TSC2
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Homo sapiens |
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TSC2 is differentially expressed in 223 experiments: 78 organism parts: cerebellum, salivary gland, ... (76 more);, 118 disease states: normal, prostate carcinoma, ... (116 more);, 55 cell types 235 cell lines 42 compound treatments and 64 other conditions. |
| Synonyms |
tuberin, LAM, TSC4 |
| Orthologs |
Tsc2
(Rattus norvegicus)
tsc2
(Danio rerio)
TSC2
(Bos taurus)
TSC2
(Gallus gallus)
ENSCING00000007183
(Ciona intestinalis)
Tsc2
(Mus musculus)
gig
(Drosophila melanogaster)
tsc2
(Xenopus laevis)
Q9XSY8_CANFA
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0016192, GO:0048009, GO:0048015, GO:0008286, GO:0008285, GO:0016020, GO:0008104, GO:0007050, GO:0007165, GO:0008543, GO:0005901, GO:0051260, GO:0007507, GO:0051056, GO:0030425, GO:0030426, GO:0048471, GO:0005488, GO:0042803, GO:0005622, GO:0005624, GO:0005515, GO:0006953, GO:0005737, GO:0005634, GO:0006897, GO:0005829, GO:0005794, GO:0005792, GO:0006606, GO:0050680, GO:0005096, GO:0006469, GO:0043005, GO:0043025, GO:0045792, GO:0051726, GO:0046982, GO:0051898, GO:0043234, GO:0046626, GO:0043547, GO:0043491, GO:0001666, GO:0043407, GO:0030178, GO:0030030, GO:0045184, GO:0045121, GO:0050918, GO:0032007, GO:0048011, GO:0051291, GO:0014065, GO:0014067, GO:0044430, GO:0001843, GO:0030100, GO:0033596, GO:0071889 |
| InterPro ID |
IPR003913, IPR000331, IPR018515, IPR024584 |
| Gene Ontology Term |
cytosol, protein localization, protein binding, establishment of protein localization, cytoplasm, intracellular, negative regulation of cell proliferation, negative regulation of protein kinase activity, protein complex, protein import into nucleus, acute-phase response, membrane, protein homooligomerization, Golgi apparatus, cell cycle arrest, insulin-like growth factor receptor signaling pathway, insulin receptor signaling pathway, membrane raft, response to hypoxia, membrane fraction, negative regulation of Wnt receptor signaling pathway, fibroblast growth factor receptor signaling pathway, positive chemotaxis, vesicle-mediated transport, protein kinase B signaling cascade, GTPase activator activity, neuron projection, microsome, regulation of cell cycle, nucleus, heart development, protein heterodimerization activity, negative regulation of TOR signaling cascade, regulation of small GTPase mediated signal transduction, dendrite, growth cone, perinuclear region of cytoplasm, negative regulation of protein kinase B signaling cascade, protein homodimerization activity, binding, negative regulation of MAP kinase activity, cell projection organization, negative regulation of epithelial cell proliferation, signal transduction, regulation of insulin receptor signaling pathway, positive regulation of GTPase activity, negative regulation of cell size, caveola, endocytosis, neuronal cell body, TSC1-TSC2 complex, neural tube closure, cytoskeletal part, regulation of endocytosis, nerve growth factor receptor signaling pathway, protein heterooligomerization, phosphatidylinositol-mediated signaling, 14-3-3 protein binding, phosphatidylinositol 3-kinase cascade, negative regulation of phosphatidylinositol 3-kinase cascade |
| Ensembl Family |
ENSFM00250000003183 |
| Ensembl Family Description |
TUBERIN TUBEROUS SCLEROSIS 2 |
| InterPro Term |
Rap_GAP, Tuberin-type_domain, Tuberin, Tuberin_N |
| Description |
tuberous sclerosis 2 [Source:HGNC Symbol;Acc:12363] |
| Ensembl Gene ID |
ENSG00000103197 |
| EMBL-Bank ID |
AK295728, AC005600, BC025364, AK295672, BC150300, CH471112, AC093513, AB210000, BX647816, L48517, L48518, L48519, L48523, L48524, L48521, L48522, L48527, L48528, L48525, L48526, L48529, L48532, L48531, L48530, L48537, L48538, L48539, L48533, L48534, L48535, L48536, L48542, L48541, L48544, L48543, L48540, L48545, L48546, AK299343, X75621, AB014460, BC046929 |
| UniProt Accession |
Q5HYF7, P49815, C9JWX6, C9JX95, B4DIL8, E9PGN1 |
| HGNC Symbol |
TSC2 |
| Entrez Gene ID |
7249 |
| Ensembl Protein ID |
ENSP00000387937, ENSP00000387983, ENSP00000344383, ENSP00000219476, ENSP00000384468, ENSP00000399232, ENSP00000371978, ENSP00000248099, ENSP00000406980 |
| RefSeq ID |
NM_001114382, NM_001077183, NP_000539, NP_001070651, NM_000548, NP_001107854 |
| UniGene ID |
Hs.90303 |
| Ensembl Transcript ID |
ENST00000401874, ENST00000350773, ENST00000471143, ENST00000445113, ENST00000219476, ENST00000488675, ENST00000463601, ENST00000490108, ENST00000497886, ENST00000467949, ENST00000382538, ENST00000463808, ENST00000432909, ENST00000439673, ENST00000353929, ENST00000483020, ENST00000439117, ENST00000461648 |
| Gene-Disease Assocation |
TUBEROUS SCLEROSIS 1; TSC1, TUBEROUS SCLEROSIS 2; TSC2, LYMPHANGIOLEIOMYOMATOSIS; LAM |
| Design Element |
ENST00000401874, L48546_at, ENST00000488675, 215735_s_at, ENST00000463808, ENST00000467949, ENST00000353929, ENST00000497886, ENST00000439117, ENST00000382538, ENST00000461648, ENST00000445113, Hs.90303.2.S1_3p_a_at, ENST00000432909, 38813_at, ENST00000463601, ENST00000483020, ENST00000471143, ENST00000439673, ENST00000490108, ENST00000219476, ENST00000350773 |
| Search EB-eye |
ENSG00000103197
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