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PANDIT
Protein and Associated NucleotideDomains with Inferred Trees

PF00656 alignment
(120 sequences with 671 aa)


Q9ZSP8_HEVBR/3-415 KKAVLIGINYPGTK-........-AELKGCINDVKRMYRCLVDRY.G.....FSEED..ITVLI-...--.......--...DIde............................................................................syiQPTGKNIRRV.LTDLVRSAE...--PGD-.-LLFVHYSGHG.-TRLPAET-GEDDDTGF.............DECI-.V...PCDMNLI-.-----.....-TDDDFREFVDQ-............................................VPHGCRITVVSDSCHSGGLIDEAKEQigestkrkeeesesgfgfksflkqtiqdafesrgvhlpsdlhhhhghrdeedfdnrvveedygdsgyvkskslplstlieilkqktg.kddidvgklrptlfdmfgddaspkvkkfmkvilnklrhgdgesggggflgmvgslaqeflkhkldendesyvkpaletevdskqevyAGKTKRSLPDGGILISGCQTDQTSADAsps...........gksSEAYGALSNAIQTII.AET--DgAVTNQELVLKARKMLKKQGF---.....................................---TQKPGLYCSDDHVEASF
O64519_ARATH/3-366 KKALLIGINYVGTK-........-AELRGCVNDVRRMRISLVERY.G.....FSEEN..IKMLI-...--.......--...DTds............................................................................ssiKPTGKNIRQA.LLDLVEPAK...--SGD-.-VLFVHYSGHG.-TRLPAET-GEDDDTGY.............DECI-.V...PSDMNLI-.-----.....-TDDDFRDLVDM-............................................VPKDCPITIISDSCHSGGLIDEAKEQigestkkkkdsgdsstinketeaeiievgnrslpletlidmlkqetgnddievgkirttlfd..................................................mfgddsspkvkkfmnvilsnlqettttiqtvsdevlgsvenlaqefleqklsddvkpaiqdvyAGAINGALPDNGILISGCQTDQTSSDAspp...........ghpELAYGALTNAIQIII.GET--KgKISNKDLVLKARKLLRKQGF---.....................................---DQRPGLYCNDAYVNARF
O64518_ARATH/3-408 KKAVLIGINYPGTK-........-AELRGCVNDVRRVHKSLVDRF.G.....FSERN..ITELI-...--.......--...DTde............................................................................sstKPTGKNIRRA.LLNLVESAK...--PGD-.-VLVVHYSGHG.-TRLPAET-GEDDDTGY.............DECI-.V...PCDMNLI-.-----.....-TDDEFRDLVEK-............................................VPKEAHITIISDSCHSGGLIDEAKEQigestkkkpkkesggssglgikgfvreaveealeskgiaiphhkdekdenktkelkledgakvhvvnkslplqtlidilkqnt........gnndievgkirptlfnvfgedaspkvkkfmkviltklqegkteggilgmigklaqeflkhklnddeeyvkpamkthvgnkqevyAGASNGSLADNGILISGCQTDQTSADAspq...........ghpEMAYGAFTNAVQIIL.EET--KgMITYKELVLKARKLLKKQGF---.....................................---SQRPGLYCSDSFVNAPF
O64517_ARATH/3-416 KKAVLIGINYPGTK-........-AELRGCVNDVRRMYKCLVERY.G.....FSEEN..ITVLI-...--.......--...DTde............................................................................sstQPTGKNIRRA.LADLVESAD...--SGD-.-VLVVHYSGHG.-TRLPAET-GEDDDTGF.............DECI-.V...PCDMNLI-.-----.....-TDDDFRDLVDK-............................................VPPGCRMTIISDSCHSGGLIDEAKEQigestkkeaededeseesssrfgfrkflrskvegaiesrgfhiggnkkdedeaeeietkeieledgetihakdkslplqtlidilkqqtgndnievgkirpslfdafgddsspkvkkfmkvilgklqagngeegglmgmlgklasgflegklndedyvkpamqthvgskeevyagGSRGSVPLPDSGILISGCQTDQTSADAtpa...........gkpTEAYGAMSNSIQTIL.EET--DgEISNREMVTRARKALKKQGF---.....................................---TQQPGLYCHDGYANAPF
O64520_ARATH/3-386 KRALLIGINYPGTT-........-EELQGCVNDVHRMHKCLVDRF.G.....FAEED..ITVLI-...--.......--...DTde............................................................................sytQPTGKNIRQA.LSELIKPAK...--SGD-.-VLFVHYSGHG.-TRVPPET-GEEDD---.............-----.-...--------.-----.....-TDDDFRDLVEQ-............................................VPEGCQITIVSDSCHSGGLIDEAKEQigestttkpnreskvssfefefknclhsifvkllafcgigsshvetreivevgegdevvrsrylplerfiellkqqtgqd..............nieigkirptlfdvfgedsspkikkfmkviltklrktndqstllgkieesargyieetlndehymkpamqaqvksdreiygGRSSNGLFPDRGILLSGCQTDETSADVkk..............kGEAFGAFSNAIQMVL.SETDHKdKITNKEMVLRAREILKKQMF---.....................................---IQRPGLYCNDRFVNAPF
Q70VV0_PICAB/3-415 KKAVLVGCNYPGTK-........-AELKGCVNDVNRMYKCLVERY.G.....FEEEN..IRVLI-...--.......--...DTdd............................................................................sypQPTGANVRRA.LKTLVEGSR...--AGD-.-IIFFHYSGHG.-VRLPAET-GDQVDTGY.............DECI-.V...PCDMNLI-.-----.....-TDDDFREFIDK-............................................VPRDCFCTIVSDSCHSGGLIERAKEQigestkdgderpehkkqggfgfrdllsesvhgafesrgihlpsrhehkdrresdegetqeieyhgkgraknrslplstlieilnekt.grhdidvgkirptlfdmfgddaspkvkkfvkvlvtklqssgneggllgaignlaqqflkqkldgsdggseyvkpalqeevsstqeiyAGSGKRGLPDMGILVSGCQSDQTSADAnpt...........gnpAHAYGALSNAIQTIL.AEH--DgPIPNRQLVMKARQILSKQGF---.....................................---AQRPGLYCTDRLANAPF
Q8LCR8_ARATH/5-316 RLAVLVGCNYPNTR-........-NELHGCINDVLAMKETILSRF.G.....FKQDD..IEVLT-...--.......--...DEpe............................................................................skvKPTGANIKAA.LRRMVDKAQ...AGSGD-.-ILFFHYSGHG.-TRIPSVKSAHPFKQ--.............DEAI-.V...PCDFNLI-.-----.....-TDVDFRELVNQ-............................................LPKGTSFTMISDSCHSGGLIDKEKEQigpssvssnispaiettnktitsralpfkavldhlss.....................................................................................................ltgittsdigthllelfgrdaglkfrlpamdlmdlleTMTAREKHVDSGILMSGCQADETSADVgv.............gnGKAYGAFSNAIQRVL.--NENEgAMKNKQLVMMARDVLERLGF---.....................................---HQHPCLYCSDQNADATF
Q9SA41_ARATH/3-378 KKALLIGINYPGTA-........-VELRGCVNDVHRMQKCLIELY.G.....FANKD..IVIMI-...--.......--...DTdk............................................................................sciQPTGKNICDE.LDNLIASGQ...--SGD-.-FLVFHYSGHG.-TRIPPGIEDSEDPTGF.............DECI-.T...PCDMNLI-.-----.....-KDQQFREMVSR-............................................VKEGCQLTIISDSCHSGGLIQEVKEQigeshmkpvdkvkeqieeshmkqpklgiasyflnivmnllatcgvsksqrdrgggeesfrgeielek.........................................detldiktrylpfesylsllkeqtgqtniepvrirqtllklfgedpspnrqrglsdlgncevdagdsGASRLNAVTDNGILLSGCQTDQRSEDVyvt............rtGKAYGAFSDAIQMILsAPRKDKkKITNKELVSEARVFLKKRGY---.....................................---SQRPGLYCHDRFVDKPF
Q8T8E8_9TRYP/84-341 R-ALFIGIDYKGTP-........-AELRGCQADAVMMAGTM-EKI.G.....IPITErcVLMDT-...--.......--...DDprf...........................................................................naiKPTRANILQH.MAWLVKDAK...--PGD-.-ALFLHYSGYG.-AQVRAEE---DKEEEF.............DQCI-.V...PCDYEENGcI----.....-LDNELHEIIST-............................................LPRGVRLTAVFDCSHAGTLLDLPFSLicssndc.................................................................................................................................................................savgemkRIRTGGDVNAHVLMFSACGDDEAAADLpnagd.......fvegaSGSGGAATQCFISML.---LNKtPGTIYSLLSTTRDKLREKGF---.....................................---KQSPQMSASRCLSLTEK
Q8T8E6_9TRYP/84-343 R-ALFIGINYYGTS-........-AALSGCCNDVKQMLATL-QKK.G.....LPINE..AVILV-...--.......--...DEdnfp.........................................................................grtdQPTRDNIVRY.MAWLVKDAK...--PGD-.-VLFFHYSGHG.-TQCKSRG---DSDEKY.............DQCI-.A...PVDFQKSGcI----.....-VDDDIHKLLFSR............................................LPEKVRLTAVFDCCHSGSIMDLPFTYvcsggeq................................................................................................................................................................asgtphmkRIREGNDVLGDVMMISGCADEQTSADVkntat.......fgtgsTGAGGAATQCITCML.---MNNqSLSYGKLLIETRDMLKRKRF---.....................................---KQVPQLSASKAIDLDQT
Q8IEW1_9TRYP/63-322 K-ALFIGINYTGSS-........-AQLGGCVNDVMHMLQTL-QRI.E.....FPISE..CCILV-...--.......--...DDrrfp.........................................................................nftaMPTRENIIKY.MAWLVYDVR...--PGD-.-VLFFHFSGHG.-AETKGGR---DSNEKM.............DQCL-.V...PLDYDKAGaI----.....-LDDDLFELMIKG............................................LPAGVRMTAVFDCCHSASLLDLPFAFvagrnvs................................................................................................................................................................snqrhemrMVRKDNYSRGDVVMFSGCEDSGTSADVtntss.......fgngtVAAGGAATQAFTWAL.---LNTtGYSYIDIFMKTREVLRQKGY---.....................................---KQVPQLSSSKPVDLYKQ
Q7XJE5_ARATH/116-414 KRAVIVGVSYKNTK-........-DELKGCINDANCMKFMLMKRF.Q.....FPESC..ILMLT-...--.......--...EEead...........................................................................pmrWPTKNNITMA.MHWLVLSCK...--PGD-.-SLVFHFSGHG.-NNQMDDN--GDEVDGF.............DETL-.L...PVDHRTSGvI----.....-VDDEINATIVRP............................................LPYGVKLHAIVDACHSGTVMDLPYLCrmdrlgny...............................................................................................................................................................ewedhrpkTGMWKGTSGGEVFSFTGCDDDQTSADTpql............sgSAWTGAMTYAFIQAI.----ERgHGMTYGSLLNAMRSTVHEIFDKNkgrelvevggadflstllgllilgasppdeeeevnqaPQKTQEPQLSANEAFAVYEK
Q7XC24_ORYSA/76-374 KRAVICGISYKFSR-........-HELKGCINDAKCMRHLLTTRF.H.....FPDDS..IIMLTGnypILppywlnsGS...EEqtd...........................................................................pykIPTKHNIRMA.MYWLVQGCQ...--PGD-.-SLVFHYSGHG.-AQQRNYS--GDEVDGM.............DETL-.C...PLDFETQGmI----.....-VDDEINTALVRP............................................LTPGVKLHALIDACHSGTALDLPFLCrmnrsgqy...............................................................................................................................................................vwedhrprSGVWKGTSGGECISFSGCDDDQTSADTsal............skITSTGAMTFCFIQAI.----ERgQGTTYGSILTSMRSTIRSTGDSMgsgggavtsli...............tmlltggsvssGGLKQDPQLTANEPFDVYAK
O81911_ARATH/80-386 KRAVICGISYRFSR-........-HELKGCINDAKCMRHLLINKF.K.....FSPDS..ILMLT-...--.......--...EEetd...........................................................................pyrIPTKQNMRMA.LYWLVQGCT...--AGD-.-SLVFHYSGHG.-SRQRNYN--GDEVDGY.............DETL-.C...PLDFETQGmI----.....-VDDEINATIVRP............................................LPHGVKLHSIIDACHSGTVLDLPFLCrmnrllvpqpllk....................................................................................................................................................giagqyvwedhrprSGLWKGTAGGEAISISGCDDDQTSADTslvpplmikthtqalskITSTGAMTFCFIQAI.---ERSaQGTTYGSLLNSMRTTIRNTGNDGggsggvvttv................lsmlltggsaiGGLRQEPQLTACQTFDVYAK
Q75B43_ASHGO/154-449 RKALLIGINYFNSS-........-AELRGCINDVQNIKNFLISRY.G.....YREEN..MVILT-...--.......--...DDqhd...........................................................................pvrIPTKANILRA.MHWLVQGAQ...--PND-.-SLFLHYSGHG.-GETEDLD--GDEQDGK.............DSTL-.Y...PVDFETNGhI----.....-VDDEIHDILVKP............................................LAPGVRLTALIDACHSGSALDLPYMYstkgiikepnvwkdigsnsmqaamayvtg.....................................................................................................................ntgdmftslkslastvsrkatgsggvdteRVRQTKFSPADVIMFSGSKDNQTSADAve..............nGVATGAMSYSFVKVM.----SQqPQQTYLSLLQNMRTELKGKY---.....................................---TQKPQLSCSHPLDVNLQ
