ABL1
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Homo sapiens |
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ABL1 is differentially expressed in 262 experiments: 103 organism parts: liver, bone marrow, ... (101 more);, 160 disease states: normal, acute promyelocytic leukemia, ... (158 more);, 78 cell types 341 cell lines 45 compound treatments and 67 other conditions. |
| Synonyms |
p150, c-ABL, JTK7, ABL |
| Orthologs |
Abl1
(Rattus norvegicus)
ENSCING00000003255
(Ciona intestinalis)
ABL1
(Bos taurus)
Abl1
(Mus musculus)
ABL1
(Gallus gallus)
abl1
(Danio rerio)
Abl
(Drosophila melanogaster)
abl1
(Xenopus laevis)
ABL1
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR001452, IPR011511, IPR001245, IPR017442, IPR000719, IPR000980, IPR015015, IPR020635, IPR013247 |
| Gene Ontology Term |
cytosol, regulation of cell adhesion, DNA binding, protein binding, actin monomer binding, regulation of transcription, DNA-dependent, cytoplasm, DNA damage response, signal transduction resulting in induction of apoptosis, membrane, SH3 domain binding, peptidyl-tyrosine phosphorylation, protein tyrosine kinase activity, blood coagulation, protein domain specific binding, positive regulation of apoptosis, regulation of autophagy, ATP binding, actin cytoskeleton organization, magnesium ion binding, axon guidance, actin cytoskeleton, protein modification process, regulation of cell cycle, nucleus, manganese ion binding, muscle cell differentiation, mismatch repair, receptor activity, nucleotide binding, kinase activity, protein serine/threonine kinase activity, perinuclear region of cytoplasm, protein C-terminus binding, non-membrane spanning protein tyrosine kinase activity, protein kinase activity, nucleolus, nuclear membrane, mitochondrion, proline-rich region binding, regulation of endocytosis, nicotinate-nucleotide adenylyltransferase activity, DNA damage induced protein phosphorylation, positive regulation of oxidoreductase activity, positive regulation of muscle cell differentiation, mitogen-activated protein kinase binding, protein phosphorylation, regulation of transcription involved in S phase of mitotic cell cycle, negative regulation of protein serine/threonine kinase activity, regulation of cell motility, signal transduction in response to DNA damage, regulation of actin cytoskeleton reorganization, regulation of response to DNA damage stimulus |
| InterPro Term |
SH2, SH3_domain, F-actin_binding, Prot_kinase_cat_dom, SH3_2, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom, SH3_3 |
| Gene Ontology ID |
GO:0003677, GO:0016020, GO:0003785, GO:0010506, GO:0008022, GO:0008630, GO:0016301, GO:0007411, GO:0031965, GO:0007596, GO:0048471, GO:0004713, GO:0004715, GO:0042692, GO:0005524, GO:0005515, GO:0004872, GO:0005730, GO:0005737, GO:0005739, GO:0015629, GO:0005634, GO:0005829, GO:0004672, GO:0004674, GO:0043065, GO:0019904, GO:0006468, GO:0006464, GO:0000166, GO:0018108, GO:0051726, GO:0006355, GO:0000287, GO:0006298, GO:0030155, GO:0030145, GO:0030036, GO:0017124, GO:0051353, GO:0051149, GO:0051019, GO:0042770, GO:0004515, GO:0006975, GO:0030100, GO:0070064, GO:0000115, GO:0071901, GO:2000145, GO:2000249, GO:2001020 |
| Ensembl Family |
ENSFM00570000851013 |
| Entrez Gene ID |
25 |
| UniProt Accession |
P00519, Q13688, Q59F19, Q59FK4 |
| UniGene ID |
Hs.431048, Hs.597020 |
| EMBL-Bank ID |
AL161733, X16416, M14752, M14753, AB209456, AL359092, AB209642, CH471090, S69223, U07561, U07563, BC117451, DQ145721 |
| RefSeq ID |
NM_005157, NP_005148, NM_007313, NP_009297 |
| Ensembl Protein ID |
ENSP00000376971, ENSP00000361423, ENSP00000407756, ENSP00000400412, ENSP00000323315 |
| Ensembl Gene ID |
ENSG00000097007 |
| Description |
c-abl oncogene 1, non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:76] |
| HGNC Symbol |
ABL1 |
| Ensembl Transcript ID |
ENST00000444970, ENST00000393293, ENST00000438426, ENST00000318560, ENST00000372348 |
| Gene-Disease Assocation |
LEUKEMIA, CHRONIC MYELOID; CML |
| Ensembl Family Description |
TYROSINE KINASE EC_2.7.10.2 ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG ABELSON TYROSINE KINASE |
| Design Element |
1635_at, ENST00000318560, ENST00000438426, 2041_i_at, ENST00000444970, 1656_s_at, 39730_at, ENST00000393293, 202123_s_at, X16416_at, ENST00000372348, 2040_s_at, 52316_s_at, g6382056_3p_a_at, 1636_g_at |
| Search EB-eye |
ENSG00000097007
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