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NBN Homo sapiens
NBN is differentially expressed in 143 experiments [172 up/171 dn]: 40 organism parts: skeletal muscle [1 up/1 dn], bone marrow [1 up/1 dn], ...; 44 disease states: normal [5 up/14 dn], breast carcinoma [2 up/0 dn], ...; 35 cell types, 34 cell lines, 38 compound treatments and 23 other conditions.
Synonyms NBN, NBS, NBS1, P95
Orthologs zgc:194152 (Danio rerio)  Nbn (Mus musculus)  nbs (Drosophila melanogaster)  NBN_RAT (Rattus norvegicus)  (Compare orthologs)
InterPro Term BRCT, DNA repair Nbs1, C-terminal, Forkhead-associated, SMAD/FHA domain, Nibrin
Diseases Leukemia, acute lymphoblastic, Nijmegen breakage syndrome
GO Terms DNA damage response, signal transduction by p53 class mediator, DNA duplex unwinding, G1/S transition checkpoint, Mre11 complex, double-strand break repair
Uniprot O60934 
Search EB-eye ENSG00000104320
REST API
Expression Summary
280 factor values, click each to filter
Factor Value Factor Up/Down
Legend: - number of studies the gene is up/down in
Normal Disease state
14
5
None Compound treatment
10
1
Homo sapiens Organism
1
3
Control Compound treatment
3
Stromal cell Cell type
1
2
Monocyte Cell type
2
1
SW480 Cell line
2
SW620 Cell line
2
Invasive ductal carcinoma Histology
2
Lipopolysaccharide Compound treatment
2
FLAP Compound treatment
2
MK886 Compound treatment
2
Not applicable Histology
2
Dimethyl sulfoxide Compound treatment
2
Breast carcinoma Disease state
2
PC3 Cell line
2
MCF-7 Cell line
2
0 cm away from the tumor bound... Observation
2
Acute promyelocytic leukemia Disease state
2
N/a Test result
2
HNRPA2B Compound treatment
2
Endothelial cell Cell type
2
17beta-estradiol Compound treatment
1
1
Skeletal muscle Organism part
1
1
Estrogen receptor 1 negative; ... Test result
2
Fibroblast Cell type
1
1
Cystic change Histology
2
Primary Disease staging
1
1
Interferon-gamma Compound treatment
2
Organism_part Material type
1
1
Cell Material type
1
1
Bone marrow Organism part
1
1
SKBR3 Cell line
1
White blood cells Organism part
1
Cerebellum Organism part
1
MDA468 Cell line
1
Circulating neutrophil Cell type
1
Caudate nucleus Organism part
1
Glucocorticoid sensitive Phenotype
1
Glucocorticoid resistant Phenotype
1
Pretreatment primary sample Clinical info
1
BT474 Cell line
1
Alveolar space neutrophil Cell type
1
Bacterial endotoxin Compound treatment
1
Malignant melanoma Disease state
1
MCF7 Cell line
1
Superior cervical ganglion Organism part
1
Frontal cortex, primary motor ... Organism part
1
Epilepsy Disease state
1
Rapamycin Compound treatment
1
Benign prostatic hyperplasia Disease state
1
Prostate carcinoma Disease state
1
Primary cells Cell line
1
Vascular smooth muscle cell Cell type
1
Enzo Labeling Protocol type
1
U937 Cell line
1
Superficial transitional cell ... Disease state
1
Chondrocyte Cell type
1
Spermatocyte Cell type
1
Heart Organism part
1
Cigarette smoke Growth condition
1
Incubator control Growth condition
1
Placebo Compound treatment
1
Glutamine Compound treatment
1
CD34+ Cell type
1
Primary gastric tumor Organism part
1
HPL1 Cell line
1
MDA-MB-231 Cell line
1
Lung Organism part
1
BT-474 Cell line
1
Stage II Disease staging
1
Trichostatin A Compound treatment
1
Experimental malaria-infected Disease state
1
Idiopathic dilated cardiomyopa... Disease state
1
Ultraviolet light Light
1
Cigarette smoke Compound treatment
1
M1 macrophage Cell type
1
SKMEL5 Cell line
1
Interferon-gamma + lipopolysac... Compound treatment
1
Lymphatic endothelial cell Cell type
1
HL-60 Cell line
1
T3aNxM1 Disease staging
1
5-aza-2'-deoxycytidine Compound treatment
1
Ischemic cardiomyopathy Disease state
