BRCA1
close
Please copy/paste those URLs into your code to get same results in machine-readable formats:
|
Homo sapiens |
|
BRCA1 is differentially expressed in 304 experiments: 101 organism parts: bone marrow, blood, ... (99 more);, 215 disease states: normal, acute myeloid leukemia, ... (213 more);, 93 cell types 370 cell lines 45 compound treatments and 78 other conditions. |
| Synonyms |
BRCC1, RNF53 |
| Orthologs |
BRCA1
(Bos taurus)
BRCA1
(Gallus gallus)
Brca1
(Mus musculus)
ENSCING00000010053
(Ciona intestinalis)
Brca1
(Rattus norvegicus)
brca1
(Xenopus laevis)
ENSCING00000010052
(Ciona intestinalis)
BRCA1_CANFA
(Canis familiaris)
(Compare orthologs)
|
| Gene Ontology Term |
focal adhesion, ligase activity, plasma membrane, condensed nuclear chromosome, gamma-tubulin ring complex, DNA binding, double-strand break repair via homologous recombination, negative regulation of transcription, DNA-dependent, protein binding, apoptosis, protein autoubiquitination, DNA repair, positive regulation of histone H3-K4 methylation, cytoplasm, damaged DNA binding, DNA damage response, signal transduction resulting in induction of apoptosis, regulation of cell proliferation, intracellular, protein complex, protein ubiquitination, ruffle, ribonucleoprotein complex, chromosome segregation, positive regulation of protein ubiquitination, metal ion binding, mitochondrial matrix, double-strand break repair, response to ionizing radiation, response to nutrient, cell cycle, positive regulation of transcription from RNA polymerase II promoter, centrosome cycle, positive regulation of histone acetylation, transcription coactivator activity, nucleus, DNA recombination, ubiquitin-protein ligase activity, ubiquitin ligase complex, regulation of transcription from RNA polymerase III promoter, postreplication repair, nucleoplasm, response to DNA damage stimulus, condensed chromosome, regulation of transcription from RNA polymerase II promoter, brain development, enzyme binding, G2/M transition DNA damage checkpoint, positive regulation of transcription, DNA-dependent, filamentous actin, RNA binding, DNA replication, zinc ion binding, regulation of apoptosis, ubiquitin protein ligase binding, androgen receptor binding, androgen receptor signaling pathway, dosage compensation, by inactivation of X chromosome, negative regulation of histone H3-K9 methylation, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, substrate adhesion-dependent cell spreading, negative regulation of histone acetylation, response to estrogen stimulus, regulation of gene expression by genetic imprinting, negative regulation of fatty acid biosynthetic process, chordate embryonic development, tubulin binding, protein K6-linked ubiquitination, cellular response to indole-3-methanol, negative regulation of histone H3-K4 methylation, positive regulation of DNA repair, regulation of DNA methylation, BRCA1-A complex, response to lipid, response to estradiol stimulus, BRCA1-BARD1 complex, positive regulation of cell cycle arrest, response to organic substance, positive regulation of histone H3-K9 methylation, negative regulation of centriole replication, regulation of cell motility, positive regulation of histone H4-K20 methylation, positive regulation of histone H3-K9 acetylation, positive regulation of histone H4-K16 acetylation, transcription regulatory region DNA binding |
| InterPro ID |
IPR002378, IPR018957, IPR001357, IPR001841, IPR011364, IPR006957 |
| Gene Ontology ID |
