BTK
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Homo sapiens |
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BTK is differentially expressed in 199 experiments: 80 organism parts: lung, bone marrow, ... (78 more);, 207 disease states: normal, lung adenocarcinoma, ... (205 more);, 85 cell types 329 cell lines 19 compound treatments and 64 other conditions. |
| Synonyms |
PSCTK1, IMD1, AGMX1, XLA, ATK |
| Orthologs |
D3ZHD2_RAT
(Rattus norvegicus)
btk
(Danio rerio)
Btk
(Mus musculus)
Q5ZLF2_CHICK
(Gallus gallus)
Q3ZC95_BOVIN
(Bos taurus)
btk
(Xenopus laevis)
BTK
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR001562, IPR002290, IPR001452, IPR011511, IPR001245, IPR017442, IPR000719, IPR000980, IPR001849, IPR020635 |
| Gene Ontology Term |
cytosol, plasma membrane, protein binding, cytoplasm, innate immune response, peptidyl-tyrosine phosphorylation, metal ion binding, protein tyrosine kinase activity, membrane raft, I-kappaB kinase/NF-kappaB cascade, identical protein binding, ATP binding, nucleus, mesoderm development, nucleotide binding, kinase activity, protein serine/threonine kinase activity, cytoplasmic vesicle, positive regulation of NF-kappaB transcription factor activity, calcium-mediated signaling, non-membrane spanning protein tyrosine kinase activity, protein kinase activity, positive regulation of B cell differentiation, phosphatidylinositol-3,4,5-trisphosphate binding, B cell receptor signaling pathway, B cell activation, cell maturation, induction of apoptosis by extracellular signals, adaptive immune response, regulation of B cell apoptosis, protein phosphorylation, intracellular signal transduction, regulation of B cell cytokine production |
| InterPro Term |
SH2, SH3_domain, Znf_Btk_motif, Prot_kinase_cat_dom, Pleckstrin_homology, SH3_2, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| Gene Ontology ID |
GO:0007249, GO:0016301, GO:0007498, GO:0051092, GO:0004713, GO:0004715, GO:0042802, GO:0005524, GO:0005515, GO:0005737, GO:0005634, GO:0005886, GO:0005829, GO:0004672, GO:0004674, GO:0019722, GO:0006468, GO:0000166, GO:0018108, GO:0046872, GO:0031410, GO:0045121, GO:0045087, GO:0008624, GO:0048469, GO:0005547, GO:0002250, GO:0050853, GO:0042113, GO:0045579, GO:0002902, GO:0035556, GO:0002721 |
| Ensembl Family |
ENSFM00280000058686 |
| Ensembl Family Description |
TYROSINE KINASE EC_2.7.10.2 |
| Description |
Bruton agammaglobulinemia tyrosine kinase [Source:HGNC Symbol;Acc:1133] |
| EMBL-Bank ID |
AM051282, AM051284, AM051278, AM051277, AM051276, L31568, L31569, L31566, L31567, L31564, L31565, L31563, L31561, L31557, L31558, L31559, L31571, L31570, L31572, AL035422, BC109080, BC109079, X58957, AK057105, U78027, CH471115, AJ888376, U10087, U10086, U10085, U10084, U13410, U13412, U13417, U13414, U13413, U13416, U13415, U13423, U13424, U13422, U13429, U13428, U13427, U13425, U13430, U13431, U13432, U13433, AF153763 |
| UniProt Accession |
Q5JY90, Q3MS88, Q3MS90, Q06187, Q3MS94, Q3MS95, Q3MS96, Q572P5, Q9P0L4 |
| Ensembl Protein ID |
ENSP00000378608, ENSP00000361946, ENSP00000361951, ENSP00000361950, ENSP00000361960, ENSP00000361971, ENSP00000416302, ENSP00000308176, ENSP00000443512 |
| Ensembl Gene ID |
ENSG00000010671 |
| UniGene ID |
Hs.159494 |
| HGNC Symbol |
BTK |
| RefSeq ID |
NP_000052, NM_000061 |
| Entrez Gene ID |
695 |
| Ensembl Transcript ID |
ENST00000308731, ENST00000478995, ENST00000395179, ENST00000372880, ENST00000372860, ENST00000372869, ENST00000372859, ENST00000372855, ENST00000443591, ENST00000488970, ENST00000470329, ENST00000540426, ENST00000470069, ENST00000464006, ENST00000464567 |
| Gene-Disease Assocation |
AGAMMAGLOBULINEMIA, X-LINKED; XLA, ISOLATED GROWTH HORMONE DEFICIENCY, TYPE III; IGHD3 |
| Design Element |
ENST00000464567, ENST00000372869, 71820_at, ENST00000488970, 38213_at, U78027_rna4_at, ENST00000470069, ENST00000478995, g4557376_3p_at, ENST00000308731, ENST00000540426, ENST00000443591, ENST00000372860, ENST00000372859, ENST00000464006, 205504_at, ENST00000372855, ENST00000372880, ENST00000395179, ENST00000470329 |
| Search EB-eye |
ENSG00000010671
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