PTGS2
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Homo sapiens |
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PTGS2 is differentially expressed in 300 experiments: 117 organism parts: lung, prostate, ... (115 more);, 160 disease states: normal, control, ... (158 more);, 99 cell types 331 cell lines 50 compound treatments and 61 other conditions. |
| Synonyms |
COX2 |
| Orthologs |
ptgs2b
(Danio rerio)
ptgs2a
(Danio rerio)
PGH2_CHICK
(Gallus gallus)
Ptgs2
(Mus musculus)
Q9TVB3_BOVIN
(Bos taurus)
ENSCING00000006498
(Ciona intestinalis)
ENSCING00000006154
(Ciona intestinalis)
Ptgs2
(Rattus norvegicus)
ptgs2
(Xenopus laevis)
NP_001003354.1
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology Term |
oxidoreductase activity, response to oxidative stress, positive regulation of nitric oxide biosynthetic process, endoplasmic reticulum, protein binding, cytoplasm, ovulation, cellular component movement, fatty acid biosynthetic process, memory, regulation of cell proliferation, negative regulation of cell proliferation, protein complex, membrane, peroxidase activity, prostaglandin metabolic process, lipid binding, metal ion binding, heme binding, positive regulation of apoptosis, neuron projection, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, microsome, regulation of cell cycle, nucleus, response to lipopolysaccharide, response to drug, endoplasmic reticulum membrane, enzyme binding, endoplasmic reticulum lumen, caveola, positive regulation of cell migration involved in sprouting angiogenesis, response to cytokine stimulus, prostaglandin-endoperoxide synthase activity, negative regulation of synaptic transmission, dopaminergic, response to vitamin D, response to organic nitrogen, xenobiotic metabolic process, positive regulation of smooth muscle contraction, bone mineralization, decidualization, negative regulation of calcium ion transport, cyclooxygenase pathway, anagen, prostaglandin biosynthetic process, response to estradiol stimulus, inflammatory response, regulation of blood pressure, regulation of inflammatory response, positive regulation of synaptic transmission, glutamatergic, positive regulation of prostaglandin biosynthetic process, response to organic substance, positive regulation of smooth muscle cell proliferation, brown fat cell differentiation, response to manganese ion, positive regulation vascular endothelial growth factor production, embryo implantation, positive regulation of synaptic plasticity, response to glucocorticoid stimulus, response to fructose stimulus, positive regulation of vasoconstriction, oxidation-reduction process, positive regulation of fibroblast growth factor production, positive regulation of brown fat cell differentiation, positive regulation of fever generation, response to organic cyclic compound, prostanoid metabolic process, positive regulation of platelet-derived growth factor production, positive regulation of transforming growth factor beta production |
| Gene Ontology ID |
GO:0008289, GO:0008285, GO:0016020, GO:0016491, GO:0005901, GO:0030728, GO:0042493, GO:0007613, GO:0016702, GO:0005515, GO:0006928, GO:0005737, GO:0005634, GO:0005788, GO:0005789, GO:0005783, GO:0004601, GO:0005792, GO:0006979, GO:0032496, GO:0055114, GO:0006633, GO:0006693, GO:0043065, GO:0043005, GO:0019899, GO:0051726, GO:0046872, GO:0042127, GO:0043234, GO:0045429, GO:0020037, GO:0034097, GO:0008217, GO:0010575, GO:0010243, GO:0010042, GO:0010033, GO:0009750, GO:0051384, GO:0031915, GO:0007566, GO:0048661, GO:0042640, GO:0014070, GO:0006954, GO:0004666, GO:0006805, GO:0031394, GO:0051968, GO:0050727, GO:0051926, GO:0090050, GO:0050873, GO:0031622, GO:0019371, GO:0045987, GO:0001516, GO:0045907, GO:0046697, GO:0030282, GO:0033280, GO:0032227, GO:0032355, GO:0090271, GO:0071636, GO:0090336, GO:0090362, GO:0006692 |
| InterPro ID |
IPR000742, IPR019791, IPR002007 |
| InterPro Term |
Haem_peroxidase_animal, EGF_3, Haem_peroxidase_animal_subgr |
| Ensembl Family |
ENSFM00250000001175 |
| Ensembl Family Description |
PROSTAGLANDIN G/H SYNTHASE 2 PRECURSOR EC_1.14.99.1 CYCLOOXYGENASE 2 COX 2 PHS II PROSTAGLANDIN H2 SYNTHASE 2 PGH SYNTHASE 2 PGHS 2 PROSTAGLANDIN ENDOPEROXIDE SYNTHASE 2 |
| EMBL-Bank ID |
AY229989, D28235, M90100, U04636, L15326, CH471067, AL033533, AK292167, BC013734, AJ634912, AY382629, AY462100, HM473188 |
| RefSeq ID |
NM_000963, NP_000954 |
| UniProt Accession |
P35354, Q6ZYK7, D9MWI3 |
| UniGene ID |
Hs.196384 |
| HGNC Symbol |
PTGS2 |
| Entrez Gene ID |
5743 |
| Ensembl Gene ID |
ENSG00000073756 |
| Ensembl Protein ID |
ENSP00000356438, ENSP00000454130 |
| Description |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [Source:HGNC Symbol;Acc:9605] |
| Ensembl Transcript ID |
ENST00000490885, ENST00000367468, ENST00000466691, ENST00000559800, ENST00000559627 |
| Design Element |
ENST00000559627, 1554997_a_at, L15326_s_at, ENST00000367468, U04636_rna1_at, ENST00000466691, 204748_at, Hs2.196384.2.S1_3p_s_at, D28235_s_at, ENST00000559800, ENST00000490885, g4506264_3p_at, g4506264_3p_x_at, 1069_at |
| Search EB-eye |
ENSG00000073756
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