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GRN Homo sapiens
GRN is differentially expressed in 146 experiments [181 up/157 dn]: 20 organism parts: cerebellum [0 up/2 dn], skeletal muscle [0 up/2 dn], ...; 40 disease states: normal [4 up/17 dn], glioblastoma [2 up/0 dn], ...; 54 cell types, 37 cell lines, 31 compound treatments and 20 other conditions.
Synonyms GRN
Orthologs Grn (Mus musculus)  GRN_RAT (Rattus norvegicus)  T22H2.6 (Caenorhabditis elegans)  grnb (Danio rerio)  grna (Danio rerio)  (Compare orthologs)
InterPro Term Cysteine-rich repeat, Granulin
Diseases Frontotemporal lobar degeneration with ubiquitin-positive inclusions
GO Terms signal transduction, positive regulation of epithelial cell proliferation, blastocyst hatching, cytoplasm, extracellular space
Uniprot P28799  Q53HQ8  Q9H8S1 
Search EB-eye ENSG00000030582
REST API
Expression Summary
269 factor values, click each to filter
Factor Value Factor Up/Down
Legend: - number of studies the gene is up/down in
Normal Disease state
17
4
None Compound treatment
8
2
Monocyte Cell type
2
2
Macrophage Cell type
3
Stromal cell Cell type
2
1
Cerebellum Organism part
2
HL-60 Cell line
2
FLAP Compound treatment
2
CD34+ Cell type
2
Glioblastoma Disease state
2
MK886 Compound treatment
2
HNRPA2B Compound treatment
2
ERalpha transfected Genotype
2
Fibroblast Cell type
2
N/a Test result
2
Invasive ductal carcinoma Histology
2
Breast carcinoma Disease state
2
Not applicable Histology
2
Placebo Compound treatment
1
1
0 cm away from the tumor bound... Observation
2
Dimethyl sulfoxide Compound treatment
1
1
Acute myeloid leukemia Disease state
2
Skeletal muscle Organism part
2
Lung Organism part
2
Control Compound treatment
1
1
CD8+ T cell Cell type
1
1
Duchenne muscular dystrophy Disease state
2
PC3 Cell line
2
Dermatomyositis Disease state
2
Peripheral blood Organism part
1
1
Bone marrow Organism part
1
1
SW480 Cell line
1
1
SW620 Cell line
1
1
Estrogen receptor 1 positive; ... Test result
2
Homo sapiens Organism
1
1
Phorbol 12-myristate 13-acetat... Compound treatment
1
1
Organism_part Material type
1
1
Cell Material type
1
1
Ultraviolet light Light
1
MCF7 Cell line
1
None Light
1
Glucocorticoid resistant Phenotype
1
Glucocorticoid sensitive Phenotype
1
Caudate nucleus Organism part
1
Pretreatment primary sample Clinical info
1
Rapamycin Compound treatment
1
Grade IV Tumor grading
1
Acute promyelocytic leukemia Disease state
1
U937 Cell line
1
T84 Cell line
1
Caco-2 Cell line
1
Chronic lymphocytic leukemia Disease state
1
T cell Cell type
1
Peripheral blood mononuclear c... Cell type
1
ERbeta transfected Genotype
1
Epidermal growth factor Compound treatment
1
Epilepsy Disease state
1
IgV status unknown Genotype
1
Unknown_sex Sex
1
Lymphatic endothelial cell Cell type
1
Beas2B Cell line
1
Endothelial cell Cell type
1
Kaposi's sarcoma-associated he... Infection
1
MDA-MB-231 Cell line
1
Glutamine Compound treatment
1
Control for heregulin Compound treatment
1
Idiopathic dilated cardiomyopa... Disease state
1
Differentiated Cell type
1
Naive Cell type
1
HPL1 Cell line
1
CD16+ dendritic cell Cell type
1
Johnsen score count 2: Sertoli... Histology
1
Plasma cell Cell type
1
B lymphocyte Cell type
1
Chondrocyte Cell type
1
SKMEL5 Cell line
1
IgV mutated Genotype
1
Superficial transitional cell ... Disease state
1
Vascular smooth muscle cell Cell type
1
Granulocyte Cell type
1
CD105+ endothelial Cell type
1
A549 Cell line
1
Bacterial endotoxin Compound treatment
1
Epithelial cell Cell type
