JAK2
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Homo sapiens |
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JAK2 is differentially expressed in 285 experiments: 107 organism parts: liver, lung, ... (105 more);, 202 disease states: normal, chronic myelogenous leukemia, ... (200 more);, 94 cell types 286 cell lines 49 compound treatments and 69 other conditions. |
| Synonyms |
JTK10 |
| Orthologs |
F1NQU4_CHICK
(Gallus gallus)
Jak2
(Rattus norvegicus)
Jak2
(Mus musculus)
E1BCP6_BOVIN
(Bos taurus)
jak2a
(Danio rerio)
Q4H3A3_CIOIN
(Ciona intestinalis)
jak2b
(Danio rerio)
PR2
(Drosophila melanogaster)
jak2
(Xenopus laevis)
JAK2
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR000299, IPR001245, IPR017442, IPR000719, IPR019749, IPR000980, IPR020635, IPR016251, IPR020693 |
| Gene Ontology Term |
endomembrane system, cytosol, response to antibiotic, response to oxidative stress, positive regulation of nitric oxide biosynthetic process, elevation of cytosolic calcium ion concentration, negative regulation of DNA binding, protein binding, apoptosis, SH2 domain binding, cytoskeleton, cytokine-mediated signaling pathway, cytoplasm, cellular component movement, histone binding, negative regulation of cell proliferation, innate immune response, positive regulation of cell proliferation, membrane, tyrosine phosphorylation of STAT protein, peptidyl-tyrosine phosphorylation, hormone-mediated signaling pathway, G-protein coupled receptor protein signaling pathway, protein tyrosine kinase activity, receptor binding, insulin receptor substrate binding, blood coagulation, membrane raft, negative regulation of heart contraction, nuclear matrix, heme binding, membrane fraction, positive regulation of apoptosis, cell differentiation, positive regulation of phosphoprotein phosphatase activity, activation of MAPKK activity, actin filament polymerization, ATP binding, protein kinase binding, nucleus, mesoderm development, response to lipopolysaccharide, nucleotide binding, protein serine/threonine kinase activity, acetylcholine receptor binding, JAK-STAT cascade, chromatin modification, non-membrane spanning protein tyrosine kinase activity, signal transduction, protein kinase activity, caveola, intracellular protein kinase cascade, positive regulation of cell-substrate adhesion, tumor necrosis factor-mediated signaling pathway, regulation of interferon-gamma-mediated signaling pathway, positive regulation of growth hormone receptor signaling pathway, mineralocorticoid receptor signaling pathway, response to hydroperoxide, neuroprotection, positive regulation of peptidyl-tyrosine phosphorylation, negative regulation of cell-cell adhesion, response to tumor necrosis factor, positive regulation of protein import into nucleus, translocation, histone kinase activity (H3-Y41 specific), axon regeneration, platelet-derived growth factor receptor signaling pathway, erythrocyte differentiation, positive regulation of DNA binding, growth hormone receptor binding, positive regulation of cell migration, histone H3-Y41 phosphorylation, positive regulation of insulin secretion, interleukin-12 receptor binding, tyrosine phosphorylation of Stat1 protein, positive regulation of tyrosine phosphorylation of Stat5 protein, positive regulation of cell differentiation, positive regulation of tumor necrosis factor production, growth hormone receptor signaling pathway, positive regulation of inflammatory response, induction of apoptosis by oxidative stress, regulation of inflammatory response, response