FGFR2
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Homo sapiens |
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FGFR2 is differentially expressed in 353 experiments: 188 organism parts: bone marrow, lung, ... (186 more);, 269 disease states: normal, prostate carcinoma, ... (267 more);, 127 cell types 532 cell lines 41 compound treatments and 77 other conditions. |
| Synonyms |
ECT1, CD332, JWS, BEK, TK14, TK25, CEK3, CFD1, KGFR, K-SAM |
| Orthologs |
Fgfr2
(Mus musculus)
Fgfr2
(Rattus norvegicus)
FGFR_CIOIN
(Ciona intestinalis)
fgfr2
(Danio rerio)
FGFR2
(Gallus gallus)
A7E310_BOVIN
(Bos taurus)
htl
(Drosophila melanogaster)
btl
(Drosophila melanogaster)
fgfr2
(Xenopus laevis)
NP_001003336.1
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR001245, IPR016248, IPR017442, IPR000719, IPR007110, IPR013151, IPR020635, IPR003598, IPR003599, IPR003596, IPR013098 |
| Gene Ontology Term |
angiogenesis, regulation of multicellular organism growth, plasma membrane, positive regulation of cell division, fibroblast growth factor binding, protein binding, neuromuscular junction development, cytoplasm, regulation of cell proliferation, cell cortex, negative regulation of cell proliferation, positive regulation of cell proliferation, membrane, heparin binding, epidermis morphogenesis, peptidyl-tyrosine phosphorylation, protein tyrosine kinase activity, extracellular region, insulin receptor signaling pathway, cell-cell signaling, fibroblast growth factor receptor signaling pathway, organ growth, multicellular organism growth, synaptic vesicle transport, ATP binding, positive regulation of transcription from RNA polymerase II promoter, integral to plasma membrane, nucleus, receptor activity, nucleotide binding, post-embryonic development, cell fate commitment, positive regulation of cell cycle, protein serine/threonine kinase activity, axonogenesis, protein homodimerization activity, integral to membrane, regulation of smoothened signaling pathway, negative regulation of transcription from RNA polymerase II promoter, cell surface, extracellular matrix, positive regulation of Wnt receptor signaling pathway, organ morphogenesis, morphogenesis of embryonic epithelium, protein kinase activity, digestive tract development, embryonic pattern specification, negative regulation of mitosis, positive regulation of mesenchymal cell proliferation, branching morphogenesis of a nerve, mesenchymal cell differentiation, embryonic organ development, positive regulation of epithelial cell proliferation involved in lung morphogenesis, bone morphogenesis, regulation of smooth muscle cell differentiation, branch elongation involved in salivary gland morphogenesis, epithelial cell proliferation, lung lobe morphogenesis, reproductive structure development, orbitofrontal cortex development, membranous septum morphogenesis, regulation of ERK1 and ERK2 cascade, regulation of osteoblast proliferation, in utero embryonic development, outflow tract septum morphogenesis, bone mineralization, positive regulation of ERK1 and ERK2 cascade, fibroblast growth factor receptor signaling pathway involved in mammary gland specification, prostate epithelial cord elongation, bone development, branching involved in salivary gland morphogenesis, squamous basal epithelial stem cell differentiation involved in prostate gland acinus development, regulation of morphogenesis of a branching structure, lung-associated