1
Training set Population
1
Test set Population
1
4OH-tamoxifen Compound treatment
1
Methotrexate Compound treatment
1
Affymetrix Labeling Protocol type
1
Epidermal keratinocyte Cell type
1
SkinEthic keratinocyte Cell type
1
Baseline uninfected Disease state
1
Term Developmental stage
1
Midgestation Developmental stage
1
Trigeminal ganglion Organism part
1
HaCaT Cell line
1
T47-D Cell line
1
Oligodendroglioma Disease state
1
Liver Organism part
1
Hydrogen peroxide Compound treatment
1
Testis Organism part
1
Skin Organism part
1
A549 Cell line
1
Infrared light Light
1
GLI60 Cell line
1
GLI56 Cell line
1
Heregulin Compound treatment
1
Johnsen score count 2: Sertoli... Histology
1
Huntington's disease Disease state
1
CD3+ CD4+ CD8- CD45RA+ CD62L+ Phenotype
1
Naive T cell Cell type
1
Beas2B Cell line
1
Tumor Organism part
1
Cancer13 Replicate
1
Grade II Tumor grading
1
Smooth muscle Organism part
1
YCC1 Cell line
1
Seminiferous tubule Organism part
1
CodeLink Labeling Protocol type
1
Glioblastoma Disease state
1
White blood cell Cell type
1
Platelet Cell type
1
Native skin Cell type
1
Cartilage Organism part
1
Mannitol Compound treatment
1
Kaposi's sarcoma-associated he... Infection
1
Childhood acute myeloid leukem... Disease state
1
Chronic myelogenous leukemia Disease state
1
Malignant pleural mesothelioma Disease state
1
In vitro neutrophil Cell type
1
2-(3,4,5-trimethoxy-phenylamin... Compound treatment
1
Ovary Organism part
1
Respiratory syncytial virus Infection
1
Cadmium chloride 2.5-hydrate Compound treatment
1
MiR15a/miR16-1 transfection Gene modification
1
MKN74 Cell line
1
Normal Disease staging
1
Cyclosporin A, mycophenolate m... Clinical treatment
1
Sirolimus, mycophenolate mofet... Clinical treatment
1
Stage I Disease staging
1
Empty vector Gene modification
1
Dermal fibroblast Cell type
1
Astrocytoma Disease state
1
Synovial fluid Organism part
1
Peripheral blood Organism part
1
Monoclonal gammopathy of undet... Disease state
1
Testicular seminoma Disease state
1
Spermatid Cell type
1
Hypericin incubated, not irrad... Growth condition
1
Hypericin incubated, irradiate... Growth condition
1
Geriatric Developmental stage
1
Pediatric Developmental stage
1
Heat-killed HL60 cell lysate Infection
1
Basal cell Cell type
1
Filtered air Compound treatment
1
Infergen + interferon-gamma Compound treatment
1
Salivary gland Organism part
1
Serum starvation synchronizati... Growth condition
1
No decrease in symptoms Clinical info
1
Macaca mulatta Organism
1
Carcinoma in situ lesion Disease state
1
U87 Cell line
1
U373 Cell line
1
Ciliary ganglion Organism part
1
Mature monocyte derived dendri... Cell type
1
Gastric cancer Disease state
1
Carboplatin resistant Test result
1
Carboplatin sensitive Test result
1
Ductal carcinoma in situ Disease state
1
Invasive ductal carcinoma Disease state
1
Dorsal root ganglion Organism part
1
Down syndrome Disease state
1
BL41K3 Cell line
1
BJABK3 Cell line
1
Beta cell islets Organism part
1
Testis - interstitial Organism part
1
Ethanol Vehicle
1
HMEC184 Cell line
1
Anaplastic mixed oligo-astrocy... Disease state
1
Actinomycin D Compound treatment
1
Sporadic basal-like breast can... Disease state
1
CD3- CD4+ CD8- Phenotype
1
Intrathymic T progenitor cell Cell type
1
Kaposi's sarcoma Disease state
1
PT2 Disease staging
1
Monocyte at intermediate diffe... Cell type
1
Female Sex
1
Male Sex
1
Interferon alpha Compound treatment
1
Non-ischemic cardiomyopathy Disease state
1
Johnsen score count 3.2: Serto... Histology
1
Endotoxin Compound treatment
1
Vanadium pentoxide Compound treatment
1
Subthalamic nucleus Organism part
1
Medulla oblongata Organism part
