CASP8
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Homo sapiens |
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CASP8 is differentially expressed in 319 experiments: 135 organism parts: bone marrow, brain, ... (133 more);, 231 disease states: normal, Huntington's disease, ... (229 more);, 102 cell types 424 cell lines 42 compound treatments and 72 other conditions. |
| Synonyms |
Casp-8, FLICE, MACH, MCH5 |
| Orthologs |
Casp8
(Mus musculus)
Dcp-1
(Drosophila melanogaster)
Q2LGB8_BOVIN
(Bos taurus)
decay
(Drosophila melanogaster)
casp8
(Danio rerio)
casp8l1
(Danio rerio)
Ice
(Drosophila melanogaster)
F7BL88_CIOIN
(Ciona intestinalis)
F1NXP6_CHICK
(Gallus gallus)
Casp8
(Rattus norvegicus)
Q38JA9_CANFA
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology Term |
angiogenesis, cytosol, response to antibiotic, protein binding, apoptosis, cytoskeleton, cytoplasm, innate immune response, protein complex, tumor necrosis factor receptor binding, peptidase activity, metabolic process, activation of caspase activity, membrane raft, mitochondrial outer membrane, identical protein binding, neuron projection, centrosome, cysteine-type endopeptidase activity, nucleus, heart development, response to lipopolysaccharide, proteolysis, proteolysis involved in cellular protein catabolic process, response to cold, response to ethanol, cysteine-type peptidase activity, mitochondrion, regulation of apoptosis, positive regulation of I-kappaB kinase/NF-kappaB cascade, neural tube formation, activation of pro-apoptotic gene products, cellular response to mechanical stimulus, response to tumor necrosis factor, activation of innate immune response, induction of apoptosis by intracellular signals, death-inducing signaling complex, response to cobalt ion, response to estradiol stimulus, induction of apoptosis by extracellular signals, Noc1p-Noc2p complex, macrophage differentiation, protein heterooligomerization, cellular component disassembly involved in apoptosis, CD95 death-inducing signaling complex, cell body, nucleotide-binding oligomerization domain containing signaling pathway |
| Gene Ontology ID |
GO:0008152, GO:0008234, GO:0008233, GO:0009409, GO:0007507, GO:0004197, GO:0042802, GO:0005515, GO:0006915, GO:0006919, GO:0005737, GO:0005739, GO:0005741, GO:0005634, GO:0005856, GO:0005829, GO:0005813, GO:0042981, GO:0032496, GO:0005164, GO:0006508, GO:0043005, GO:0043234, GO:0001525, GO:0051603, GO:0046677, GO:0045121, GO:0045471, GO:0045087, GO:0008629, GO:0008624, GO:0008633, GO:0051291, GO:0030690, GO:0002218, GO:0031264, GO:0043123, GO:0001841, GO:0071260, GO:0030225, GO:0032025, GO:0034612, GO:0032355, GO:0006921, GO:0031265, GO:0044297, GO:0070423 |
| InterPro Term |
Pept_C14_p10, Pept_C14_ICE_p20, Pept_C14_p45_core, Pept_C14_cat, DED |
| InterPro ID |
IPR001309, IPR011600, IPR015917, IPR002138, IPR001875 |
| Ensembl Family |
ENSFM00500000269928 |
| Ensembl Family Description |
CASPASE PRECURSOR CASP APOPTOTIC PROTEASE MCH ICE APOPTOTIC PROTEASE [CONTAINS CASPASE SUBUNIT CASPASE SUBUNIT |
| RefSeq ID |
NP_001073593, NP_001073594, NM_033358, NM_033355, NM_033356, NM_001080124, NM_001080125, NP_001219, NP_203519, NP_203520, NP_203522, NM_001228 |
| EMBL-Bank ID |
AC007256, AC007283, AF380342, AF102139, AF102141, AF102140, AF102146, AF102143, AF102142, AF102145, AF102144, EU670044, BC028223, U60520, U58143, X98176, X98177, X98178, X98175, X98174, X98173, X98172, AF422925, AF422926, AF422927, AF422928, AF422929, AF009620, AB038985, DQ355026 |
| UniGene ID |
Hs.599762, Hs.715120 |
| Ensembl Protein ID |
ENSP00000391709, ENSP00000407378, ENSP00000351273, ENSP00000396869, ENSP00000394434, ENSP00000264275, ENSP00000264274, ENSP00000397528, ENSP00000325722, ENSP00000390641, ENSP00000390346, ENSP00000376091, ENSP00000376087, ENSP00000376088, ENSP00000376089, ENSP00000376094, ENSP00000388306, ENSP00000412523 |
| UniProt Accession |
A8MU92, C9JB29, C3S3G0, Q14790, E7EQ06, E7EQ01, E7ETB7, E7EVN1, F8WF39 |
| Gene-Disease Assocation |
CASPASE 8 DEFICIENCY, HEPATOCELLULAR CARCINOMA, LUNG CANCER, BREAST CANCER |
| Ensembl Gene ID |
ENSG00000064012 |
| Entrez Gene ID |
841 |
| Description |
caspase 8, apoptosis-related cysteine peptidase [Source:HGNC Symbol;Acc:1509] |
| HGNC Symbol |
CASP8 |
| Ensembl Transcript ID |
ENST00000442304, ENST00000450491, ENST00000444430, ENST00000323492, ENST00000424461, ENST00000339403, ENST00000358485, ENST00000471383, ENST00000490682, ENST00000447616, ENST00000490412, ENST00000429881, ENST00000440732, ENST00000432109, ENST00000392259, ENST00000392258, ENST00000392261, ENST00000392263, ENST00000392266, ENST00000413726, ENST00000437283, ENST00000264275, ENST00000264274 |
| Design Element |
ENST00000447616, ENST00000264274, ENST00000264275, X98172_at, ENST00000471383, ENST00000432109, ENST00000323492, ENST00000490412, ENST00000392261, ENST00000413726, Hs.19949.2.S2_3p_a_at, ENST00000442304, ENST00000490682, ENST00000392266, ENST00000444430, g4502582_3p_a_at, 213373_s_at, 207686_s_at, ENST00000392263, ENST00000358485, X98178_s_at, ENST00000429881, ENST00000392259, X98176_at, ENST00000450491, 1553306_at, ENST00000424461, ENST00000440732, ENST00000437283, ENST00000339403, ENST00000392258, 33774_at, 31491_s_at, Hs2.381231.5.S1_3p_at, 33775_s_at |
| Search EB-eye |
ENSG00000064012
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