3, JAK3_HUMAN |
| Orthologs |
jak3
(Danio rerio)
Jak3
(Mus musculus)
E1BEL4_BOVIN
(Bos taurus)
Jak3
(Rattus norvegicus)
Q4H3A3_CIOIN
(Ciona intestinalis)
PR2
(Drosophila melanogaster)
jak3
(Xenopus laevis)
JAK3
(Canis familiaris)
(Compare orthologs)
|
| InterPro ID |
IPR002290, IPR000299, IPR001245, IPR017442, IPR000719, IPR019749, IPR000980, IPR020635, IPR016251, IPR020775 |
| Gene Ontology Term |
endomembrane system, cytosol, elevation of cytosolic calcium ion concentration, protein binding, cytoskeleton, cytokine-mediated signaling pathway, cytoplasm, innate immune response, membrane, tyrosine phosphorylation of STAT protein, peptidyl-tyrosine phosphorylation, protein tyrosine kinase activity, ATP binding, positive regulation of transcription from RNA polymerase II promoter, nucleotide binding, protein serine/threonine kinase activity, positive regulation of calcium ion transport, non-membrane spanning protein tyrosine kinase activity, protein kinase activity, intracellular protein kinase cascade, regulation of apoptosis, positive regulation of immune response, B cell differentiation, tyrosine phosphorylation of Stat5 protein, negative regulation of T-helper 1 cell differentiation, negative regulation of T cell activation, negative regulation of thymocyte apoptosis, positive regulation of anti-apoptosis, response to interleukin-2, response to interleukin-4, response to interleukin-9, positive regulation of activated T cell proliferation, negative regulation of interleukin-10 production, T cell homeostasis, response to interleukin-15, enzyme linked receptor protein signaling pathway, negative regulation of interleukin-12 production, JAK-STAT cascade involved in growth hormone signaling pathway, protein autophosphorylation, protein phosphorylation, STAT protein import into nucleus, regulation of T cell apoptosis, negative regulation of FasL biosynthetic process, negative regulation of dendritic cell cytokine production |
| InterPro Term |
SH2, Prot_kinase_cat_dom, Band_41_domain, FERM_domain, Tyr_kinase_non-rcpt_Jak/Tyk2, Tyr_kinase_non-rcpt_Jak3, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| Gene Ontology ID |
GO:0016020, GO:0007243, GO:0007260, GO:0007262, GO:0007204, GO:0004713, GO:0004715, GO:0005524, GO:0005515, GO:0012505, GO:0005737, GO:0005856, GO:0005829, GO:0004672, GO:0004674, GO:0042981, GO:0051928, GO:0006468, GO:0000166, GO:0018108, GO:0046777, GO:0019221, GO:0045944, GO:0045087, GO:0060397, GO:0007167, GO:0042506, GO:0050778, GO:0032695, GO:0032693, GO:0050868, GO:0043029, GO:0045768, GO:0042104, GO:0070670, GO:0070669, GO:0070672, GO:0045626, GO:0070244, GO:0030183, GO:0071104, GO:0002731, GO:0070232, GO:0045221 |
| Ensembl Family |
ENSFM00250000000777 |
| Ensembl Family Description |
TYROSINE KINASE EC_2.7.10.2 JANUS KINASE JAK |
| EMBL-Bank ID |
AC007201, U70065, U08340, U31602, U31601, BC028068, AF513860, U31317, CH471106, U09607, U57096 |
| Ensembl Protein ID |
ENSP00000391676, ENSP00000413248, ENSP00000436421, ENSP00000432511 |
| UniProt Accession |
P52333, Q9UMU1, Q6LD09, Q8N1E8 |
| Ensembl Gene ID |
ENSG00000105639 |
| Gene-Disease Assocation |
SEVERE COMBINED IMMUNODEFICIENCY, AUTOSOMAL RECESSIVE, T CELL-NEGATIVE, |
| UniGene ID |
Hs.622989, Hs.515247 |
| Entrez Gene ID |
3718 |
| HGNC Symbol |
JAK3 |
| RefSeq ID |
NP_000206, NM_000215 |
| Description |
Janus kinase 3 [Source:HGNC Symbol;Acc:6193] |
| Ensembl Transcript ID |
ENST00000528705, ENST00000526008, ENST00000458235, ENST00000528293, ENST00000534444, ENST00000527670, ENST00000527031, ENST00000428406 |
| Design Element |
46152_at, 2005_s_at, ENST00000526008, ENST00000534444, ENST00000458235, 211108_s_at, ENST00000428406, ENST00000528293, 207187_at, g1039418_3p_at, 207187_3p_at, 2007_g_at, U09607_at, ENST00000527670, 211109_at, Hs.58643.0.A1_3p_at, ENST00000528705, ENST00000527031, 227677_at, g4557680_3p_at, 2006_at, 1547_at |
| Search EB-eye |
ENSG00000105639
|
 Show more
properties
|
|