Q6FPX9_CANGA/98-389 RKALLIGINYIGSK-........-NALRGCINDAHNIFNYLTTYC.G.....YRPED..IVMLT-...--.......--...DDqre...........................................................................mvkIPLKENIIRA.MQWLVKDAQ...--PND-.-ALFFHYSGHG.-GQTKDLD--GDEEDGM.............DDVI-.Y...PVDFESVGpL----.....-IDDTMHDIMVKS............................................LPQGARLTALFDSCHSGTVLDLPYTYstkgvikepnmwkdvgsdgiqaamaya.........................................................................................................................tgnrsalfssignmvssvtkkqnvdreRVRQIKFSPADVIMLSGSKDNQTSADTfa..............dGQNIGAMSHAFISVM.----TRqPQQSYLSLLQNLRNELAGKY---.....................................---SQKPQLSASHPIDVNLQ
Q08601_YEAST/157-450 RKALIIGINYIGSK-........-NQLRGCINDAHNIFNFLTNGY.G.....YSSDD..IVILT-...--.......--...DDqnd...........................................................................lvrVPTRANMIRA.MQWLVKDAQ...--PND-.-SLFLHYSGHG.-GQTEDLD--GDEEDGM.............DDVI-.Y...PVDFETQGpI----.....-IDDEMHDIMVKP............................................LQQGVRLTALFDSCHSGTVLDLPYTYstkgiikepniwkdvgqdglqaaisyat.......................................................................................................................gnraaligslgsifktvkggmgnnvdreRVRQIKFSAADVVMLSGSKDNQTSADAve..............dGQNTGAMSHAFIKVM.----TLqPQQSYLSLLQNMRKELAGKY---.....................................---SQKPQLSSSHPIDVNLQ
Q6CLS0_KLULA/161-453 RKALLIGINYFGSA-........-NELRGCINDSHNMFNFLTQRY.G.....YKAED..IVMLN-...--.......--...DDttd...........................................................................pvrVPTKANMLRA.MQWLVKDAR...--PND-.-ALFFHYSGHG.-GQTEDLD--GDEEDGM.............DDVI-.Y...PVDFQMAGhI----.....-VDDDMHAIMVSP............................................LQPGVRLTALFDSCHSGTVLDLPYTYstkgvikepnmwkdvgssglqaamaya........................................................................................................................tgnttslvsslgnvfttitksnnnvdreRVKQIKFSPADVIMFSGSKDNQTSADAte..............nGQNTGAMSWAFLTVL.----SKqPQQSYLSLLQNMRAELSSKY---.....................................---TQKPQLSCSHEIDTNLQ
Q6C2Y6_YARLI/168-458 KKALLIGCNYIGSK-........-NALRGCINDVHNLQRYLVQRA.G.....YKPDD..MVILT-...--.......--...DDqrd...........................................................................qrsIPTKQNILQA.CQWLVKGAQ...--PND-.-SLVFHFSGHG.-GQEKDVD--GDEDDGY.............DECI-.Y...PVDFQRAGsI----.....-IDDVLHDILVKS............................................LPPGCRLTALFDSCHSGTALDLPYVYstkgilkepnlakeagqgllgavssy..........................................................................................................................argdiggalssimgtvkqattgsganqRAKQTKTAPCDAISISGCKDSQTSADAme..............gGTATGAMSFAFIEVM.----TRdPNQSYLSLLNNMREVLRGKY---.....................................---SQKPQLSASHPTDVNLK
Q6BH13_DEBHA/146-437 KKALLVGINYTGSK-........-NQLRGCINDVKNMSNFLNQHF.G.....YSYDD..MVILT-...--.......--...DDqnq...........................................................................rarIPTKENIIRA.MQWLVKDAR...--PND-.-SLVFHYSGHG.-GVTKDLV--GDEESGM.............DDVI-.Y...PLDFEVNGhI----.....-IDDIMHDIMVKP............................................LPQGCRLTALYDSCHSGTALDLPYVYstkgvvkepnllkdagtgafnallsye.........................................................................................................................tgnisgaisslsgivkkisnlastnrdQVIRMKASPADVISISGCKDDQTSADAre..............gGQSTGAMSWSFITTM.----NQmPNQSYLSLLNNMRTLLKSKY---.....................................---SQKPQLSCSHPQDMNLK
O74477_SCHPO/130-422 RKALLIGINYLNTQ-........-NELQGCINDVMSMSQLLIQRY.G.....YKQED..MVIMT-...--.......--...DTasn...........................................................................qraIPTRQNMLDA.MRWLVSDAQ...--PND-.-ALFFHYSGHG.-GQTKDLD--GDEVDGY.............DETI-.Y...PLDHQYAGqI----.....-IDDEMHEIMVKP............................................LPAGCRLTALFDSCHSGGALDLPFTYstkgvlkepnmlkesgmdvlhaglsya........................................................................................................................sgdimgainnvkniftsatngfnnnalqYSRQVKFSPADVISLSGCKDNQTSADTsv..............nGFATGALSYAFREVV.----TQnPQLSYLQLLRGIRQVLSNKY---.....................................---SQLPQLSCSHPLDMNLA
Q74F93_GEOSL/6-270 ALALGLNAVDPKHYGg......wAGKLNACEADAEDMAAIA-AER.G.....FAVTT..------...-L.......MT...KA.................................................................................-ATRAKVIDA.IGKAAKALG...--KGD-.-IFMLSYSGHG.-GQVPDTSNDEPDGV--.............DETW-.C...LFDGEL--.-----.....-IDDELYALLGK-............................................FAAGVRVLVFSDSCHSGTVVKMAYYNgttaarsagpdegeiryramp....................................................................................................................................qsvamrtyranrefydtiqqktKKVDLADVKASILLISGCQDNQLSQDG.................-AFNGAFTGQLLRVW.------.KNGLYKGSYRSFHKAIVRRMP--.....................................--PDQTPNFFTAGTPDPAFL
Q7RFI8_PLAYO/964-1364 KKAVVIGCNYMGEKD.......sINQLHGSANDAYVFSRALVKYF.N.....FLPEN..ILLLI-...--.......--...DSfpsnayiyddfdmnrtkyineknnytyneekkekkylfnlfnkkniydnkevsndyennnscvdvdiknvdlssknidfslWPTRINILKA.VNWLVRDSV...--PNG-.-SYVFYYAGKS.-IQVDNMS--GWEGEGY.............DEAF-.LcsdPVNKNEEDnIL---.....-TTIQLKDLLLS-............................................INSTAQMTIILDTSGGQTILDPAGTEnssyikgckqkgiwpitnptnkvykaiyditi...............................................................................................................ldnnsmkkymcksrysklievdstsamidpllQSISSFPLPTKAYCLCAATWEQISIEGlfpifefariaqkkkkkTLSKSIENKNGDNNM.KGNNEDvENDSQHMLDNSSHLNNVKKN---.....................................---MYEPNISFNINSLTKFF
Q87Z21_PSESM/2-225 KKALVIGIDNYPT--........-APLMGCVNDAVAIAELL-END.GngdpnFSVIK..------...--.......LVsneQD.................................................................................-VTSESLINA.ISELFSGEA...----D-.-TALLYFAGHGiIVPETN-----------.............AGYI-.V...SCDGRRGAwGTS--.....-LSEILGLANKAH............................................PKIKSC-VIILDCCHSGYAGEVAGV-...............................................................................................................................................................................-DGNASAIGTGVTILTASHREGGAMEE.................-DGRGIFTDILLDGL.---RGGcSDILGNITPAAIYSHVDQTLG--.....................................-PWEQRPMYKANVQHFVTLR
Q7NPG1_GLOVI/7-278 K-ALIVAINDYPGT-........TNDLPSCLEDARKFIEVL-KSP.S.....YGLRT..------...--.......--...QQlrt..........................................................................lydaEATIKNVTDG.LDWLLSGVSrsaNGKQDA.-RRILYFSGHGfRTELEGIL---------.............RECLClHdgfFFDQQ---.-----.....-LSAKTQGLPPGM............................................L------TVILDSCHSGGMEKPFLLVvstdeseertrnkvwipedlskeiaveldqt................................................................................................................vslpfkafggpvepplaasksgamrlmatsaiARQKADAPRVNGLVLSACRAEQTAAASts..............rTNGMSAFTYGIVTALtKAG---.-----------------------.....................................---QSLPSYDRLSNARLLQA
Q82I86_STRAW/5-276 H-ALLVGIDDYPSQT........ATPLRGAVTDVEEAARLV-TELvGeradlLFLRD..------...--.......--...GE.................................................................................-ATVAAVEDAvVRQLGAAGP...---GD-.-TALLWFSGHGtQQRATGADLLIEATGQ-.............NQAL-.V...CVDGPL--.-----.....-LDKRLGALLERV............................................AEGGAHVVAVLDCCYAGGGTRAGVLTprfappspdwdwgegeggg........................................................................................................................................gdggegwdfgaderargvvaAAGSGTPAPTRHVLLAASRLDQQSFEG.................-HFGGRRMGAFTYALlGAVREAgPGLGYRELLAAADARLRRSG---.....................................--GRQQPVLYPVTPGGPADQ
Q53839_STRCO/9-268 SRVVLVGVADYDHL-........-PPLPGIRNNLAALAEFFTSPQ.G.....WGLPP..-----EhctVV.......T-...NP.................................................................................-CQSSEFIDP.VQRAAAEAT...----D-.-TLLVYYSGHG.-HLDDELRYSVSVTGSR............qDQPWTcL...PYSW----.-----.....-LKSVLIQTRAQR............................................R------VVILDSCFSGQAHGLMTDA..............................................................................................................................................................................aDALRVQVATSGAVVISSARHDLPALAPv................GETYTAFTGELLDVLtHGIPGGsPEISVDAAYAHVKAALAARGRPTpdrtgtdtsgali...........iarnpgfrphtpaATLRPVPGTHLRALAERLYP
P74453_SYNY3/40-299 KWALLLAAGQGNGANg......dRRGLMGCTTDRQLLGEVLTGRY.G.....FDQAK..------...IA.......GL...DP................................................................................qGITLSALEILfDEHLRQQVQ...--KGD-.-PVVVAFSGYG.SYNPPAAMTPNPTWEQAlphlglfldgegeDNFL-.-...PLTT----.-----.....-LINWLQSLKTKQ............................................V------YLVLDCGFSTGVEEFEGNLrgrsggrg..............................................................................................................................................................gpippevnpSNPPTKASLGNITLISATSPGQTAVEVql..............gKQSAGLFTLALTQSLwENSSTSvMASLWDHSRNLLVPRLGT-----.....................................---EQIPQWRSPNNSPDFLA
Q8YS65_ANASP/4-245 NWAIAIGVNQYDYL-........-EPLNYAKRDAELIQQFLIKEA.G.....FDQVI..------...LF.......SD...DSpnfg.........................................................................vsstRPTRTHLRRV.LLTLFESLS...MGAGD-.-NFWFFFSGHG.-MRHNGR----------.............DYLM-.-...PSDGNPRDiADTAI.....SINFVTENLRCSG............................................ADNL---VLILDACRNEGKIDGIKGGhi..........................................................................................................................................................................gigQETSAEARQKGVISIFSCSPQEYSYEIe................ALQQGAFTTALLEGFrDGYTTAaSLNQYLQRRVSEIVSSHSKG---.....................................---KQTPYIIAEPVTKSHLI
Q7WDK3_BORBR/552-800 H-AMIVGINEFGEA-........SLNLQYAVNDANAIAREL-RERtRglyrdVRIEL..------...LT.......TP...QQ.................................................................................-TSRASLIES.LRRYQQLDA...---GD-.-VFMFYVSTHG.-AVMGDKPV--------.............DQEYFlI...PSNAKSPVfAHDAIsq..hELKRLFSSIPAGK............................................K------LLLFDTCFAGALGEALYQPaver......................................................................................................................................................................gvaenGAVNVLATAIGSTTLAASAPLEMSYEG.................YQEHGTFTWVVLQAFrGKAGGGkGNVVLTADLARYVAREVPALARR.....................................LQREQNPAVYATGQPFPVVA
