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JAG1 Homo sapiens
JAG1 is differentially expressed in 176 experiments [215 up/214 dn]: 39 organism parts: bone marrow [1 up/3 dn], cerebellum [0 up/2 dn], ...; 51 disease states: normal [9 up/10 dn], glioblastoma [2 up/0 dn], ...; 56 cell types, 62 cell lines, 36 compound treatments and 22 other conditions.
Synonyms JAG1, JAGL1
Orthologs JAG1_RAT (Rattus norvegicus)  crb-1 (Caenorhabditis elegans)  Jag1 (Mus musculus)  jag1a (Danio rerio)  (Compare orthologs)
InterPro Term Delta/Serrate/lag-2 (DSL) protein, EGF calcium-binding, EGF-like, EGF-like calcium-binding, conserved site, EGF-like, type 2
Diseases Alagille syndrome, Deafness, congenital heart defects, and posterior embryotoxon, Tetralogy of Fallot
GO Terms Notch binding, Notch signaling pathway, angiogenesis, calcium ion binding, endothelial cell differentiation
Uniprot P78504  Q4KMR2  Q99740 
Search EB-eye ENSG00000101384
REST API
Expression Summary
349 factor values, click each to filter
Factor Value Factor Up/Down
Legend: - number of studies the gene is up/down in
Normal Disease state
10
9
None Compound treatment
4
4
Stromal cell Cell type
2
3
Epithelial cell Cell type
3
1
Control Compound treatment
2
2
Bone marrow Organism part
3
1
Fibroblast Cell type
3
HeLa Cell line
3
Primary Disease staging
2
1
PC3 Cell line
2
SW480 Cell line
2
SW620 Cell line
2
Cerebellum Organism part
2
Endothelial cell Cell type
2
Glioblastoma Disease state
2
N/a Test result
1
1
Breast carcinoma Disease state
1
1
Homo sapiens Organism
2
MCF-7 Cell line
2
Not applicable Histology
1
1
BT-474 Cell line
2
Cervical cancer Disease state
2
FLAP Compound treatment
2
MK886 Compound treatment
2
CD14+ monocyte Cell type
2
Chronic lymphocytic leukemia Disease state
2
Invasive ductal carcinoma Histology
1
1
Macrophage Cell type
2
Dendritic cell Cell type
2
Cystic change Histology
2
MDA-MB-231 Cell line
1
1
Lymph node metastasis Disease staging
2
HNRPA2B Compound treatment
2
Liver Organism part
2
Organism_part Material type
1
1
Cell Material type
1
1
Prostate Organism part
1
1
Huntington's disease Disease state
2
Estrogen receptor 1 negative; ... Test result
2
Lymph node Organism part
2
0 cm away from the tumor bound... Observation
1
1
Peripheral blood Organism part
1
1
Skin Organism part
1
1
Lung Organism part
1
1
Monocyte Cell type
1
1
MCF7 Cell line
1
White blood cells Organism part
1
MDA468 Cell line
1
Tumor Organism part
1
SKMEL5 Cell line
1
Caudate nucleus Organism part
1
Grade IV Tumor grading
1
Malignant melanoma Disease state
1
Kidney Organism part
1
T47D Cell line
1
Lipopolysaccharide Compound treatment
1
SCH Cell line
1
Kaposi's sarcoma-associated he... Infection
1
Multiple myeloma Disease state
1
SsMCF7 Cell line
1
Ultraviolet light Light
1
Primary gastric tumor Organism part
1
Uninfected Infection
1
Plasma cell Cell type
1
B lymphocyte Cell type
1
Atrial mycocardium Organism part
1
Ventricular myocardium Organism part
1
Idiopathic dilated cardiomyopa... Disease state
1
Epilepsy Disease state
1
HTERT/HPVE6/HPVE7/SV40t transf... Gene modification
1
Lymphatic endothelial cell Cell type
1
Stage I Disease staging
1
Native skin Cell type
1
SNU1 Cell line
1
Acute promyelocytic leukemia Disease state
