jnk-1
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Caenorhabditis elegans |
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jnk-1 is differentially expressed in 3 experiments: 5 genotypes: pie-1(zu154), pie-1(zu154)+pal-1(RNAi), ... (3 more);, 4 strain or lines: BB1, CB189, ... (2 more); |
| Orthologs |
HOG1
(Saccharomyces cerevisiae)
Q4H3A2_CIOIN
(Ciona intestinalis)
Q2KI72_BOVIN
(Bos taurus)
Mapk9
(Rattus norvegicus)
Mapk8
(Mus musculus)
MAPK8
(Bos taurus)
MAPK10
(Gallus gallus)
Mapk10
(Mus musculus)
mapk8b
(Danio rerio)
Mapk9
(Mus musculus)
MAPK8
(Homo sapiens)
mapk10
(Danio rerio)
mapk8a
(Danio rerio)
mapk9
(Danio rerio)
A4FV00_BOVIN
(Bos taurus)
MAPK8
(Gallus gallus)
MAPK9
(Homo sapiens)
MAPK10
(Homo sapiens)
MK09_CHICK
(Gallus gallus)
MK08_RAT
(Rattus norvegicus)
Mapk10
(Rattus norvegicus)
mapk10
(Xenopus laevis)
mapk8
(Xenopus laevis)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR001245, IPR017442, IPR008351, IPR008271, IPR020635, IPR003527, IPR010440 |
| InterPro Term |
Se/Thr_prot_kinase-like_dom, Ser/Thr_prot_kinase_dom, MAP_kinase_CS, Tyr_Pkinase_cat_dom, Ser/Thr_prot_kinase_AS, JNK_MAPK, Ser-Thr/Tyr-Pkinase, LipoPS_kinase |
| Ensembl Family Description |
MITOGEN ACTIVATED KINASE MAP KINASE MAPK EC_2.7.11.24 STRESS ACTIVATED KINASE C JUN N TERMINAL KINASE |
| Ensembl Family |
ENSFM00460000244930 |
| Ensembl Protein ID |
B0478.1a, B0478.1b.2, B0478.1b.3, B0478.1b.1 |
| Ensembl Gene ID |
B0478.1 |
| RefSeq ID |
NP_001021270, NP_741434, NM_001026099, NM_171371 |
| Description |
jnk-1 encodes a serine/threonine kinase that is the sole C. elegans member of the c-Jun N-terminal kinase (JNK) subgroup of mitogen-activated protein (MAP) kinases. jnk-1 is required for normal coordinated locomotion as well as for normal adult lifespan and response to heat and oxidative stress. JNK-1 exhibits kinase activity in vitro that is dependent upon activation by the JKK-1/MAPKK. in addition, JKK-1-dependent JNK-1 phosphorylation is required for JNK-1-mediated lifespan extension, as is DAF-16, with which JNK-1 physically interacts and phosphorylates and whose nuclear translocation is under JNK-1 control. a JNK-1::GFP translational fusion protein is expressed in nearly all neuronal cell bodies and processes, including the nerve ring, head and tail ganglions, and the dorsal and ventral nerve cords, at all stages of development. [Source: WormBase] |
| EMBL-Bank ID |
AB024085, U57054 |
| Entrez Gene ID |
177460 |
| UniProt Accession |
Q8WQG9 |
| UniGene ID |
Cel.18197 |
| Ensembl Transcript ID |
B0478.1b.3, B0478.1b.2, B0478.1b.1, B0478.1a |
| Design Element |
175640_at, 190415_s_at |
| Search EB-eye |
B0478.1
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