Q9GPM2_DICDI/188-405 RISFIIGNSKYSQH-........-RKLDGVINDVNSFYCAL-LGC.S.....FHSDN..------...--.......-IvwlID.................................................................................-SDLRTFYDK.WYTFLQLVQ...--SFQSyIEVVVYYAGHG.-RSDNG-----------.............NLKLImTdgnPVQ-----.-----.....-LSIIASTLTESI............................................KNSDSLCLFIVDCCRDGENVLPFHY-...............................................................................................................................................................................-PIESFDDKKNIAVLFACKYGELSYESl................ELNAGIFTRSFVKTI.-----TeRKNNNISTICNLTDIAIKRIY--.....................................--KNYSGCSLIGNFDCSLLE
Q86JK1_DICDI/22-316 KVAFVCGNTYQDNPD........YRRLSKVENDVIKMTEVL-TKC.G.....FKCYQ..------...--.......--...--.................................................................................CLNKDSILIQ.FDKFLKSIV...---FGLhMEIVFYFSGHGfVGNNNNNINNNNINNNNsnne....dkfmgKKHLLlVnniKRNNENELpLNKRYa....SLIDIVKKLEAKEaiirtrqrkkldedfqeayqpidenasteekeknqqkkklnsmfLDIEFRKVFILDCCRNDLNLKNYIE-...............................................................................................................................................................................SEKLENMERPDTAFLYGCTPGSVSYILs................NDENSLLTSCFLRRI.----QSdEKKEKSRNLSKIAKVIQIDIA--.....................................--NKLSGLKSWGRDVKDCFD
Q9DDL2_BRARE/323-560 KVALLIGNMNYLHH-........-RQLRAPMADVHELTNLL-RQL.D.....FKVVS..------...--.......-L...LD.................................................................................-LNWQEMHSA.VTEFLLLLD...--RGV-.-YGLLYFAGHG.-YENYG-----------.............NSFM-.V...PIDAPASYtFKHCL.....WVQEVLQRMQERQ............................................TGLN---VFLLDMCRKRNPNDEGIP-...............................................................................................................................................................................-QPDPLRVTANIVFGYATCVDAEAFEVnk..............dDLSNGIFMSFLKKRL.------.---MEPEKVTVILDKVAEDMGRCeitrgrqale................lrsnlserralTDKIQAPACQIAASTRNLQW
Q8BFT0_MOUSE/340-577 KVALLIGNMSYWEH-........-PKLKAPLVDVYELTNLL-RQL.D.....FKVVS..------...--.......-L...LD.................................................................................-LTEYEMCNA.VDEFLLLLD...--KGV-.-YGLLYYAGHG.-YENFG-----------.............NSFM-.V...PVDAPNPYrSENCL.....CVQNILKLMQEKE............................................TGLN---VFLLDMCRKRNDYDDTIP-...............................................................................................................................................................................-ILDALKVTANIVFGYATCQGAEAFEIqh..............sGLANGIFMKFLKDRL.------.---LEDKKITVLLDEVAEDMGKChltkgrqale................irsslsekralTDPVQGAPCSAEALVRNLQW
Q19719_CAEEL/252-476 KVALIMSNCSYVHL-........-PELRTPHCDAQTLADAL-QKM.N.....YKTVT..------...--.......-L...AD.................................................................................-LTLDEMRYF.IRVYQKLIG...--NGV-.-YAVFYFVGHGfEVN--------------.............GQCYLlGvdaPADAHQPQhSMS--.....-MDWLLSIFRHKT............................................PDLN---LLLLDVCRKFVPYDAISAFve..........................................................................................................................................................................yseQFKKFHRAHRNMVYGYSTSGGVGAYEVk................GEVNGVFMKYLKNHV.------.---QLEISVIDMLNKVLLDIGDDq...................................kVCDLQVPEIRSTLTHPRSLA
Q98JS7_RHILO/35-253 RAAIVVGNSEYPF--........-APLTNPRNDAKLIANTL-TEL.K.....FDVLL..------...--.......-F...YD.................................................................................-VKKSAEKDL.NDAIRAHLI...--GAD-.-MAVFYYAGHA.-LQYNG-----------.............QNLL-.L...PVDT--RIsSAKEVaadamRLNDLIDIVKNDP............................................VGVK---VFILDACRNNPVAKEKGLQ..............................................................................................................................................................................qGLAYTEAGSGQVLVAFATSAGEVAYDG.................TGINSPYSSALANAL.------.--LMPNLDVYDTFRTVRGDVRQA.....................................TGGSQIPWITGSIE-TKFVF
Q98IJ9_RHILO/30-261 RVALVIGNSKYVNA-........-VALPNPANDAHLIASTL-RNA.G.....FDVIE..------...--.......-G...VD.................................................................................-QDNAGMHGL.ISKFTEESY...--NAD-.-LAVIFYAGHG.-MQVDG-----------.............KNYL-.I...PVDA--DLtSPAYLktrtvQIDEFMAALPAD-............................................PAVG---VIILDACRDNPLGRTLAAAlpksrsl.................................................................................................................................................................gaglapvDAKADGVGTGGVLIAYATDPGAIAFDG.................DGVDSPYSLALAKHL.------.--TEPGVEIQSALTRVRGDVTDA.....................................TQGRQRPWHNASLG-REVFL
Q89HP3_BRAJA/336-569 RMALIIGNGAYAHV-........-KALPNPPNDARAVAKSL-RDI.G.....FTVSE..------...--.......-G...VD.................................................................................-LDRAAMQKM.TRDFLRDAA...--RAQ-.-VAVVYYAGHG.-VQVDG-----------.............RNYL-.I...PVDV--ELkPGTAMteamiDMDTIMAGLDDQ-............................................VRTN---ILIFDACRNNPMAQQVASAaanrgieg...............................................................................................................................................................asglaaptSLGAGATLGAGTLIAFATAPGQVALDG.................DGANSPFSAALSRHI.------.--GTLGLEVQQMLTRVRAEVVST.....................................TKNKQVPWSNSSLL-GEVYL
Q98IJ6_RHILO/11-238 RIALVLGNSQYQHA-........-APLANPARDAQAMAERL-QNL.G.....FEVVS..------...--.......-G...FD.................................................................................-LTKQQTQVT.VAQFAKQVR...--GAD-.-VALFFYAGHG.-LQVSG-----------.............KNYL-.L...PVDA--ALeDETSLdfeavSVDFILRQMSRE-............................................TSIR---LVFLDACRDNPLADVLAKTagikg.....................................................................................................................................................................assglAEIPIENGGAGTLVAFAASPNQLAYDG.................SSDHSPFTTALLQHI.------.--GESNVSITEAMNRVTSDVFKA.....................................TAGKQRPWINVSLT-TEVVL
Q98G71_RHILO/26-252 RVALVIGNGTYAEA-........-GTLANPVNDALDIADKL-RSI.G.....FEVIE..------...--.......-G...ND.................................................................................-LGKRELERS.IGEFSDALE...--GAG-.-VGLFYYAGHG.-LQVDG-----------.............RNYI-.V...PVDA--KLdMPVKLqleavPIDEVLDIMEQQ-............................................TKVS---LVFLDACRNNPFARSLSRTattr......................................................................................................................................................................satalAGLAQFDSTRGSFIAFSTAPGAVAMDG.................TGRNSPFASALLRHI.------.--AEPGQSINDMMIAVRRDVVSQ.....................................TREGQRPWEQGSLL-ERFEF
Q89IK1_BRAJA/30-253 RVALVIGNGAYAST-........-AQLPNPPHDAEDVASSL-RRS.G.....FEVLQ..------...--.......-G...ID.................................................................................-LRQADMQDL.TIRFARAAS...--RAD-.-VAMFYYSGHA.-MQYNG-----------.............VNYL-.M...PVDA--VLtDEADLkr.fvRVDDIVNDLQQA-............................................KNLR---ILVLDSCRDNPLAESLKRSatra.......................................................................................................................................................................aslgRGLSKVEAPRGTIVSFSTQSGQVAADG.................TGRNSPYTTAFLKHI.------.--EEPQ-EIGDVFRDISSDVYDA.....................................SGKTQLPELSLSII-GKFYL
Q89MV1_BRAJA/176-400 RIALVVGNSAYKNI-........-TPLDNPSKDASLMAETL-STL.G.....FTLVG..------...--.......-GraqLD.................................................................................-LDKGAMDIA.VRSFGRQAQ...--GAD-.-VALFYYAGHG.-VQVAG-----------.............SNYL-.V...PVGA--NPtREADVdfqmtDVNLVLRQMQGSG............................................TRLN---LVILDACRNNPFGSRGLRSs.............................................................................................................................................................................dGGLAQMRAPEGTLISYATQPGNVAQDGs................DG-HSPYTKALAATI.------.--RTAGLDVFQTFNQVGLAVKRA.....................................TSGAQQPWVSSSPIDGTFYF
Q6AKF4_DESPS/28-248 RIALIIGNSDYRI--........-RSLKNPVNDAKDFSRTL-SAL.G.....FETII..------...--.......-K...VN.................................................................................-ADQEGFEES.VRKFGKKIR...--GDT-.-VGLFYFSGHG.-VQYEG-----------.............RNYL-.I...PIGAMPKIsSPDHLkyktvDVGYVLGVMKHAN............................................NGLN---IVILDACRNNPFQSFARDM..............................................................................................................................................................................gDGLSRVSDADGCLIAYSTAPGKVALDG.................VGRNSPYTGSLIELM.------.--KYPNLPVELMFKKVREKVKKQ.....................................TNGKQSPWYEASID-GDFSF
Q89HT8_BRAJA/51-272 RVALVIGNSNYQNA-........-PQLQNPDNDAESMAKFL-NSA.G.....FEVVA..------...--.......-A...TD.................................................................................-LTQNDMLRV.VQDFSAKVS...--ARGPnTVAMVYYAGHG.-VQLAG-----------.............ENYL-.V...PVDA--RVsSPTELvnnsvRLVDVMSTLETIP............................................SRMR---IVILDACRNNPFPSVNDAG...............................................................................................................................................................................RGLAIVDAPNGSIVGYSTAPGAEALDG.................TGGHSPYTQAFLNVA.------.--REPNVPIEQLFKRVRLAVNQT.....................................TSGAQIPWESSSLT-SDFTF
Q89FZ4_BRAJA/32-256 RLALVIGQSAYRTV-........-PELPNAANDAKGMTELL-GNA.G.....FTVTT..------...--.......-A...AN.................................................................................-LAQNEMRTA.ISDFAGKVS...--ASGAdTVALVFYAGHG.-LQIDG-----------.............ENYL-.V...PVDL--DPkREADIplqgvRLNDLLNTLGALP............................................TRAR---IFMLDACRNNPFPALSGAGh............................................................................................................................................................................glAIVDTKAGAPGSFISYSTSPGAEAEDG.................SGIDSPYTTAALSVA.------.--KQPNLPIEEVFKRIRIAVAQS.....................................TDGRQIPWESSSLT-TDFKF