1
U937 Cell line
1
GLI72 Cell line
1
SM1 Cell line
1
Methotrexate Compound treatment
1
BT474 Cell line
1
Arsenic oxide Compound treatment
1
Uterine cervix Organism part
1
BCKN-1 Cell line
1
None Gene modification
1
Epidermal keratinocyte Cell type
1
SkinEthic keratinocyte Cell type
1
GLI60 Cell line
1
Dimethyl sulfoxide Compound treatment
1
2-(3,4,5-trimethoxy-phenylamin... Compound treatment
1
Fu97 Cell line
1
Johnsen score count 2: Sertoli... Histology
1
HTERT/HPVE6/HPVE7/SV40t/hRas t... Gene modification
1
T-cell lymphoblastic lymphoma Disease state
1
Enzo Labeling Protocol type
1
Vanadium pentoxide Compound treatment
1
Wilms' tumor Disease state
1
HTERT/HPVE6/HPVE7 transfection Gene modification
1
HL-60 Cell line
1
T-cell acute lymphoblastic leu... Disease state
1
HGF stimulation Growth condition
1
Adenocarcinoma Disease state
1
Dorsal root ganglion Organism part
1
Astrocyte Cell type
1
Serum starvation + thymidine b... Growth condition
1
Keratinocyte Cell type
1
Uninfected control RNAi
1
Lymphoid tissue Organism part
1
MiR15a/miR16-1 transfection Gene modification
1
Fetal bovine serum in media Growth condition
1
IBL4 Cell line
1
Bacterial endotoxin Compound treatment
1
Caco-2 Cell line
1
T84 Cell line
1
M2 macrophage Cell type
1
ERalpha transfected Genotype
1
ERbeta transfected Genotype
1
HPL1 Cell line
1
U87 Cell line
1
U373 Cell line
1
Whole blood Organism part
1
Bronchial epithelial cell Cell type
1
IL-4 Compound treatment
1
T3aNxM1 Disease staging
1
Empty vector Gene modification
1
Adipose tissue-derived stem ce... Cell type
1
Hematopoietic stem cell Cell type
1
AGS Cell line
1
Training set Population
1
Test set Population
1
IgV status unknown Genotype
1
Primary bone marrow CD34+ stem... Cell type
1
Benign nevi Disease state
1
Benign prostatic hyperplasia Disease state
1
Prostate carcinoma Disease state
1
Primary cells Cell line
1
Skin substitute Cell type
1
Unknown_sex Sex
1
IgV mutated Genotype
1
M1 macrophage Cell type
1
X-linked chronic granulomatous Disease state
1
Primary lymphatic endothelial ... Cell type
1
CD3+ CD4+ CD8- CD45RA+ CD62L+ Phenotype
1
Naive T cell Cell type
1
HaCaT Cell line
1
Granulocyte macrophage-colony ... Compound treatment
1
Vasectomized Clinical history
1
Secretory cell Cell type
1
TIVE Cell line
1
LacZ control RNAi
1
Interferon-gamma + lipopolysac... Compound treatment
1
Macaca mulatta Organism
1
Stage II Disease staging
1
Hydrogen peroxide Compound treatment
1
Affymetrix Labeling Protocol type
1
CD3int CD4+ CD8+ Phenotype
1
Double positive thymocyte Cell type
1
Mannitol Compound treatment
1
MCF10A Cell line
1
Infrared light Light
1
Control RNAi
1
SIM2s RNAi
1
Granulocyte Cell type
1
Spermatid Cell type
1
Pretreatment primary sample Clinical info
1
CD3- CD4+ CD8- Phenotype
1
Intrathymic T progenitor cell Cell type
1
Jurkat Cell line
1
Vascular smooth muscle cell Cell type
1
Trichostatin A Compound treatment
1
Epidermal growth factor Compound treatment
1
Chondrocyte Cell type
1
Tumor necrosis factor Compound treatment
1
SKBR3 Cell line
1
Placenta Organism part
1
Pan troglodytes Organism
1
Stroma from endometriotic nodu... Organism part
1
MKN74 Cell line
1
MKN1 Cell line
1
Testis Organism part
1
Superior cervical ganglion Organism part
