MRE11A
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Homo sapiens |
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MRE11A is differentially expressed in 283 experiments: 130 organism parts: thymus, lung, ... (128 more);, 208 disease states: normal, prostate carcinoma, ... (206 more);, 85 cell types 364 cell lines 34 compound treatments and 71 other conditions. |
| Synonyms |
MRE11, ATLD |
| Orthologs |
Mre11a
(Mus musculus)
E1BIN9_BOVIN
(Bos taurus)
Mre11a
(Rattus norvegicus)
ENSCING00000004996
(Ciona intestinalis)
mre11a
(Danio rerio)
ENSCING00000011661
(Ciona intestinalis)
MRE11
(Saccharomyces cerevisiae)
F1N9H0_CHICK
(Gallus gallus)
ENSCING00000015559
(Ciona intestinalis)
mre11
(Drosophila melanogaster)
mre11a
(Xenopus laevis)
Q5SBJ0_CANFA
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology Term |
chromosome, telomeric region, condensed nuclear chromosome, reciprocal meiotic recombination, DNA binding, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, protein binding, DNA repair, nuclear chromatin, double-stranded DNA binding, nuclease activity, cell proliferation, Mre11 complex, 3'-5' exonuclease activity, meiosis, double-strand break repair, DNA duplex unwinding, sister chromatid cohesion, nucleus, ATP-dependent DNA helicase activity, manganese ion binding, heart development, endodeoxyribonuclease activity, DNA recombination, synapsis, perinuclear region of cytoplasm, hydrolase activity, endonuclease activity, protein C-terminus binding, nucleoplasm, cell cycle checkpoint, response to DNA damage stimulus, exonuclease activity, chromosome organization, DNA metabolic process, regulation of mitotic recombination, telomere maintenance via telomerase, negative regulation of DNA endoreduplication, positive regulation of kinase activity, single-stranded DNA specific endodeoxyribonuclease activity, positive regulation of protein autophosphorylation |
| Gene Ontology ID |
GO:0003677, GO:0003690, GO:0008283, GO:0008022, GO:0007062, GO:0007131, GO:0007126, GO:0007129, GO:0008408, GO:0051276, GO:0007507, GO:0004003, GO:0016787, GO:0048471, GO:0000075, GO:0005515, GO:0005634, GO:0005654, GO:0004518, GO:0004519, GO:0004527, GO:0004520, GO:0030870, GO:0006974, GO:0000724, GO:0032508, GO:0000781, GO:0000790, GO:0000794, GO:0006302, GO:0006303, GO:0006310, GO:0006281, GO:0006259, GO:0030145, GO:0007004, GO:0031954, GO:0000019, GO:0000014, GO:0032876, GO:0033674 |
| InterPro ID |
IPR003701, IPR007281, IPR004843 |
| Ensembl Family |
ENSFM00250000003656 |
| Ensembl Family Description |
DOUBLE STRAND BREAK REPAIR |
| InterPro Term |
DNA_repair, Mre11_DNA-bd, Metallo_PEstase_dom |
| HGNC Symbol |
MRE11A |
| UniGene ID |
Hs.192649 |
| EMBL-Bank ID |
AK095388, AY584241, BC063458, AF073362, AF303394, AF303395, AF303392, AF303393, AF303390, AF303391, AF303379, AF303380, AF303381, AF303382, AF303383, AF303384, AF303385, AF303386, AF303387, AF303388, AF303389, U37359, BT006730, AF022778, BC005241, AP000786, AP000765 |
| RefSeq ID |
NM_005590, NM_005591, NP_005582, NP_005581 |
| Ensembl Protein ID |
ENSP00000376933, ENSP00000385614, ENSP00000326094, ENSP00000325863, ENSP00000439511, ENSP00000440986, ENSP00000442809 |
| Ensembl Gene ID |
ENSG00000020922 |
| Entrez Gene ID |
4361 |
| Description |
MRE11 meiotic recombination 11 homolog A (S. cerevisiae) [Source:HGNC Symbol;Acc:7230] |
| UniProt Accession |
P49959, B3KTC7, Q9BS79, F5GXT0, F5H256, F5H742, F8W7U8 |
| Ensembl Transcript ID |
ENST00000536754, ENST00000323929, ENST00000323977, ENST00000536550, ENST00000540013, ENST00000393241, ENST00000407439, ENST00000536144, ENST00000538923, ENST00000535120, ENST00000541157 |
| Gene-Disease Assocation |
ATAXIA-TELANGIECTASIA-LIKE DISORDER; ATLD |
| Design Element |
g13528887_3p_x_at, ENST00000323929, ENST00000541157, g13528887_3p_at, 39233_at, ENST00000540013, ENST00000407439, ENST00000536144, ENST00000536754, ENST00000535120, 32869_at, ENST00000323977, ENST00000536550, 205395_s_at, 32870_g_at, U37359_at, ENST00000538923, g5031920_3p_s_at, 211334_at, ENST00000393241 |
| Search EB-eye |
ENSG00000020922
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