Q6N329_RHOPA/73-298 RVALVIGQSAYRAV-........-PALPNPVNDAKAIAALL-GEA.G.....FEVTE..------...--.......-A...SD.................................................................................-LGQTELRTK.VGDFAATVV...--AKGPeTVALVFYAGHG.-IQVDG-----------.............ENYL-.I...PVDI--DPkREADIplqavRLDDVLNTLGSVP............................................SKSR---IIMLDACRNNPFPSINKTTgq...........................................................................................................................................................................glALVDTKSGAPGTLLSYSTSPGAEAEDG.................GGTNSPYTTALLKAG.------.--RENGLKIEDTLKRVRLAVHQA.....................................TKGRQTPWESSSLV-DDFQF
Q985X8_RHILO/35-256 RLAFVIGNAAYPS--........-GSLATPANDAGLIAQTL-QAA.G.....FDVVG..------...--.......-A...RD.................................................................................-VDQESLRGA.YRDFLAKAT...--AAGPnAVVFVYLAGQG.-LQFEG-----------.............ENYF-.A...PVDA--QIaNAADVpmaavRISDLTKPLAALP............................................TKVN---IVVLDAARPNSFAKSNQPL..............................................................................................................................................................................aGGLALVDPDPNMLIAFNTAPGTVAPEG.................KGPYGAYAQALAEMI.------.--REGGLQLGDVFDRTRLRVNEV.....................................TQGAELPWNASKIT-LPFLF
Q89KP2_BRAJA/86-307 RIALVVGNGAYAK--........-SPLATTANDAGLIAQTL-QAA.G.....FDVVG..------...--.......-A...RD.................................................................................-LDGDTLRKS.FRDFIQKAQ...--ASGPgTVAMVYLAGYG.-VQLAG-----------.............ENYF-.I...PVDS--NItRDTDIptealRISDYARQLAAIP............................................LKAN---IVVLDAARAQPFIEGGQPI..............................................................................................................................................................................aSGLALVEPDQNMLIAFNAAPGTVAPEE.................PGPYGIYAQSLAEMI.------.--RTGGLPLPDVFDRVRLRVNEA.....................................SKGAQVPWNEQKIS-APFSF
Q6N5Q1_RHOPA/33-253 RIALVIGNGAYAK--........-APLSTAANDGGLIAQTL-QAA.G.....FDVSG..------...--.......-A...RD.................................................................................-LDGDTLRGA.FRDFVKKAE...--DSGPdTVAAVYLAGYG.-VQYAG-----------.............ENYF-.I...PVDS--RLsRDTEIpteglRISDYLRQLAALP............................................LKTS---VVVLDLAREQPFVPGGSVA...............................................................................................................................................................................SGLAMVEPNPKMLIAFNAAPGTVAPEE.................RGAYGVYAQALAEMI.------.--RTGGLTLPQLFDRVRLRVNET.....................................TKGAQVPWDTQSVE-SNFMF
Q98CE0_RHILO/5-238 RVALVMADNDYRLV-........-RPLANPIHDGEAMEAAL-KKL.G.....FEVIL..------...--.......-E...TN.................................................................................-RDLRRMRRA.LDDFREDAK...--GAD-.-VALVYFSGHG.-VEISG-----------.............DNRL-.L...PVDADASSvDQLDKts..lPLEEVRDAVAAT-............................................AKVG---LIVLDACRSDPFSASSGDGrgatslt................................................................................................................................................................kdvadkvkPGLGRVGRAENILFAFSAAPGETAADG.................TGENSPFTTALTKYL.------.--ATDGLEIRSVLTLVQQEVYDL.....................................SRGKQLPYVESGLPKLFFAA
Q89XG2_BRAJA/27-248 RYALVIGNAKYPDA-........DAPLKEPLNDARDVADEL-KRD.G.....FSVEI..------...--.......-G...EN.................................................................................-LTGDGMRRA.FDKLYGKIK...--PGS-.-VALVFFSGFG.-IQSAR-----------.............QSYM-.L...PIDAQIWTeSDVRRdg..fSLEAVLGELNTRG............................................AGVK---IALIDASRRNPFERRFRSF..............................................................................................................................................................................sAGLTPVIAPNGTLVMYSAALASVVSDA.................GGEHSLFVQELLKEI.------.--RVPDLMAEETLNRTKMGVTRA.....................................SRGEQVPWISSSLAEDFSFI
Q6N0T4_RHOPA/30-251 RVALVIGNSKYPDA-........DKPLSQAVSDARELADDL-KRA.G.....FDAEL..------...--.......-G...ED.................................................................................-LSGDAMRRA.FDRLYQRTK...--PGA-.-AALVFFSGFG.-IQSGR-----------.............QSYL-.I...PADAQIWTePDVRRdg..iALETVLNELNSRG............................................ASVK---IALIDASRRNPFERRFRSF..............................................................................................................................................................................sAGLAPVIAPSGSLVMYAAALSAVVTDN.................DSARSPFVTALREEV.------.--RAAGRSAEEAFNRARTAVTRA.....................................SRGEQVPWISSSLAEDFVFT
Q89XE4_BRAJA/58-278 RLALVIGNGHYPDA-........NAPLTQSINDARALSSTL-RKN.G.....FDVDM..------...--.......-V...ED.................................................................................-ATKDDMVRA.VNRLKSRIK...--RDT-.-VVMLFFGGYG.-VQAGR-----------.............QSYM-.L...PIDAVIWKeSDVRRqg..vSIDGVLDMMKEQG............................................AKAK---LVVVDASRRNPYERRFRSY..............................................................................................................................................................................sHGLAPISAPDNALILSSASPGKVVDDG.................KGEHSVLVSELLGNL.------.---AAQGSAESAFNKTRVAISRA.....................................SEGDQVPTVSSSLLEDVHFG
Q6NBN5_RHOPA/57-277 RLALVIGNAHYPDA-........ASPLLQPINDARLLSASL-RHE.G.....YDVDM..------...--.......-I...ED.................................................................................-ASRDEILRA.VERIKARAG...--KDA-.-TVMLFFGGYG.-IQSGR-----------.............DNYM-.I...PVDAKIWTeADVRRsg..vSVEQVLAEIKAAG............................................AHTN---LAVLDASRRNPYERRFRAY..............................................................................................................................................................................sHGLAPIETPANALVLSSATPGQVADDN.................NGPNSMVVGELVGSL.------.---SSPASAEAAFAKARQAVIKA.....................................TNGAQVPSMTSSLVADVPLV
Q9Y1U6_PRIPA/173-413 GYALIISNEHFRTM-........-PQRRGTKADVIALKNLFISKL.G.....YEVEV..------...--.......-H...EN.................................................................................-LTGKELHNN.IKSFASSTK...HSFTS-.-SAIVCILTHG.-EH--------DVLYGV.............DDQV-.V...DVHY----.-----.....-LLSSFNTHNAPH............................................LAGKPK-IILLQACRGERKDIGYEETdsgrpfafl............................................................................................................................................................eclgmggggmMTRNKRPAESDILVAYATPAHYVSWRN.................SEKGSWFIQSFVEVA.EKRSHD.------SDLLSILTQVNAKVAETyka..............................nsstGEYKQISEF-SSKLTKKFFF
CED3_CAEEL/243-494 GMCLIINNEHFEQM-........-PTRNGTKADKDNLTNLF-RCM.G.....YTVIC..------...--.......-K...DN.................................................................................-LTGRGMLLT.IRDFAKHES...--HGD-.-SAILVILSHG.-EE--------NVIIGV.............DDIP-.I...STHE----.-----.....-IYDLLNAANAPR............................................LANKPK-IVFVQACRGERRDNGFPVLdsvdgvpaflrrgwdn..............................................................................................................................................rdgplfnflgcvrpqvqQVWRKKPSQADILIAYATTAQYVSWRN.................SARGSWFIQAVCEVF.STHAKD.------MDVVELLTEVNKKVACGfqt..............................sqgsNILKQMPEM-TSRLLKKFYF
Q9NHF9_DROME/56-302 GIALILNHKDVKGQ-........-KQRVGTERDRDDMEATL-QGF.G.....FDVRT..------...--.......-F...DD.................................................................................-LTFSEINDT.LKEVA-RED...HSQND-.-CFVLAVMSHG.-TE--------GKVYAK.............DMSY-.-...PVER----.-----.....-LWNPFLGDNCKT............................................LKNKPK-LFFIQACRGANLEKAVEFSsfavmtrel.............................................................................................................................................................vpepaaavqPITYAIPSTADILVFYSTFDKFFSFRN.................VDDGSWFIQSLCRVL.DQAAANeAATPEGVELLRLLTAVNRKVAYEyqsnt...........................knealNQMKEMPNF-MSTLTKTFQL
Q86FL0_ANOST/52-286 GIAIIINQVNFSGM-........-AKREGSDRDRDSIGAVL-ESI.G.....FDVRV..------...--.......-F...NN.................................................................................-LDKKDLLDE.LDKVA-HED...HLQSD-.-CLVVVIMTHG.-DK--------DVLYAS.............DKC--.Y...PIGC----.-----.....-LWEPFLGDECSS............................................LRGKPK-LFFVQACRGNAFDKGVKLDkavtdt...................................................................................................................................................................vdssskRLLFLIPTMADLLVMYSTYDGHYSWSH.................PINGSWFIQSLSTEL.EQHAHT.------KEILQLLTAVSRRVAYQyqsnv..........................pdnlamDAMKQMPCV-VSMLTKAFYI
Q7PV92_ANOGA/18-255 GIALIINQVIFSSM-........-AVRVGSSKDRTDISTVL-QRI.G.....FEVRV..------...--.......-M...DD.................................................................................-PNRKQLLSA.LKQLA-GED...HSHSD-.-CLVVVVMTHG.-KE-------NNLLYAS.............DKS--.Y...EANQ----.-----.....-LWEPFIGDACPS............................................LIGKPK-LFFVQACRGKKLDEGVIQAtisidsv.................................................................................................................................................................dtqsspgSMRYVIPAMADLLVMYSTYDGHYSWRN.................PSKGSWFIQSLCAEL.------.GASAHCKELLHILTAVSRRVAYHyqsnv..........................pdnakiDAKKQMPCM-VSMLTKLLYL
Q7Q803_ANOGA/54-306 GVAAVFNHRKFLHA-........-SERKGTDADCDNIRQVL-IYL.Q.....FEVRV..------...--.......-Y...DD.................................................................................-LTRKEIKQV.LDDLA-EED...HKNSD-.-CLLVVIMTHG.-DD--------DVLHAK.............DGT--.F...NVDR----.-----.....-LWENFIGDSCPS............................................LLGKPK-LFFIQACRGSSFDTGVHFSqcmtqvaktvvpyam.................................................................................................................................................relpqpsivpgcpksSIQYAIPSMADLLVMYSTYKGHYSWRN.................PSTGSWFIRALCDEL.REHGNS.------KELLQLLTSVSRRVAYEfqsnv..........................pnnsqiDCQKQMPCI-VSMLTRRIYF