1
Lung adenocarcinoma Disease state
1
Ischemic cardiomyopathy Disease state
1
HTERT/HPVE6 transfection Gene modification
1
Poorly differentiated gastric ... Disease state
1
BCBL-1 Cell line
1
Age-related macular degenerati... Disease state
1
YCC1 Cell line
1
CD3high CD4+ CD8- Phenotype
1
Single positive thymocyte Cell type
1
In vitro neutrophil Cell type
1
KSHV latent infection Disease state
1
CFT-2 Cell line
1
NT-1 Cell line
1
Wild_type Genotype
1
17beta-estradiol Compound treatment
1
BL41K3 Cell line
1
BJABK3 Cell line
1
Down syndrome Disease state
1
Heregulin Compound treatment
1
Primary culture 2 Cell line
1
ATM knockdown RNAi
1
Mature monocyte derived dendri... Cell type
1
Proliferative Developmental stage
1
Differentiated Developmental stage
1
CD34+ Cell type
1
Naive CD4 T cell Target cell type
1
B-precursor acute lymphoblasti... Disease state
1
GLI56 Cell line
1
Muscle invasive carcinoma Disease state
1
Adrenal cortex Organism part
1
Fibromuscular tissue from endo... Organism part
1
Adrenal gland pheochromocytoma Disease state
1
Extra-adrenal sympathetic para... Disease state
1
Pt45P1 Cell line
1
Trigeminal ganglion Organism part
1
Male Sex
1
Baseline uninfected Disease state
1
Estrogen receptor 1 positive; ... Test result
1
Normal Histology
1
Seminiferous tubule Organism part
1
Media only Growth condition
1
5-aza-2'-deoxycytidine + trich... Compound treatment
1
Monoclonal gammopathy of undet... Disease state
1
T cell Cell type
1
Peripheral blood mononuclear c... Cell type
1
Differentiated Cell type
1
Naive Cell type
1
Spermatocyte Cell type
1
Duchenne muscular dystrophy Disease state
1
Superficial transitional cell ... Disease state
1
Limited radiation toxicity Clinical history
1
Blood Organism part
1
Non-ischemic cardiomyopathy Disease state
1
Thymus Organism part
1
Obesity Disease state
1
Testis - interstitial Organism part
1
4OH-tamoxifen Compound treatment
1
Cardiac myocyte Cell type
1
Respiratory syncytial virus Infection
1
10 ng/ml LPS in media Growth condition
1
BDCA4+ dentritic cell Cell type
1
CD4+ T-cell Cell type
1
Grade II Tumor grading
1
MKN28 Cell line
1
All-trans retinoic acid Compound treatment
1
Placebo Compound treatment
1
Glutamine Compound treatment
1
CodeLink Labeling Protocol type
1
YCC16 Cell line
1
Burkitt's lymphoma Disease state
1
Sulmazole Compound treatment
1
IMP(1,3)A RNAi
1
Ciliary ganglion Organism part
1
No induction Protocol type
1
HMEC184 Cell line
1
CSB mutant rescue Phenotype
1
HTERT-immortalized, CSB mut-re... Cell line
1
White blood cell Cell type
1
Platelet Cell type
1
Waldenstrom's macroglobulinemi... Disease state
1
MKN7 Cell line
1
Tonsil Organism part
1
Hypericin incubated, not irrad... Growth condition
1
Hypericin incubated, irradiate... Growth condition
1
Malignant pleural mesothelioma Disease state
1
Unsynchronized Growth condition
1
267B1 Cell line
1
267B1_Ki-ras Cell line
1
ITS medium Growth condition
1
Inter-prandial lipid micelles ... Growth condition
1
ITS medium with albumin-bound ... Growth condition
1
Postprandial lipid micelles in... Growth condition
1
Anaplasma phagocytophilum Infection
1
YCC11 Cell line
1
Term Developmental stage
1
Midgestation Developmental stage
1
Endometrioid carcinoma Disease state
1