mesenchyme development, positive regulation of canonical Wnt receptor signaling pathway, otic vesicle formation, branching involved in embryonic placenta morphogenesis, hair follicle morphogenesis, prostate gland morphogenesis, positive regulation of epithelial cell proliferation, lacrimal gland development, branching involved in prostate gland morphogenesis, bud elongation involved in lung branching, regulation of epithelial cell proliferation, odontogenesis, lens fiber cell development, limb bud formation, lung alveolus development, regulation of cell fate commitment, excitatory synapse, gland morphogenesis, pyramidal neuron development, embryonic digestive tract morphogenesis, regulation of branching involved in prostate gland morphogenesis, regulation of osteoblast differentiation, mammary gland bud formation, regulation of fibroblast growth factor receptor signaling pathway, mesenchymal cell differentiation involved in lung development, positive regulation of phospholipase activity, embryonic organ morphogenesis, lateral sprouting from an epithelium, epithelial cell proliferation involved in salivary gland morphogenesis, lung development, inner ear morphogenesis, skeletal system morphogenesis, mesenchymal cell proliferation involved in lung development, positive regulation of cardiac muscle cell proliferation, prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis, positive regulation of MAPKKK cascade, ventricular cardiac muscle tissue morphogenesis, midbrain development, ureteric bud development, epithelial cell differentiation, protein autophosphorylation, protein phosphorylation, ventricular zone neuroblast division, fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development, fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow, fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow, fibroblast growth factor receptor signaling pathway involved in hemopoiesis, fibroblast growth factor-activated receptor activity |
| Gene Ontology ID |
GO:0009880, GO:0009887, GO:0008201, GO:0008286, GO:0008285, GO:0008284, GO:0009986, GO:0016020, GO:0016021, GO:0007267, GO:0016331, GO:0009791, GO:0008543, GO:0008589, GO:0005938, GO:0007409, GO:0048730, GO:0007528, GO:0048565, GO:0048489, GO:0004713, GO:0042803, GO:0005524, GO:0005515, GO:0005576, GO:0004872, GO:0005737, GO:0005634, GO:0005886, GO:0005887, GO:0004672, GO:0004674, GO:0005007, GO:0040014, GO:0031012, GO:0006468, GO:0000166, GO:0051781, GO:0000122, GO:0018108, GO:0045787, GO:0046777, GO:0042127, GO:0045944, GO:0001525, GO:0045839, GO:0030177, GO:0045165, GO:0035265, GO:0035264, GO:0017134, GO:0060463, GO:0060484, GO:0060445, GO:0060442, GO:0060449, GO:0060349, GO:0060348, GO:0010518, GO:0060601, GO:0060615, GO:0010453, GO:0060687, GO:0060688, GO:0060664, GO:0060667, GO:0060670, GO:0060595, GO:0060529, GO:0060523, GO:0060527, GO:0060501, GO:0060512, GO:0060045, GO:0060076, GO:0060174, GO:0048705, GO:0048755, GO:0048762, GO:0042476, GO:0042472, GO:0051150, GO:0048608, GO:0048568, GO:0048562, GO:0048557, GO:0003149, GO:0003148, GO:0048286, GO:0030901, GO:0030916, GO:0002053, GO:0030855, GO:0040036, GO:0050678, GO:0050679, GO:0050673, GO:0055010, GO:0031069, GO:0032808, GO:0001701, GO:0045667, GO:0001657, GO:0043410, GO:0033688, GO:0022612, GO:0021860, GO:0030324, GO:0021769, GO:0070372, GO:0070374, GO:0030282, GO:0060916, GO:0060915, GO:0070307, GO:0090263, GO:0021847, GO:0035607, GO:0035602, GO:0035603, GO:0035604 |
