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JAK2 Homo sapiens
JAK2 is differentially expressed in 115 experiments [111 up/113 dn]: 26 organism parts: lung [1 up/1 dn], primary gastric tumor [1 up/0 dn], ...; 26 disease states: normal [2 up/8 dn], breast carcinoma [2 up/0 dn], ...; 23 cell types, 26 cell lines, 31 compound treatments and 17 other conditions.
Synonyms JAK2
Orthologs jak2a (Danio rerio)  JAK2_RAT (Rattus norvegicus)  Jak2 (Mus musculus)  jak2b (Danio rerio)  (Compare orthologs)
InterPro Term Band 4.1 domain, FERM domain, Protein kinase, ATP binding site, Protein kinase-like domain, Tyrosine-protein kinase
Diseases Budd-Chiari syndrome, Leukemia, acute myelogenous, Myelofibrosis, idiopathic, Polycythemia vera, Thrombocythemia, essential
GO Terms ATP binding, G-protein coupled receptor protein signaling pathway, JAK-STAT cascade involved in growth hormone signaling pathway, SH2 domain binding, acetylcholine receptor binding
Uniprot O60674  Q506Q0  Q52R86  Q8IXP2 
Search EB-eye ENSG00000096968
REST API
Expression Summary
184 factor values, click each to filter
Factor Value Factor Up/Down
Legend: - number of studies the gene is up/down in
Normal Disease state
8
2
None Compound treatment
7
2
Homo sapiens Organism
3
Pan troglodytes Organism
3
Control Compound treatment
2
Breast carcinoma Disease state
2
Not applicable Histology
2
N/a Test result
2
FLAP Compound treatment
2
MDA-MB-231 Cell line
2
MK886 Compound treatment
2
Chronic lymphocytic leukemia Disease state
2
Invasive ductal carcinoma Histology
2
BT-474 Cell line
1
1
Cystic change Histology
2
Interferon-gamma Compound treatment
2
Estrogen receptor 1 negative; ... Test result
2
0 cm away from the tumor bound... Observation
2
Stromal cell Cell type
2
Macrophage Cell type
2
Dendritic cell Cell type
2
HNRPA2B Compound treatment
2
Lung Organism part
1
1
SW480 Cell line
1
SW620 Cell line
1
Bacterial endotoxin Compound treatment
1
Primary gastric tumor Organism part
1
BT474 Cell line
1
MDA468 Cell line
1
Lipopolysaccharide Compound treatment
1
Tumor Organism part
1
Experimental malaria-infected Disease state
1
Glucocorticoid sensitive Phenotype
1
Granulocyte Cell type
1
Caudate nucleus Organism part
1
Pretreatment primary sample Clinical info
1
Vascular smooth muscle cell Cell type
1
Chondrocyte Cell type
1
Spermatocyte Cell type
1
MCF-7 Cell line
1
M1 macrophage Cell type
1
Acute promyelocytic leukemia Disease state
1
U937 Cell line
1
Interferon-gamma + lipopolysac... Compound treatment
1
MCF10A Cell line
1
SKBR3 Cell line
1
T47D Cell line
1
Clear cell sarcoma of the kidn... Disease state
1
Wilms' tumor Disease state
1
Huntington's disease Disease state
1
Infergen + interferon-gamma Compound treatment
1
M-CSF Compound treatment
1
Idiopathic dilated cardiomyopa... Disease state
1
Fetal bovine serum in media Growth condition
1
Monocyte Cell type
1
Respiratory syncytial virus Infection
1
CodeLink Labeling Protocol type
1
Testis Organism part
1
Cerebellum Organism part
1
Organism_part Material type
1
Cell Material type
1
Normal Disease staging
1
Infergen Compound treatment
1
Lung adenocarcinoma Disease state
1
Methotrexate Compound treatment
1
HL-60 Cell line
1
Vanadium pentoxide Compound treatment
1
Superficial transitional cell ... Disease state
1
Hydrogen peroxide Compound treatment
1
Seminiferous tubule Organism part
1
Skeletal muscle Organism part
1
Cartilage Organism part
1
Trichostatin A Compound treatment
1
Thymus Organism part
1
Atrial mycocardium Organism part
1
Ventricular myocardium Organism part
1
SkinEthic keratinocyte Cell type
1
Epidermal keratinocyte Cell type
1
Serum starvation + thymidine b... Growth condition
1
Plasma cell Cell type
1
B lymphocyte Cell type
1
Cigarette smoke Growth condition
1
Incubator control Growth condition
1
Waldenstrom's macroglobulinemi... Disease state
1
Symptomatic Disease staging
1
U87 Cell line
1
U373 Cell line
1
T47-D Cell line
1
Filtered air Compound treatment
1
Monocyte at intermediate diffe... Cell type
1
Synovial fluid Organism part
1
Peripheral blood Organism part
1
HaCaT Cell line
1
Pseudomonas aeruginosa Infection