Q98UI8_BRARE/48-280 GHCIIINNKNFDRRT.......gMNPRNGTDVDAGNVMNVF-RKL.G.....YIVKV..------...--.......-Y...ND.................................................................................-QTVAQIMQV.LTTVA-HDD...HSRCA-.-SLVCVLLSHG.-DE--------GVFFGT.............DTS--.V...DLKS----.-----.....-LTSLFRGDRCPS............................................LVGKPK-LFFIQACRGTELDPGVETDhtdh.......................................................................................................................................................................pdipDGRERIPVEADFLYAYSTVPGYYSWRN.................TMTGSWFIQSLCEMM.TKYGSE.------LELLQIMTRVNHKVALDfests...........................nmpgfDAKKQIPCI-VSMLTKEMYF
Q8JG42_FUGRU/51-279 GHCIIINNKNFDRRT.......gMNTRNGTDVDAANAMKVF-LSL.G.....YKVKV..------...--.......-H...ND.................................................................................-QTVNQMKQL.LVSAA-EED...HSACA-.-SFVCVLLSHG.-DE--------GVFFGT.............DGS--.V...ELKY----.-----.....-LTSLFRGDRCKS............................................LVGKPK-LFFIQACRGNDLDGGIETDsa...........................................................................................................................................................................adSSTTKIPVEADFLYAFSTAPGYYSWRN.................TTSGSWFMQSLCDAI.SKYGKE.------LELQHILTRVNHKVAVDfesvs...........................nlpgfDAKKQIPCI-VSMLTKEMYF
O93417_CHICK/53-281 GVCVIINNKNFHRDT.......gLSSRSGTDADAASVREVF-MKL.G.....YKVKL..------...--.......-N...ND.................................................................................-LSSRDIFKL.LKNVS-EED...HSKRS-.-SFVCVLLSHG.-DE--------GLFYGT.............DGP--.L...ELKV----.-----.....-LTSLFRGDKCRS............................................LAGKPK-LFFIQACRGTELDSGIEADsg..........................................................................................................................................................................pdeTVCQKIPVEADFLYAYSTAPGYYSWRN.................AAEGSWFIQSLCRML.KEHARK.------LELMQILTRVNRRVAEYescs............................trqdfNAKKQIPCI-VSMLTKEFYF
CASP3_XENLA/56-280 GMCLIINNKNFHSSN........MAVRNGTDVDALKLHETF-TGL.G.....YEVMV..------...--.......-C...ND.................................................................................-QKSSDIIGR.LKKIS-EED...HSKRS-.-SFVCAILSHG.-EE-------DGSICGV.............DVP--.I...HIKN----.-----.....-LTDLFRGDRCKT............................................LVGKPK-IFFIQACRGTELDSGIETDscs.........................................................................................................................................................................eprEEIQRIPVEADFLYAYSTVPGYCSWRD.................KMDGSWFIQSLCKMI.KLYGSH.------LELIQILTCVNHMVALDfe.................................tfHAKKQIPCV-VSMLTKSFYF
Q8JIS8_ORYLA/58-285 GICLIINNKNFHKDS.......gMGPRNGTDNDAAAAWKSF-MKL.G.....YEIQM..------...--.......-Y...ND.................................................................................-QTVDQMKKL.FRQMS-NQD...HSKFA-.-SFACVILSHG.-EE--------GVIYGT.............DGP--.V...SFNK----.-----.....-LIECLKGRSCLS............................................LVGKPK-LFFIQACRGMLFDEGIEHDa............................................................................................................................................................................kdDTSEKIPLEADFLFAYSTVSGYYSWRS.................TANGSWFIQSLCEML.EKFSKT.------LDLMQIMTRVNHKVATHfesss...........................napgfSGKKQIPCI-VSMLTKDFYF
Q6DCI2_XENLA/78-314 GRCIIINNKIFDKIT.......gMGARNGTDIDARELLRCF-KGL.G.....FDVNV..------...--.......-Y...NN.................................................................................-KSCEEMENL.LRTVA-QQD...HKDSA-.-CFACIFLSHG.-EE--------GLIYGT.............DGA--.M...PIKV----.-----.....-LTTFFRGDNCRS............................................LVGKPK-LFFIQACRGHEFDDGLEADsgsvnd...................................................................................................................................................................sletdaNPRHKIPVEADFLYAYSTVPGYYSWRN.................PGMGSWFVQALCSVL.NEYGKE.------LEVMQILTRVNFLVATQfesys...........................ddpqfSKKKQIPCV-VSMLTKELYF
O88550_RAT/68-301 GKCIIINNKNFDKAT.......gMDVRNGTDKDAEALFKCF-RSL.G.....FEVTV..------...--.......-Y...ND.................................................................................-CSCAKMQDL.LRRAS-EED...HSNSA-.-CFACVLLSHG.-EE--------NLIYGK.............DGV--.T...PIKD----.-----.....-LTAHFRGDRCKT............................................LLEKPK-LFFIQACRGTELDDGIQADsgpi......................................................................................................................................................................ndtdaNPRYKIPVEADFLFAYSTVPGYYSWRN.................PGKGSWFVQALCSIL.NEHGKD.------LEIMQILTRVNDRVARHfesqs...........................ddprfNEKKQIPCM-VSMLTKELYF
Q8ITP3_BRAFL/87-323 GQAIIINNKDFEKHT.......gMNTRRGTDLDANNLYRIF-SKL.G.....FETKV..------...--.......-F...DN.................................................................................-LPCRKILSV.LQLAA-RED...HRDVD-.-CFACAILSHG.-EE--------GVIYGT.............DGH--.M...EVTE----.-----.....-VTKPFRGDRCPG............................................LVGKPK-LFFLQACRGNEFDHGVDMPdalpev...................................................................................................................................................................qdeldaGNKATLPAEADFLLAYSTVPGYYSWRN.................PGRGSWYIQALCAVL.EREGTD.------LEIMQLLTRVNKLVAYDfhsns...........................dnpymNRKKQIPCI-MSMLTKDLFL
CASP1_SPOFR/61-293 GMAIIFNHEHFDIHS........LKSRTGTNVDSDNLSKVL-KTL.G.....FKVTV..------...--.......-F...PN.................................................................................-LKSEEINKF.IQQTA-EMD...HSDAD-.-CLLVAVLTHG.-EL--------GMLYAK.............DTH--.Y...KPDN----.-----.....-LWYYFTADKCPT............................................LAGKPK-LFFIQACQGDRLDGGITLSrtet.......................................................................................................................................................................dgspSTSYRIPVHADFLIAFSTVPGYFSWRN.................TTRGSWFMQALCEEL.RYAGTE.------RDILTLLTFVCQKVALDfesna..........................pdsammHQQKQVPCI-TSMLTRLLVF
CASP1_DROME/79-313 GVALIFNHEFFDIPS........LKSRTGTNVDAQELKKAF-ENL.G.....FAVSV..------...--.......-H...KD.................................................................................-CKLRDILKH.VGKAA-ELD...HTDND-.-CLAVAILSHG.-EH--------GYLYAK.............DTQ--.Y...KLDN----.-----.....-IWHYFTATFCPS............................................LAGKPK-LFFIQACQGDRLDGGITLEkgvte.....................................................................................................................................................................tdgesSTSYKIPIHADFLFSYSTIPGYFSWRN.................INNGSWYMQSLIREL.NANGKK.------YDLLTLLTFVNQRVALDfesnv..........................patpmmDRQKQIPCL-TSMLTRILRF
ICE_DROME/94-328 GMALIFNHEHFEVPT........LKSRAGTNVDCENLTRVL-KQL.D.....FEVTV..------...--.......-Y...KD.................................................................................-CRYKDILRT.IEYAA-SQN...HSDSD-.-CILVAILSHG.-EM--------GYIYAK.............DTQ--.Y...KLDN----.-----.....-IWSFFTANHCPS............................................LAGKPK-LFFIQACQGDRLDGGVTMQrsqte.....................................................................................................................................................................tdgdsSMSYKIPVHADFLIAYSTVPGFYSWRN.................TTRGSWFMQSLCAEL.AANGKR.------LDILTLLTFVCQRVAVDfesct..........................pdtpemHQQKQIPCI-TTMLTRILRF
Q7Q4X6_ANOGA/73-309 GLALIFNHENFDVPQ........LRSRAGTNVDCENLTASL-KGL.D.....FEVHV..------...--.......-F...KD.................................................................................-LKLRDLQKE.VERVS-QMD...HSDAD-.-CLLVTILSHG.-EL--------GYLYAK.............DCQ--.Y...KLDT----.-----.....-IWTYFTANHCPS............................................LAGKPK-LFFIQACQGDQLDGGVVLEakdrte...................................................................................................................................................................tdssssMLTFKIPMYADFMIAYSTIPGFYSWRN.................TQKGSWFIQSLCHEL.NQNGRK.------YDLMVLLTFVTQRVAYDfesnt..........................pdipmmHQQKQIPCT-TSMLTRLVYF
Q7Q1E0_ANOGA/53-282 GMALIFSHNKYNVRNv......sLPVREGSAIDCKRLKETL-ELF.R.....FDVKV..------...--.......-Y...PD.................................................................................-FKLEEIKSV.IGKVS-SMD...HSDSD-.-CFLVAILTHG.-ED-------GGIVYAY.............DQP--.Y...ELSL----.-----.....-IWSFFTADNCPS............................................LAGRPK-IFVVQACRGNQLDHGVKVQk............................................................................................................................................................................dgVARYSIPTHADFLFAYATIPGFMAFRN.................TTEGSWFINELCKEL.QENGHR.------YDINTLLTFVTQKVAYDhesvs...........................nmpeyNMRKQTPCV-VSMLTRLLLF
Q8I6Y2_GEOCY/158-414 GMALIINNRNFTCG-........MKERVGTDKDAENLYGLF-NWL.G.....MATIR..------...--.......-K...DN.................................................................................-LTGKAMTRE.FEDLA-RRD...HSAYD-.-CVVVAILTHG.-IS--------GRLYST.............DGDL-.I...PVED----.-----.....-LTKYFDGVNRPS............................................LIGKPK-VFVVQACRGGKFDYGVESEstdgegesvnketanemme........................................................................................................................................kqfdkvvekaldadetdgggYSREALPTEADFVLAYATVPGYVSWRN.................SEYGSWFIKAFVDTM.RDLASK.------EHFMDILTEVNRKVAYDfq.................................srGRNKQIPAP-VTMLTRKLYF
Q9IB66_XENLA/58-298 GLALIFNHEDFYWQL.......rLGSRRGTNTDSMNLNRIL-TDL.G.....FDVQN..------...--.......-Y...YN.................................................................................-LRTMDVLEK.IQEAS-TTD...HSNAD-.-CFLCVFLSHG.-ED--------KHIYSY.............DSL--.I...DIQE----.-----.....-LTNPFKGDKCKS............................................LVGKPK-IFILQACRGEKHDEPVLPKdevdsvpl...............................................................................................................................................................tnvtevdaASLCTLPAGADFIMCYSVAEGYYSHRE.................TVNGSWYIQDLCAVV.KAYAAS.------LEFTEILTLVNRKVSQRsveyc...........................ndpkaIGKKQIPCF-ASMLTKKLFL
