FGFR3
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Homo sapiens |
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FGFR3 is differentially expressed in 269 experiments: 197 organism parts: lung, amygdala, ... (195 more);, 195 disease states: normal, colorectal adenocarcinoma, ... (193 more);, 81 cell types 451 cell lines 27 compound treatments and 78 other conditions. |
| Synonyms |
CD333, JTK4, CEK2, ACH |
| Orthologs |
fgfr3
(Danio rerio)
FGFR3_CHICK
(Gallus gallus)
Q95KL3_BOVIN
(Bos taurus)
FGFR_CIOIN
(Ciona intestinalis)
Fgfr3
(Rattus norvegicus)
Fgfr3
(Mus musculus)
htl
(Drosophila melanogaster)
btl
(Drosophila melanogaster)
fgfr3
(Xenopus laevis)
O62790_CANFA
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR001245, IPR016248, IPR017442, IPR000719, IPR007110, IPR013151, IPR020635, IPR003598, IPR003599, IPR013098 |
| Gene Ontology ID |
GO:0002009, GO:0008286, GO:0008285, GO:0008284, GO:0016021, GO:0007259, GO:0008543, GO:0005925, GO:0048678, GO:0016772, GO:0048546, GO:0048471, GO:0004713, GO:0005524, GO:0005515, GO:0004872, GO:0005886, GO:0005887, GO:0005764, GO:0004672, GO:0004674, GO:0042981, GO:0005007, GO:0050680, GO:0031398, GO:0043065, GO:0043066, GO:0006468, GO:0000165, GO:0000166, GO:0000122, GO:0018108, GO:0046777, GO:0045839, GO:0045879, GO:0030154, GO:0035019, GO:0017134, GO:0009898, GO:0060349, GO:0010518, GO:0022010, GO:0060113, GO:0048839, GO:0051216, GO:0048712, GO:0042511, GO:0042517, GO:0014003, GO:0030900, GO:0002062, GO:0002089, GO:0090080, GO:0001938, GO:0050731, GO:0001958, GO:0090102, GO:0045597, GO:0001501, GO:0043552, GO:0043410, GO:0070374, GO:0070307, GO:0090263, GO:0048640, GO:0060385, GO:0070977, GO:0072148, GO:0021762, GO:0061144, GO:0003416, GO:0035988 |
| Gene Ontology Term |
focal adhesion, plasma membrane, fibroblast growth factor binding, protein binding, morphogenesis of an epithelium, digestive tract morphogenesis, negative regulation of cell proliferation, negative regulation of smoothened signaling pathway, positive regulation of cell proliferation, lysosome, negative regulation of apoptosis, peptidyl-tyrosine phosphorylation, positive regulation of protein ubiquitination, MAPKKK cascade, protein tyrosine kinase activity, insulin receptor signaling pathway, positive regulation of apoptosis, fibroblast growth factor receptor signaling pathway, cell differentiation, ATP binding, transferase activity, transferring phosphorus-containing groups, integral to plasma membrane, response to axon injury, somatic stem cell maintenance, receptor activity, nucleotide binding, protein serine/threonine kinase activity, JAK-STAT cascade, perinuclear region of cytoplasm, integral to membrane, negative regulation of transcription from RNA polymerase II promoter, negative regulation of epithelial cell proliferation, protein kinase activity, regulation of apoptosis, negative regulation of mitosis, positive regulation of tyrosine phosphorylation of Stat1 protein, internal side of plasma membrane, bone morphogenesis, endochondral ossification, positive regulation of peptidyl-tyrosine phosphorylation, chondrocyte differentiation, lens morphogenesis in camera-type eye, positive regulation of ERK1 and ERK2 cascade, inner ear development, forebrain development, positive regulation of canonical Wnt receptor signaling pathway, positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway, lens fiber cell development, positive regulation of cell differentiation, cartilage development, positive regulation of phospholipase activity, cochlea development, skeletal system development, negative regulation of astrocyte differentiation, positive regulation of endothelial cell proliferation, oligodendrocyte development, positive regulation of MAPKKK cascade, inner ear receptor cell differentiation, positive regulation of tyrosine phosphorylation of Stat3 protein, protein autophosphorylation, protein phosphorylation, central nervous system myelination, negative regulation of developmental growth, axonogenesis involved in innervation, substantia nigra development, endochondral bone growth, alveolar secondary septum development, epithelial cell fate commitment, positive regulation of phosphatidylinositol 3-kinase activity, bone maturation, fibroblast growth factor-activated receptor activity, chondrocyte proliferation |
| InterPro Term |
Ig_sub, Immunoglobulin, Tyr_kinase_fibroblast_GF_rcpt, Prot_kinase_cat_dom, Ig-like, Ig_sub2, Ig_I-set, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| Ensembl Family |
ENSFM00250000000093 |
| Ensembl Family Description |
FIBROBLAST GROWTH FACTOR RECEPTOR PRECURSOR FGFR EC_2.7.10.1 |
| EMBL-Bank ID |
AY768549, M59374, AC016773, AF487554, AF369211, AF369213, AB209441, X84939, M58051, CH471131, M64347, S76733, AF238374, AF245114, U22410 |
| Ensembl Protein ID |
ENSP00000414914, ENSP00000427289, ENSP00000260795, ENSP00000231803, ENSP00000339824, ENSP00000323596, ENSP00000420533, ENSP00000412903 |
| RefSeq ID |
NM_022965, NM_001163213, NP_075254, NP_000133, NM_000142, NP_001156685 |
| UniProt Accession |
Q96T36, Q96T34, P22607, Q9NRB6, Q8NI16, Q8NI15, F8W9L4 |
| Entrez Gene ID |
2261 |
| Gene-Disease Assocation |
CAMPTODACTYLY, TALL STATURE, AND HEARING LOSS SYNDROME, TESTICULAR TUMORS, BLADDER CANCER, MYELOMA, MULTIPLE, CERVICAL CANCER, KERATOSIS, SEBORRHEIC, NEVUS, EPIDERMAL, MUENKE SYNDROME, THANATOPHORIC DYSPLASIA, TYPE II; TD2, COLORECTAL CANCER; CRC, LACRIMOAURICULODENTODIGITAL SYNDROME; LADD, CROUZON SYNDROME WITH ACANTHOSIS NIGRICANS; CAN, HYPOCHONDROPLASIA; HCH, ACHONDROPLASIA; ACH, THANATOPHORIC DYSPLASIA, TYPE I; TD1 |
| UniGene ID |
Hs.1420 |
| Ensembl Gene ID |
ENSG00000068078 |
| Description |
fibroblast growth factor receptor 3 [Source:HGNC Symbol;Acc:3690] |
| HGNC Symbol |
FGFR3 |
| Ensembl Transcript ID |
ENST00000507588, ENST00000469068, ENST00000340107, ENST00000352904, ENST00000260795, ENST00000412135, ENST00000481110, ENST00000440486, ENST00000474521, ENST00000312875 |
| Design Element |
gnf1h01649_x_at, ENST00000507588, ENST00000340107, 204380_s_at, g13112046_3p_a_at, ENST00000440486, ENST00000312875, ENST00000481110, g182568_3p_a_at, M64347_at, 31805_at, gnf1h01648_at, ENST00000352904, ENST00000412135, ENST00000469068, ENST00000260795, ENST00000474521, 204379_s_at |
| Search EB-eye |
ENSG00000068078
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