1
Unknown_sex Sex
1
IgV status unknown Genotype
1
Macaca mulatta Organism
1
Frontal cortex, superior motor... Organism part
1
SKMEL5 Cell line
1
5-aza-2'-deoxycytidine Compound treatment
1
Fisetin Compound treatment
1
SsMCF7 Cell line
1
Granulocyte macrophage-colony ... Compound treatment
1
HeLa Cell line
1
Erythrocyte Cell type
1
Control - IL-1b Compound treatment
1
Peripheral blood mononuclear c... Cell type
1
T cell Cell type
1
Oligodendroglioma Disease state
1
Gastric cancer Disease state
1
KSHV-negative EBV-positive Clinical info
1
Benign nevi Disease state
1
BL41K3 Cell line
1
BJABK3 Cell line
1
Baseline uninfected Disease state
1
ITM-E6E7-ST Cell line
1
Multiple myeloma Disease state
1
Central memory 1 CD4 T cell Target cell type
1
Control - interferon-gamma Compound treatment
1
Granulocyte-colony stimulating... Compound treatment
1
Aortic stenosis Disease state
1
Actinomycin D Compound treatment
1
Control - untreated Compound treatment
1
Temporal lobe Organism part
1
Spermatid Cell type
1
HTERT/HPVE6/HPVE7/SV40t transf... Gene modification
1
HTERT/HPVE6 transfection Gene modification
1
Bladder carcinoma Disease state
1
Enzo Labeling Protocol type
1
Senescence bypassed Phenotype
1
Affymetrix Labeling Protocol type
1
Postprandial lipid micelles in... Growth condition
1
PC3 Cell line
1
Control for heregulin Compound treatment
1
Rapamycin Compound treatment
1
Smooth muscle Organism part
1
BDCA1+ dendritic cell Cell type
1
HPL1 Cell line
1
Glucocorticoid resistant Phenotype
1
Grade IV Tumor grading
1
KSHV-positive EBV-negative Clinical info
1
Adult Developmental stage
1
Infant Developmental stage
1
Estrogen receptor 1 negative; ... Test result
1
Chronic myelogenous leukemia Disease state
1
ERalpha transfected Genotype
1
ERbeta transfected Genotype
1
STK3 overexpression Genotype
1
Lymphoid tissue Organism part
1
Bone marrow Organism part
1
Frontal cortex, primary motor ... Organism part
1
Epidermal growth factor Compound treatment
1
Female Sex
1
Lymphatic endothelial cell Cell type
1
ITM-ST Cell line
1
Basal cell Cell type
1
T-cell lymphoblastic lymphoma Disease state
1
Atrioventricular node Organism part
1
Dorsal root ganglion Organism part
1
Non-ischemic cardiomyopathy Disease state
1
5-aza-2'-deoxycytidine + trich... Compound treatment
1
Serum starvation synchronizati... Growth condition
1
ITS medium Growth condition
1
Inter-prandial lipid micelles ... Growth condition
1
ITS medium with albumin-bound ... Growth condition
1
Poorly differentiated gastric ... Disease state
1
G1 Tumor grading
1
Acute rejection Clinical info
1
CD3int CD4+ CD8+ Phenotype
1
Double positive thymocyte Cell type
1
Jurkat Cell line
1
Stage IIIc/2 Disease staging
1
MDS-associated acute myeloid l... Disease state
1
Acute myeloid leukemia Disease state
1
Parietal lobe Organism part
1
CD8+ naive CD8 T cell Cell type
1
Pancreas Organism part
1
Astrocytoma Disease state
1
Subthalamic nucleus Organism part
1
Stage II Disease staging
1
IgV unmutated Genotype
1
Cingulate cortex Organism part
1
Cigarette smoke Compound treatment
1
Interferon alpha Compound treatment
1
Expression Profiles
E-MEXP-1014: Transcription profiling of two human colon cancer cell lines treated with n-3 PUFA docosahexaenoic acid for 3 different time points
Experimental Factors
Show expression profile  /  experiment details

 
E-GEOD-4646: Transcription profiling of human HUVEC cells infected with Neisseria meningitidis wild type and mutants vs uninfected sampled at 3 time points
Experimental Factors
Time Infection
Show expression profile  /  experiment details

 
E-GEOD-3284: Transcription profiling of human leukocytes after an inflammatory stimulus (bacterial endotoxin) to identify significant functional modules perturbed in response to this stimulus using network analysis
Experimental Factors
Time Individual Compound treatment
Show expression profile  /  experiment details

 
E-GEOD-15460: Transcription profiling of human gastric cancers, cell lines and controls
Experimental Factors
Show expression profile  /  experiment details

 
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