1
SKBR3 Cell line
1
Malignant melanoma Disease state
1
Carcinoma in situ lesion Disease state
1
T3aNxM1 Disease staging
1
MCF10A Cell line
1
Baseline uninfected Disease state
1
Johnsen score count 5: no sper... Histology
1
Lipopolysaccharide Compound treatment
1
BT474 Cell line
1
KSHV-negative EBV-positive Clinical info
1
Female Sex
1
T47-D Cell line
1
Stage II Disease staging
1
2-(3,4,5-trimethoxy-phenylamin... Compound treatment
1
Spermatocyte Cell type
1
Male Sex
1
Selenium Compound treatment
1
Testis Organism part
1
Muscle invasive carcinoma Disease state
1
TIVE Cell line
1
Seminiferous tubule Organism part
1
BDCA1+ dendritic cell Cell type
1
Johnsen score count 10: full s... Histology
1
CD19+ B cells (neg. sel.) Cell type
1
Capra hircus Organism
1
Ductal carcinoma in situ Disease state
1
Invasive ductal carcinoma Disease state
1
Testicular seminoma Disease state
1
All-trans retinoic acid Compound treatment
1
Cartilage Organism part
1
Lymphoid tissue Organism part
1
T-cell lymphoblastic lymphoma Disease state
1
Epidermal keratinocyte Cell type
1
SkinEthic keratinocyte Cell type
1
BT-474 Cell line
1
T3bN1M0 Disease staging
1
KSHV-positive EBV-negative Clinical info
1
GLI56 Cell line
1
CD4+ T cell Cell type
1
IgV unmutated Genotype
1
17beta-estradiol Compound treatment
1
Normal donor Clinical info
1
No induction Protocol type
1
M2 macrophage Cell type
1
Experimental malaria-infected Disease state
1
Infrared light Light
1
Benign prostatic hyperplasia Disease state
1
Prostate carcinoma Disease state
1
Primary cells Cell line
1
Immediately after exercise Clinical info
1
GLI60 Cell line
1
Placenta Organism part
1
CodeLink Labeling Protocol type
1
Estrogen receptor 1 negative; ... Test result
1
Primary culture 2 Cell line
1
Secretory cell Cell type
1
Granulocyte macrophage-colony ... Compound treatment
1
60 min after exercise Clinical info
1
Obesity Disease state
1
Erythrocyte Cell type
1
Kidney Organism part
1
BDCA3+ dendritic cell Cell type
1
Adipose-derived stem cell Cell type
1
Actinomycin D Compound treatment
1
Control RNAi
1
SIM2s RNAi
1
IBL4 Cell line
1
2,3-dimethoxy-1,4-naphthoquino... Compound treatment
1
Synovial fluid Organism part
1
White blood cell Cell type
1
Platelet Cell type
1
Geriatric Developmental stage
1
Pediatric Developmental stage
1
IL-4 Compound treatment
1
White blood cells Organism part
1
Enzo Labeling Protocol type
1
KSHV infection Disease state
1
Atrial mycocardium Organism part
1
Ventricular myocardium Organism part
1
Heregulin Compound treatment
1
Johnsen score count 3.2: Serto... Histology
1
T2N0M0 Disease staging
1
Skin substitute Cell type
1
X-linked chronic granulomatous Disease state
1
ERalpha L540Q transfected Genotype
1
CD14+ monocyte Cell type
1
Cystic change Histology
1
CD19+ B-cell Cell type
1
Dendritic cell Cell type
1
Spermatid Cell type
1
Brain Organism part
1
5-aza-2'-deoxycytidine + trich... Compound treatment
1
CD11c+ dendritic cell Cell type
1
Undifferentiated Phenotype
1
Differentiated Phenotype
1
MDS-associated acute myeloid l... Disease state
1
BCKN-1 Cell line
1
N-nitrosodimethylamine Compound treatment
1
CD4+ T-cell Cell type
1
Stage I Disease staging
1
HMEC184 Cell line
1
Well-functioning transplant Clinical info
1
Psoriatic lesional biopsy Clinical info
1
Uninvolved biopsy Clinical info
1
Teratozoospermia Disease state
1
Normospermic Disease state
1
Wild_type Genotype
1
CD71+ early erythroid Cell type
1
Kaposi's sarcoma Disease state
1
T-cell acute lymphoblastic leu... Disease state