Q9I8S9_ONCMY/57-297 GLALIFNQEHFFWHL.......rMPPRNGTNADRSNLVKRF-EDL.N.....FEVQA..------...--.......-F...DN.................................................................................-LKVEEVLDQ.ISQAA-EAN...HADAD-.-CFVCVFLSHG.-EN--------DHVYAY.............DDK--.I...AIQD----.-----.....-ITALFKGDKCKS............................................LVGKPK-IFILQACRGDKHDDPVTPMdvvdsevk...............................................................................................................................................................tnevvvdaGVVYTLPAGADFIMCYSVAEGYYSHRE.................TINGSWYIQDLCGAM.RKFGDS.------LEFTELLTLVNRKVSMRsvgnc...........................ndktaIGKKQVPCF-ASMLTRKLYF
O93415_CHICK/57-299 GVALIFNHEHFFWHL.......rLPDRRGTLADRNNLKRSL-TDL.G.....FEVRI..------...--.......-F...DD.................................................................................-LKAEDVLKK.VFEAS-RDD...YSNAD-.-CFVCVFLSHG.-EN--------DHVYAY.............DAQ--.I...KIET----.-----.....-ITNMFRGDKCQS............................................LVGKPK-IFIIQACRGDKHDDPVLVQdsvdskdet.............................................................................................................................................................tvnqtevdaAGVYTLPAGADFIMCYSVAQGYFSHRE.................TVNGSWYIQDLCEAL.GKHGSS.------LEFTELLTVVNRKVSHRkvdic...........................rdinaIGKKQIPCF-ASMLTKKLYF
CASP6_MOUSE/28-270 GVALIFNHERFFWHL.......tLPERRGTNADRDNLTRRF-SDL.G.....FEVKC..------...--.......-F...ND.................................................................................-LRAEELLLK.IHEVS-TSS...HIDAD-.-CFICVFLSHG.-EG--------NHVYAY.............DAK--.I...EIQT----.-----.....-LTGLFKGDKCQS............................................LVGKPK-IFIIQACRGSQHDVPVVPLdmvdhqtdk.............................................................................................................................................................ldnvtqvdaASVYTLPAGADFLMCYSVAEGYYSHRE.................TVNGSWYIQDLCEML.ARYGSS.------LEFTELLTLVNRKVSQRrvdfc...........................kdpdaIGKKQVPCF-ASMLTKKLHF
Q8ITP2_BRAFL/151-396 GLCLVFDNEEFHWTT.......kMNRRRGSHVDAGNLKVMF-EGL.G.....FSVEV..------...--.......-L...KD.................................................................................-KEITEIRQI.LHSAALKYD...HSQSD-.-CFVCVFLSHG.-ED--------GMIYGY.............NGT--.V...PIKE----.-----.....-LTDMFRADRCTS............................................LKGKPK-LFFIQACRGAKHEIPVEPLdepdglegsg...........................................................................................................................................................eaepmdmvdaGVRPTLPAGADFLMAYSVSEGFYSHRD.................TVNGSWYVQDLCAAL.KQHGTN.------MEVHQILALVNRMVSCRevert...........................tdqrsLGMKQMPCF-LSMLTKRLVF
Q9IB64_XENLA/261-494 GWCVVINNYDFKEARsq...dckYTDREGTAKDAEEITRIF-NAR.G.....YITEE..------...--.......-H...RD.................................................................................-LTAANIQKT.LEMYS-KKD...HAEKD-.-SFVCFILSHG.-GV--------GTVCGC.............DGEE-.V...EIKR----.-----.....-LTKYFNGQHCRS............................................LINKPK-IFFIQACQGKESHPKVDMDmdts......................................................................................................................................................................fyepdANGSHLPLEADFLTAFATVEDYTSLRH.................RENGSIYIQQLCKAL.TTYTNQ.-------DLIDILTSVNSDVANMlfr...............................lwrKNVTQMPSF-KSELRKKLIL
Q9I8J3_BRARE/238-473 GYCLIINNYNFLEST.......nLLKRTGTDMDKDRLAKLF-SRM.H.....FQIEV..------...--.......-R...ND.................................................................................-LEAWAIKDE.IKQFA-NRN...HASMG-.-AFVCCILSHG.-EK--------GTVLGT.............DGKP-.V...EIRE----.-----.....-VTLPFAG--CRT............................................LASKPK-LFFIQACQGDENQAGVWTSdgredapee............................................................................................................................................................deeyeedagiIVLRKIPIEADFLIGMATVEHYLSYRH.................TKKGSIFIQELCKKM.EELCPK.-----KEDMLSILTKVNFEVSKRi...................................lKGYKQMPEP-RYTLTKKLVL
Q90WU1_CHICK/237-479 GVCLILNNHNFAKAReavpelrrMKDRNGTHVDADALRKVF-SNL.H.....FTVAE..------...--.......-Y...KD.................................................................................-CTAEEIRNI.VNNYR-CMD...HNNKD-.-CFVCCILSHG.-KK--------DIIYGV.............DGQE-.V...PIQE----.-----.....-LTTSFTGQNCQS............................................LAGKPK-VFFVQACQGDAYQKGVTIEtdsgeqd................................................................................................................................................................ysletdarFQLDCIPSEADFLLGMTTLQDYVSYRS.................PSQGTWYIQSLCQHL.ESSCPR.-----GEDILTILTAVNQEVSSKid.................................kqNAGKQMPQP-SFTLRKKLIF
CASP8_HUMAN/234-476 GYCLIINNHNFAKARekvpklhsIRDRNGTHLDAGALTTTF-EEL.H.....FEIKP..------...--.......-H...DD.................................................................................-CTVEQIYEI.LKIYQ-LMD...HSNMD-.-CFICCILSHG.-DK--------GIIYGT.............DGQE-.A...PIYE----.-----.....-LTSQFTGLKCPS............................................LAGKPK-VFFIQACQGDNYQKGIPVEtdseeqp................................................................................................................................................................ylemdlssPQTRYIPDEADFLLGMATVNNCVSYRN.................PAEGTWYIQSLCQSL.RERCPR.-----GDDILTILTEVNYEVSNKdd.................................kkNMGKQMPQP-TFTLRKKLVF
CASP8_MOUSE/236-478 GYCLIINNHDFSKAReditqlrkMKDRKGTDCDKEALSKTF-KEL.H.....FEIVS..------...--.......-Y...DD.................................................................................-CTANEIHEI.LEGYQ-SAD...HKNKD-.-CFICCILSHG.-DK--------GVVYGT.............DGKE-.A...SIYD----.-----.....-LTSYFTGSKCPS............................................LSGKPK-IFFIQACQGSNFQKGVPDEagfeqqn................................................................................................................................................................htlevdssSHKNYIPDEADFLLGMATVKNCVSYRD.................PVNGTWYIQSLCQSL.RERCPQ.-----GDDILSILTGVNYDVSNKdd.................................rrNKGKQMPQP-TFTLRKKLFF
Q6PAD9_XENLA/268-495 GYCLIIDNSIFAKG-........-KRREGSDKDAGALRDVF-KWL.G.....LDVEI..------...--.......-V...EN.................................................................................-LGSEEIRDR.IKKFK-SKD...HSERD-.-CFVCCILTHG.-ES--------GTVLGS.............DDEE-.V...SIRE----.-----.....-IMSYFTPTSCLS............................................LALKPK-LFFIQACQGRYTHPSSKVEadatv.....................................................................................................................................................................pvehkKYIVNVPKEADFLLGMSTVDGYFAFRH.................RTEGSWYIQALCKNL.VEMVPR.-----GEDILSILTKVNKDVSLKed.................................seGILKQMPQP-SYTLLKKLIF
Q6E5N8_ICTPU/119-362 GFCVIINNVNFASP-........LKERYGSKLDEDSLKEVF-QWL.G.....FNVCV..------...--.......-H...KN.................................................................................-QTAEQMKDL.LKKYSQQ--...HHDGD-.-CFVCCIMSHG.-SS--------DGVHGT.............DGAI-.A...SRDD----.-----.....-IFGPFSGNSCPS............................................LINKPK-VFIIQACRGKEYHLPVEVQpdsyeeedtea........................................................................................................................................................etedeksletdaVQMMTIPADADFLIARSTVKGYYSMRD.................TISGSWFIQSLCQQL.KTYCPG.-----GEDIPTILLCVNKEVSEKatt..............................vrmkGIVKQMPIH-KVTLRKKLVF
Q9IB63_XENLA/144-396 GFCLIINNMNFHECT.......gLSTRTGSDIDRDKLANRM-RSF.H.....FEVTV..------...--.......-K...DN.................................................................................-LTGQAMHDH.LQALA-DQD...HSLQD-.-CCLVVILSHGcETR---HIQFPGGVYGT.............DGIR-.I...PVER----.-----.....-IVSYFNGSKCPS............................................LRGKPK-IFIIQACGGDQKDKGCEVTsetpplsptstslqs.................................................................................................................................................datpvfsgegdrdevDAVSNIPTPSDILVSYSTFPGYVSWRD.................KHTGSWYVEVLDSVL.AEHAAA.------DDLQSLLVMVADGVSSK.....................................GTYKQIPGY-FNFLRKRFYF
Q90WU0_CHICK/148-400 GHCLIFNNVSFSRDS.......dLSTRAGSDIDCEKLEKRF-RSL.C.....FHVRT..------...--.......-L...RN.................................................................................-LKAQEIDVE.LRKLA-RLD...HSALD-.-CCLVVILSHGcQTS---HIQFPGGIYGT.............DGKI-.I...PIER----.-----.....-IVNYFNGSQCPS............................................LRGKPK-LFFIQACGGEQKDQGFEVDcespqdetcrrsies.................................................................................................................................................daipfqapsgnedepDAVASLPTPGDILVSYSTFPGFVSWRD.................KVSGSWYVETLDSVL.EHYARS.------EDLLTKLLRVSDIVSSK.....................................GRYKQIPGC-FNFLRKKIFF
CASP9_HUMAN/161-413 GHCLIINNVNFCRES.......gLRTRTGSNIDCEKLRRRF-SSL.H.....FMVEV..------...--.......-K...GD.................................................................................-LTAKKMVLA.LLELA-QQD...HGALD-.-CCVVVILSHGcQAS---HLQFPGAVYGT.............DGCP-.V...SVEK----.-----.....-IVNIFNGTSCPS............................................LGGKPK-LFFIQACGGEQKDHGFEVAstspedespgsnpep.................................................................................................................................................datpfqeglrtfdqlDAISSLPTPSDIFVSYSTFPGFVSWRD.................PKSGSWYVETLDDIF.EQWAHS.------EDLQSLLLRVANAVSVK.....................................GIYKQMPGC-FNFLRKKLFF
Q7QKT2_ANOGA/35-260 GIAVVINNNRD----........---RKGSEKDVKALQAVL-SHL.Q.....FDVRL..------...--.......-L...SD.................................................................................-KTTVEIRHA.LKEVS-KED...HTNND-.-CLAIIAMAHG.-YN--------DRIKFD.............DDYL-.-...HIDE----.-----.....-LWTNFVGNKCPS............................................LIGKPK-LVFIQSCRGGKLDYGASIAtadar.....................................................................................................................................................................pgleePVDVKIPMYADLLVMYSSFEHHSSIRC.................RNEGSWFIQSFCQVL.GANIAK.------TELQALLCHVSYLVSIRsdqt............................idpegKVVKQIPMV-TSMLTKAFYF
