NOTCH3
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Homo sapiens |
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NOTCH3 is differentially expressed in 269 experiments: 170 organism parts: bone marrow, liver, ... (168 more);, 254 disease states: normal, prostate carcinoma, ... (252 more);, 79 cell types 435 cell lines 29 compound treatments and 74 other conditions. |
| Synonyms |
CADASIL, CASIL |
| Orthologs |
notch3
(Danio rerio)
Q2L697_CIOIN
(Ciona intestinalis)
Notch3
(Rattus norvegicus)
Notch3
(Mus musculus)
NOTCH3
(Bos taurus)
N
(Drosophila melanogaster)
notch3
(Xenopus laevis)
NOTCH3
(Canis familiaris)
(Compare orthologs)
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| InterPro Term |
Notch_dom, Notch_NOD_dom, Ankyrin_rpt, Ankyrin_rpt-contain_dom, EGF_extracell, EGF, EGF_3, Notch, Notch_NODP_dom, EGF-like, Notch_3, DUF3454_notch, EGF-like_Ca-bd |
| Gene Ontology Term |
cytosol, plasma membrane, protein binding, regulation of transcription, DNA-dependent, membrane, extracellular region, cell differentiation, tissue regeneration, Notch receptor processing, multicellular organismal development, nucleus, receptor activity, Notch signaling pathway, regulation of developmental process, integral to membrane, nucleoplasm, negative regulation of cell differentiation, endoplasmic reticulum lumen, calcium ion binding, Golgi lumen, forebrain development, gene expression, glomerular capillary formation, negative regulation of neuron differentiation, neuron fate commitment, positive regulation of smooth muscle cell proliferation |
| InterPro ID |
IPR010660, IPR011656, IPR000742, IPR000800, IPR006209, IPR006210, IPR001881, IPR008297, IPR013111, IPR020683, IPR002110, IPR022331, IPR024600 |
| Gene Ontology ID |
GO:0016020, GO:0016021, GO:0007275, GO:0007220, GO:0007219, GO:0042246, GO:0005509, GO:0005515, GO:0005576, GO:0004872, GO:0005634, GO:0005654, GO:0005886, GO:0005829, GO:0005788, GO:0050793, GO:0006355, GO:0045596, GO:0030154, GO:0010467, GO:0072104, GO:0048661, GO:0048663, GO:0030900, GO:0005796, GO:0045665 |
| Ensembl Family |
ENSFM00500000269589 |
| UniProt Accession |
B8XFT4, Q9UM47 |
| Entrez Gene ID |
4854 |
| EMBL-Bank ID |
FJ264199, U97669, AC004257, AC004663, AF058884, AF058885, AF058882, AF058883, AF058881, AF058889, AF058888, AF058887, AF058886, AF058894, AF058895, AF058896, AF058897, AF058890, AF058891, AF058892, AF058893, AF058899, AF058898, AF058900 |
| Ensembl Gene ID |
ENSG00000074181 |
| Ensembl Protein ID |
ENSP00000263388, ENSP00000446150 |
| Description |
notch 3 [Source:HGNC Symbol;Acc:7883] |
| UniGene ID |
Hs.8546 |
| RefSeq ID |
NP_000426, NM_000435 |
| Gene-Disease Assocation |
CEREBRAL ARTERIOPATHY, AUTOSOMAL DOMINANT, WITH SUBCORTICAL INFARCTS |
| HGNC Symbol |
NOTCH3 |
| Ensembl Family Description |
NEUROGENIC LOCUS NOTCH HOMOLOG PRECURSOR NOTCH [CONTAINS NOTCH EXTRACELLULAR TRUNCATION; NOTCH INTRACELLULAR |
| Ensembl Transcript ID |
ENST00000539383, ENST00000263388 |
| Design Element |
ENST00000539383, g4557798_3p_a_at, 203238_s_at, Hs.8546.0.A1_3p_a_at, ENST00000263388, 38750_at, 203237_s_at |
| Search EB-eye |
ENSG00000074181
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