GO:0003684, GO:0003677, GO:0008270, GO:0008274, GO:0003723, GO:0003713, GO:0007049, GO:0008630, GO:0007059, GO:0010212, GO:0016567, GO:0007098, GO:0007420, GO:0005925, GO:0031941, GO:0007584, GO:0030529, GO:0016874, GO:0005622, GO:0005515, GO:0004842, GO:0006915, GO:0005737, GO:0005759, GO:0005634, GO:0005654, GO:0005886, GO:0006974, GO:0042981, GO:0000724, GO:0031398, GO:0000794, GO:0000793, GO:0019899, GO:0031625, GO:0006302, GO:0006301, GO:0006310, GO:0000151, GO:0046872, GO:0042127, GO:0006359, GO:0006357, GO:0001726, GO:0051865, GO:0043234, GO:0006281, GO:0006260, GO:0051571, GO:0045944, GO:0045892, GO:0045893, GO:0031572, GO:0035066, GO:0010033, GO:0030521, GO:0043627, GO:0015631, GO:0006978, GO:0050681, GO:0043009, GO:0045739, GO:0045717, GO:0006349, GO:0070531, GO:0051573, GO:0051572, GO:0031436, GO:0044212, GO:0033993, GO:0044030, GO:0071158, GO:0085020, GO:0034446, GO:0035067, GO:0071681, GO:0009048, GO:0032355, GO:0051574, GO:0046600, GO:2000620, GO:2000617, GO:0070512, GO:2000145 |
| InterPro Term |
Znf_RING, Brst_cancerI, Znf_C3HC4_RING-type, BRCT, BRCA1, EIN3 |
| Ensembl Family |
ENSFM00250000000446 |
| Ensembl Family Description |
BREAST CANCER TYPE 1 SUSCEPTIBILITY HOMOLOG EC_6.3.2.- |
| UniProt Accession |
Q3LRJ6, Q3LRH8, Q92897, Q3B891, B7ZA85, Q4EW25, Q6IN79, Q9UE29, Q9NQR3, C9IZW4, Q7KYU6, P38398, Q3YB50, Q3YB53, Q3YB49, B4DES0, C4PFY7, E7EMP0, E7EN90, E7ENB7, E7EP71, E7EP70, E7EQW4, E7ETR2, E7EUM2, E7EWN5, E9PC22, E9PFC7, E9PFZ0, E9PH68, E7ERL4, F8W8H7 |
| EMBL-Bank ID |
L78833, AF507078, AF507076, DQ190456, DQ190457, DQ190452, DQ190453, DQ190454, DQ190455, DQ190450, DQ190451, AK293762, AK316200, U14680, DQ478408, AY093487, AY093486, AY093489, AY093485, AY093493, AY093490, DQ299331, DQ299330, DQ299327, DQ299326, DQ299328, DQ299324, DQ299325, DQ299322, DQ299323, DQ299321, DQ299329, DQ299310, DQ299311, DQ299312, DQ299313, DQ299314, DQ299315, DQ299307, DQ299308, DQ299305, DQ299306, DQ299309, AC060780, AY273801, DQ116737, FJ940752, AF284812, BC106745, U64805, U61268, AC135721, AF005068, BC072418, DQ145822, DQ145825, DQ145826, U68041, Y08757, U37574 |
| Ensembl Protein ID |
ENSP00000418212, ENSP00000350283, ENSP00000418775, ENSP00000418819, ENSP00000418986, ENSP00000418960, ENSP00000418548, ENSP00000326002, ENSP00000310938, ENSP00000377294, ENSP00000246907, ENSP00000419988, ENSP00000312236, ENSP00000338007, ENSP00000397145, ENSP00000417554, ENSP00000419103, ENSP00000417148, ENSP00000417241, ENSP00000419481, ENSP00000419274, ENSP00000420253, ENSP00000420201, ENSP00000420412, ENSP00000420705, ENSP00000420781, ENSP00000417988 |
| UniGene ID |
Hs.194143, Hs.622171 |
| Description |
breast cancer 1, early onset [Source:HGNC Symbol;Acc:1100] |
| RefSeq ID |
NR_027676, NM_007300, NP_009231, NP_009230, NP_009228, NP_009229, NP_009225, NM_007297, NM_007298, NM_007299, NM_007294 |
| Ensembl Gene ID |
ENSG00000012048 |
| Gene-Disease Assocation |
BREAST CANCER, BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1; BROVCA1 |
| Entrez Gene ID |
672 |
| HGNC Symbol |
BRCA1 |
| Ensembl Transcript ID |
ENST00000487825, ENST00000493919, ENST00000467274, ENST00000493795, ENST00000309486, ENST00000476777, ENST00000471181, ENST00000352993, ENST00000478531, ENST00000497488, ENST00000492859, ENST00000393691, ENST00000473961, ENST00000412061, ENST00000477152, ENST00000354071, ENST00000468300, ENST00000484087, ENST00000494123, ENST00000351666, ENST00000470026, ENST00000472490, ENST00000346315, ENST00000491747, ENST00000461221, ENST00000357654, ENST00000461574, ENST00000489037, ENST00000461798 |
| Design Element |
ENST00000473961, 69578_at, g2218153_3p_a_at, ENST00000471181, ENST00000487825, ENST00000484087, ENST00000351666, ENST00000461798, 204531_s_at, ENST00000352993, L78833_cds1_at, ENST00000497488, ENST00000393691, ENST00000491747, ENST00000476777, ENST00000489037, ENST00000470026, g6552300_3p_a_at, 1993_s_at, ENST00000346315, ENST00000493919, 604_at, ENST00000494123, 211851_x_at, ENST00000477152, ENST00000478531, ENST00000461221, ENST00000461574, ENST00000412061, ENST00000468300, 33724_at, ENST00000309486, ENST00000357654, ENST00000354071, ENST00000472490, ENST00000467274, 83730_at, ENST00000492859, ENST00000493795, U64805_s_at |
| Search EB-eye |
ENSG00000012048
|
 Show more
properties
|
|