Q7PZJ9_ANOGA/20-250 GIAVVINDSEN----........---RDGWEKDLEAVETVL-QRL.K.....CDVRT..------...--.......-F...CD.................................................................................-KTKHEIRDA.LRNVS-KED...HTKSD-.-CLVIVAMAHG.-NN--------DKITLR.............RGEM-.-...HIDE----.-----.....-LWTDFVGNGCPS............................................LIGKPK-LVFIQSCRGNKHDYLVGGAavdav.....................................................................................................................................................................pspekPICVEIPMYADLLVMYSSYDQYVSYRD.................KEEGSWFIQSLCQVL.GANIAG.------KDLLTLLTHVSYLVSVRsflmese.......................vnmvkrtGVLKQIPSI-NSMLTKAFYF
Q9GV88_HYDAT/84-316 GTLTIINVKNFMKSSn.....khEYPRLGTDVDAESLCDLF-LKL.G.....FKIDR..------...--.......-L...NN.................................................................................-PKSTDVLNI.LKQAA-NED...YSSMS-.-CCVVALLSHG.-EE--------GKIICT.............NESL-.-...NIRE----.-----.....-ITNLF---CTKA............................................LAGKPK-LFLIQACRGTEYMESLDTVdglgp.....................................................................................................................................................................glsnePNVLDVTVESDFLYAYSTVLGYYSWSS.................QKLGSWFINAAVSVF.RDYAHK.------MDVLRLLTRVNKEVSEKtsit............................dnltkDNKKQIGSL-ISLLRKELFF
Q9GV89_HYDAT/93-318 GFVLIINNEKFVEE-........-ENRDGSEVDVQALNSFFKGTL.G.....WCVKS..------...--.......-C...NN.................................................................................-LKREDIINI.VYSLSQVKCfpfS-----.-ALFIVILSHG.-SE--------SGILGI.............DSSEE.I...KINS----.-----.....-LLENFKADNAPA............................................FDKKPK-VFIVQACRGEKDDIRKDGIkda........................................................................................................................................................................krtyYNESTIPMLSDFVVAYPCAAGYTALRS.................TVKGSWFIQELVKCL.------.SIFYDKEDFLSILNRVNFKVANVt..................................lpQGLKEQPCFEVGLRTRCFFQ
O55194_RAT/200-445 GLALVMSNVHFTGEK.......dLEFRSGGDVDHTTLVTLF-KLL.G.....YNVHV..------...--.......-L...YD.................................................................................-QTAQEMQEK.LQNFAQLPA...HRVTD-.-SCIVALLSHG.-VE--------GGIYGV.............DGKL-.L...QLQE----.-----.....-VFRLFDNANCPS............................................LQNKPK-MFFIQACRGDETDRGVDQQdgknhaqspg...........................................................................................................................................................ceesdagkeeLMKMRLPTRSDMICGYACLKGNAAMRN.................TKRGSWYIEALTQVF.SERACD.------MHVADMLVKVNALIKERegya............................pgtefHRCKEMSEY-CSTLCQQLYL
CASPE_HUMAN/18-241 RLALILCVTKA----........---REGSEEDLDALEHMF-RQL.R.....FESTM..------...--.......-K...RD.................................................................................-PTAEQFQEE.LEKFQQAID...-SREDPvSCAFVVLMAHG.-RE--------GFLKGE.............DGEM-.V...KLEN----.-----.....-LFEALNNKNCQA............................................LRAKPK-VYIIQACRGEQRDPGETVGgdei......................................................................................................................................................................vmvikDSPQTIPTYTDALHVYSTVEGYIAYRH.................DQKGSCFIQTLVDVFtKRKG--.-------HILELLTEVTRRMAEAelv...............................qegKARKTNPEI-QSTLRKRLYL
CASPE_MOUSE/22-256 RLALTLCVTKA----........---REGSEVDMEALERMF-RYL.K.....FESTM..------...--.......-K...RD.................................................................................-PTAQQFLEE.LDEFQQTID...-NWEEPvSCAFVVLMAHG.-EE--------GLLKGE.............DEKM-.V...RLED----.-----.....-LFEVLNNKNCKA............................................LRGKPK-VYIIQACRGEHRDPGEELRgneelggdee...........................................................................................................................................................lggdevavlkNNPQSIPTYTDTLHIYSTVEGYLSYRH.................DEKGSGFIQTLTDVFiHKKG--.-------SILELTEEITRLMANTevm...............................qegKPRKVNPEV-QSTLRKKLYL
Q8I749_SUBDO/254-491 GICLIINNHQFYHSDpe....kcHSNRGGAHIDVHNLTQTF-KYL.R.....YKVEV..------...--.......-V...EN.................................................................................-ISSSEMNKVmLRKASEDHP...--QYD-.-SFVCIIMTQG.---------GSNIVHGA.............DSEAVnL...--------.-----.....-YDLTGVMKMCPT............................................LRGKPK-IFFVQACRGDIESMGFKNEevsktedd..............................................................................................................................................................lqadmpgghLHTDTIPQEADFFYGFATPLGYAAYRS.................RRHGSWYISELCQVF.------.IKHPFTHSLGSMMKKVNNRVSKAy..................................tkDGYKQCTEFVDRLRFEVHFF
Q9TZP5_CAEEL/26-261 CRAIIINNVVFCGM-........-EKRIGSDKDKKKLSKLF-ERL.G.....YQSTS..------...--.......-Y...DN.................................................................................-LKSSEILET.VRQFTQSNH...---GD-.-SLIITIMSHG.-DQ--------GLLYGV.............DG---.V...PVQ-----.-----.....-MLDIIDLMCTAS............................................LAKKPK-WLMCVCCRGDRIDRAVRCDgfidnffdrf..........................................................................................................................................................pkffqfmkskfPSHQTSSSQADLLVSFSTSPGFLSFRD.................ETKGTWYIQELYRVI.IENAKD.------THLADLLMETNRRVVEKyea..............................dkvvIVCKQAPEF-WSRFTKQLFF
O18203_CAEEL/293-532 GTVLILSNENFKNM-........-ERRVGTKQDEVNLTKLF-QKL.Q.....YTVIC..------...--.......-K...RN.................................................................................-LEAESMLEA.IKEFAEMAH...---TD-.-SIILFLLSHG.--------DGAGSVFGI.............DD---.M...PVNV----.-----.....-MEVSTYLAYHQN............................................LLLKPK-WVAVSACRGGKLNMGVPVDglpaledkcap........................................................................................................................................................iskfwnlmmsriMPGTFTSLNADVIISFSTTDGFTSYRD.................EEAGTWYIKSMCKVF.NKHSKT.------MHLLDILTETGRNVVTKyen..............................vqgnVVLKQAPEI-LSRLTKQWHF
Q9V9J6_DROME/313-523 ARVYIFNHERFDNK-........NEFRKGSAQDVKVLRATF-EQL.K.....CKVEV..------...--.......-I...TD.................................................................................-ATLVTIKKT.VRMLQ-TKD...FEDKS-.-ALVLVILSHG.-TR-------HDQIAAK.............DDDY-.-...SLDD----.-----.....--DVVFPILRNRT............................................LKDKPK-LIFVQACKGDCQLGGFMT-...............................................................................................................................................................................DAAQPNGSPNEILKCYSTYEGFVSFRT.................-EDGTPFIQTLCEAL.NRSGKT.------SDIDTIMMNVRQVVKMQ.....................................SKDRQIPSV-TSTLTSKYVF
Q9NBW3_DROME/38-248 PAVYILNHEQFPQDS........QLNRKGSSNDVNALRKTF-ESL.K.....CRVEV..------...--.......-I...SN.................................................................................-PALPDVKNK.VKEWSAKR-...FTQDA-.-GFVLFILSHGdRKE---------KILAC.............DHRE-.Y...HLDD----.-----.....--DVLFPLFRNPT............................................LSGKPK-ILIVQACKGPLRADA----...............................................................................................................................................................................----KKMNNEPYIKCYSCSEGYLSYRN.................ENHGSVFIQTLCEVM.DQYGLT.------RDFQSIFKHVKAEVERRs..................................tmTGSKQVPSEESHNFDKPFYF
Q7QGM9_ANOGA/4-212 AYVLVFHHDQFKNP-........KNNREGSANDMKQIKEFC-QHY.R.....CDRLD..----I-...--.......-N...EN.................................................................................-KTKAEVTRK.MGEIS-RKD...FTKNS-.-CLIVFIMSHG.SAN--------DTIMAK.............DGQF-.Y...SFQD----.-----.....--DVVEYCTSNRT............................................LNDKPK-LFVLQACRGDATMVADA--...............................................................................................................................................................................--TPSMSYKGDIIIFQSSYQGAVSFRD.................TESGSFFMQAFLRLA.HEHNSE.-------SIVKINPLLNQEFTN-.....................................KKIRQTPTL-MTTLRKDLIL
CASP1_PIG/163-400 RLALIICNTEFENL-........-PRRDGADVDIRDMKILL-EDL.G.....YSVDV..------...--.......-R...EN.................................................................................-LTASDMAIE.LKAFAARPE...HKSSD-.-STFLVLMSHG.--------IQAGICGKKys.........eeVPDV-.L...EVNT----.-----.....-VFQILNTLNCPS............................................LKDKPK-VIIIQACRGEKQGVVWIKDsvgpsgnss.............................................................................................................................................................llaaedfeyDAIKKAHIEKDFIAFCSSTPDNVSWRH.................PLLGSLFIIKLIKIL.------.QEHAWSCGLEEIFRKVRFSFELA.....................................DGRAQMPTAERVTLTRSFYL
CASP1_HUMAN/163-400 RLALIICNEEFDSI-........-PRRTGAEVDITGMTMLL-QNL.G.....YSVDV..------...--.......-K...KN.................................................................................-LTASDMTTE.LEAFAHRPE...HKTSD-.-STFLVFMSHG.--------IREGICGKKhs.........eqVPDI-.L...QLNA----.-----.....-IFNMLNTKNCPS............................................LKDKPK-VIIIQACRGDSPGVVWFKDsvgvsgnls.............................................................................................................................................................lptteefedDAIKKAHIEKDFIAFCSSTPDNVSWRH.................PTMGSVFIGRLIEHM.------.QEYACSCDVEEIFRKVRFSFEQP.....................................DGRAQMPTTERVTLTRCFYL
CASP1_MOUSE/162-398 RLALIICNTEFQHL-........-SPRVGAQVDLREMKLLL-EDL.G.....YTVKV..------...--.......-K...EN.................................................................................-LTALEMVKE.VKEFAACPE...HKTSD-.-STFLVFMSHG.--------IQEGICGTTys.........neVSDI-.L...KVDT----.-----.....-IFQMMNTLKCPS............................................LKDKPK-VIIIQACRGEKQGVVLLKDsvrdseed..............................................................................................................................................................fltdaifedDGIKKAHIEKDFIAFCSSTPDNVSWRH.................PVRGSLFIESLIKHM.------.KEYAWSCDLEDIFRKVRFSFEQP.....................................EFRLQMPTADRVTLTKRFYL