to interleukin-12, positive regulation of interleukin-1 beta production, positive regulation of cell activation, peptide hormone receptor binding, enzyme linked receptor protein signaling pathway, activation of JAK2 kinase activity, JAK-STAT cascade involved in growth hormone signaling pathway, mammary gland epithelium development, tyrosine phosphorylation of Stat3 protein, positive regulation of nitric-oxide synthase biosynthetic process, positive regulation of tyrosine phosphorylation of Stat3 protein, protein autophosphorylation, protein phosphorylation, intracellular signal transduction, interferon-gamma-mediated signaling pathway, interleukin-12-mediated signaling pathway, STAT protein import into nucleus, phosphatidylinositol 3-kinase binding, positive regulation of phosphatidylinositol 3-kinase cascade, positive regulation of sequence-specific DNA binding transcription factor activity, activation of caspase activity by protein phosphorylation |
| InterPro Term |
SH2, Prot_kinase_cat_dom, Band_41_domain, FERM_domain, Tyr_kinase_non-rcpt_Jak/Tyk2, Tyr_kinase_non-rcpt_Jak2, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| Gene Ontology ID |
GO:0008285, GO:0008284, GO:0016020, GO:0016568, GO:0007186, GO:0007165, GO:0016363, GO:0007243, GO:0007259, GO:0007260, GO:0007262, GO:0007204, GO:0009755, GO:0007498, GO:0005901, GO:0042393, GO:0007596, GO:0004713, GO:0004715, GO:0005624, GO:0005524, GO:0005515, GO:0012505, GO:0006915, GO:0006928, GO:0005737, GO:0005634, GO:0005856, GO:0005829, GO:0006979, GO:0004672, GO:0004674, GO:0005102, GO:0032496, GO:0032516, GO:0043065, GO:0019901, GO:0006468, GO:0000166, GO:0000186, GO:0018108, GO:0046777, GO:0043392, GO:0042169, GO:0019221, GO:0043560, GO:0043548, GO:0045822, GO:0046677, GO:0030154, GO:0045121, GO:0030041, GO:0045429, GO:0033130, GO:0045087, GO:0020037, GO:0048008, GO:0060334, GO:0060397, GO:0060399, GO:0060396, GO:0008631, GO:0007167, GO:0022408, GO:0051428, GO:0031959, GO:0051091, GO:0042508, GO:0042503, GO:0042523, GO:0042517, GO:0061180, GO:0014068, GO:0042977, GO:0005131, GO:0005143, GO:0050731, GO:0050729, GO:0050727, GO:0032731, GO:0031103, GO:0050867, GO:0032760, GO:0051770, GO:0043388, GO:0070671, GO:0045597, GO:0043526, GO:0035401, GO:0035409, GO:0030335, GO:0030218, GO:0033194, GO:0033160, GO:0033209, GO:0032024, GO:0034612, GO:0010811, GO:0035556, GO:0060333, GO:0035722, GO:0008636 |
| Ensembl Family |
ENSFM00250000000777 |
| Ensembl Family Description |
TYROSINE KINASE EC_2.7.10.2 JANUS KINASE JAK |
| Gene-Disease Assocation |
POLYCYTHEMIA VERA, MYELOFIBROSIS, THROMBOCYTHEMIA, ESSENTIAL, LEUKEMIA, ACUTE MYELOID; AML, BUDD-CHIARI SYNDROME; BDCHS |
| EMBL-Bank ID |
AL161450, AL158147, AF001362, AF005216, BC039695, EU272048, AF058925, AL513350 |
| UniGene ID |
Hs.656213 |
| UniProt Accession |
Q8IXP2, O60674, A9QVL8, F5H5U8 |
| Ensembl Gene ID |
ENSG00000096968 |
| Entrez Gene ID |
3717 |
| Description |
Janus kinase 2 [Source:HGNC Symbol;Acc:6192] |
| HGNC Symbol |
JAK2 |
| Ensembl Protein ID |
ENSP00000371067, ENSP00000440387, ENSP00000443103 |
| RefSeq ID |
NP_004963, NM_004972 |
| Ensembl Transcript ID |
ENST00000476574, ENST00000539801, ENST00000381652, ENST00000544510, ENST00000472549, ENST00000487310 |
| Design Element |
g13325062_3p_at, ENST00000472549, 205841_at, ENST00000476574, ENST00000381652, ENST00000487310, ENST00000544510, 78910_i_at, 205842_s_at, g3236321_3p_a_at, ENST00000539801, 37468_at |
| Search EB-eye |
ENSG00000096968
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