| InterPro Term |
Ig_sub, Immunoglobulin, Tyr_kinase_fibroblast_GF_rcpt, Prot_kinase_cat_dom, Ig-like, Ig_sub2, Ig_I-set, Ig_V-set_subgr, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| Ensembl Family |
ENSFM00250000000093 |
| Ensembl Family Description |
FIBROBLAST GROWTH FACTOR RECEPTOR PRECURSOR FGFR EC_2.7.10.1 |
| Gene-Disease Assocation |
PFEIFFER SYNDROME, APERT SYNDROME, CROUZON SYNDROME, SCAPHOCEPHALY, MAXILLARY RETRUSION, AND MENTAL RETARDATION, GASTRIC CANCER, HEREDITARY DIFFUSE; HDGC, BEARE-STEVENSON CUTIS GYRATA SYNDROME; BSTVS, ANTLEY-BIXLER SYNDROME WITHOUT GENITAL ANOMALIES OR DISORDERED STEROIDOGENESIS;, JACKSON-WEISS SYNDROME; JWS, LACRIMOAURICULODENTODIGITAL SYNDROME; LADD, SAETHRE-CHOTZEN SYNDROME; SCS |
| EMBL-Bank ID |
AB084153, M87772, M87771, M87770, AF410480, M55614, AF487553, Y17131, X52832, AF097351, AF097352, AF097350, AF097353, AF097354, AF097348, AF097347, AF097346, AF097345, AF097349, AF097339, AF097337, AF097338, AF097344, AF097343, AF097342, AF097341, AF097340, S40858, S40853, S40851, X56191, Z71929, BC039243, AF169399, AB030076, AB030077, AB030078, AB030073, AB030074, AB030075, M35718, CH471066, S41350, M97193, M80634, DQ493927, S41878, S82438, AF360695, L49240, L49241, L49242, L49239, L49238, L49237, U11814, AC009988, AH003714, AH003713 |
| Ensembl Protein ID |
ENSP00000350166, ENSP00000309878, ENSP00000263451, ENSP00000351276, ENSP00000353262, ENSP00000337665, ENSP00000348559, ENSP00000352309, ENSP00000358052, ENSP00000358055, ENSP00000358054, ENSP00000358057, ENSP00000358056, ENSP00000358058, ENSP00000404219, ENSP00000410294 |
| RefSeq ID |
NM_022970, NP_075259, NP_001138389, NP_001138387, NP_001138388, NP_001138385, NP_001138386, NP_001138391, NP_001138390, NM_001144913, NM_001144914, NM_001144915, NM_001144916, NM_001144917, NM_001144918, NM_001144919, NP_000132, NM_000141 |
| Entrez Gene ID |
2263 |
| UniProt Accession |
P21802, Q9UMB0, Q9UMA9, Q8IXC7, Q9UEH2, Q16888, D3DRD4, D3DRD5, D3DRD6, D3DRD3, D3DRE0, D3DRD9, E7EVR6, E7EVR7, E9PCR0, Q7KZ14, E9PES7, E9PFE7 |
| Ensembl Gene ID |
ENSG00000066468 |
| UniGene ID |
Hs.533683, Hs.607420, Hs.622244 |
| Description |
fibroblast growth factor receptor 2 [Source:HGNC Symbol;Acc:3689] |
| HGNC Symbol |
FGFR2 |
| Ensembl Transcript ID |
ENST00000491111, ENST00000467584, ENST00000360144, ENST00000336553, ENST00000457416, ENST00000358487, ENST00000369062, ENST00000369061, ENST00000369060, ENST00000369059, ENST00000369058, ENST00000369056, ENST00000490349, ENST00000478859, ENST00000356226, ENST00000429361, ENST00000359354, ENST00000463870, ENST00000351936, ENST00000346997, ENST00000357555, ENST00000491475 |
| Design Element |
208228_s_at, 34354_at, 1145_g_at, ENST00000491111, g13186256_3p_at, 1970_s_at, g13186252_3p_a_at, ENST00000429361, 1144_at, ENST00000478859, ENST00000359354, g186740_3p_a_at, ENST00000457416, 208225_at, ENST00000491475, ENST00000358487, ENST00000346997, 211401_s_at, ENST00000369058, ENST00000490349, 203638_s_at, ENST00000369056, ENST00000336553, 1363_at, g6691454_3p_a_at, M87770_at, ENST00000357555, ENST00000369059, ENST00000463870, ENST00000351936, g6691454_3p_x_at, ENST00000467584, 203639_s_at, ENST00000356226, g186781_3p_a_at, ENST00000360144, 1143_s_at, ENST00000369060, ENST00000369061, 73572_at, g13186266_3p_a_at, ENST00000369062, 208234_x_at |
| Search EB-eye |
ENSG00000066468
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