CASP1_CANFA/163-400 RLALIICNIEFDHL-........-STRDGAELDIAGMESLL-EGL.G.....YSVVV..------...--.......-K...RK.................................................................................-LTAKGMESV.LREFAARPE...HKSSD-.-STFLVLMSHG.--------ILNGICGTAhs.........veNPDV-.L...AYDT----.-----.....-IFQIFNNRHCLN............................................LKDKPK-VIIIQACRGENPGELWVSDspkastdsw.............................................................................................................................................................thqplmlqsDAIHKVHVEKDFIAFCSSTPHNVSWRH.................ITKGSLFIAQLITCF.------.QKYSWCCHLEGVFRKVQQSFEKP.....................................DVKAQMPTIERVSMTRYFYL
CASP1_FELCA/161-406 RLALIICNTTFDHL-........-SLRKGADLDVAGMRRLL-TDL.G.....YSVHI..------...--.......-K...EE.................................................................................-LTAKDMESE.LRAFAARPE...HKSSD-.-STFLVFMSHG.--------ILSGICGTKys........aegDPDV-.L...AYDT----.-----.....-IFQIFNNRNCLS............................................LKDKPK-VIIVQACRGENLGELLISDspaapmdstsqm......................................................................................................................................................gsslsqvgdnledDAIYKVHVEKDFIAFCSSTPHHVSWRD.................VNKGSLFITQLITCF.------.QKYSWCFHLEEVFRKVQQSFEKP.....................................NVRAQMPTIERLSMTRYFYL
CASPD_BOVIN/136-373 RLALIICNTEFDHM-........-PPRNGAALDILGMKQLL-EGL.G.....YTVEV..------...--.......-E...EK.................................................................................-LTARDMESV.LWKFAAREE...HKSSD-.-STFLVFMSHG.--------ILDGICGTMhs.........eeEPDV-.L...PYDT----.-----.....-IFRTFNNRNCLS............................................LKDKPK-VIIVQACRGANRGELWVSDsppaladsf.............................................................................................................................................................sqssenleeDAVYKTHVEKDFIAFCSSTPHNVSWRD.................IKKGSLFITRLITCF.------.QKYAWCCHLEEVFRKVQQSFEKP.....................................NVKAQMPTVERLSMTRYFYL
CASP5_HUMAN/177-414 RLALIICNTKFDHL-........-PARNGAHYDIVGMKRLL-QGL.G.....YTVVD..------...--.......-E...KN.................................................................................-LTARDMESV.LRAFAARPE...HKSSD-.-STFLVLMSHG.--------ILEGICGTAhk.........kkKPDV-.L...LYDT----.-----.....-IFQIFNNRNCLS............................................LKDKPK-VIIVQACRGEKHGELWVRDspaslavis.............................................................................................................................................................sqssenleaDSVCKIHEEKDFIAFCSSTPHNVSWRD.................RTRGSIFITELITCF.------.QKYSCCCHLMEIFRKVQKSFEVP.....................................QAKAQMPTIERATLTRDFYL
CASP4_MOUSE/132-369 RKALIICNTEFKHL-........-SLRYGAKFDIIGMKGLL-EDL.G.....YDVVV..------...--.......-K...EE.................................................................................-LTAEGMESE.MKDFAALSE...HQTSD-.-STFLVLMSHG.--------TLHGICGTMhs.........ekTPDV-.L...QYDT----.-----.....-IYQIFNNCHCPG............................................LRDKPK-VIIVQACRGGNSGEMWIREsskpqlcrg.............................................................................................................................................................vdlprnmeaDAVKLSHVEKDFIAFYSTTPHHLSYRD.................KTGGSYFITRLISCF.------.RKHACSCHLFDIFLKVQQSFEKA.....................................SIHSQMPTIDRATLTRYFYL
CASPC_MOUSE/176-415 RLALIICNKKFDYL-........-FDRDNADTDILNMQELL-ENL.G.....YSVVL..------...--.......-K...EN.................................................................................-LTAQEMETE.LMQFAGRPE...HQSSD-.-STFLVFMSHG.--------ILEGICGVKhr.........nkKPDV-.L...HDDT----.-----.....-IFKIFNNSNCRS............................................LRNKPK-ILIMQACRGRYNGTIWVSTnkgiatadtd...........................................................................................................................................................eervlsckwnNSITKAHVETDFIAFKSSTPHNISWKV.................GKTGSLFISKLIDCF.------.KKYCWCYHLEEIFRKVQHSFEVP.....................................GELTQMPTIERVSMTRYFYL
CAS1A_XENLA/144-382 GLALIICNEKFENL-........-NERHGAKVDLDGMTKLL-NEL.G.....YQVHP..------...--.......-H...TN.................................................................................-LTKTEMVKV.MKEFAAQEE...HADSD-.-STFIVLMSHG.--------DRQGVCGTDskktek.ekgqyeVTNL-.L...EIDE----.-----.....-IFSTFNNVNCSK............................................LRNKPK-VIIIQACRGENKGGLLVRDdvas......................................................................................................................................................................ppledDGLHFVQREADFICFCSSTPDTVSWRD.................PTKGSVFITHLIEKM.------.NEYAHCQPLGDIFLEVQSLFKDKc...................................pNSRSQMPTQERCTLTKKFYL
O42284_CHICK/42-279 RRALLICNTKFKHL-........-RQRDGAEVDVKEMTKLL-EGL.G.....YNVEC..------...--.......-H...ED.................................................................................-KTSQEMTTV.MKKFADHKD...HLTSD-.-STFLVFMSHG.--------MSTGICGTKs..........ngTTDI-.L...SFNT----.-----.....-IYENFNNKHCRA............................................LMGKPK-VVIIQCCRGDNIGSVQIRDsidpemptst..........................................................................................................................................................sdgwrcvelqgSKTREAHLESDFATLYSSTPDTVSWRS.................PTEGSVFIQRLVEQF.------.RNHAFNSDLQEMFRKVQRSFEN-.....................................-FPRQLPTQERTTMLKKFYL
Q9I9L7_BRARE/145-379 RLALLINNVDFDDK-........AMKRSGSEKDEENMEKLL-KEL.D.....YQVVK..------...--.......-R...PN.................................................................................-LSAKEMDEA.IRDFAQREE...HKYSD-.-SAFVVIMSHG.--------KRDAIMGVHyh.........rtNNPSDsF...PVDN----.-----.....-VYRRLNSENCPA............................................LRDKPK-VILIQACRGGEHGRVWASDgepd......................................................................................................................................................................epieiEDDDFVHKEKDFISLMSCTPDTKSYRH.................VQNGTFYVQTLVDVF.------.IKCAHEDHIEELFRKVLRRFEHPn..................................miGNFKQMACKDRATLPKLFYL
Q9DDJ2_BRARE/174-400 GLALLITNIQFANT-........QHNRDGADRDEENAEWLL-RSL.G.....FAVMK..------...--.......-Y...RN.................................................................................-LSGKDIRRA.VENFSKRRE...HEDAD-.-STFIVIMSHG.-TRIDNKDAIVGV----.............SDDV-.Y...FIEE----.-----.....-TFAHLNSVNCPA............................................LIDKPK-VILIQACRGGQSSGVLAQDs............................................................................................................................................................................vfASDSWVHMEKDFVCFMSTMPNTFAYRN.................PIEGSFFISYIVDVF.------.CSSAHRDDIMELFRKVTLRMEKDqr.................................fkGQAKLLPCIERTSISKRFYL
ICENC_DROME/196-443 GVLLMVNIMDYPDQ-........NRRRIGAEKDSKSLIHLF-QEL.N.....FTIFP..------...--.......-Y...GN.................................................................................-VNQDQFFKL.LTMVTSSSY...VQNTE-.-CFVMVLMTHGnSVEGKEKVEFC------.............DGSV-.V...DMQK----.-----.....-IKDHFQTAKCPY............................................LVNKPK-VLMFPFCRGDEYDLGHPKNqgnlmepvytaq......................................................................................................................................................eekwpdtqtegipSPSTNVPSLADTLVCYANTPGYVTHRD.................LDTGSWYIQKFCQVM.------.ADHAHDTDLEDILKKTSEAVGNKr..................................tkKGSMQTGAYDNLGFNKKLYF
Q6QN97_PIG/259-484 GICLIIDCVG-----........--------NDTDVLRDTF-SSL.G.....YEVQY..------...--.......-F...LY.................................................................................-LKVEQISKI.LRKVARMPQ...HQDYD-.-SFVCVLVSRG.-GSQSVFGV--------.............DKTLSgF...PLDH----.-----.....-IRRMFMADVCPT............................................LLGKPK-LFFIQIYVTSEGQLEDSSFlevdgpsv...............................................................................................................................................................ksmdskarQPGTCTVHREADFFWSLCKADVSLLERp................SSSSSVYLQCLSQKL.-----GkERKVS---LLELHVDLNSKVYDWns.................................rvSAKERYYVRLQHTLRKKVIL
CFLAR_HUMAN/252-477 GICLIIDCIG-----........--------NETELLRDTF-TSL.G.....YEVQK..------...--.......-F...LH.................................................................................-LSMHGISQI.LGQFACMPE...HRDYD-.-SFVCVLVSRG.-GSQSVYGV--------.............DQTHSgL...PLHH----.-----.....-IRRMFMGDSCPY............................................LAGKPK-MFFIQNYVVSEGQLEDSSLlevdgpam...............................................................................................................................................................knvefkaqKRGLCTVHREADFFWSLCTADMSLLEQs................HSSPSLYLQCLSQKL.-----RqERKRP---LLDLHIELNGYMYDWns.................................rvSAKEKYYVWLQHTLRKKLIL
CFLAR_MOUSE/257-481 GICLIIDCIG-----........--------NDTKYLQETF-TSL.G.....YHIQL..------...--.......-F...LF.................................................................................-PKSHDITQI.VRRYASMAQ...HQDYD-.-SFACVLVSLG.-GSQSMMGR--------.............DQVHSgF...SLDH----.-----.....-VKNMFTGDTCPS............................................LRGKPK-LFFIQNYESLGSQLEDSSLevdgpsi................................................................................................................................................................knvdskplQPRHCTTHPEADIFWSLCTADVSHLEKp................SSSSSVYLQKLSQQL.-----KqGRRRP---LVDLHVELMDKVYAWns.................................gvSSKEKYSLSLQHTLRKKLIL
Q6NTR7_XENLA/280-494 GFCLIIDCVG-----........--------NDASLLENTF-KSL.R.....FTVRT..------...--.......-D...RY.................................................................................-CNVEHLESI.LKDVANMEQ...HKNHD-.-IFVCIIISRG.-TSNSIFCI--------.............DSCSLgF...SLDR----.-----.....-IKHIFTGKSCPD............................................LLGKPK-LFFVQNYIAQEDEDLDKMIeadg.......................................................................................................................................................................ptsaCAHSPKIPVEADIFWSHCKVAERYLHQs................PSLPSLYFTYLSQLL.-----NdVEKRKQMHLLDIHTELNRIICH-.....................................-RQEGCNIYQQHTLTKKLFF