1
Thymus Organism part
1
Neo-resistant Genotype
1
Atrioventricular node Organism part
1
Granulocyte macrophage-colony ... Compound treatment
1
T1bN0M0 Disease staging
1
CD3int CD4+ CD8+ Phenotype
1
Double positive thymocyte Cell type
1
Ethanol Compound treatment
1
Ponasterone A Compound treatment
1
MCF10A Cell line
1
DMSO Vehicle
1
Placenta Organism part
1
Congestive cardiomyopathy Disease state
1
M-CSF Compound treatment
1
PT1 Disease staging
1
Pancreas Organism part
1
Parietal lobe Organism part
1
Lymph node metastasis Disease staging
1
X-linked chronic granulomatous Disease state
1
LacZ control RNAi
1
Vitamin E Compound treatment
1
Granulocyte-colony stimulating... Compound treatment
1
Capra hircus Organism
1
Pan troglodytes Organism
1
Frontal cortex, superior motor... Organism part
1
Lin- CD34- Phenotype
1
Multiple myeloma Disease state
1
HGF stimulation Growth condition
1
60 min after exercise Clinical info
1
Neuroblastoma cell Cell type
1
Pons Organism part
1
Epithelial cell Cell type
1
Growth medium Vehicle
1
CD16+ dendritic cell Cell type
1
SCH Cell line
1
MDS-associated acute myeloid l... Disease state
1
Acute myeloid leukemia Disease state
1
T4bN1M0 Disease staging
1
SM1 Cell line
1
HeLa Cell line
1
Measles virus Chicago-1 strain Infection
1
Uninfected Infection
1
T47D Cell line
1
Secretory cell Cell type
1
Johnsen score count 10: full s... Histology
1
PDGF-A dominant-negative Genotype
1
Grade III Tumor grading
1
Control Clinical info
1
Plasma cell Cell type
1
B lymphocyte Cell type
1
Lin+ CD34+ Phenotype
1
Amygdala Organism part
1
Umbilical cord Organism part
1
Adult Developmental stage
1
Infant Developmental stage
1
Estrogen receptor 1 negative; ... Test result
1
B-precursor acute lymphoblasti... Disease state
1
Johnsen score count 5: no sper... Histology
1
Lymph node Organism part
1
Tonsil Organism part
1
Cancer9 Replicate
1
Johnsen score count 8: hypospe... Histology
1
Permanent atrial fibrillation Disease state
1
No atrial fibrillation Disease state
1
T3bN1M0 Disease staging
1
Immediately after exercise Clinical info
1
Immature monocyte derived dend... Cell type
1
Uninfected control RNAi
1
Diarrhea-predominant Clinical info
1
T3aNxMx Disease staging
1
Teratozoospermia Disease state
1
Normospermic Disease state
1
Adrenal gland Organism part
1
Plasmacytoid dendritic cell Cell type
1
Selenium Compound treatment
1
Hs746T Cell line
1
Sevoflurane Compound treatment
1
Normal Histology
1
BDCA1+ dendritic cell Cell type
1
Breast cancer Disease state
1
Cervical cancer Disease state
1
Acute radiation toxicity Clinical history
1
Treated malaria, natural infec... Disease state
1
T-cell lymphoblastic lymphoma Disease state
1
Mycobacterium tuberculosis Infection
1
Expression Profiles
E-MEXP-440: Transcription profiling of lapatinib treated of breast cancer cell lines
Experimental Factors
Show expression profile  /  experiment details

 
E-MEXP-1014: Transcription profiling of two human colon cancer cell lines treated with n-3 PUFA docosahexaenoic acid for 3 different time points
Experimental Factors
Show expression profile  /  experiment details

 
E-GEOD-5824: Transcription profiling of human Acute Lymphoblastic Leukemia CEM_C1 cells treated with rapamycin identifies rapamycin as a glucocorticoid resistance reversal agent
Experimental Factors
Phenotype Time Clinical info Dose Compound treatment
Show expression profile  /  experiment details

 
E-AFMX-5: Transcription profiling of human cell lines and tissues (GNF/Novartis)
Experimental Factors
Cell type Organism part Disease state
Show expression profile  /  experiment details

 
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