PDGFB
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Homo sapiens |
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PDGFB is differentially expressed in 259 experiments: 127 organism parts: thymus, kidney, ... (125 more);, 226 disease states: normal, lung adenocarcinoma, ... (224 more);, 69 cell types 366 cell lines 37 compound treatments and 67 other conditions. |
| Synonyms |
SSV, SIS |
| Orthologs |
PDGFB (1 of 3)
(Danio rerio)
PDGFB (2 of 3)
(Danio rerio)
Pdgfb
(Mus musculus)
pdgfb
(Danio rerio)
F1NE37_CHICK
(Gallus gallus)
Q58D48_BOVIN
(Bos taurus)
Pdgfb
(Rattus norvegicus)
pdgfb
(Xenopus laevis)
PDGFB_CANFA
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR000072, IPR006782 |
| Gene Ontology ID |
GO:0008284, GO:0009986, GO:0016049, GO:0016020, GO:0008083, GO:0007179, GO:0009611, GO:0016323, GO:0007596, GO:0007507, GO:0042493, GO:0004713, GO:0042803, GO:0005515, GO:0005576, GO:0005737, GO:0005788, GO:0006468, GO:0045740, GO:0051781, GO:0000139, GO:0018108, GO:0018105, GO:0042127, GO:0046982, GO:0042060, GO:0006260, GO:0045892, GO:0045893, GO:0043498, GO:0043499, GO:0001666, GO:0043406, GO:0030036, GO:0030031, GO:0030097, GO:0030336, GO:0032147, GO:0016176, GO:0048008, GO:0060445, GO:0060326, GO:0010544, GO:0010512, GO:0060664, GO:0010033, GO:0031954, GO:0048661, GO:0002548, GO:0002576, GO:0048407, GO:0014070, GO:0014068, GO:0005518, GO:0061098, GO:0006929, GO:0043627, GO:0048146, GO:0005161, GO:0001938, GO:0050731, GO:0050730, GO:0045737, GO:0045743, GO:0032868, GO:0001892, GO:0014911, GO:0001568, GO:0043552, GO:0043536, GO:0045840, GO:0043410, GO:0030168, GO:0030335, GO:0070374, GO:0050921, GO:0032148, GO:0032355, GO:0071506, GO:0031093, GO:2000591, GO:2000573, GO:0035793, GO:0072126, GO:0072255, GO:0072264, GO:0072262, GO:0072593, GO:0003104, GO:0090280, GO:2000379, GO:0038001 |
| Gene Ontology Term |
positive regulation of cell division, negative regulation of transcription, DNA-dependent, protein binding, response to wounding, cytoplasm, regulation of cell proliferation, peptidyl-serine phosphorylation, wound healing, positive regulation of cell proliferation, membrane, Golgi membrane, eukaryotic cell surface binding, peptidyl-tyrosine phosphorylation, growth factor activity, protein tyrosine kinase activity, transforming growth factor beta receptor signaling pathway, extracellular region, positive regulation of MAP kinase activity, blood coagulation, response to hypoxia, cell growth, basolateral plasma membrane, hemopoiesis, actin cytoskeleton organization, cell projection assembly, heart development, negative regulation of cell migration, protein heterodimerization activity, positive regulation of DNA replication, response to drug, protein homodimerization activity, activation of protein kinase activity, cell surface, cell surface binding, endoplasmic reticulum lumen, positive regulation of transcription, DNA-dependent, DNA replication, activation of protein kinase B activity, cellular response to mycophenolic acid, cell chemotaxis, superoxide-generating NADPH oxidase activator activity, platelet degranulation, positive regulation of smooth muscle cell migration, regulation of peptidyl-tyrosine phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of ERK1 and ERK2 cascade, negative regulation of phosphatidylinositol biosynthetic process, branching involved in salivary gland morphogenesis, platelet-derived growth factor receptor signaling pathway, positive regulation of cell migration, response to estrogen stimulus, positive regulation of chemotaxis, blood vessel development, response to insulin stimulus, positive regulation of fibroblast proliferation, response to estradiol stimulus, epithelial cell proliferation involved in salivary gland morphogenesis, positive regulation of cyclin-dependent protein kinase activity, platelet-derived growth factor binding, monocyte chemotaxis, collagen binding, response to organic substance, positive regulation of endothelial cell proliferation, positive regulation of smooth muscle cell proliferation, negative regulation of platelet activation, positive regulation of blood vessel endothelial cell migration, positive regulation of MAPKKK cascade, positive regulation of fibroblast growth factor receptor signaling pathway, positive regulation of protein tyrosine kinase activity, platelet-derived growth factor receptor binding, positive regulation of mitosis, embryonic placenta development, platelet activation, protein phosphorylation, positive regulation of protein autophosphorylation, platelet alpha granule lumen, paracrine signaling, positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway, metanephric glomerular mesangial cell proliferation involved in metanephros development, positive regulation of metanephric mesenchymal cell migration, positive regulation of glomerular filtration, metanephric glomerular endothelium development, response to organic cyclic compound, substrate-dependent cell migration, positive regulation of reactive oxygen species metabolic process, positive regulation of phosphatidylinositol 3-kinase activity, positive regulation of calcium ion import, reactive oxygen species metabolic process, positive regulation of phosphatidylinositol 3-kinase cascade, positive regulation of glomerular mesangial cell proliferation, metanephric glomerular mesangial cell development, positive regulation of DNA biosynthetic process |
| InterPro Term |
PD_growth_factor, PDGF_N |
| Ensembl Family |
ENSFM00500000272092 |
| EMBL-Bank ID |
J00121, M12783, X03702, X00562, X00561, X00560, M19719, CH471095, X98706, K01401, K01400, K01399, K01398, X02811, Z81010, X02744, BC077725, K01917, K01916, K01915, K01918, K01914, K01913, BC029822, CR456538, X83705, CR541807 |
| UniProt Accession |
Q15354, A9UJP0, A9UJN9, Q9UE56, Q9UE57, P01127, P78450 |
| RefSeq ID |
NM_033016, NP_002599, NP_148937, NM_002608 |
| UniGene ID |
Hs.1976, Hs.710710 |
| Ensembl Gene ID |
ENSG00000100311 |
| Ensembl Protein ID |
ENSP00000370963, ENSP00000405780, ENSP00000330382, ENSP00000402306 |
| HGNC Symbol |
PDGFB |
| Entrez Gene ID |
5155 |
| Ensembl Family Description |
PLATELET DERIVED GROWTH FACTOR SUBUNIT B PRECURSOR PDGF SUBUNIT B PDGF 2 PLATELET DERIVED GROWTH FACTOR B CHAIN PLATELET DERIVED GROWTH FACTOR BETA POLYPEPTIDE PROTO ONCOGENE C SIS |
| Ensembl Transcript ID |
ENST00000381551, ENST00000331163, ENST00000440375, ENST00000455790 |
| Description |
platelet-derived growth factor beta polypeptide [Source:HGNC Symbol;Acc:8800] |
| Gene-Disease Assocation |
DERMATOFIBROSARCOMA PROTUBERANS; DFSP |
| Design Element |
ENST00000331163, ENST00000381551, 1573_at, X83705_s_at, 204200_s_at, ENST00000455790, g4505680_3p_a_at, Hs.172928.1.A1_3p_s_at, ENST00000440375, Hs.1976.2.S1_3p_at, M12783_at, 216061_x_at, 217112_at |
| Search EB-eye |
ENSG00000100311
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