1
Endometrioid carcinoma Disease state
1
Multiple myeloma Disease state
1
Pulmonary arterial hypertensio... Disease state
1
Granulocyte-colony stimulating... Compound treatment
1
ATM knockdown RNAi
1
Primary Disease staging
1
Lymph node metastasis Disease staging
1
Mononuclear cell Cell type
1
PT1 Disease staging
1
Vasectomized Clinical history
1
Adipose tissue-derived stem ce... Cell type
1
Hematopoietic stem cell Cell type
1
Differentiated Developmental stage
1
BC-5 Cell line
1
SM1 Cell line
1
U0126 Compound treatment
1
Stimulated polymorphonuclear l... Cell type
1
Unstimulated polymorphonuclear... Cell type
1
Control - interferon-gamma Compound treatment
1
Lin- CD34- Phenotype
1
ITM Cell line
1
10 ng/ml LPS in media Growth condition
1
Pan troglodytes Organism
1
Mature monocyte derived dendri... Cell type
1
HaCaT Cell line
1
BDCA4+ dentritic cell Cell type
1
Native skin Cell type
1
Plasma cell leukemia Disease state
1
PCep4 control vector transfect... Gene modification
1
ETat plasmid transfection Gene modification
1
Stage IIIc/2 Disease staging
1
Lin- CD34+ Phenotype
1
ITM-E6E7 Cell line
1
Cancer23 Replicate
1
A. fumigatus condia in media Growth condition
1
Astrocytoma Disease state
1
Term Developmental stage
1
Midgestation Developmental stage
1
Tissue culture polystyrene dis... Growth condition
1
Collagen/chondroitin tissue en... Growth condition
1
Spleen Organism part
1
Chronic myelogenous leukemia Disease state
1
BCBL-1 Cell line
1
BL41K3 Cell line
1
BJABK3 Cell line
1
Total_RNA Material type
1
Polysome-associated RNA Material type
1
M-CSF Compound treatment
1
Cyclazosin HCl Compound treatment
1
STK3 overexpression Genotype
1
Mock induction Protocol type
1
BC-2 Cell line
1
Metastatic Disease staging
1
Circulating neutrophil Cell type
1
Conjunctival epithelium Organism part
1
Cornea epithelium Organism part
1
T4aN0M0 Disease staging
1
Aggregatibacter actinomycetemc... Infection
1
T4aN2M1 Disease staging
1
Keratinocyte Cell type
1
Pancreatic cancer Disease state
1
Down syndrome Disease state
1
Phenol Compound treatment
1
Normal Histology
1
Poor prognosis Clinical info
1
Good prognosis Clinical info
1
ZAP-70-CD38- Cell type
1
ZAP-70+CD38+ Cell type
1
Ischemic cardiomyopathy Disease state
1
YCC1 Cell line
1
LANA induction Protocol type
1
Primary lymphatic endothelial ... Cell type
1
Ulcerative colitis Disease state
1
HMT3522S1 Cell line
1
T4aN2Mx Disease staging
1
Expression Profiles
E-GEOD-1725: Transcription profiling of human lymphoblastoid cells from patients with limited or acute radiation toxicity, skin cancer patients and normal controls, exposed to UV or IR light
Experimental Factors
Show expression profile  /  experiment details

 
E-GEOD-5824: Transcription profiling of human Acute Lymphoblastic Leukemia CEM_C1 cells treated with rapamycin identifies rapamycin as a glucocorticoid resistance reversal agent
Experimental Factors
Phenotype Time Clinical info Dose Compound treatment
Show expression profile  /  experiment details

 
E-GEOD-5258: Transcription profiling of human cell lines freely cycling treated with 164 distinct small molecules - Broad Connectivity Map CMAP Set 1
Experimental Factors
Show expression profile  /  experiment details

 
E-MEXP-1014: Transcription profiling of two human colon cancer cell lines treated with n-3 PUFA docosahexaenoic acid for 3 different time points
Experimental Factors
Show expression profile  /  experiment details

 
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