MSH2
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Homo sapiens |
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MSH2 is differentially expressed in 306 experiments: 87 organism parts: liver, thymus, ... (85 more);, 204 disease states: normal, prostate carcinoma, ... (202 more);, 99 cell types 338 cell lines 40 compound treatments and 70 other conditions. |
| Synonyms |
COCA1, HNPCC1, HNPCC |
| Orthologs |
F1NFH4_CHICK
(Gallus gallus)
MSH2
(Saccharomyces cerevisiae)
Msh2
(Rattus norvegicus)
msh2
(Danio rerio)
MSH2_BOVIN
(Bos taurus)
Msh2
(Mus musculus)
F6UC46_CIOIN
(Ciona intestinalis)
spel1
(Drosophila melanogaster)
msh2
(Xenopus laevis)
Q5SBJ2_CANFA
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology Term |
intra-S DNA damage checkpoint, DNA binding, protein binding, apoptosis, DNA repair, double-stranded DNA binding, damaged DNA binding, ATPase activity, negative regulation of apoptosis, nuclear chromosome, cell cycle arrest, spermatogenesis, male gonad development, MutSalpha complex, single-stranded DNA binding, double-strand break repair, determination of adult lifespan, MutSbeta complex, mismatched DNA binding, meiotic mismatch repair, ATP binding, magnesium ion binding, Y-form DNA binding, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, DNA-dependent ATPase activity, protein kinase binding, nucleus, mismatch repair, germ cell development, maintenance of DNA repeat elements, nucleotide binding, response to drug, protein homodimerization activity, four-way junction DNA binding, postreplication repair, protein C-terminus binding, response to DNA damage stimulus, response to X-ray, enzyme binding, negative regulation of neuron apoptosis, guanine/thymine mispair binding, B cell differentiation, MutLalpha complex binding, in utero embryonic development, dinucleotide repeat insertion binding, somatic recombination of immunoglobulin gene segments, ATP catabolic process, ADP binding, dinucleotide insertion or deletion binding, positive regulation of helicase activity, somatic recombination of immunoglobulin genes involved in immune response, response to UV-B, B cell mediated immunity, oxidized purine DNA binding, somatic hypermutation of immunoglobulin genes, centromeric DNA binding, negative regulation of DNA recombination, response to amino acid stimulus, isotype switching, single guanine insertion binding, oxidative phosphorylation, single thymine insertion binding, negative regulation of reciprocal meiotic recombination, loop DNA binding, double-strand/single-strand DNA junction binding, meiotic gene conversion, response to organic cyclic compound |
| Gene Ontology ID |
GO:0003684, GO:0003677, GO:0003690, GO:0003697, GO:0008340, GO:0008094, GO:0008022, GO:0007050, GO:0010165, GO:0007283, GO:0007281, GO:0008584, GO:0042493, GO:0016887, GO:0042803, GO:0042771, GO:0005524, GO:0005515, GO:0006915, GO:0005634, GO:0030983, GO:0006974, GO:0000710, GO:0043066, GO:0019901, GO:0019899, GO:0000166, GO:0006302, GO:0006301, GO:0000287, GO:0000228, GO:0006298, GO:0006281, GO:0043524, GO:0043570, GO:0000403, GO:0000400, GO:0031573, GO:0032302, GO:0032301, GO:0010224, GO:0016446, GO:0016447, GO:0051096, GO:0014070, GO:0002204, GO:0032405, GO:0019724, GO:0001701, GO:0006200, GO:0019237, GO:0043200, GO:0043531, GO:0045910, GO:0006119, GO:0030183, GO:0045190, GO:0032142, GO:0032143, GO:0032139, GO:0032137, GO:0032181, GO:0032357, GO:0045128, GO:0006311, GO:0000406, GO:0000404 |
| InterPro Term |
DNA_mismatch_repair_MutS_core, DNA_mismatch_repair_MutS_clamp, DNA_mismatch_repair_MutS-lik_N, DNA_mismatch_repair_MutS_connt, DNA_mismatch_repair_MutS_C, DNA_mismatch_repair_MSH2 |
| InterPro ID |
IPR007861, IPR007860, IPR007695, IPR007696, IPR000432, IPR011184 |
| Ensembl Family Description |
DNA MISMATCH REPAIR MSH2 MUTS HOMOLOG 2 |
| Ensembl Family |
ENSFM00500000270061 |
| EMBL-Bank ID |
U03911, AC138655, L47583, L47581, L47582, BC021566, U04045, AF066081, AK299667, U41206, U41207, U41208, U41211, U41210, U41218, U41219, U41216, U41217, U41214, U41215, U41212, U41213, U41221, U41220, AY601851, AK296831, AC079775, AK304496 |
| Ensembl Gene ID |
ENSG00000095002 |
| Ensembl Protein ID |
ENSP00000378272, ENSP00000391195, ENSP00000411482, ENSP00000233146, ENSP00000402969, ENSP00000389452, ENSP00000390362, ENSP00000384199, ENSP00000415023, ENSP00000395752, ENSP00000442697 |
| HGNC Symbol |
MSH2 |
| Description |
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) [Source:HGNC Symbol;Acc:7325] |
| Entrez Gene ID |
4436 |
| UniProt Accession |
Q53RU4, C9J809, P43246, B4DSB9, B4E2Z2, B4DL39, E7EQQ1, E7EU21, E9PCI8, E9PHA6 |
| Gene-Disease Assocation |
CAFE-AU-LAIT SPOTS, MULTIPLE, LYNCH SYNDROME I, ENDOMETRIAL CANCER, MISMATCH REPAIR CANCER SYNDROME, GLIOMA SUSCEPTIBILITY 1; GLM1, NEUROFIBROMATOSIS, TYPE I; NF1, COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 8; HNPCC8, MUIR-TORRE SYNDROME; MRTES |
| RefSeq ID |
NP_000242, NM_000251 |
| Ensembl Transcript ID |
ENST00000467323, ENST00000543555, ENST00000454849, ENST00000419559, ENST00000422810, ENST00000406134, ENST00000453755, ENST00000413880, ENST00000432737, ENST00000448533, ENST00000461394, ENST00000394792, ENST00000233146 |
| Design Element |
ENST00000419559, ENST00000467323, ENST00000233146, 861_g_at, g432997_3p_x_at, 86665_at, U03911_at, 860_at, ENST00000422810, ENST00000432737, ENST00000461394, ENST00000448533, g432997_3p_at, 209421_at, ENST00000406134, ENST00000413880, ENST00000394792, ENST00000454849, ENST00000453755, ENST00000543555 |
| Search EB-eye |
ENSG00000095002
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