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PANDIT
Protein and Associated NucleotideDomains with Inferred Trees

PF01007 alignment
(12 sequences with 378 aa)


IRK12_HUMAN/47-380 VKKNGQCNIEFANMDEK.SQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLEPAE..............--GRGRTP......CVMQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGL.DRIFLVSPITILHEIDEASPLFGIS-QDLET.DDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFE--EKNQYKIDYSHFHKTYEVPS-..TPRCSAKDLVENKF-.--LLPSAN---------SFCYENEL
IRK2_CAVPO/48-380 VKKDGHCNVQFINVGEK.GQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDAS-..............---KESKA......CVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGI.DRIFLVSPITIVHEIDEDSPLYDLSKQDIDN.ADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFE--EKHYYKVDYSRFHKTYEVPN-..TPLCSARDLAEKKY-.--ILSNAN---------SFCYENEV
IRK4_HUMAN/22-377 VKKNGQCNVYFANLSNK.SQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPgvpaaggpaaggggAAPVAPKP......CIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGL.DRIFLVSPIIIVHEIDEDSPLYGMGKEELES.EDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFE--EKSHYKVDYSRFHKTYEVAG-..TPCCSARELQESKI-.--TVLPAPPPPP----SAFCYENEL
IRK9_HUMAN/25-362 VEKDGRCNVQQGNVR-E.TYRYLTDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEH--..............LEDTAWTP......CVNNLNGFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTDLSVGFDTGD.DRLFLVSPLVISHEIDAASPFWEASRRALER.DDFEIVVILEGMVEATGMTCQARSSYLVDEVLWGHRFTSVLTL--EDGFYEVDYASFHETFEVP--..TPSCSARELAEAAARlDAHLYWSIPSR--------LDEKVE
IRK5_HUMAN/54-390 MEKSGKCNVHHGNVQ-E.TYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDH--..............VGDQEWIP......CVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGD.DRLFLVSPLIISHEINEKSPFWEMSQAQLHQ.EEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTL--EKGFYEVDYNTFHDTYETN--..TPSCCAKELAEMKR-.EGRLLQYLPSPP-------LLGGCA
IRK3_CHICK/39-385 VDKNGRCNVQHGNLGGE.TSRYLSDLFTTLVDLKWRWNLFIFVLTYTVAWLFMASMWWVIAYMRGDLNK--..............AHDDSYTP......CVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAAISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGA.DQLFLVSPLTICHVIDAKSPFYDLSQRTMQT.EQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISL--EEGFFKVDYSQFHATFEVP--..TPPYSVKEQEEMLLMsSPLIAPAVSNSKERNNSVECLDGLD
IRK11_HUMAN/36-368 VSKKGNCNVAHKNIR-E.QGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAP--..............-SEGTAEP......CVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILSLIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGG.NSIFLVAPLIIYHVIDANSPLYDLAPSDLHHhQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAE--EDGRYSVDYSKFGNTIKVP--..TPLCTARQLDEDHS-.---LLEALTLA--------SARGPL
IRK8_HUMAN/37-380 IAKSGACNLAHKNIR-E.QGRFLQDIFTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIYAYM..............EKSGMEKSglestvCVTNVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQNIVGLIINAVMLGCIFMKTAQAHRRAETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQVVKKTTTPEGEVVPIHQLDIPVDNPIES.NNIFLVAPLIICHVIDKRSPLYDISATDLAN.QDLEVIVILEGVVETTGITTQARTSYIAEEIQWGHRFVSIVTE--EEGVYSVDYSKFGNTVKVA--..APRCSARELDEKPSI.---LIQTLQKSE-----L-SHQNSL
IRK16_RAT/37-358 LHKDGSCNVYFKHIFGE.WGSYMVDIFTTLVDTKWRHMFVVFSLSYILSWLIFGSIFWLIALHHGDLLS--..............--DPDITP......CVDNVHSFTAAFLFSLETQTTIGYGYRCVTEECSVAVLTVILQSILSCIINTFIIGAALAKMATARKRAQTIRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYSEDSEG-RMTMAFKDLKLVNDQ--.--IILVTPVTIVHEIDHESPLYALDRKAVAK.DNFEILVTFIYTGDSTGTSHQSRSSYVPREILWGHRFHDVLEV--KRKYYKVNCLQFEGSVEVY--..APFCSAKQLDWKDQ-.-----QLN-----------NLEKTS
IRK15_HUMAN/30-365 MSKSGHSNVRIDKVDGI.YLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVIYYAIAFIHGDLEPDE..............-PISNHTP......CIMKVDSLTGAFLFSLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVITKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVDSSS.ESPFLILPMTFYHVLDETSPLRDLTPQNLKE.KEFELVVLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLS-KNGKYVADFSQFEQIRKSP--..--DCTFYCADSEKQ-.--QLEEKYRQE-------DQREREL
IRK10_HUMAN/31-369 LTKDGRSNVRMEHIADK.RFLYLKDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELD..............-PPANHTP......CVVQVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIRFSQHAVVASHNGKPCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQVDTAS.DSPFLILPLTFYHVVDETSPLKDLPLRSG-E.GDFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLS-ASGKYIADFSLFDQVVKVASPsgLRDSTVRYGDPEKL-.--KLEESLR---------EQAEKEG
IRK1_HUMAN/43-380 VSKDGRCNIEFGNVEAQsRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFH..............-PSANHTP......CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGN.ENLFFISPLTIYHVIDHNSPFFHMAAETLLQ.QDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKT-KEGKYRVDFHNFSKTVEVETP..---HCAMCLYNEKD-.--VRARMKRGY-------DNPNFIL