Lin- CD34- Phenotype
1
T47-D Cell line
1
Johnsen score count 5: no sper... Histology
1
Acute myeloid leukemia Disease state
1
MDS-associated acute myeloid l... Disease state
1
Grade III Tumor grading
1
Estrogen receptor 1 negative; ... Test result
1
Granulocyte-colony stimulating... Compound treatment
1
Gorilla gorilla Organism
1
Treated malaria, natural infec... Disease state
1
Synovial fluid Organism part
1
Cyclosporin A, mycophenolate m... Clinical treatment
1
Sirolimus, mycophenolate mofet... Clinical treatment
1
Johnsen score count 3.2: Serto... Histology
1
Glucocorticoid resistant Phenotype
1
Skeletal muscle Organism part
1
Normospermic Disease state
1
Teratozoospermia Disease state
1
Hippocampus Organism part
1
CD56+ NK cell Cell type
1
Cartilage Organism part
1
Immature monocyte derived dend... Cell type
1
Neuroblastoma Disease state
1
Ewing family tumor Disease state
1
Refractory anemia with ringed ... Clinical info
1
PT3 Disease staging
1
None Light
1
Pseudomonas aeruginosa Infection
1
Ethanol Compound treatment
1
Ponasterone A Compound treatment
1
Cadmium chloride 2.5-hydrate Compound treatment
1
Female Sex
1
Superficial transitional cell ... Disease state
1
Uterus Organism part
1
Leydig cell Cell type
1
Estrogen receptor 1 positive; ... Test result
1
Plasma cell leukemia Disease state
1
T1aN0M0 Disease staging
1
Doxycycline Compound treatment
1
Estrogen receptor 1 negative; ... Test result
1
T3aN0M0 Disease staging
1
YCC6 Cell line
1
CD4+ T cell Cell type
1
CD8+ T cell Cell type
1
Lin+ CD34+ Phenotype
1
ITV Cell line
1
Atrioventricular node Organism part
1
RWPE1 Cell line
1
Decrease in CD4 cells Clinical history
1
Hydroxyurea Compound treatment
1
Johnsen score count 10: full s... Histology
1
Multipotent adult progenitor c... Cell type
1
Adipose-derived stem cell Cell type
1
Beas2B Cell line
1
Dermatomyositis Disease state
1
Interferon-gamma Compound treatment
1
Cingulate cortex Organism part
1
CD16+ dendritic cell Cell type
1
Total_RNA Material type
1
Polysome-associated RNA Material type
1
AZ521 Cell line
1
Cigarette smoke Growth condition
1
Incubator control Growth condition
1
Primary blood vessel endotheli... Cell type
1
Control - untreated Compound treatment
1
BC-5 Cell line
1
PEL-5 Cell line
1
Breast cancer Disease state
1
Basal cell Cell type
1
Mock RNAi
1
Severe inflammation Disease staging
1
KSHV infection Disease state
1
Expression Profiles
E-GEOD-5258: Transcription profiling of human cell lines freely cycling treated with 164 distinct small molecules - Broad Connectivity Map CMAP Set 1
Experimental Factors
Show expression profile  /  experiment details

 
E-AFMX-5: Transcription profiling of human cell lines and tissues (GNF/Novartis)
Experimental Factors
Cell type Organism part Disease state
Show expression profile  /  experiment details

 
E-MEXP-1014: Transcription profiling of two human colon cancer cell lines treated with n-3 PUFA docosahexaenoic acid for 3 different time points
Experimental Factors
Show expression profile  /  experiment details

 
E-MEXP-440: Transcription profiling of lapatinib treated of breast cancer cell lines
Experimental Factors
Show expression profile  /  experiment details

 
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